mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ELK1
Gene summary
Basic gene Info.Gene symbolELK1
Gene nameELK1, member of ETS oncogene family
CytomapUCSC genome browser: Xp11.2
Type of geneprotein-coding
DescriptionETS domain-containing protein Elk-1ETS-like gene 1tyrosine kinase (ELK1) oncogene
Modification date20141207
dbXrefs MIM : 311040
Ensembl : ENSG00000126767
HPRD : 02407
Vega : OTTHUMG00000021452
ProteinUniProt: P19419
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ELK1
BioGPS: 2002
PathwayNCI Pathway Interaction Database: ELK1
Pathway Commons: ELK1
ContextiHOP: ELK1
ligand binding site mutation search in PubMed: ELK1
UCL Cancer Institute: ELK1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0045893positive regulation of transcription, DNA-templated15790681
GO:0045944positive regulation of transcription from RNA polymerase II promoter12750007

Ligand binding site mutations for ELK1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ELK1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ELK1 from PDB

Differential gene expression and gene-gene network for ELK1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ELK1 and the right PPI network was created from samples without mutations in the LBS of ELK1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ELK1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ELK1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ELK1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids1duxCK50 K59 R62
NUCNucleic Acids1duxFK50 K59 R62
NUCNucleic Acids1duxCR62
NUCNucleic Acids1duxFR62

Conservation information for LBS of ELK1
Multiple alignments for P19419 in multiple species
LBSAA sequence# speciesSpecies
D58TNMNYDKLSRA3Homo sapiens, Mus musculus, Rattus norvegicus
F81VSGQKFVYKFV3Homo sapiens, Mus musculus, Rattus norvegicus
K50LWGLRKNKTNM3Homo sapiens, Mus musculus, Rattus norvegicus
K52GLRKNKTNMNY3Homo sapiens, Mus musculus, Rattus norvegicus
K59NMNYDKLSRAL3Homo sapiens, Mus musculus, Rattus norvegicus
K75KNIIRKVSGQK3Homo sapiens, Mus musculus, Rattus norvegicus
K80KVSGQKFVYKF3Homo sapiens, Mus musculus, Rattus norvegicus
L7DPSVTLWQFLL3Homo sapiens, Mus musculus, Rattus norvegicus
M55KNKTNMNYDKL3Homo sapiens, Mus musculus, Rattus norvegicus
R62YDKLSRALRYY3Homo sapiens, Mus musculus, Rattus norvegicus
R65LSRALRYYYDK3Homo sapiens, Mus musculus, Rattus norvegicus
T6MDPSVTLWQFL3Homo sapiens, Mus musculus, Rattus norvegicus
W46EVARLWGLRKN3Homo sapiens, Mus musculus, Rattus norvegicus
Y57KTNMNYDKLSR3Homo sapiens, Mus musculus, Rattus norvegicus
Y66SRALRYYYDKN3Homo sapiens, Mus musculus, Rattus norvegicus
Y67RALRYYYDKNI3Homo sapiens, Mus musculus, Rattus norvegicus
Y68ALRYYYDKNII3Homo sapiens, Mus musculus, Rattus norvegicus

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