mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for ESR1

Gene summary

Basic gene Info.	Gene symbol	ESR1
	Gene name	estrogen receptor 1
	Synonyms	ER\|ESR\|ESRA\|ESTRR\|Era\|NR3A1
	Cytomap	UCSC genome browser: 6q25.1
	Type of gene	protein-coding
	RefGenes	NM_000125.3, NM_001122740.1,NM_001122741.1,NM_001122742.1,NM_001291230.1, NM_001291241.1,
	Description	ER-alphaestradiol receptorestrogen nuclear receptor alphaestrogen receptorestrogen receptor alpha E1-E2-1-2estrogen receptor alpha E1-N2-E2-1-2nuclear receptor subfamily 3 group A member 1
	Modification date	20141222
dbXrefs	MIM : 133430
	HGNC : HGNC
	Ensembl : ENSG00000091831
	HPRD : 00589
	Vega : OTTHUMG00000016103
Protein	UniProt: P03372 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_ESR1
	BioGPS: 2099
Pathway	NCI Pathway Interaction Database: ESR1
	KEGG: ESR1
	REACTOME: ESR1
	Pathway Commons: ESR1
Context	iHOP: ESR1
	ligand binding site mutation search in PubMed: ESR1
	UCL Cancer Institute: ESR1
Assigned class in mutLBSgeneDB	A: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for ESR1.	1. "Takeshita T, Yamamoto Y, Yamamoto-Ibusuki M, Inao T, Sueta A, Fujiwara S, Omoto Y, Iwase H. Droplet digital polymerase chain reaction assay for screening of ESR1 mutations in 325 breast cancer specimens. Transl Res. 2015 Dec;166(6):540-553.e2. doi: 10.1016/j.trsl.2015.09.003. Epub 2015 Sep 14. PubMed PMID: 26434753. " 26434753 2. "Niu J, Andres G, Kramer K, Kundranda MN, Alvarez RH, Klimant E, Parikh AR, Tan B, Staren ED, Markman M. Incidence and clinical significance of ESR1 mutations in heavily pretreated metastatic breast cancer patients. Onco Targets Ther. 2015 Nov 11;8:3323-8. doi: 10.2147/OTT.S92443. eCollection 2015. PubMed PMID: 26648736; PubMed Central PMCID: PMC4648593. " 26648736 3. "Fanning SW, Mayne CG, Dharmarajan V, Carlson KE, Martin TA, Novick SJ, Toy W, Green B, Panchamukhi S, Katzenellenbogen BS, Tajkhorshid E, Griffin PR, Shen Y, Chandarlapaty S, Katzenellenbogen JA, Greene GL. Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation. Elife. 2016 Feb 2;5. pii: e12792. doi: 10.7554/eLife.12792. PubMed PMID: 26836308; PubMed Central PMCID: PMC4821807. " 26836308

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0010629	negative regulation of gene expression	21695196
GO:0032355	response to estradiol	15304487
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	16043358
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	10816575
GO:0043627	response to estrogen	11581164
GO:0045429	positive regulation of nitric oxide biosynthetic process	21937726
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	12047722
GO:0048386	positive regulation of retinoic acid receptor signaling pathway	15831516
GO:0051000	positive regulation of nitric-oxide synthase activity	21937726
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	10681512

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Ligand binding site mutations for ESR1

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
R394	R394L	COAD	1
P406	P406H	COAD	1
G521	N519S	COAD	1
E443	E443D	COAD	1
C188	D190N	COAD	1
Y197	Y197C	HNSC	1
E397	P399R	LUAD	1
L391,W393	V392I	LUAD	1
L540,E542	L541Q	LUAD	1
H373	H373N	LUSC	1
H196	H196R	LUSC	1
T334	P336T	OV	1
R241	R243C	SKCM	1
V376	V376A	STAD	1
L354	L354M	STAD	1
Y537	Y537C	UCEC	1
V418	K416N	UCEC	1
Y537	Y537N	UCEC	1
Y537	Y537S	UCEC	1
D538	D538G	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for ESR1

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
R241	R243C	-1.5398228
C188	D190N	-1.2737098
L354	L354M	-1.2376596
H373	H373N	-1.2362343
V376	V376A	-1.1808581
Y537	Y537N	-1.1617073
Y537	Y537S	-1.0458579
G521	N519S	-1.020436
E542	L541Q	-0.99237364
L540	L541Q	-0.99237364
E443	E443D	-0.96747678
V418	K416N	-0.86597891
Y537	Y537C	-0.80294669
T334	P336T	-0.7794062
P406	P406H	-0.70998485
H196	H196R	-0.7006232
Y197	Y197C	-0.59449563
W393	V392I	-0.57734686
L391	V392I	-0.57734686
D538	D538G	-0.53550876
R394	R394L	-0.49115487
E397	P399R	-0.14225486

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ESR1 from PDB

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Differential gene expression and gene-gene network for ESR1

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of ESR1 and the right PPI network was created from samples without mutations in the LBS of ESR1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for ESR1

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C1458155	Breast Neoplasms	428	AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0027627	Neoplasm Metastasis	95	AlteredExpression, Biomarker, GeneticVariation
umls:C0007097	Carcinoma	77	AlteredExpression, Biomarker, GeneticVariation
umls:C0023267	Leiomyoma	35	AlteredExpression, Biomarker, GeneticVariation
umls:C0028754	Obesity	30	Biomarker, GeneticVariation
umls:C2239176	Carcinoma, Hepatocellular	27	Biomarker, GeneticVariation
umls:C1956346	Coronary Artery Disease	25	Biomarker, GeneticVariation
umls:C0002395	Alzheimer Disease	23	AlteredExpression, Biomarker, GeneticVariation
umls:C0001418	Adenocarcinoma	23	AlteredExpression, Biomarker
umls:C0014170	Endometrial Neoplasms	18	AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0027051	Myocardial Infarction	14	Biomarker, GeneticVariation
umls:C0149931	Migraine Disorders	14	Biomarker, GeneticVariation
umls:C0033578	Prostatic Neoplasms	12	AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0021364	Infertility, Male	11	Biomarker, GeneticVariation
umls:C3809250	ESTROGEN RESISTANCE	11	Biomarker, GeneticVariation
umls:C0004153	Atherosclerosis	9	Biomarker, GeneticVariation
