mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for EPHA7
Gene summary
Basic gene Info.Gene symbolEPHA7
Gene nameEPH receptor A7
CytomapUCSC genome browser: 6q16.1
Type of geneprotein-coding
DescriptionEPH homology kinase 3EPH-like kinase 11Eph homology kinase-3ephrin type-A receptor 7receptor protein-tyrosine kinase HEK11tyrosine-protein kinase receptor EHK-3
Modification date20141207
dbXrefs MIM : 602190
Ensembl : ENSG00000135333
HPRD : 03721
Vega : OTTHUMG00000015228
ProteinUniProt: Q15375
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_EPHA7
BioGPS: 2045
PathwayNCI Pathway Interaction Database: EPHA7
Pathway Commons: EPHA7
ContextiHOP: EPHA7
ligand binding site mutation search in PubMed: EPHA7
UCL Cancer Institute: EPHA7
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0048013ephrin receptor signaling pathway17726105
GO:0050730regulation of peptidyl-tyrosine phosphorylation17726105
GO:0070372regulation of ERK1 and ERK2 cascade17726105

Ligand binding site mutations for EPHA7
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for EPHA7
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for EPHA7 from PDB

Differential gene expression and gene-gene network for EPHA7
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of EPHA7 and the right PPI network was created from samples without mutations in the LBS of EPHA7. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for EPHA7
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0149925Small Cell Lung Carcinoma1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for EPHA7
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB079705-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamideSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of EPHA7 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of EPHA7
Multiple alignments for Q15375 in multiple species
LBSAA sequence# speciesSpecies
A663RDVAVAIKTLK4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
E682RDFLCEASIMG4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
E712VMIVIEFMENG3Homo sapiens, Mus musculus, Rattus norvegicus
E712VMIVIEYMENG1Gallus gallus
F689SIMGQFDHPNV4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
I711PVMIVIEFMEN3Homo sapiens, Mus musculus, Rattus norvegicus
I711PVMIVIEYMEN1Gallus gallus
K665VAVAIKTLKVG4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
L765AARNILVNSNL4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
M686CEASIMGQFDH4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
M714IVIEFMENGAL3Homo sapiens, Mus musculus, Rattus norvegicus
M714IVIEYMENGAL1Gallus gallus
V647GEFGEVCSGRL4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
V695DHPNVVHLEGV4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus

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