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mutLBSgeneDB |
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| Gene summary for METTL21C |
 Gene summary |
| Basic gene Info. | Gene symbol | METTL21C |
| Gene name | methyltransferase like 21C | |
| Synonyms | C13orf39 | |
| Cytomap | UCSC genome browser: 13q33.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001010977.2, | |
| Description | methyltransferase-like protein 21Cprotein-lysine methyltransferase METTL21C | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 615259 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000139780 | ||
| HPRD : 17315 | ||
| Vega : OTTHUMG00000017304 | ||
| Protein | UniProt: Q5VZV1 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_METTL21C | |
| BioGPS: 196541 | ||
| Pathway | NCI Pathway Interaction Database: METTL21C | |
| KEGG: METTL21C | ||
| REACTOME: METTL21C | ||
| Pathway Commons: METTL21C | ||
| Context | iHOP: METTL21C | |
| ligand binding site mutation search in PubMed: METTL21C | ||
| UCL Cancer Institute: METTL21C | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006479 | protein methylation | 22948820 | GO:0018022 | peptidyl-lysine methylation | 22948820 |
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| Ligand binding site mutations for METTL21C |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | A95 | A97S | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for METTL21C |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | A95 | A97S | -0.82778214 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for METTL21C from PDB |
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| Differential gene expression and gene-gene network for METTL21C |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for METTL21C |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for METTL21C |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of METTL21C go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | SAH | S-ADENOSYL-L-HOMOCYSTEINE | 4mtl | A | A95 | SAH | S-ADENOSYL-L-HOMOCYSTEINE | 4mtl | B | A95 |
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| Conservation information for LBS of METTL21C |
| Multiple alignments for Q5VZV1 in multiple species |
| LBS | AA sequence | # species | Species | A121 | ILEIGAGPGLV | 2 | Homo sapiens, Bos taurus | A121 | ILEIGAGAGLV | 1 | Mus musculus | A95 | VVWPGAMALCQ | 2 | Homo sapiens, Bos taurus | A95 | VVWPGATALCQ | 1 | Mus musculus | D141 | QVTATDLPDVL | 3 | Homo sapiens, Mus musculus, Bos taurus | D194 | YVLASDVVYHH | 3 | Homo sapiens, Mus musculus, Bos taurus | F201 | VYHHYFLDKLL | 3 | Homo sapiens, Mus musculus, Bos taurus | G120 | KILEIGAGPGL | 2 | Homo sapiens, Bos taurus | G120 | KILEIGAGAGL | 1 | Mus musculus | G122 | LEIGAGPGLVS | 2 | Homo sapiens, Bos taurus | G122 | LEIGAGAGLVS | 1 | Mus musculus | G88 | SIESYGAVVWP | 2 | Homo sapiens, Bos taurus | G88 | SIENYGTVVWP | 1 | Mus musculus | L142 | VTATDLPDVLG | 3 | Homo sapiens, Mus musculus, Bos taurus | L170 | PEVKELVWGED | 1 | Homo sapiens | L170 | PEVRELVWGED | 1 | Mus musculus | L170 | PEVKELVWGEG | 1 | Bos taurus | S193 | DYVLASDVVYH | 3 | Homo sapiens, Mus musculus, Bos taurus | V145 | TDLPDVLGNLQ | 3 | Homo sapiens, Mus musculus, Bos taurus | V171 | EVKELVWGEDL | 1 | Homo sapiens | V171 | EVRELVWGEDL | 1 | Mus musculus | V171 | EVKELVWGEGL | 1 | Bos taurus | V90 | ESYGAVVWPGA | 2 | Homo sapiens, Bos taurus | V90 | ENYGTVVWPGA | 1 | Mus musculus | V91 | SYGAVVWPGAM | 2 | Homo sapiens, Bos taurus | V91 | NYGTVVWPGAT | 1 | Mus musculus | W172 | VKELVWGEDLD | 1 | Homo sapiens | W172 | VRELVWGEDLE | 1 | Mus musculus | W172 | VKELVWGEGLE | 1 | Bos taurus | W92 | YGAVVWPGAMA | 2 | Homo sapiens, Bos taurus | W92 | YGTVVWPGATA | 1 | Mus musculus | Y197 | ASDVVYHHYFL | 3 | Homo sapiens, Mus musculus, Bos taurus | Y200 | VVYHHYFLDKL | 3 | Homo sapiens, Mus musculus, Bos taurus |
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