umls:C0024667	Mammary Neoplasms, Animal	8	Biomarker, GeneticVariation
umls:C0023903	Liver Neoplasms	7	Biomarker, GeneticVariation
umls:C0024121	Lung Neoplasms	6	Biomarker, PostTranslationalModification
umls:C0023418	Leukemia	6	Biomarker, GeneticVariation
umls:C0021361	Infertility, Female	3	Biomarker, GeneticVariation
umls:C0028960	Oligospermia	3	Biomarker, GeneticVariation
umls:C0282612	Prostatic Intraepithelial Neoplasia	2	Biomarker
umls:C0242656	Disease Progression	2	Biomarker, GeneticVariation
umls:C0025500	Mesothelioma	2	Biomarker
umls:C0024668	Mammary Neoplasms, Experimental	1	Biomarker
umls:C0005944	Bone Diseases, Metabolic	1	Biomarker
umls:C0012644	Disease Models, Animal	1	Biomarker
umls:C1720887	Female Urogenital Diseases	1	Biomarker
umls:C0015799	Feminization	1	Biomarker
umls:C0017658	Glomerulonephritis	1	Biomarker
umls:C0027643	Neoplasm Recurrence, Local	1	Biomarker
umls:C0031117	Peripheral Nervous System Diseases	1	Biomarker
umls:C0033941	Psychoses, Substance-Induced	1	Biomarker
umls:C0005695	Urinary Bladder Neoplasms	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for ESR1

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Approved	DB00255	Diethylstilbestrol	Small molecule
Withdrawn	DB00269	Chlorotrianisene	Small molecule
Approved	DB00286	Conjugated Estrogens	Small molecule
Approved\|investigational	DB00294	Etonogestrel	Small molecule
Approved	DB00304	Desogestrel	Small molecule
Approved\|investigational	DB00367	Levonorgestrel	Small molecule
Approved\|vet_approved	DB00396	Progesterone	Small molecule
Approved\|investigational	DB00481	Raloxifene	Small molecule
Approved\|investigational	DB00539	Toremifene	Small molecule
Approved\|investigational	DB00603	Medroxyprogesterone acetate	Small molecule
Approved	DB00655	Estrone	Small molecule
Approved	DB00675	Tamoxifen	Small molecule
Approved\|investigational\|vet_approved	DB00783	Estradiol	Small molecule
Approved	DB00823	Ethynodiol diacetate	Small molecule
Approved\|investigational	DB00882	Clomifene	Small molecule
Approved	DB00890	Dienestrol	Small molecule
Approved\|investigational	DB00947	Fulvestrant	Small molecule
Approved	DB00957	Norgestimate	Small molecule
Approved	DB00977	Ethinyl Estradiol	Small molecule
Approved\|nutraceutical\|vet_approved	DB01065	Melatonin	Small molecule
Approved\|investigational\|vet_approved\|withdrawn	DB01108	Trilostane	Small molecule
Approved\|vet_approved	DB01183	Naloxone	Small molecule
Approved\|illicit	DB01185	Fluoxymesterone	Small molecule
Approved	DB01196	Estramustine	Small molecule
Approved	DB01357	Mestranol	Small molecule
Approved	DB01406	Danazol	Small molecule
Approved	DB01431	Allylestrenol	Small molecule
Investigational	DB01645	Genistein	Small molecule
Nutraceutical	DB01708	Dehydroepiandrosterone	Small molecule
Experimental	DB02615	Compound 19	Small molecule
Experimental	DB02715	Compound 18	Small molecule
Experimental	DB03742	Compound 4-D	Small molecule
Experimental	DB03802	1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol	Small molecule
Investigational	DB04468	Afimoxifene	Small molecule
Experimental	DB04471	2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol	Small molecule
Approved\|vet_approved	DB04573	Estriol	Small molecule
Approved	DB04574	Estrone sulfate	Small molecule
Approved	DB04575	Quinestrol	Small molecule
Approved	DB04938	Ospemifene	Small molecule
Investigational	DB05233	AP1081	Small molecule
Investigational	DB05338	atamestane-plus-toremifene	Small molecule
Investigational	DB05487	CC-8490	Small molecule
Investigational	DB05662	NP-50301	Small molecule
Investigational	DB05882	CHF 4227	Small molecule
Approved\|investigational	DB06401	Bazedoxifene	Small molecule
Experimental	DB06871	17-METHYL-17-ALPHA-DIHYDROEQUILENIN	Small molecule
Experimental	DB06898	4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol	Small molecule
Experimental	DB06927	[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE	Small molecule
Experimental	DB07086	4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	Small molecule
Experimental	DB07087	4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	Small molecule
Experimental	DB07195	4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	Small molecule
Experimental	DB07567	(2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL	Small molecule
Experimental	DB07638	(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	Small molecule
Experimental	DB07678	(9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL	Small molecule
Experimental	DB07707	(9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL	Small molecule
Experimental	DB07708	3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL	Small molecule
Experimental	DB07712	3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL	Small molecule
Experimental	DB07932	dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate	Small molecule
Experimental	DB07933	(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	Small molecule
Experimental	DB07991	N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE	Small molecule
Experimental	DB08020	(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	Small molecule
Experimental	DB08047	4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol	Small molecule
Experimental	DB08048	4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL	Small molecule
Experimental	DB08320	DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE	Small molecule
Experimental	DB08398	2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	Small molecule
Experimental	DB08595	4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	Small molecule
Experimental	DB08737	(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL	Small molecule
