mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for EIF4E
Gene summary
Basic gene Info.Gene symbolEIF4E
Gene nameeukaryotic translation initiation factor 4E
SynonymsAUTS19|CBP|EIF4E1|EIF4EL1|EIF4F
CytomapUCSC genome browser: 4q23
Type of geneprotein-coding
RefGenesNM_001130678.1,
NM_001130679.1,NM_001968.3,
DescriptioneIF-4EeIF-4F 25 kDa subuniteukaryotic translation initiation factor 4E-like 1mRNA cap-binding protein
Modification date20141207
dbXrefs MIM : 133440
HGNC : HGNC
HPRD : 00591
ProteinUniProt: P06730
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_EIF4E
BioGPS: 1977
PathwayNCI Pathway Interaction Database: EIF4E
KEGG: EIF4E
REACTOME: EIF4E
Pathway Commons: EIF4E
ContextiHOP: EIF4E
ligand binding site mutation search in PubMed: EIF4E
UCL Cancer Institute: EIF4E
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006417regulation of translation22578813


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Ligand binding site mutations for EIF4E

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
S83S82CLUAD1
M101M101IUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for EIF4E
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
M101M101I-0.75713194
S83S82C-0.25272341
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for EIF4E from PDB

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Differential gene expression and gene-gene network for EIF4E
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of EIF4E and the right PPI network was created from samples without mutations in the LBS of EIF4E. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for EIF4E
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0334634Lymphoma, Mantle-Cell2Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for EIF4E
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB016497-Methyl-GpppaSmall molecule
ExperimentalDB019607n-Methyl-8-Hydroguanosine-5'-DiphosphateSmall molecule
ExperimentalDB027167-Methyl-Guanosine-5'-TriphosphateSmall molecule
InvestigationalDB05165LY2275796Small molecule
ExperimentalDB082172,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OLSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of EIF4E go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
GTAP1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE1ipbAM101
MGP7-METHYL-GUANOSINE-5'-TRIPHOSPHATE1ipcAM101
GTAP1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE1wkwAM101
MGO[[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL]PHOSPHONO HYDROGEN PHOSPHATE2v8wAM101
MGO[[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL]PHOSPHONO HYDROGEN PHOSPHATE2v8wEM101
MGQ7-BENZYL GUANINE MONOPHOSPHATE2v8xAM101
MGQ7-BENZYL GUANINE MONOPHOSPHATE2v8xEM101
MGVP-FLUORO-7-BENZYL GUANINE MONOPHOSPHATE2v8yAM101
MGVP-FLUORO-7-BENZYL GUANINE MONOPHOSPHATE2v8yEM101
MGO[[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL]PHOSPHONO HYDROGEN PHOSPHATE2w97AM101
MGP7-METHYL-GUANOSINE-5'-TRIPHOSPHATE3am7AM101
MGO[[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL]PHOSPHONO HYDROGEN PHOSPHATE4azaAM101
MGO[[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL]PHOSPHONO HYDROGEN PHOSPHATE4azaCM101
6LI7-[2-(4-CHLOROPHENOXY)ETHYL]GUANOSINE 5'-(DIHYDROGENPHOSPHATE)4dt6AM101
HLI(4-{7-[2-(4-CHLOROPHENOXY)ETHYL]-2-(METHYLAMINO)-6-OXO-6,7-DIHYDRO-1H-PURIN-8-YL}PHENYL)PHOSPHONIC ACID4dumAM101
MGP7-METHYL-GUANOSINE-5'-TRIPHOSPHATE4tpwAM101
MGP7-METHYL-GUANOSINE-5'-TRIPHOSPHATE4tpwBM101
MGT7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE4tqbAM101
