mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for METTL21C
Gene summary
Basic gene Info.Gene symbolMETTL21C
Gene namemethyltransferase like 21C
CytomapUCSC genome browser: 13q33.1
Type of geneprotein-coding
Descriptionmethyltransferase-like protein 21Cprotein-lysine methyltransferase METTL21C
Modification date20141207
dbXrefs MIM : 615259
Ensembl : ENSG00000139780
HPRD : 17315
Vega : OTTHUMG00000017304
ProteinUniProt: Q5VZV1
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_METTL21C
BioGPS: 196541
PathwayNCI Pathway Interaction Database: METTL21C
Pathway Commons: METTL21C
ContextiHOP: METTL21C
ligand binding site mutation search in PubMed: METTL21C
UCL Cancer Institute: METTL21C
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006479protein methylation22948820
GO:0018022peptidyl-lysine methylation22948820

Ligand binding site mutations for METTL21C

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for METTL21C
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for METTL21C from PDB

Differential gene expression and gene-gene network for METTL21C
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of METTL21C and the right PPI network was created from samples without mutations in the LBS of METTL21C. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for METTL21C
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for METTL21C
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of METTL21C go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of METTL21C
Multiple alignments for Q5VZV1 in multiple species
LBSAA sequence# speciesSpecies
A121ILEIGAGPGLV2Homo sapiens, Bos taurus
A121ILEIGAGAGLV1Mus musculus
A95VVWPGAMALCQ2Homo sapiens, Bos taurus
A95VVWPGATALCQ1Mus musculus
D141QVTATDLPDVL3Homo sapiens, Mus musculus, Bos taurus
D194YVLASDVVYHH3Homo sapiens, Mus musculus, Bos taurus
F201VYHHYFLDKLL3Homo sapiens, Mus musculus, Bos taurus
G120KILEIGAGPGL2Homo sapiens, Bos taurus
G120KILEIGAGAGL1Mus musculus
G122LEIGAGPGLVS2Homo sapiens, Bos taurus
G122LEIGAGAGLVS1Mus musculus
G88SIESYGAVVWP2Homo sapiens, Bos taurus
G88SIENYGTVVWP1Mus musculus
L142VTATDLPDVLG3Homo sapiens, Mus musculus, Bos taurus
L170PEVKELVWGED1Homo sapiens
L170PEVRELVWGED1Mus musculus
L170PEVKELVWGEG1Bos taurus
S193DYVLASDVVYH3Homo sapiens, Mus musculus, Bos taurus
V145TDLPDVLGNLQ3Homo sapiens, Mus musculus, Bos taurus
V171EVKELVWGEDL1Homo sapiens
V171EVRELVWGEDL1Mus musculus
V171EVKELVWGEGL1Bos taurus
V90ESYGAVVWPGA2Homo sapiens, Bos taurus
V90ENYGTVVWPGA1Mus musculus
V91SYGAVVWPGAM2Homo sapiens, Bos taurus
V91NYGTVVWPGAT1Mus musculus
W172VKELVWGEDLD1Homo sapiens
W172VRELVWGEDLE1Mus musculus
W172VKELVWGEGLE1Bos taurus
W92YGAVVWPGAMA2Homo sapiens, Bos taurus
W92YGTVVWPGATA1Mus musculus
Y197ASDVVYHHYFL3Homo sapiens, Mus musculus, Bos taurus
Y200VVYHHYFLDKL3Homo sapiens, Mus musculus, Bos taurus

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