Experimental	DB08773	RALOXIFENE CORE	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ESR1 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
ZN		ZINC(2+)	4aa6	A	C188
ZN		ZINC(2+)	4aa6	B	C188
ZN		ZINC(2+)	4aa6	E	C188
ZN		ZINC(2+)	4aa6	F	C188
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2q6j	B	E542
459		4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	2fai	B	G521
KN1		4-[1-ALLYL-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	3os9	A	G521
KN1		4-[1-ALLYL-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	3os9	B	G521
KN1		4-[1-ALLYL-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	3os9	C	G521
KN1		4-[1-ALLYL-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	3os9	D	G521
27H	FERUTININE	(3R,3AS,4S,8AR)-3-HYDROXY-6,8A-DIMETHYL-3-(PROPAN-2- YL)-1,2,3,3A,4,5,8,8A-OCTAHYDROAZULEN-4-YL 4- HYDROXYBENZOATE	4mg7	A	G521
27H	FERUTININE	(3R,3AS,4S,8AR)-3-HYDROXY-6,8A-DIMETHYL-3-(PROPAN-2- YL)-1,2,3,3A,4,5,8,8A-OCTAHYDROAZULEN-4-YL 4- HYDROXYBENZOATE	4mg7	B	G521
XBR		3-(1-(4-CHLOROPHENYL)-3,4-DIHYDRO-1H- PYRIDO(3,4-B)INDOL-2(9H)-YL)PROPANOIC ACID	5aau	A	G521
GW5		GW5638	5aav	B	G521
ODE		DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE	2qh6	A	G521 L540
GW5		GW5638	1r5k	A	G521 Y537
GW5		GW5638	1r5k	B	G521 Y537
GW5		GW5638	1r5k	C	G521 Y537
NUC		Nucleic Acids	4aa6	A	H196 Y197
NUC		Nucleic Acids	4aa6	B	H196 Y197
NUC		Nucleic Acids	4aa6	E	H196 Y197
NUC		Nucleic Acids	4aa6	F	H196 Y197
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	1zky	A	H373 V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2qa8	A	H373 V376 D538 E542
III		Peptide ligand (LYS,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2qgw	A	H373 V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2qh6	B	H373 V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2qzo	B	H373 V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4iv2	A	H373 V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4pp6	B	H373 V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN)	4q13	B	H373 V376 E542
RAL		RALOXIFENE	1err	A	L354 L391 R394
RAL		RALOXIFENE	1err	B	L354 L391 R394
L4G		6-(4-METHYLSULFONYL-PHENYL)-5-[4-(2-PIPERIDIN-1-YLETHOXY)PHENOXY]NAPHTHALEN-2-OL	2ayr	A	L354 L391 R394
RAL		RALOXIFENE	2jfa	A	L354 L391 R394
RAL		RALOXIFENE	2jfa	B	L354 L391 R394
C3D		(5R,6S)-6-PHENYL-5-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]-5,6,7,8-TETRAHYDRONAPHTHALEN-2-OL	2ouz	A	L354 L391 R394
RAL		RALOXIFENE	2qxs	A	L354 L391 R394
RAL		RALOXIFENE	2qxs	B	L354 L391 R394
LLB		[6-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOTHIEN-3-YL]{4-[2-(4-METHYLPIPERIDIN-1-YL)ETHOXY]PHENYL}METHANONE	2r6w	B	L354 L391 R394
29S	BAZEDOXIFENE	1-{4-[2-(AZEPAN-1-YL)ETHOXY]BENZYL}-2-(4- HYDROXYPHENYL)-3-METHYL-1H-INDOL-5-OL	4xi3	A	L354 L391 R394
29S	BAZEDOXIFENE	1-{4-[2-(AZEPAN-1-YL)ETHOXY]BENZYL}-2-(4- HYDROXYPHENYL)-3-METHYL-1H-INDOL-5-OL	4xi3	B	L354 L391 R394
29S	BAZEDOXIFENE	1-{4-[2-(AZEPAN-1-YL)ETHOXY]BENZYL}-2-(4- HYDROXYPHENYL)-3-METHYL-1H-INDOL-5-OL	4xi3	C	L354 L391 R394
29S	BAZEDOXIFENE	1-{4-[2-(AZEPAN-1-YL)ETHOXY]BENZYL}-2-(4- HYDROXYPHENYL)-3-METHYL-1H-INDOL-5-OL	4xi3	D	L354 L391 R394
CM4		(2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL	1yim	A	L354 L391 R394 G521
CM3		(2R,3R,4S)-5-FLUORO-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL	1yin	A	L354 L391 R394 G521
LLB		[6-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOTHIEN-3-YL]{4-[2-(4-METHYLPIPERIDIN-1-YL)ETHOXY]PHENYL}METHANONE	2r6w	A	L354 L391 R394 G521
IOG		N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-[2-PHENYL-6-(2-PIPERIDIN-1-YLETHOXY)-1H-INDOL-3-YL]ACETAMIDE	2iog	A	L354 L391 R394 V418 G521
OHT		AFIMOXIFENE	4q50	G	L354 R394
E4D		COMPOUND 4-D	1sj0	A	L354 R394 G521
AIH		COMPOUND 15	1xp1	A	L354 R394 G521
AIU		COMPOUND 16	1xp6	A	L354 R394 G521
AIJ		COMPOUND 18	1xp9	A	L354 R394 G521
AIT		COMPOUND 19	1xpc	A	L354 R394 G521
AEJ		1-[4-(OCTAHYDRO-PYRIDO[1,2-A]PYRAZIN-2-YL)-PHENYL]-2-PHENYL-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL	1xqc	D	L354 R394 G521
OHT		AFIMOXIFENE	2bj4	A	L354 R394 G521
OHT		AFIMOXIFENE	2bj4	B	L354 R394 G521
OHT		AFIMOXIFENE	2jf9	A	L354 R394 G521
III		Peptide ligand (SER,PRO,GLY,SER,ARG,GLU,TRP,PHE,LYS,ASP,MET,LEU,SER)	2jf9	A	L354 V376
III		Peptide ligand (SER,PRO,GLY,SER,ARG,GLU,TRP,PHE,LYS,ASP,MET,LEU,SER)	2jf9	B	L354 V376
III		Peptide ligand (SER,PRO,GLY,SER,ARG,GLU,TRP,PHE,LYS,ASP,MET,LEU,SER)	2jf9	C	L354 V376
III		Peptide ligand (ASP,ALA,PHE,GLN,LEU,ARG,GLN,LEU,ILE,LEU,ARG,GLY,LEU,GLN,ASP)	2jfa	A	L354 V376
III		Peptide ligand (ASP,ALA,PHE,GLN,LEU,ARG,GLN,LEU,ILE,LEU,ARG,GLY,LEU,GLN,ASP)	2jfa	B	L354 V376
KN1		4-[1-ALLYL-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	3os9	A	L391
STL		RESVERATROL	4pp6	B	L391
FSV	FLUORO-RESVERATROL	5-[(E)-2-(3-FLUORO-4-HYDROXYPHENYL)ETHENYL]BENZENE-1,3- DIOL	4ppp	B	L391
XDH		TETRACHLORODIAN	4mgb	B	L391
27M		BIS(2,4-DIHYDROXYPHENYL)METHANONE	4mgc	A	L391
27M		BIS(2,4-DIHYDROXYPHENYL)METHANONE	4mgc	B	L391
PIQ		PHIP	2qxm	A	L391 G521
J3Z		ESTRONE	3hm1	A	L391 G521
27E	CHLORDECONE	(1R,3AR,5BS,6S)-1,1A,3,3A,4,5,5,5A,5B,6- DECACHLOROOCTAHYDRO-2H-1,3,4-(METHANETRIYL) CYCLOBUTA[CD]PENTALEN-2-ONE	4mg5	A	L391 G521
27E	CHLORDECONE	(1R,3AR,5BS,6S)-1,1A,3,3A,4,5,5,5A,5B,6- DECACHLOROOCTAHYDRO-2H-1,3,4-(METHANETRIYL) CYCLOBUTA[CD]PENTALEN-2-ONE	4mg5	B	L391 G521
27G		BENZYL BUTYL BENZENE-1,2-DICARBOXYLATE	4mg6	A	L391 G521
27J	ALPHA-ZEARALANOL	(3S,7R)-7,14,16-TRIHYDROXY-3-METHYL-3,4,5,6,7,8,9,10, 11,12-DECAHYDRO-1H-2-BENZOXACYCLOTETRADECIN-1-ONE	4mg8	A	L391 G521
27J	ALPHA-ZEARALANOL	(3S,7R)-7,14,16-TRIHYDROXY-3-METHYL-3,4,5,6,7,8,9,10, 11,12-DECAHYDRO-1H-2-BENZOXACYCLOTETRADECIN-1-ONE	4mg8	B	L391 G521
