mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for EPHX2
Gene summary
Basic gene Info.Gene symbolEPHX2
Gene nameepoxide hydrolase 2, cytoplasmic
SynonymsCEH|SEH
CytomapUCSC genome browser: 8p21
Type of geneprotein-coding
RefGenesNM_001256482.1,
NM_001256483.1,NM_001256484.1,NM_001979.5,
Descriptionbifunctional epoxide hydrolase 2epoxide hydrataseepoxide hydrolase 2, cytosolicepoxide hydrolase, soluble
Modification date20141207
dbXrefs MIM : 132811
HGNC : HGNC
Ensembl : ENSG00000120915
HPRD : 00582
Vega : OTTHUMG00000102115
ProteinUniProt: P34913
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_EPHX2
BioGPS: 2053
PathwayNCI Pathway Interaction Database: EPHX2
KEGG: EPHX2
REACTOME: EPHX2
Pathway Commons: EPHX2
ContextiHOP: EPHX2
ligand binding site mutation search in PubMed: EPHX2
UCL Cancer Institute: EPHX2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0010628positive regulation of gene expression18974052
GO:0016311dephosphorylation12574508
GO:0042632cholesterol homeostasis18974052
GO:0046272stilbene catabolic process8342951
GO:0046839phospholipid dephosphorylation12574510


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Ligand binding site mutations for EPHX2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
V498V498MHNSC1
N124N124YKIRC1
L417L417SSKCM1
L417,M419S418FSKCM1
D11G12ESKCM1
V159M158ISTAD1
D185D185VSTAD1
I375A377TSTAD1
L428G426VSTAD1
L417,M419S418YUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for EPHX2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
D11G12E0.017467003
L428G426V0.014804878
V498V498M-1.3819497
L417L417S-1.2940981
V159M158I-1.0526394
I375A377T-0.77864179
D185D185V-0.69964798
M419S418Y-0.48265852
L417S418Y-0.48265852
L417S418F-0.45282503
M419S418F-0.45282503
N124N124Y-0.1170037
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for EPHX2 from PDB

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Differential gene expression and gene-gene network for EPHX2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of EPHX2 and the right PPI network was created from samples without mutations in the LBS of EPHX2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for EPHX2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0018801Heart Failure1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for EPHX2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB02029N-Cyclohexyl-N'-(4-Iodophenyl)UreaSmall molecule
