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mutLBSgeneDB |
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| Gene summary for ERG |
 Gene summary |
| Basic gene Info. | Gene symbol | ERG |
| Gene name | v-ets avian erythroblastosis virus E26 oncogene homolog | |
| Synonyms | erg-3|p55 | |
| Cytomap | UCSC genome browser: 21q22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001136154.1, NM_001136155.1,NM_001243428.1,NM_001243429.1,NM_001243432.2, NM_001291391.1,NM_004449.4,NM_182918.3,NR_111949.1, NM_001243433.1, | |
| Description | TMPRSS2/ERG fusionets-relatedtranscriptional regulator ERGtranscriptional regulator ERG (transforming protein ERG)v-ets avian erythroblastosis virus E26 oncogene relatedv-ets erythroblastosis virus E26 oncogene homologv-ets erythroblastosis virus E2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 165080 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000157554 | ||
| HPRD : 01298 | ||
| Vega : OTTHUMG00000090767 | ||
| Protein | UniProt: P11308 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ERG | |
| BioGPS: 2078 | ||
| Pathway | NCI Pathway Interaction Database: ERG | |
| KEGG: ERG | ||
| REACTOME: ERG | ||
| Pathway Commons: ERG | ||
| Context | iHOP: ERG | |
| ligand binding site mutation search in PubMed: ERG | ||
| UCL Cancer Institute: ERG | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for ERG |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | K362 | M361V | BLCA | 1 | R377 | G377W | BLCA | 1 | K382 | L382I | COAD | 1 | K364 | V364A | GBM | 1 | K387 | H385Y | SKCM | 1 | Y393 | P395H | SKCM | 1 | R374 | D374N | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ERG |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ERG from PDB |
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| Differential gene expression and gene-gene network for ERG |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ERG |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0033578 | Prostatic Neoplasms | 33 | Biomarker, GeneticVariation |
| umls:C0023467 | Leukemia, Myeloid, Acute | 31 | AlteredExpression, Biomarker |
| umls:C0023418 | Leukemia | 15 | AlteredExpression, Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ERG |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ERG go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of ERG |
| Multiple alignments for P11308 in multiple species |
| LBS | AA sequence | # species | Species | G316 | ANPGSGQIQLW | 3 | Homo sapiens, Gallus gallus, Mus musculus | K362 | RWGERKSKPNM | 3 | Homo sapiens, Gallus gallus, Mus musculus | K364 | GERKSKPNMNY | 3 | Homo sapiens, Gallus gallus, Mus musculus | K371 | NMNYDKLSRAL | 3 | Homo sapiens, Gallus gallus, Mus musculus | K382 | RYYYDKNIMTK | 3 | Homo sapiens, Gallus gallus, Mus musculus | K387 | KNIMTKVHGKR | 3 | Homo sapiens, Gallus gallus, Mus musculus | L320 | SGQIQLWQFLL | 3 | Homo sapiens, Gallus gallus, Mus musculus | M367 | KSKPNMNYDKL | 3 | Homo sapiens, Gallus gallus, Mus musculus | Q319 | GSGQIQLWQFL | 3 | Homo sapiens, Gallus gallus, Mus musculus | R374 | YDKLSRALRYY | 3 | Homo sapiens, Gallus gallus, Mus musculus | R377 | LSRALRYYYDK | 3 | Homo sapiens, Gallus gallus, Mus musculus | R392 | KVHGKRYAYKF | 3 | Homo sapiens, Gallus gallus, Mus musculus | W358 | EVARRWGERKS | 3 | Homo sapiens, Gallus gallus, Mus musculus | Y369 | KPNMNYDKLSR | 3 | Homo sapiens, Gallus gallus, Mus musculus | Y378 | SRALRYYYDKN | 3 | Homo sapiens, Gallus gallus, Mus musculus | Y379 | RALRYYYDKNI | 3 | Homo sapiens, Gallus gallus, Mus musculus | Y380 | ALRYYYDKNIM | 3 | Homo sapiens, Gallus gallus, Mus musculus | Y393 | VHGKRYAYKFD | 3 | Homo sapiens, Gallus gallus, Mus musculus |
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