XDH		TETRACHLORODIAN	4mgb	A	L391 G521
36J		(3S,7R,11E)-7,14,16-TRIHYDROXY-3-METHYL-3,4,5,6,7,8,9, 10-OCTAHYDRO-1H-2-BENZOXACYCLOTETRADECIN-1-ONE	4tuz	A	L391 G521
36J		(3S,7R,11E)-7,14,16-TRIHYDROXY-3-METHYL-3,4,5,6,7,8,9, 10-OCTAHYDRO-1H-2-BENZOXACYCLOTETRADECIN-1-ONE	4tuz	B	L391 G521
GW5		GW5638	5aav	A	L391 G521
A48		(N-2,2,2-TRIFLUOROETHYL-P-HYDROXYLANILINO)DIMESITYLBORANE	2q6j	A	L391 G521 L540
EST		ESTRADIOL	1a52	A	L391 R394
EST		ESTRADIOL	1a52	B	L391 R394
EST		ESTRADIOL	1ere	A	L391 R394
EST		ESTRADIOL	1ere	B	L391 R394
EST		ESTRADIOL	1ere	C	L391 R394
EST		ESTRADIOL	1ere	D	L391 R394
EST		ESTRADIOL	1ere	E	L391 R394
EST		ESTRADIOL	1ere	F	L391 R394
EST		ESTRADIOL	1gwr	A	L391 R394
EST		ESTRADIOL	1pcg	A	L391 R394
EST		ESTRADIOL	1pcg	B	L391 R394
EST		ESTRADIOL	1qkt	A	L391 R394
244		[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE	1x7e	A	L391 R394
458		4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	2b1v	A	L391 R394
458		4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	2b1v	B	L391 R394
17M		17-METHYL-17-ALPHA-DIHYDROEQUILENIN	2b1z	A	L391 R394
17M		17-METHYL-17-ALPHA-DIHYDROEQUILENIN	2b1z	B	L391 R394
459		4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	2fai	A	L391 R394
DRQ		(9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL	2g5o	A	L391 R394
OHT		AFIMOXIFENE	2jf9	C	L391 R394
DC8		(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	2q70	B	L391 R394
GEN		GENISTEIN	2qa8	B	L391 R394
EED		(9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL	2qgt	A	L391 R394
EED		(9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL	2qgt	B	L391 R394
PIQ		PHIP	2qxm	B	L391 R394
LLC		[6-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOTHIEN-3-YL][4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]METHANONE	2r6y	A	L391 R394
LLC		[6-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOTHIEN-3-YL][4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]METHANONE	2r6y	B	L391 R394
EST		ESTRADIOL	2yja	B	L391 R394
369		5-(4-HYDROXYPHENOXY)-6-(3-HYDROXYPHENYL)-7-METHYLNAPHTHALEN-2-OL	3dt3	A	L391 R394
KN1		4-[1-ALLYL-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	3os9	C	L391 R394
KN1		4-[1-ALLYL-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	3os9	D	L391 R394
KN3		4-[1-(3-METHYLBUT-2-EN-1-YL)-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	3osa	D	L391 R394
ESL		ESTRIOL	3q95	A	L391 R394
0CZ	BISPHENOL AF	4,4'-(1,1,1,3,3,3-HEXAFLUOROPROPANE-2,2-DIYL)DIPHENOL	3uua	A	L391 R394
15Q		2-CHLORO-3'-FLUORO-3-[(E)-(HYDROXYIMINO) METHYL]BIPHENYL-4,4'-DIOL	4iwf	A	L391 R394
15Q		2-CHLORO-3'-FLUORO-3-[(E)-(HYDROXYIMINO) METHYL]BIPHENYL-4,4'-DIOL	4iwf	B	L391 R394
FSV	FLUORO-RESVERATROL	5-[(E)-2-(3-FLUORO-4-HYDROXYPHENYL)ETHENYL]BENZENE-1,3- DIOL	4ppp	A	L391 R394
27K		BUTYL 4-HYDROXYBENZOATE	4mg9	B	L391 R394
27L		4-(2,4,4-TRIMETHYLPENTAN-2-YL)PHENOL	4mga	A	L391 R394
OHT		AFIMOXIFENE	4q50	A	L391 R394
OHT		AFIMOXIFENE	4q50	B	L391 R394
OHT		AFIMOXIFENE	4q50	H	L391 R394
85Z		(E)-3-[4-[[3-(4-FLUORANYL-2-METHYL-PHENYL)-7- OXIDANYL-2-OXIDANYLIDENE-CHROMEN-4-YL]METHYL] PHENYL]PROP-2-ENOIC ACID	5ak2	B	L391 R394
ETC		(R,R)-CIS-DIETHYLTETRAHYDRO-2,8-CHRYSENEDIOL	1l2i	B	L391 R394 G521
EST		ESTRADIOL	1qku	A	L391 R394 G521
EST		ESTRADIOL	1qku	B	L391 R394 G521
EST		ESTRADIOL	1qku	C	L391 R394 G521
PTI		2-PHENYL-1-[4-(2-PIPERIDIN-1-YL-ETHOXY)-PHENYL]-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL	1uom	A	L391 R394 G521
DRQ		(9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL	2g5o	B	L391 R394 G521
EZT		(17BETA)-17-{(E)-2-[2-(TRIFLUOROMETHYL)PHENYL]VINYL}ESTRA-1(10),2,4-TRIENE-3,17-DIOL	2p15	B	L391 R394 G521
KN2		4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL	2qa6	B	L391 R394 G521
KN1		4-[1-ALLYL-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	2qzo	A	L391 R394 G521
KN1		4-[1-ALLYL-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	2qzo	B	L391 R394 G521
EEU		ESTRADIOL-PYRIDINIUM TETRAACETIC ACID	2yat	A	L391 R394 G521
369		5-(4-HYDROXYPHENOXY)-6-(3-HYDROXYPHENYL)-7-METHYLNAPHTHALEN-2-OL	3dt3	B	L391 R394 G521
J2Z		(9BETA,13ALPHA,16BETA)-3,16-DIHYDROXYESTRA-1,3,5(10)-TRIEN-17-ONE	3hlv	A	L391 R394 G521
J2Z		(9BETA,13ALPHA,16BETA)-3,16-DIHYDROXYESTRA-1,3,5(10)-TRIEN-17-ONE	3hlv	B	L391 R394 G521
4OH		ESTRA-1,3,5(10)-TRIENE-3,15 ALPHA,16ALPHA,17BETA-TETROL	3l03	B	L391 R394 G521
KN0		4-[1-BENZYL-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	3os8	A	L391 R394 G521
KN0		4-[1-BENZYL-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	3os8	B	L391 R394 G521
KN0		4-[1-BENZYL-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	3os8	C	L391 R394 G521
KN0		4-[1-BENZYL-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	3os8	D	L391 R394 G521
KN3		4-[1-(3-METHYLBUT-2-EN-1-YL)-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	3osa	A	L391 R394 G521
KN3		4-[1-(3-METHYLBUT-2-EN-1-YL)-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	3osa	B	L391 R394 G521
KN3		4-[1-(3-METHYLBUT-2-EN-1-YL)-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	3osa	C	L391 R394 G521
Q97		4,4'-[(1Z)-1-(4-ETHOXYPHENYL)BUT-1-ENE-1,2-DIYL]DIPHENOL	3q97	B	L391 R394 G521
1GQ		4-[1-BUTYL-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE- 1,3-DIOL	4iui	A	L391 R394 G521
1GQ		4-[1-BUTYL-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE- 1,3-DIOL	4iui	B	L391 R394 G521
1GR		4-[1-(2-METHYLPROPYL)-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3- YL]BENZENE-1,3-DIOL	4iv2	B	L391 R394 G521
1GT		4-[1-(BUT-3-EN-1-YL)-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3- YL]BENZENE-1,3-DIOL	4ivy	A	L391 R394 G521