ExperimentalDB03677N-Cyclohexyl-N'-DecylureaSmall molecule
ExperimentalDB04213N-Cyclohexyl-N'-(Propyl)Phenyl UreaSmall molecule
ExperimentalDB08256N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINESmall molecule
ExperimentalDB082574-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACIDSmall molecule
ExperimentalDB082586-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACIDSmall molecule
ExperimentalDB082597-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACIDSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of EPHX2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
MGMAGNESIUM(2+)1vj5AD11 D185
MGMAGNESIUM(2+)1zd2PD11 D185
MGMAGNESIUM(2+)1zd3AD11 D185
MGMAGNESIUM(2+)1zd4AD11 D185
MGMAGNESIUM(2+)1zd5AD11 D185
MGMAGNESIUM(2+)4haiAD11 D185
MGMAGNESIUM(2+)4j03AD11 D185
MGMAGNESIUM(2+)3wk4AD11 D185
MGMAGNESIUM(2+)3wk5AD11 D185
MGMAGNESIUM(2+)3wk6AD11 D185
MGMAGNESIUM(2+)3wk7AD11 D185
MGMAGNESIUM(2+)3wk8AD11 D185
MGMAGNESIUM(2+)3wk9AD11 D185
MGMAGNESIUM(2+)3wkaAD11 D185
MGMAGNESIUM(2+)3wkbAD11 D185
MGMAGNESIUM(2+)3wkcAD11 D185
MGMAGNESIUM(2+)3wkdAD11 D185
MGMAGNESIUM(2+)3wkeAD11 D185
MGMAGNESIUM(2+)4oczAD11 D185
MGMAGNESIUM(2+)4od0AD11 D185
MGMAGNESIUM(2+)4y2jAD11 D185
MGMAGNESIUM(2+)4y2pAD11 D185
MGMAGNESIUM(2+)4y2qAD11 D185
MGMAGNESIUM(2+)4y2rAD11 D185
MGMAGNESIUM(2+)4y2sAD11 D185
MGMAGNESIUM(2+)4y2tAD11 D185
MGMAGNESIUM(2+)4y2uAD11 D185
MGMAGNESIUM(2+)4y2vAD11 D185
MGMAGNESIUM(2+)4y2xAD11 D185
MGMAGNESIUM(2+)4y2yAD11 D185
PO4PHOSPHATE ION1vj5AD11 N124
HD24-CYCLOPENTYL-N-[(1S,3R)-5-OXIDANYL-2- ADAMANTYL]-2-[[(3S)-OXOLAN-3-YL]AMINO]PYRIMIDINE-5- CARBOXAMIDE5aluAD11 N124 V159 D185
S0I4-BENZYL-3,4-DIHYDROQUINOXALIN-2(1H)-ONE3wkbAI375
S0J4-{2,5-DIMETHYL-1-[(2R)-TETRAHYDROFURAN-2-YLMETHYL]-1H- PYRROL-3-YL}-1,3-THIAZOL-2-AMINE3wkcAI375
49Q3-[4-(BENZYLOXY)PHENYL]PROPAN-1-OL4y2tAI375
GVG3-METHYL-4-PHENYL-1H-PYRAZOLE5ak4AI375
1P86-BROMO-1,3-DIHYDRO-2H-INDOL-2-ONE5akkAI375
6NJ3-(2-PHENYLETHYL)-1H-INDAZOLE5akyAI375
OE12-PHENYL-N,N-DIPROPYL-1H-BENZIMIDAZOLE-5- SULFONAMIDE5alfAI375
A0J3-BENZYL-3-METHYL-5-(1-METHYLPYRAZOL-4-YL) INDOLIN-2-ONE5aloAI375