MGT7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE4tqbBM101
M7G7-METHYL-7,8-DIHYDROGUANOSINE-5'-DIPHOSPHATE4tqcAM101
M7G7-METHYL-7,8-DIHYDROGUANOSINE-5'-DIPHOSPHATE4tqcBM101
33R(2E)-2-{2-[4-(3,4-DICHLOROPHENYL)-1,3-THIAZOL-2- YL]HYDRAZINYLIDENE}-3-(2-NITROPHENYL)PROPANOIC ACID4tpwAS83


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Conservation information for LBS of EIF4E
Multiple alignments for P06730 in multiple species
LBSAA sequence# speciesSpecies
A204SHADTATKSGS5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
A204IHED-AKKLDR1Arabidopsis thaliana
A204VHDD-AKKMDK1Oryza sativa subsp. japonica
A204VHKDSSARTSS1Caenorhabditis elegans
A204LHKDTMVKQGS1Drosophila melanogaster
D143IGESFDDYSDD4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D143IGEQF-DHGDE1Arabidopsis thaliana
D143IGEQF-DYGDE1Oryza sativa subsp. japonica
D143VGEQFDEYGDY1Caenorhabditis elegans
D143IGEAF-DHSDQ1Drosophila melanogaster
D143VGEAFDDHSDD1Danio rerio
D144GESFDDYSDDV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D144GEQF-DHGDEI1Arabidopsis thaliana
D144GEQF-DYGDEI1Oryza sativa subsp. japonica
D144GEQFDEYGDYI1Caenorhabditis elegans
D144GEAF-DHSDQI1Drosophila melanogaster
D144GEAFDDHSDDV1Danio rerio
D147FDDYSDDVCGA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D147F-DHGDEICGA1Arabidopsis thaliana
D147F-DYGDEICGA1Oryza sativa subsp. japonica
D147FDEYGDYICGA1Caenorhabditis elegans
D147F-DHSDQICGA1Drosophila melanogaster
D147FDDHSDDVCGA1Danio rerio
D90LMPGCDYSLFK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D90LAHGADFYCFK1Arabidopsis thaliana
D90LVVGADFHCFK1Oryza sativa subsp. japonica
D90LNWGSDYYLFK1Caenorhabditis elegans
D90IKLGSDYSLFK1Drosophila melanogaster
D90LMSGCDYSLFK1Danio rerio
E103IEPMWEDEKNK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E103IEPKWEDPICA2Arabidopsis thaliana, Oryza sativa subsp. japonica
E103IKPMWEDVNNV1Caenorhabditis elegans
E103IRPMWEDAANK1Drosophila melanogaster
E103IEPMWEDERNK1Danio rerio
E132DRFWLETLLCL4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
E132-KSWLYTLLAL1Arabidopsis thaliana
E132-TMWLHTLLAM1Oryza sativa subsp. japonica
E132DHYWLELLMAI1Caenorhabditis elegans
E132DNLWLDVLLCL1Drosophila melanogaster
E132DRFWLETVLCL1Bos taurus
E140LCLIGESFDDY4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E140LALIGEQF-DH1Arabidopsis thaliana
E140LAMIGEQF-DY1Oryza sativa subsp. japonica
E140MAIVGEQFDEY1Caenorhabditis elegans
E140LCLIGEAF-DH1Drosophila melanogaster
E140LCLVGEAFDDH1Danio rerio
E70KFDTVEDFWAL5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
E70TFSTVEEFWSL1Arabidopsis thaliana
E70TFSTVEDFWSL1Oryza sativa subsp. japonica
E70LFDTVEDFWSL1Caenorhabditis elegans
E70SFDTVEDFWSL1Drosophila melanogaster
F47RWALWF---FK5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
F47SWTFWFDNPAV1Arabidopsis thaliana
F47AWTFWFDNPQG1Oryza sativa subsp. japonica
F47RWALWY---LK1Caenorhabditis elegans
F47VWTLWY---LE1Drosophila melanogaster
F48WF---FKNDKS5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
F48WFDNPAVKSKQ1Arabidopsis thaliana
F48WFDNPQGKSKQ1Oryza sativa subsp. japonica
F48WY---LKADRN1Caenorhabditis elegans
F48WY---LENDRS1Drosophila melanogaster
G139LLCLIGESFDD3Homo sapiens, Mus musculus, Rattus norvegicus
G139LLALIGEQF-D1Arabidopsis thaliana
G139LLAMIGEQF-D1Oryza sativa subsp. japonica
G139LMAIVGEQFDE1Caenorhabditis elegans
G139LLCLIGEAF-D1Drosophila melanogaster
G139LLCLVGEAFDD1Danio rerio
G139VLCLIGESFDD1Bos taurus