1GT		4-[1-(BUT-3-EN-1-YL)-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3- YL]BENZENE-1,3-DIOL	4ivy	B	L391 R394 G521
KN3		4-[1-(3-METHYLBUT-2-EN-1-YL)-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	4iw8	A	L391 R394 G521
1GV		4,4'-THIENE-2,5-DIYLBIS(3-METHYLPHENOL)	4iwc	A	L391 R394 G521
STL		RESVERATROL	4pp6	A	L391 R394 G521
27G		BENZYL BUTYL BENZENE-1,2-DICARBOXYLATE	4mg6	B	L391 R394 G521
27K		BUTYL 4-HYDROXYBENZOATE	4mg9	A	L391 R394 G521
OHT		AFIMOXIFENE	4q50	C	L391 R394 G521
OHT		AFIMOXIFENE	4q50	D	L391 R394 G521
85Z		(E)-3-[4-[[3-(4-FLUORANYL-2-METHYL-PHENYL)-7- OXIDANYL-2-OXIDANYLIDENE-CHROMEN-4-YL]METHYL] PHENYL]PROP-2-ENOIC ACID	5ak2	A	L391 R394 G521
OBH		CYCLOHEXA-2,5-DIEN-1-YL (1S,2R,4S)-5,6-BIS(4- HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2- SULFONATE	4zn9	A	L391 R394 G521
XBR		3-(1-(4-CHLOROPHENYL)-3,4-DIHYDRO-1H- PYRIDO(3,4-B)INDOL-2(9H)-YL)PROPANOIC ACID	5aau	B	L391 R394 G521
1GJ		4-[2-BENZYL-7-(TRIFLUOROMETHYL)-2H-INDAZOL-3- YL]BENZENE-1,3-DIOL	4ivw	A	L391 R394 G521 L540
1GJ		4-[2-BENZYL-7-(TRIFLUOROMETHYL)-2H-INDAZOL-3- YL]BENZENE-1,3-DIOL	4ivw	B	L391 R394 G521 L540
1GU		4-[2-(BUT-3-EN-1-YL)-7-(TRIFLUOROMETHYL)-2H-INDAZOL-3- YL]BENZENE-1,3-DIOL	4iw6	B	L391 R394 G521 L540
KN3		4-[1-(3-METHYLBUT-2-EN-1-YL)-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3-YL]BENZENE-1,3-DIOL	4iw8	B	L391 R394 G521 L540
OBH		CYCLOHEXA-2,5-DIEN-1-YL (1S,2R,4S)-5,6-BIS(4- HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2- SULFONATE	4zn9	B	L391 R394 G521 L540
HZ3		DIMETHYL (1R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPTA-2,5-DIENE-2,3-DICARBOXYLATE	2qr9	A	L391 R394 L540
IOK		N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE	2iok	A	L391 V418
A48		(N-2,2,2-TRIFLUOROETHYL-P-HYDROXYLANILINO)DIMESITYLBORANE	2q6j	B	L391 V418 L540
ODE		DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE	2qh6	B	L540
NUC		Nucleic Acids	4aa6	A	R241
NUC		Nucleic Acids	4aa6	B	R241
NUC		Nucleic Acids	4aa6	E	R241
NUC		Nucleic Acids	4aa6	F	R241
EST		ESTRADIOL	1g50	A	R394
ZTW		2-(4-HYDROXYPHENYL)-BENZO[B]THIOPHENE-6-OL	1gwq	A	R394
ZTW		2-(4-HYDROXYPHENYL)-BENZO[B]THIOPHENE-6-OL	1gwq	B	R394
EST		ESTRADIOL	1gwr	B	R394
244		[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE	1x7e	B	R394
GEN		GENISTEIN	1x7r	A	R394
AEJ		1-[4-(OCTAHYDRO-PYRIDO[1,2-A]PYRAZIN-2-YL)-PHENYL]-2-PHENYL-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL	1xqc	A	R394
689		4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	1zky	A	R394
T3O		4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	2g44	A	R394
I0G		(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	2i0j	A	R394
I0G		(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	2i0j	B	R394
I0G		(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	2i0j	C	R394
I0G		(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	2i0j	D	R394
EST		ESTRADIOL	2ocf	A	R394
WST		(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL	2pog	A	R394
WST		(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL	2pog	B	R394
DC8		(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	2q70	A	R394
GEN		GENISTEIN	2qa8	A	R394
EI1		3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL	2qab	A	R394
EI1		3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL	2qab	B	R394
JJ3		(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	2qe4	A	R394
JJ3		(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	2qe4	B	R394
EES		3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL	2qgw	A	R394
EES		3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL	2qgw	B	R394
1HP		4-(2-AMINO-1-METHYL-1H-IMIDAZO[4,5-B]PYRIDIN-6-YL)PHENOL	2qse	A	R394
DES		DIETHYLSTILBESTROL	3erd	B	R394
ESL		ESTRIOL	3q95	B	R394
SRR		4,4'-[2-(4-ETHOXYPHENYL)BUT-1-ENE-1,1-DIYL]DIPHENOL	3q97	B	R394
0D1		4,4'-(2,2-DICHLOROETHENE-1,1-DIYL)DIPHENOL	3uuc	A	R394
0D1		4,4'-(2,2-DICHLOROETHENE-1,1-DIYL)DIPHENOL	3uuc	B	R394
0D1		4,4'-(2,2-DICHLOROETHENE-1,1-DIYL)DIPHENOL	3uuc	C	R394
0D1		4,4'-(2,2-DICHLOROETHENE-1,1-DIYL)DIPHENOL	3uuc	D	R394
EST		ESTRADIOL	3uud	A	R394
EST		ESTRADIOL	3uud	B	R394
36M		PROPYL 4-HYDROXYBENZOATE	4tv1	A	R394
36M		PROPYL 4-HYDROXYBENZOATE	4tv1	B	R394
EST		ESTRADIOL	4pxm	B	R394
ETC		(R,R)-CIS-DIETHYLTETRAHYDRO-2,8-CHRYSENEDIOL	1l2i	A	R394 G521
AEJ		1-[4-(OCTAHYDRO-PYRIDO[1,2-A]PYRAZIN-2-YL)-PHENYL]-2-PHENYL-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL	1xqc	B	R394 G521
AEJ		1-[4-(OCTAHYDRO-PYRIDO[1,2-A]PYRAZIN-2-YL)-PHENYL]-2-PHENYL-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL	1xqc	C	R394 G521
689		4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL	1zky	B	R394 G521
OHT		AFIMOXIFENE	2jf9	B	R394 G521
KN2		4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL	2qa6	A	R394 G521
1HP		4-(2-AMINO-1-METHYL-1H-IMIDAZO[4,5-B]PYRIDIN-6-YL)PHENOL	2qse	B	R394 G521
DES		DIETHYLSTILBESTROL	3erd	A	R394 G521
OHT		AFIMOXIFENE	3ert	A	R394 G521
J3Z		ESTRONE	3hm1	B	R394 G521
4OH		ESTRA-1,3,5(10)-TRIENE-3,15 ALPHA,16ALPHA,17BETA-TETROL	3l03	A	R394 G521
1GM		4-[2-ETHYL-7-(TRIFLUOROMETHYL)-2H-INDAZOL-3-YL]BENZENE- 1,3-DIOL	4iu7	A	R394 G521
1GM		4-[2-ETHYL-7-(TRIFLUOROMETHYL)-2H-INDAZOL-3-YL]BENZENE- 1,3-DIOL	4iu7	B	R394 G521
1GR		4-[1-(2-METHYLPROPYL)-7-(TRIFLUOROMETHYL)-1H-INDAZOL-3- YL]BENZENE-1,3-DIOL	4iv2	A	R394 G521
1GS		4-[2-(2-METHYLPROPYL)-7-(TRIFLUOROMETHYL)-2H-INDAZOL-3- YL]BENZENE-1,3-DIOL	4iv4	A	R394 G521
1GV		4,4'-THIENE-2,5-DIYLBIS(3-METHYLPHENOL)	4iwc	B	R394 G521
ESE		(1S,3AR,5R,7AS)-5-(4-HYDROXYPHENYL)-7A-METHYLOCTAHYDRO- 1H-INDEN-1-OL	4pps	A	R394 G521
ESE		(1S,3AR,5R,7AS)-5-(4-HYDROXYPHENYL)-7A-METHYLOCTAHYDRO- 1H-INDEN-1-OL	4pps	B	R394 G521
EST		ESTRADIOL	4pxm	A	R394 G521
OHT		AFIMOXIFENE	4q50	E	R394 G521