9XZ3-(2-METHYLTETRAZOL-5-YL)-5-(3-THIENYL) PYRIDIN-2-AMINE5altAI375
HD24-CYCLOPENTYL-N-[(1S,3R)-5-OXIDANYL-2- ADAMANTYL]-2-[[(3S)-OXOLAN-3-YL]AMINO]PYRIMIDINE-5- CARBOXAMIDE5aluAI375
6NZ5-CYCLOHEXYL-3-PROPYL-1H-PYRIDIN-2-ONE5am5AI375
4UA4-[[(2-METHOXY-5-METHYL-PHENYL)SULFONYLAMINO] METHYL]-4-PHENYL-N-(P-TOLYLMETHYL)PIPERIDINE- 1-CARBOXAMIDE5alhAI375 M419 V498
MZLN-[4-(5-ETHYL-3-PYRIDIN-3-YL-1H-PYRAZOL-1-YL)PHENYL]PYRIDINE-3-CARBOXAMIDE3otqAL417 M419 L428 V498
I23N-CYCLOHEPTYL-1-[(2,4,6-TRIMETHYLPHENYL) SULFONYL]PIPERIDINE-4-CARBOXAMIDE4haiAL417 M419 L428 V498
6N0N-(5,5-DIOXODIBENZOTHIOPHEN-2-YL)-4,4- DIFLUORO-PIPERIDINE-1-CARBOXAMIDE5akeAL417 M419 L428 V498
JQN5-[2-(4-METHYLPHENYL)SULFANYLETHANOYL]-1,3- DIHYDROINDOL-2-ONE5alwAL417 M419 L428 V498
34N4-CYANO-N-{(3S)-3-(4-FLUOROPHENYL)-3-[4-(METHYLSULFONYL)PHENYL]PROPYL}BENZAMIDE3i28AL417 M419 V498
DUL5-(3-ETHYLSULFANYLPHENYL)THIOPHENE-2- CARBOXAMIDE5alxAL417 M419 V498
B7H5-(7-FLUORANYL-3,3-DIMETHYL-2-OXIDANYLIDENE- 1H-INDOL-5-YL)-4-METHYL-1H-PYRAZOLE-3- CARBONITRILE5alyAL417 M419 V498
MVJ5-CYCLOHEXYLSPIRO[1H-INDOLE-3,4'-OXANE]-2-ONE5am4AL417 M419 V498
FVSFULVESTRANT(7BETA,9BETA,13ALPHA,17BETA)-7-{9-[(R)-(4,4,5,5,5- PENTAFLUOROPENTYL)SULFINYL]NONYL}ESTRA-1(10),2,4- TRIENE-3,17-DIOL4j03AL428
7WI1-(3-CHLOROPHENYL)-3-(2-METHOXYETHYL)UREA4c4yAL428
KUF7-METHYL-2H-ISOQUINOLIN-1-ONE5am2AL428
S944-PHENOXY-N-[(1S,2R)-2-PHENYLCYCLOPROPYL]PIPERIDINE-1- CARBOXAMIDE4x6yBL428 V498
8TMN-[4-(TRIFLUOROMETHYLSULFANYL)PHENYL] QUINAZOLIN-4-AMINE5alrAL428 V498
S824-[3-(1-METHYLETHYL)-1,2,4-OXADIAZOL-5-YL]-N-[(1S,2R)-2-PHENYLCYCLOPROPYL]PIPERIDINE-1-CARBOXAMIDE3antBM419
S0A1-[(1R)-1-CYCLOPROPYLETHYL]-3-PHENYLUREA3wk4AM419
S0C2-CYCLOPENTYL-N-(1,3-THIAZOL-2-YL)ACETAMIDE3wk5AM419
S0B(5R)-5-METHYL-N-(2-PHENYLETHYL)-4,5-DIHYDRO-1,3- THIAZOL-2-AMINE3wk6AM419
AUB4-[(TRANS-4-{[(3S,5S,7S)-TRICYCLO[3.3.1.1~3,7~]DEC-1- YLCARBAMOYL]AMINO}CYCLOHEXYL)OXY]BENZOIC ACID3wkeAM419
49GN-[(1-METHYL-1H-PYRAZOL-3-YL)METHYL]-2-PHENYLETHANAMINE4y2jAM419
49O2-(PIPERAZIN-1-YL)PYRIDINE-3-CARBONITRILE4y2rAM419
49RTERT-BUTYL (3R)-1,2,3,4-TETRAHYDROQUINOLIN-3- YLCARBAMATE4y2uAM419
4A02-[({2-[(3S,5S,7S)-TRICYCLO[3.3.1.1~3,7~]DEC-1- YL]ETHYL}AMINO)METHYL]PHENOL4y2xAM419
4VY2-[(5-BROMO-2-PYRIDYL)-METHYL-AMINO]ETHANOL5ai4AM419