G208TATKSGSTTKN5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
G208-AKKLDRNAKN1Arabidopsis thaliana
G208-AKKMDKGLKN1Oryza sativa subsp. japonica
G208SSARTSSTVKP1Caenorhabditis elegans
G208TMVKQGSNVKS1Drosophila melanogaster
H200IGYQSHADTAT5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
H200IGFIIHED-AK1Arabidopsis thaliana
H200IGFIVHDD-AK1Oryza sativa subsp. japonica
H200LRYEVHKDSSA1Caenorhabditis elegans
H200LQYQLHKDTMV1Drosophila melanogaster
H37EHYIKHPLQNR4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H37GVPESHPLEHS1Arabidopsis thaliana
H37NPAAPHPLEHA1Oryza sativa subsp. japonica
H37ELLTRHPLQNR1Caenorhabditis elegans
H37EHLYKHPLMNV1Drosophila melanogaster
H37EDYIKHPLQNR1Danio rerio
H78WALYNHIQLSS5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
H78WSLYNNMKHPS1Arabidopsis thaliana
H78WSLYNNIHHPS1Oryza sativa subsp. japonica
H78WSLYNHIQSAG1Caenorhabditis elegans
H78WSLYNHIKPPS1Drosophila melanogaster
I115GGRWLITLNKQ4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I115GGKWTMTFPKE1Arabidopsis thaliana
I115GGKWTFSCGRG1Oryza sativa subsp. japonica
I115GGRWLVVVDKQ1Caenorhabditis elegans
I115GGRWVITLNKS1Drosophila melanogaster
I115GGRWLITLSKQ1Danio rerio
I138TLLCLIGESFD3Homo sapiens, Mus musculus, Rattus norvegicus
I138TLLALIGEQF-1Arabidopsis thaliana
I138TLLAMIGEQF-1Oryza sativa subsp. japonica
I138LLMAIVGEQFD1Caenorhabditis elegans
I138VLLCLIGEAF-1Drosophila melanogaster
I138TLLCLVGEAFD1Danio rerio
I138TVLCLIGESFD1Bos taurus
I195PPKIVIGYQSH4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I195--NNSIGFIIH1Arabidopsis thaliana
I195--KDSIGFIVH1Oryza sativa subsp. japonica
I195PDTEILRYEVH1Caenorhabditis elegans
I195GRNNSLQYQLH1Drosophila melanogaster
I195PPKVIIGYQSH1Danio rerio
I63ANLRLISKFDT5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
I63SSLRPVFTFST1Arabidopsis thaliana
I63SSIRPIHTFST1Oryza sativa subsp. japonica
I63DCLKMVSLFDT1Caenorhabditis elegans
I63DMQNEITSFDT1Drosophila melanogaster
I79ALYNHIQLSSN5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
I79SLYNNMKHPSK1Arabidopsis thaliana
I79SLYNNIHHPSK1Oryza sativa subsp. japonica
I79SLYNHIQSAGG1Caenorhabditis elegans
I79SLYNHIKPPSE1Drosophila melanogaster
K159VNVRAKGDKIA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K159VNIRGKQERIS1Arabidopsis thaliana
K159VSVRGKQERIA1Oryza sativa subsp. japonica
K159VNVRQKGDKVS1Caenorhabditis elegans
K159INIRGKSNKIS1Drosophila melanogaster
K159VNIRTKGDKIA1Danio rerio
K162RAKGDKIAIWT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K162RGKQERISIWT1Arabidopsis thaliana
K162RGKQERIAIWT1Oryza sativa subsp. japonica
K162RQKGDKVSLWT1Caenorhabditis elegans
K162RGKSNKISIWT1Drosophila melanogaster
K162RTKGDKIAIWT1Danio rerio
K206ADTATKSGSTT5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
K206ED-AKKLDRNA1Arabidopsis thaliana
K206DD-AKKMDKGL1Oryza sativa subsp. japonica
K206KDSSARTSSTV1Caenorhabditis elegans
K206KDTMVKQGSNV1Drosophila melanogaster
K49F---FKNDKSK5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
K49FDNPAVKSKQT1Arabidopsis thaliana
K49FDNPQGKSKQA1Oryza sativa subsp. japonica
K49Y---LKADRNK1Caenorhabditis elegans
K49Y---LENDRSK1Drosophila melanogaster
L135WLETLLCLIGE3Homo sapiens, Mus musculus, Rattus norvegicus
L135WLYTLLALIGE1Arabidopsis thaliana
L135WLHTLLAMIGE1Oryza sativa subsp. japonica
L135WLELLMAIVGE1Caenorhabditis elegans
L135WLDVLLCLIGE1Drosophila melanogaster
L135WLETLLCLVGE1Danio rerio
L135WLETVLCLIGE1Bos taurus
L39YIKHPLQNRWA5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