OHT		AFIMOXIFENE	4q50	F	R394 G521
KE9		(E)-3-(3,5-DIFLUORO-4-((1R,3R)-2-(2-FLUORO-2- METHYLPROPYL)-3-METHYL-2,3,4,9-TETRAHYDRO- 1H-PYRIDO(3,4-B)INDOL-1-YL)PHENYL)ACRYLIC ACID	5acc	A	R394 G521
Q97		4,4'-[(1Z)-1-(4-ETHOXYPHENYL)BUT-1-ENE-1,2-DIYL]DIPHENOL	3q97	A	R394 G521 L540
0L8		2'-BROMO-6'-(FURAN-3-YL)-4'-(HYDROXYMETHYL)BIPHENYL-4-OL	4dma	A	R394 G521 L540
1GS		4-[2-(2-METHYLPROPYL)-7-(TRIFLUOROMETHYL)-2H-INDAZOL-3- YL]BENZENE-1,3-DIOL	4iv4	B	R394 G521 L540
1GU		4-[2-(BUT-3-EN-1-YL)-7-(TRIFLUOROMETHYL)-2H-INDAZOL-3- YL]BENZENE-1,3-DIOL	4iw6	A	R394 G521 L540
HZ3		DIMETHYL (1R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPTA-2,5-DIENE-2,3-DICARBOXYLATE	2qr9	B	R394 L540
SRR		4,4'-[2-(4-ETHOXYPHENYL)BUT-1-ENE-1,1-DIYL]DIPHENOL	3q97	A	R394 L540
27N		4,4'-(2,2,2-TRICHLOROETHANE-1,1-DIYL)DIPHENOL	4mgd	A	R394 L540
27N		4,4'-(2,2,2-TRICHLOROETHANE-1,1-DIYL)DIPHENOL	4mgd	B	R394 L540
EZT		(17BETA)-17-{(E)-2-[2-(TRIFLUOROMETHYL)PHENYL]VINYL}ESTRA-1(10),2,4-TRIENE-3,17-DIOL	2p15	A	R394 V418
III		Peptide ligand (SER,PRO,GLY,SER,ARG,GLU,TRP,PHE,LYS,ASP,MET,LEU,SER)	2jf9	A	T334
III		Peptide ligand (SER,PRO,GLY,SER,ARG,GLU,TRP,PHE,LYS,ASP,MET,LEU,SER)	2jf9	C	T334
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	1gwq	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	1gwq	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	1l2i	A	V376 D538 E542
III		Peptide ligand (LYS,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN)	1l2i	B	V376 D538 E542
III		Peptide ligand (LYS,DCY,ILE,LEU,CYS,ARG,LEU,LEU,GLN)	1pcg	A	V376 D538 E542
III		Peptide ligand (LYS,DCY,ILE,LEU,CYS,ARG,LEU,LEU,GLN)	1pcg	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP,SER)	1x7e	A	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP,SER)	1x7e	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN)	1x7r	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2b1v	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2b1v	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN)	2b1z	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2b1z	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2b23	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2b23	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2fai	A	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2fai	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2g44	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2g44	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2g5o	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2g5o	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP,SER)	2p15	A	V376 D538 E542
III		Peptide ligand (LYS,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2p15	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2qa6	A	V376 D538 E542
III		Peptide ligand (LYS,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2qa6	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2qa8	B	V376 D538 E542
III		Peptide ligand (LYS,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2qab	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2qab	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP,SER)	2qgt	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2qgw	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2qr9	A	V376 D538 E542
III		Peptide ligand (LYS,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2qr9	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2qse	A	V376 D538 E542
III		Peptide ligand (LYS,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2qse	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP,SER)	2qxm	A	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2qxm	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN)	2qzo	A	V376 D538 E542
III		Peptide ligand (ACE,HIS,LYS,LEU,LEU,HIS,GLN,LEU,LEU,GLN,ASP,SER,NH2)	2yja	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP,SER)	3erd	A	V376 D538 E542
III		Peptide ligand (LYS,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	3erd	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	3hlv	A	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	3hlv	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	3hm1	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP,SER)	3l03	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	3l03	B	V376 D538 E542
III		Peptide ligand (LYS,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	3q95	A	V376 D538 E542
III		Peptide ligand (LYS,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP,SER,SER)	3q95	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	3q97	A	V376 D538 E542
III		Peptide ligand (LYS,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP,SER,SER)	3q97	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	3uu7	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	3uu7	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	3uua	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	3uua	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	3uud	A	V376 D538 E542