BSU1,3-DIPHENYLUREA5ai5AM419
GVG3-METHYL-4-PHENYL-1H-PYRAZOLE5ak4AM419
6NFN-(CYCLOHEXYLMETHYL)-3-(4-PYRIDYL)-1H- PYRAZOL-5-AMINE5akiAM419
Q3B1-[3-[5-(7-AMINOTHIAZOLO[5,4-D]PYRIMIDIN-2- YL)-1-[[(2S)-TETRAHYDROFURAN-2-YL]METHYL] IMIDAZOL-4-YL]PHENYL]-3-(4-METHOXYPHENYL) UREA5aliAM419
QYDN-(4-NITROPHENYL)-2-PHENYL-THIOMORPHOLINE-4- CARBOXAMIDE5alpAM419
GZP1-(3-PHENYL-1H-PYRAZOL-5-YL)CYCLOPENTANOL5alqAM419
XQ91-(1-ADAMANTYL)-3-(1-METHYLSULFONYLPIPERIDIN- 4-YL)UREA5alzAM419
I5T4-OXIDANYLIDENE-N-[(1S,2R)-2- PHENYLCYCLOPROPYL]SPIRO[3H-CHROMENE-2,4'-PIPERIDINE]-1 CARBOXAMIDE5am1AM419
AUB4-[(TRANS-4-{[(3S,5S,7S)-TRICYCLO[3.3.1.1~3, 7~]DEC-1-YLCARBAMOYL]AMINO}CYCLOHEXYL)OXY] BENZOIC ACID5am3AM419
S384-CYANO-N-[(1S,2R)-2-PHENYLCYCLOPROPYL]BENZAMIDE3ansAM419 L428
S384-CYANO-N-[(1S,2R)-2-PHENYLCYCLOPROPYL]BENZAMIDE3ansBM419 L428
S824-[3-(1-METHYLETHYL)-1,2,4-OXADIAZOL-5-YL]-N-[(1S,2R)-2-PHENYLCYCLOPROPYL]PIPERIDINE-1-CARBOXAMIDE3antAM419 L428
2RV1-(1-PROPANOYLPIPERIDIN-4-YL)-3-[4-(TRIFLUOROMETHOXY) PHENYL]UREA4od0AM419 L428
S0E6-(TRIFLUOROMETHYL)-1,3-BENZOTHIAZOL-2-AMINE3wk8AM419 L428 V498
S0F5-(4-BROMOBENZYL)-1,3-THIAZOL-2-AMINE3wk9AM419 L428 V498
S743-{4-[(1-{[(1S,2R,3S)-2,3- DIPHENYLCYCLOPROPYL]CARBAMOYL}PIPERIDIN-4-YL) OXY]PHENYL}PROPANOIC ACID4x6xBM419 L428 V498
6NM4-[5-[3-(TRIFLUOROMETHYL)PHENYL]-1H-PYRAZOL- 4-YL]PYRIDINE5akhAM419 L428 V498
6N8N-(3,3-DIPHENYLPROPYL)PYRROLIDINE-1- CARBOXAMIDE5aklAM419 L428 V498
R4N4-[(3-CHLOROPHENYL)METHYL]-N-[[(3S)-2,3- DIHYDRO-1,4-BENZODIOXIN-3-YL]METHYL]-3- OXIDANYLIDENE-1,4-BENZOTHIAZINE-6- CARBOXAMIDE5algAM419 L428 V498
WMR5-BUTYL-8,8-DIMETHYL-3,6,8,9- TETRAHYDROPYRAZOLO[3,4-B]THIOPYRANO[4,3-D]PYRIDIN-1- AMINE5alkAM419 L428 V498
33NN-(3,3-DIPHENYLPROPYL)PYRIDINE-3-CARBOXAMIDE3i1yAM419 V498
24D4-(PYRIMIDIN-2-YLOXY)-PIPERIDINE-1-CARBOXYLIC ACID 2,4-DICHLORO-BENZYLAMIDE3kooAM419 V498
1LF1-[4-METHYL-6-(METHYLAMINO)-1,3,5-TRIAZIN-2-YL]-N-[2- (TRIFLUOROMETHYL)BENZYL]PIPERIDINE-4-CARBOXAMIDE4jncAM419 V498
S0G6-AMINO-1-METHYL-5-(PIPERIDIN-1-YL)PYRIMIDINE-2,4(1H, 3H)-DIONE3wkaAM419 V498
W9M3-(3,4-DICHLOROPHENYL)-1,1-DIMETHYL-UREA4c4xAM419 V498
W9M3-(3,4-DICHLOROPHENYL)-1,1-DIMETHYL-UREA4c4xBM419 V498
W9L1-ETHYL-3-NAPHTHALEN-1-YLUREA4c4zAM419 V498
W9L1-ETHYL-3-NAPHTHALEN-1-YLUREA4c4zBM419 V498