L39PESHPLEHSWT1Arabidopsis thaliana
L39AAPHPLEHAWT1Oryza sativa subsp. japonica
L39LTRHPLQNRWA1Caenorhabditis elegans
L39LYKHPLMNVWT1Drosophila melanogaster
L60TWQANLRLISK5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
L60SWGSSLRPVFT1Arabidopsis thaliana
L60TWGSSIRPIHT1Oryza sativa subsp. japonica
L60EWEDCLKMVSL1Caenorhabditis elegans
L60SWEDMQNEITS1Drosophila melanogaster
L75EDFWALYNHIQ5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
L75EEFWSLYNNMK1Arabidopsis thaliana
L75EDFWSLYNNIH1Oryza sativa subsp. japonica
L75EDFWSLYNHIQ1Caenorhabditis elegans
L75EDFWSLYNHIK1Drosophila melanogaster
M101DGIEPMWEDEK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M101HIIEPKWEDPI1Arabidopsis thaliana
M101NKIEPKWEDPI1Oryza sativa subsp. japonica
M101EGIKPMWEDVN1Caenorhabditis elegans
M101KNIRPMWEDAA1Drosophila melanogaster
M101DGIEPMWEDER1Danio rerio
N59KTWQANLRLIS5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
N59TSWGSSLRPVF1Arabidopsis thaliana
N59ATWGSSIRPIH1Oryza sativa subsp. japonica
N59KEWEDCLKMVS1Caenorhabditis elegans
N59KSWEDMQNEIT1Drosophila melanogaster
N77FWALYNHIQLS5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
N77FWSLYNNMKHP1Arabidopsis thaliana
N77FWSLYNNIHHP1Oryza sativa subsp. japonica
N77FWSLYNHIQSA1Caenorhabditis elegans
N77FWSLYNHIKPP1Drosophila melanogaster
P100KDGIEPMWEDE5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
P100KHIIEPKWEDP1Arabidopsis thaliana
P100KNKIEPKWEDP1Oryza sativa subsp. japonica
P100KEGIKPMWEDV1Caenorhabditis elegans
P100KKNIRPMWEDA1Drosophila melanogaster
P38HYIKHPLQNRW4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
P38VPESHPLEHSW1Arabidopsis thaliana
P38PAAPHPLEHAW1Oryza sativa subsp. japonica
P38LLTRHPLQNRW1Caenorhabditis elegans
P38HLYKHPLMNVW1Drosophila melanogaster
P38DYIKHPLQNRW1Danio rerio
Q121NKQ--QRRSD-4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q121PKE----KSD-1Arabidopsis thaliana
Q121GRG----KSD-1Oryza sativa subsp. japonica
Q121DKQKLQRRTQL1Caenorhabditis elegans
Q121NKS---SKTD-1Drosophila melanogaster
Q121SKQ--QRRAD-1Danio rerio
Q40IKHPLQNRWAL5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
Q40ESHPLEHSWTF1Arabidopsis thaliana
Q40APHPLEHAWTF1Oryza sativa subsp. japonica
Q40TRHPLQNRWAL1Caenorhabditis elegans
Q40YKHPLMNVWTL1Drosophila melanogaster
Q57KSKTWQANLRL5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
Q57KQTSWGSSLRP1Arabidopsis thaliana
Q57KQATWGSSIRP1Oryza sativa subsp. japonica
Q57RNKEWEDCLKM1Caenorhabditis elegans
Q57RSKSWEDMQNE1Drosophila melanogaster
R112NKRGGRWLITL5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
R112CANGGKWTMTF1Arabidopsis thaliana
R112CANGGKWTFSC1Oryza sativa subsp. japonica
R112NVQGGRWLVVV1Caenorhabditis elegans
R112NKQGGRWVITL1Drosophila melanogaster
R157AVVNVRAKGDK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R157AVVNIRGKQER1Arabidopsis thaliana
R157AVVSVRGKQER1Oryza sativa subsp. japonica
R157AVVNVRQKGDK1Caenorhabditis elegans
R157AVINIRGKSNK1Drosophila melanogaster
R157AVVNIRTKGDK1Danio rerio
R186RVYKERLGLPP4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R186KQWKEFLDY--2Arabidopsis thaliana, Oryza sativa subsp. japonica
R186QVLKQKLSIPD1Caenorhabditis elegans
R186HKLRDALRLGR1Drosophila melanogaster
R186RVYKERLGVPP1Danio rerio
R61WQANLRLISKF5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
R61WGSSLRPVFTF1Arabidopsis thaliana
R61WGSSIRPIHTF1Oryza sativa subsp. japonica
R61WEDCLKMVSLF1Caenorhabditis elegans