III		Peptide ligand (ARG,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	3uud	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU,GLY)	4dma	A	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4iu7	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4iu7	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4iui	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4iv2	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4iv4	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4iv4	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4ivw	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4ivw	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4ivy	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4iw6	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4iw6	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4iw8	A	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4iw8	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4iwc	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4iwc	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4iwf	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4iwf	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4pp6	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4ppp	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP,SER,SER)	4pps	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4pps	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mg5	A	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mg5	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mg6	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mg6	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mg7	A	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mg7	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mg8	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mg9	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mg9	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mga	A	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mga	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mgb	A	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mgb	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mgc	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mgc	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mgd	A	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mgd	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4tuz	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4tuz	B	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4tv1	A	V376 D538 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4tv1	B	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4zn9	A	V376 D538 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN)	4zn9	B	V376 D538 E542
III		Peptide ligand (ASN,ALA,LEU,LEU,ARG,TYR,LEU,LEU,ASP)	1gwr	A	V376 E542
III		Peptide ligand (ASN,ALA,LEU,LEU,ARG,TYR,LEU,LEU,ASP)	1gwr	B	V376 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	1zky	B	V376 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP,SER)	2q6j	A	V376 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP,SER,SER)	2qgt	B	V376 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	2qh6	A	V376 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	3hm1	A	V376 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4iui	B	V376 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,ASP)	4ivy	A	V376 E542
III		Peptide ligand (LYS,ILE,LEU,HIS,ARG,LEU,LEU)	4ppp	A	V376 E542
III		Peptide ligand (HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN,GLU)	4mg8	B	V376 E542
III		Peptide ligand (ILE,LEU,HIS,ARG,LEU,LEU)	4pxm	A	V376 E542
III		Peptide ligand (ILE,LEU,HIS,ARG,LEU,LEU,GLN)	4pxm	B	V376 E542
III		Peptide ligand (ILE,LEU,HIS,ARG,LEU,LEU)	4q13	A	V376 E542
III		Peptide ligand (LEU,THR,SER,ARG,ASP,PHE,GLY,SER,TRP,TYR,ALA)	2bj4	B	W393 E397 P406 E443
III		Peptide ligand (LEU,THR,SER,ARG,ASP,PHE,GLY,SER,TRP,TYR,ALA)	2bj4	A	W393 R394 E397 P406 E443

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Conservation information for LBS of ESR1

Multiple alignments for P03372 in multiple species

LBS	AA sequence	# species	Species
A207	CEGCKAFFKRS	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
A350	LLTNLADRELV	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
A350	LLTNMADKELV	1	Danio rerio
A493	HLMAKAGLTLQ	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A493	YCISKSGASLQ	1	Danio rerio
A493	HLMAKSGLSLQ	1	Gallus gallus
C185	KETRYCAVCND	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
C185	KETRFCAVCSD	1	Danio rerio
C188	RYCAVCNDYAS	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
C188	RFCAVCSDYAS	1	Danio rerio
C202	YGVWSCEGCKA	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
C205	WSCEGCKAFFK	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
C530	LYNMKCKNVVP	3	Gallus gallus, Mus musculus, Rattus norvegicus
C530	LYSMKCKNVVP	2	Homo sapiens, Bos taurus
C530	LYRMKCKNRVP	1	Danio rerio
D332	IYSEYDPSRPF	2	Mus musculus, Rattus norvegicus
D332	LYSEYDPTRPF	1	Homo sapiens
D332	VCSRQKHSRPY	1	Danio rerio
D332	VYSEYDPNRPF	1	Gallus gallus
D332	IYSEYDPTRPF	1	Bos taurus
D351	LTNLADRELVH	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
D351	LTNMADKELVH	1	Danio rerio
D538	VVPLYDLLLEM	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
D538	RVPLYDLLLEM	1	Danio rerio
E203	GVWSCEGCKAF	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
E323	ALLDAEPPILY	1	Homo sapiens
E323	LLLGAEPPAVC	1	Danio rerio
E323	ALLEAEPPIVY	1	Gallus gallus
E323	ALLDAEPPMIY	1	Mus musculus
E323	ALLDAEPPLIY	1	Rattus norvegicus
E323	ALLEAEPPIIY	1	Bos taurus
E353	NLADRELVHMI	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
E353	NMADKELVHMI	1	Danio rerio
E380	QVHLLECAWLE	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
E380	QVQLLESSWLE	1	Danio rerio
E397	VWRSMEHPGKL	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
E397	IWRSIHSPGKL	1	Danio rerio
E419	QGKCVEGMVEI	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
E419	EGECVEGMAEI	1	Danio rerio
E423	VEGMVEIFDML	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
E423	VEGMAEIFDML	1	Danio rerio
E443	MNLQGEEFVCL	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
E443	LKLKLEEFVCL	1	Danio rerio
E444	NLQGEEFVCLK	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