S743-{4-[(1-{[(1S,2R,3S)-2,3- DIPHENYLCYCLOPROPYL]CARBAMOYL}PIPERIDIN-4-YL) OXY]PHENYL}PROPANOIC ACID4x6xAM419 V498
3C5N-METHYL-1-[3-(PYRIDIN-3-YL)PHENYL]METHANAMINE4y2pAM419 V498
49N1-[3-(TRIFLUOROMETHYL)PYRIDIN-2-YL]PIPERAZINE4y2qAM419 V498
49P1-[3-(TRIFLUOROMETHYL)PHENYL]-1H-PYRAZOL-4-OL4y2sAM419 V498
4XH5-BROMOQUINOLINE5ai6AM419 V498
K2T6-METHYL-1,3-BENZOTHIAZOL-2-AMINE5ai8AM419 V498
K782-BROMO-4-TERT-BUTYL-6-{[(3-PHENYLPROPYL) AMINO]METHYL}PHENOL5ai9AM419 V498
KWB5-CYCLOHEXYL-2-HYDROXYBENZOATE5aiaAM419 V498
KJU6-CHLORO-2H-1,4-BENZOXAZIN-3(4H)-ONE5aibAM419 V498
TGX7-METHYL-2H-1,4-BENZOTHIAZIN-3(4H)-ONE5aicAM419 V498
V2Z3-PROPYL-5-(3-PYRIDYL)-1H-PYRAZIN-2-ONE5ak5AM419 V498
YPN2-[(5-CHLORO-2-PYRIDYL)SULFANYL]ETHANOL5ak6AM419 V498
8NY5-IODANYL-1H-INDAZOLE5akxAM419 V498
6NJ3-(2-PHENYLETHYL)-1H-INDAZOLE5akyAM419 V498
FCW5-CYCLOHEXYL-1,3-DIHYDROINDOL-2-ONE5aldAM419 V498
ONR4-CHLORO-2-ISOXAZOL-5-YL-PHENOL5aleAM419 V498
5ZM5-(4-FLUOROPHENYL)-3,3-DIMETHYL-INDOLIN-2-ONE5alnAM419 V498
5DQN-CYCLOPENTYL-2-[4-(TRIFLUOROMETHYL)PHENYL]- 3H-IMIDAZO[4,5-B]PYRIDINE-7-SULFONAMIDE5alsAM419 V498
HD24-CYCLOPENTYL-N-[(1S,3R)-5-OXIDANYL-2- ADAMANTYL]-2-[[(3S)-OXOLAN-3-YL]AMINO]PYRIMIDINE-5- CARBOXAMIDE5aluAM419 V498
LWS7-FLUORANYL-3,3-DIMETHYL-5-(1-METHYLPYRROL-2- YL)-1H-INDOL-2-ONE5am0AM419 V498
6NZ5-CYCLOHEXYL-3-PROPYL-1H-PYRIDIN-2-ONE5am5AM419 V498
S944-PHENOXY-N-[(1S,2R)-2-PHENYLCYCLOPROPYL]PIPERIDINE-1- CARBOXAMIDE4x6yAV498
4A5(4-BROMO-3-CYCLOPROPYL-1H-PYRAZOL-1-YL)ACETIC ACID4y2vAV498
T5J2-(3-FLUORO-4-METHYL-ANILINO)-4-METHYL- QUINOLIN-5-OL5aljAV498
7GM(3R)-1-(CYCLOPROPYLMETHYL)-3-METHYL-3-(4- METHYLSULFANYLPHENOXY)PYRROLIDINE5almAV498
KUF7-METHYL-2H-ISOQUINOLIN-1-ONE5am2AV498


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Conservation information for LBS of EPHX2
Multiple alignments for P34913 in multiple species
LBSAA sequence# speciesSpecies
A365TPFIPANPNMS1Homo sapiens
A365TPFMPPDPDVS1Mus musculus
A365TPLMPPNPEVS1Rattus norvegicus
A476RNWKWACKSLG1Homo sapiens
A476RNWKWSCKGLG1Mus musculus
A476RNWKWSCKALG1Rattus norvegicus
D11AAFDLDGVLAL2Mus musculus, Rattus norvegicus
D11AVFDLDGVLAL1Homo sapiens
D184EVVFLDDFGSN2Mus musculus, Rattus norvegicus
D184EVVFLDDIGAN1Homo sapiens
D185VVFLDDFGSNL2Mus musculus, Rattus norvegicus