R61WEDMQNEITSF1Drosophila melanogaster
S141CLIGESFDDYS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S141ALIGEQF-DHG1Arabidopsis thaliana
S141AMIGEQF-DYG1Oryza sativa subsp. japonica
S141AIVGEQFDEYG1Caenorhabditis elegans
S141CLIGEAF-DHS1Drosophila melanogaster
S141CLVGEAFDDHS1Danio rerio
S207DTATKSGSTTK5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
S207D-AKKLDRNAK1Arabidopsis thaliana
S207D-AKKMDKGLK1Oryza sativa subsp. japonica
S207DSSARTSSTVK1Caenorhabditis elegans
S207DTMVKQGSNVK1Drosophila melanogaster
S83HIQLSSNLMPG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S83NMKHPSKLAHG1Arabidopsis thaliana
S83NIHHPSKLVVG1Oryza sativa subsp. japonica
S83HIQSAGGLNWG1Caenorhabditis elegans
S83HIKPPSEIKLG1Drosophila melanogaster
S83HIQLSSNLMSG1Danio rerio
S92PGCDYSLFKDG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S92HGADFYCFKHI1Arabidopsis thaliana
S92VGADFHCFKNK1Oryza sativa subsp. japonica
S92WGSDYYLFKEG1Caenorhabditis elegans
S92LGSDYSLFKKN1Drosophila melanogaster
S92SGCDYSLFKDG1Danio rerio
T116GRWLITLNKQ-4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T116GKWTMTFPKE-1Arabidopsis thaliana
T116GKWTFSCGRG-1Oryza sativa subsp. japonica
T116GRWLVVVDKQK1Caenorhabditis elegans
T116GRWVITLNKS-1Drosophila melanogaster
T116GRWLITLSKQ-1Danio rerio
T205HADTATKSGST5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
T205HED-AKKLDRN1Arabidopsis thaliana
T205HDD-AKKMDKG1Oryza sativa subsp. japonica
T205HKDSSARTSST1Caenorhabditis elegans
T205HKDTMVKQGSN1Drosophila melanogaster
T211KSGSTTKNRFV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T211KLDRNAKNAYT1Arabidopsis thaliana
T211KMDKGLKNRYT1Oryza sativa subsp. japonica
T211RTSSTVKPRIC1Caenorhabditis elegans
T211KQGSNVKSIYT1Drosophila melanogaster
T211KSGSTTKNKFV1Danio rerio
V69SKFDTVEDFWA5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
V69FTFSTVEEFWS1Arabidopsis thaliana
V69HTFSTVEDFWS1Oryza sativa subsp. japonica
V69SLFDTVEDFWS1Caenorhabditis elegans
V69TSFDTVEDFWS1Drosophila melanogaster
W102GIEPMWEDEKN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
W102IIEPKWEDPIC1Arabidopsis thaliana
W102KIEPKWEDPIC1Oryza sativa subsp. japonica
W102GIKPMWEDVNN1Caenorhabditis elegans
W102NIRPMWEDAAN1Drosophila melanogaster
W102GIEPMWEDERN1Danio rerio
W166DKIAIWTTECE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
W166ERISIWTKNAS1Arabidopsis thaliana
W166ERIAIWTKNAA1Oryza sativa subsp. japonica
W166DKVSLWTRDAT1Caenorhabditis elegans
W166NKISIWTADGN1Drosophila melanogaster
W166DKIAIWTTDYE1Danio rerio
W56DKSKTWQANLR5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
W56SKQTSWGSSLR1Arabidopsis thaliana
W56SKQATWGSSIR1Oryza sativa subsp. japonica
W56DRNKEWEDCLK1Caenorhabditis elegans
W56DRSKSWEDMQN1Drosophila melanogaster
W73TVEDFWALYNH5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
W73TVEDFWSLYNH2Caenorhabditis elegans, Drosophila melanogaster
W73TVEEFWSLYNN1Arabidopsis thaliana
W73TVEDFWSLYNN1Oryza sativa subsp. japonica
Y76DFWALYNHIQL5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
Y76EFWSLYNNMKH1Arabidopsis thaliana
Y76DFWSLYNNIHH1Oryza sativa subsp. japonica
Y76DFWSLYNHIQS1Caenorhabditis elegans
Y76DFWSLYNHIKP1Drosophila melanogaster
Y91MPGCDYSLFKD4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y91AHGADFYCFKH1Arabidopsis thaliana
Y91VVGADFHCFKN1Oryza sativa subsp. japonica
Y91NWGSDYYLFKE1Caenorhabditis elegans
Y91KLGSDYSLFKK1Drosophila melanogaster
Y91MSGCDYSLFKD1Danio rerio


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