mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ESD
Gene summary
Basic gene Info.Gene symbolESD
Gene nameesterase D
CytomapUCSC genome browser: 13q14.1-q14.2
Type of geneprotein-coding
DescriptionS-formylglutathione hydrolaseesterase 10esterase D/formylglutathione hydrolasemethylumbelliferyl-acetate deacetylase
Modification date20141207
dbXrefs MIM : 133280
Ensembl : ENSG00000139684
HPRD : 00588
Vega : OTTHUMG00000016878
ProteinUniProt: P10768
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ESD
BioGPS: 2098
PathwayNCI Pathway Interaction Database: ESD
Pathway Commons: ESD
ContextiHOP: ESD
ligand binding site mutation search in PubMed: ESD
UCL Cancer Institute: ESD
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for ESD

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ESD
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ESD from PDB

Differential gene expression and gene-gene network for ESD
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ESD and the right PPI network was created from samples without mutations in the LBS of ESD. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ESD
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ESD
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00143GlutathioneSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ESD go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ESD
Multiple alignments for P10768 in multiple species
LBSAA sequence# speciesSpecies
A204WKAYDATHLVK1Homo sapiens
A204WEAYDPCLLIK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A204WEEYDATCLIS1Arabidopsis thaliana
A204WKAYDATCLVK1Rattus norvegicus
A204WEAYDATYLVK1Bos taurus
D203KWKAYDATHLV1Homo sapiens
D203QWEAYDPCLLI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D203AWEEYDATCLI1Arabidopsis thaliana
D203KWKAYDATCLV1Rattus norvegicus
D203KWEAYDATYLV1Bos taurus
D225IDQGKDDQFLL1Homo sapiens
D225IHVGDSDPFLE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D225IDQGENDQFYP1Arabidopsis thaliana
D225IDQGKDDEFLS1Rattus norvegicus
D225IDQGKEDEFLS1Bos taurus
D226DQGKDDQFLLD1Homo sapiens
D226HVGDSDPFLEE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D226DQGENDQFYPD1Arabidopsis thaliana
D226DQGKDDEFLSN1Rattus norvegicus
D226DQGKEDEFLSD1Bos taurus
D259E--GYDHSYYF3Homo sapiens, Rattus norvegicus, Bos taurus
D259KVHGFDHSYYF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D259P--GYDHSYYF1Arabidopsis thaliana
G104FGTGAGFYVDA2Homo sapiens, Bos taurus
G104FGQGAGFYLNA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G104FGVGAGFYLNA1Arabidopsis thaliana
G104FGTGAGFFVNA1Rattus norvegicus
G75AASEHGLVVIA2Rattus norvegicus, Bos taurus
G75SASEHGLVVIA1Homo sapiens
G75QADKYGFAIVF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G75AASTHGIALVA1Arabidopsis thaliana
H153HSMGGHGALIC3Homo sapiens, Rattus norvegicus, Bos taurus
H153HSMGGYGAICG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H153HSMGGHGALTI1Arabidopsis thaliana
H260--GYDHSYYFI4Homo sapiens, Arabidopsis thaliana, Rattus norvegicus, Bos taurus
H260VHGFDHSYYFV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H74QAASEHGLVVI2Rattus norvegicus, Bos taurus
H74QSASEHGLVVI1Homo sapiens
H74FQADKYGFAIV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H74RAASTHGIALV1Arabidopsis thaliana
I157GHGALICALK-3Homo sapiens, Rattus norvegicus, Bos taurus
I157GYGAICGYLKG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I157GHGALTIYLR-1Arabidopsis thaliana
I175SAFAPICNPVL2Homo sapiens, Rattus norvegicus
I175SAFAPIVNPSN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I175SAFAPITNPIN1Arabidopsis thaliana
I175SAFAPLCNPVL1Bos taurus
M120KTNYRMYSYVT2Homo sapiens, Bos taurus
M120AQHYQMYDYIH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M120K-NWRMYDYVV1Arabidopsis thaliana
M120NTNYRMYSYVT1Rattus norvegicus
N9KQISSNKCFGG2Homo sapiens, Rattus norvegicus
N9KVVKEFSVCGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N9SEIGSTKMFDG1Arabidopsis thaliana
P178APICNPVLCPW2Homo sapiens, Rattus norvegicus
P178APIVNPSNVPW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P178APITNPINCAW1Arabidopsis thaliana
P178APLCNPVLCRW1Bos taurus
P46-TGKCPALYWL1Homo sapiens
P46-NKRIPTVFYL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P46SSHKSPVLYWL1Arabidopsis thaliana
P46-SAKCPALYWL1Rattus norvegicus
P46-TGKCPVLYWL1Bos taurus
Q227QGKDDQFLLDG1Homo sapiens
Q227VGDSDPFLEE-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q227QGENDQFYPD-1Arabidopsis thaliana
Q227QGKDDEFLSNG1Rattus norvegicus
Q227QGKEDEFLSDG1Bos taurus
R119WKTNYRMYSYV2Homo sapiens, Bos taurus
R119YAQHYQMYDYI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R119WK-NWRMYDYV1Arabidopsis thaliana
R119WNTNYRMYSYV1Rattus norvegicus
V107GAGFYVDATED2Homo sapiens, Bos taurus
V107GAGFYLNATQE2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana
V107GAGFFVNATED1Rattus norvegicus
Y118PWKTNYRMYSY1Homo sapiens
Y118PYAQHYQMYDY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y118KWK-NWRMYDY1Arabidopsis thaliana
Y118PWNTNYRMYSY1Rattus norvegicus
Y118LWKTNYRMYSY1Bos taurus

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