D185VVFLDDIGANL1Homo sapiens
D335VFIGHDWGGML1Homo sapiens
D335VFIGHDWAGVM1Mus musculus
D335VFIGHDWAGVL1Rattus norvegicus
D496VTAEKDIVLRP2Mus musculus, Rattus norvegicus
D496VTAEKDFVLVP1Homo sapiens
D9RVAAFDLDGVL2Mus musculus, Rattus norvegicus
D9RAAVFDLDGVL1Homo sapiens
F20ALPAVFGVLGR1Homo sapiens
F20ALPSIAGAFRR1Mus musculus
F20ALPSIAGVLRH1Rattus norvegicus
F267CLCHGFPESWF2Mus musculus, Rattus norvegicus
F267CLCHGFPESWY1Homo sapiens
F381RSIPVFNYQLY2Mus musculus, Rattus norvegicus
F381KANPVFDYQLY1Homo sapiens
F387NYQLYFQEPGV2Mus musculus, Rattus norvegicus
F387DYQLYFQEPGV1Homo sapiens
F41LLNDAFQKGGP1Homo sapiens
F41FLLGAYQTEFP1Mus musculus
F41FLLGAFQMKFP1Rattus norvegicus
F497TAEKDIVLRPE2Mus musculus, Rattus norvegicus
F497TAEKDFVLVPQ1Homo sapiens
H524IEDCGHWTQIE2Mus musculus, Rattus norvegicus
H524IEDCGHWTQMD1Homo sapiens
I186VFLDDFGSNLK2Mus musculus, Rattus norvegicus
I186VFLDDIGANLK1Homo sapiens
I363LNTPFIPANPN1Homo sapiens
I363LNTPFMPPDPD1Mus musculus
I363LNTPLMPPNPE1Rattus norvegicus
I375SPLESIKANPV1Homo sapiens
I375SPMKVIRSIPV1Mus musculus
I375SPMEVIRSIPV1Rattus norvegicus
K160QVGMIKPEPQI2Mus musculus, Rattus norvegicus
K160QVGMVKPEPQI1Homo sapiens
L10VAAFDLDGVLA2Mus musculus, Rattus norvegicus
L10AAVFDLDGVLA1Homo sapiens
L397VAEAELEKNMS2Mus musculus, Rattus norvegicus
L397VAEAELEQNLS1Homo sapiens
L408RTFKSLFRASD1Homo sapiens
L408RTFKSFFRASD1Mus musculus
L408RTFKSFFRTSD1Rattus norvegicus
L417DES-VLSMHKV1Homo sapiens
L417DETGFIAVHKA1Mus musculus
L417DDMGLLTVNKA1Rattus norvegicus
L428CEAGGLFVNSP1Homo sapiens
L428TEIGGILVNTP1Mus musculus
L428TEMGGILVGTP1Rattus norvegicus
L499EKDIVLRPEMS2Mus musculus, Rattus norvegicus
L499EKDFVLVPQMS1Homo sapiens
M310IEEYCMEVLCK1Homo sapiens
M310IEEYAMELLCK1Mus musculus
M310IEEYAMELLCE1Rattus norvegicus
M339HDWGGMLVWYM1Homo sapiens
M339HDWAGVMVWNM1Mus musculus
M339HDWAGVLVWNM1Rattus norvegicus
M419S-VLSMHKVCE1Homo sapiens
M419TGFIAVHKATE1Mus musculus
M419MGLLTVNKATE1Rattus norvegicus
M469NWYRNTERNWK2Mus musculus, Rattus norvegicus
M469NWYRNMERNWK1Homo sapiens
M503VLRPEMSKNME2Mus musculus, Rattus norvegicus
M503VLVPQMSQHME1Homo sapiens
M54PTEQLMKGKIT2Mus musculus, Rattus norvegicus
M54ATTRLMKGEIT1Homo sapiens
N124TCIVTNNWLDD2Mus musculus, Rattus norvegicus
N124TAILTNTWLDD1Homo sapiens
N366PFIPANPNMSP1Homo sapiens
N366PFMPPDPDVSP1Mus musculus
N366PLMPPNPEVSP1Rattus norvegicus
N472RNTERNWKWSC2Mus musculus, Rattus norvegicus
N472RNMERNWKWAC1Homo sapiens
P268LCHGFPESWFS2Mus musculus, Rattus norvegicus
P268LCHGFPESWYS1Homo sapiens
P361ASLNTPFIPAN1Homo sapiens
P361ASLNTPFMPPD1Mus musculus
P361ASLNTPLMPPN1Rattus norvegicus
P371NPNMSPLESIK1Homo sapiens
P371DPDVSPMKVIR1Mus musculus
P371NPEVSPMEVIR1Rattus norvegicus
Q384PVFNYQLYFQE2Mus musculus, Rattus norvegicus
Q384PVFDYQLYFQE1Homo sapiens
Q42LNDAFQKGGPE1Homo sapiens
Q42LLGAYQTEFPE1Mus musculus
Q42LLGAFQMKFPE1Rattus norvegicus
R410FKSLFRASDES1Homo sapiens
R410FKSFFRASDET1Mus musculus
R410FKSFFRTSDDM1Rattus norvegicus
S374MSPLESIKANP1Homo sapiens
S374VSPMKVIRSIP1Mus musculus
S374VSPMEVIRSIP1Rattus norvegicus
S407SRTFKSLFRAS1Homo sapiens
S407SRTFKSFFRAS1Mus musculus
S407SRTFKSFFRTS1Rattus norvegicus
S415RASDES-VLSM1Homo sapiens
S415RASDETGFIAV1Mus musculus
S415RTSDDMGLLTV1Rattus norvegicus
T123TTCIVTNNWLD2Mus musculus, Rattus norvegicus
T123TTAILTNTWLD1Homo sapiens
T360VASLNTPFIPA1Homo sapiens
T360VASLNTPFMPP1Mus musculus
T360VASLNTPLMPP1Rattus norvegicus
T50FPEGPTEQLMK2Mus musculus, Rattus norvegicus
T50GPEGATTRLMK1Homo sapiens
T51PEGPTEQLMKG2Mus musculus, Rattus norvegicus
T51PEGATTRLMKG1Homo sapiens
V159CQVGMIKPEPQ2Mus musculus, Rattus norvegicus
V159CQVGMVKPEPQ1Homo sapiens
V19LALPAVFGVLG1Homo sapiens
V19LALPSIAGAFR1Mus musculus
V19LALPSIAGVLR1Rattus norvegicus
V416SDES-VLSMHK1Homo sapiens
V416SDETGFIAVHK1Mus musculus
V416SDDMGLLTVNK1Rattus norvegicus
V498AEKDIVLRPEM2Mus musculus, Rattus norvegicus
V498AEKDFVLVPQM1Homo sapiens
W126ILTNTWLDDRA1Homo sapiens
W126IVTNNWLDDGD1Mus musculus
W126IVTNNWLDDSD1Rattus norvegicus
W336FIGHDWGGMLV1Homo sapiens
W336FIGHDWAGVMV1Mus musculus
W336FIGHDWAGVLV1Rattus norvegicus
W473NTERNWKWSCK2Mus musculus, Rattus norvegicus
W473NMERNWKWACK1Homo sapiens
W525EDCGHWTQIEK2Mus musculus, Rattus norvegicus
W525EDCGHWTQMDK1Homo sapiens
Y343GMLVWYMALFY1Homo sapiens
Y343GVMVWNMALFY1Mus musculus
Y343GVLVWNMALFH1Rattus norvegicus
Y383IPVFNYQLYFQ2Mus musculus, Rattus norvegicus
Y383NPVFDYQLYFQ1Homo sapiens
Y466GPLNWYRNTER2Mus musculus, Rattus norvegicus
Y466GPLNWYRNMER1Homo sapiens


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