E444	KLKLEEFVCLK	1	Danio rerio
E542	YDLLLEMLDAH	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
E542	YDLLLEMLDAQ	1	Danio rerio
F208	EGCKAFFKRSI	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
F367	KRVPGFVDLTL	2	Homo sapiens, Gallus gallus
F367	KRVPGFGDLNL	2	Mus musculus, Rattus norvegicus
F367	KKVPGFQDLSL	1	Danio rerio
F367	KRVPGFVDLAL	1	Bos taurus
F404	PGKLLFAPNLL	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
F404	PGKLIFAQDLI	1	Danio rerio
F425	GMVEIFDMLLA	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
F425	GMAEIFDMLLA	1	Danio rerio
F445	LQGEEFVCLKS	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
F445	LKLEEFVCLKA	1	Danio rerio
G194	NDYASGYHYGV	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
G194	SDYASGYHYGV	1	Danio rerio
G204	VWSCEGCKAFF	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
G420	GKCVEGMVEIF	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
G420	GECVEGMAEIF	1	Danio rerio
G442	MMNLQGEEFVC	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
G442	SLKLKLEEFVC	1	Danio rerio
G521	HMSNKGMEHLY	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
H196	YASGYHYGVWS	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
H373	VDLTLHDQVHL	2	Homo sapiens, Gallus gallus
H373	GDLNLHDQVHL	2	Mus musculus, Rattus norvegicus
H373	QDLSLHDQVQL	1	Danio rerio
H373	VDLALHDQVHL	1	Bos taurus
H524	NKGMEHLYNMK	3	Gallus gallus, Mus musculus, Rattus norvegicus
H524	NKGMEHLYSMK	2	Homo sapiens, Bos taurus
H524	NKGMEHLYRMK	1	Danio rerio
I326	DAEPPILYSEY	1	Homo sapiens
I326	GAEPPAVCSRQ	1	Danio rerio
I326	EAEPPIVYSEY	1	Gallus gallus
I326	DAEPPMIYSEY	1	Mus musculus
I326	DAEPPLIYSEY	1	Rattus norvegicus
I326	EAEPPIIYSEY	1	Bos taurus
I358	ELVHMINWAKR	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
I358	ELVHMIAWAKK	1	Danio rerio
I424	EGMVEIFDMLL	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
I424	EGMAEIFDMLL	1	Danio rerio
K206	SCEGCKAFFKR	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
K210	CKAFFKRSIQG	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
K231	QCTIDKNRRKS	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
K231	QCTIDRNRRKS	1	Danio rerio
K235	DKNRRKSCQAC	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
K235	DRNRRKSCQAC	1	Danio rerio
K362	MINWAKRVPGF	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
K362	MIAWAKKVPGF	1	Danio rerio
K531	YNMKCKNVVPL	3	Gallus gallus, Mus musculus, Rattus norvegicus
K531	YSMKCKNVVPL	2	Homo sapiens, Bos taurus
K531	YRMKCKNRVPL	1	Danio rerio
L320	MVSALLDAEPP	3	Homo sapiens, Mus musculus, Rattus norvegicus
L320	VLLLLLGAEPP	1	Danio rerio
L320	MVSALLEAEPP	1	Gallus gallus
L320	MISALLEAEPP	1	Bos taurus
L327	AEPPILYSEYD	1	Homo sapiens
L327	AEPPAVCSRQK	1	Danio rerio
L327	AEPPIVYSEYD	1	Gallus gallus
L327	AEPPMIYSEYD	1	Mus musculus
L327	AEPPLIYSEYD	1	Rattus norvegicus
L327	AEPPIIYSEYD	1	Bos taurus
L346	SMMGLLTNLAD	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L346	TMMSLLTNMAD	1	Danio rerio
L346	SMMTLLTNLAD	1	Gallus gallus
L349	GLLTNLADREL	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L349	SLLTNMADKEL	1	Danio rerio
L349	TLLTNLADREL	1	Gallus gallus
L354	LADRELVHMIN	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
L354	MADKELVHMIA	1	Danio rerio
L372	FVDLTLHDQVH	2	Homo sapiens, Gallus gallus
L372	FGDLNLHDQVH	2	Mus musculus, Rattus norvegicus
L372	FQDLSLHDQVQ	1	Danio rerio
L372	FVDLALHDQVH	1	Bos taurus
L379	DQVHLLECAWL	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
L379	DQVQLLESSWL	1	Danio rerio
L384	LECAWLEILMI	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
L384	LESSWLEVLMI	1	Danio rerio
L387	AWLEILMIGLV	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
L387	SWLEVLMIGLI	1	Danio rerio
L391	ILMIGLVWRSM	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
L391	VLMIGLIWRSI	1	Danio rerio
L402	EHPGKLLFAPN	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
L402	HSPGKLIFAQD	1	Danio rerio
L403	HPGKLLFAPNL	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
L403	SPGKLIFAQDL	1	Danio rerio
L428	EIFDMLLATSS	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L428	EIFDMLLATVA	1	Danio rerio
L428	EIFDMLLATAA	1	Gallus gallus
L525	KGMEHLYNMKC	3	Gallus gallus, Mus musculus, Rattus norvegicus
L525	KGMEHLYSMKC	2	Homo sapiens, Bos taurus
L525	KGMEHLYRMKC	1	Danio rerio
L536	KNVVPLYDLLL	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
L536	KNRVPLYDLLL	1	Danio rerio
L539	VPLYDLLLEML	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
L540	PLYDLLLEMLD	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
M342	FSEASMMGLLT	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M342	YTEITMMSLLT	1	Danio rerio
M342	FNEASMMTLLT	1	Gallus gallus
M343	SEASMMGLLTN	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M343	TEITMMSLLTN	1	Danio rerio
M343	NEASMMTLLTN	1	Gallus gallus
M388	WLEILMIGLVW	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
M388	WLEVLMIGLIW	1	Danio rerio
M421	KCVEGMVEIFD	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
M421	ECVEGMAEIFD	1	Danio rerio
M528	EHLYNMKCKNV	3	Gallus gallus, Mus musculus, Rattus norvegicus
M528	EHLYSMKCKNV	2	Homo sapiens, Bos taurus
M528	EHLYRMKCKNR	1	Danio rerio
M543	DLLLEMLDAHR	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
M543	DLLLEMLDAQR	1	Danio rerio
N359	LVHMINWAKRV	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
N359	LVHMIAWAKKV	1	Danio rerio
P324	LLDAEPPILYS	1	Homo sapiens
P324	LLGAEPPAVCS	1	Danio rerio
P324	LLEAEPPIVYS	1	Gallus gallus
P324	LLDAEPPMIYS	1	Mus musculus
P324	LLDAEPPLIYS	1	Rattus norvegicus
P324	LLEAEPPIIYS	1	Bos taurus
P325	LDAEPPILYSE	1	Homo sapiens
P325	LGAEPPAVCSR	1	Danio rerio
P325	LEAEPPIVYSE	1	Gallus gallus
P325	LDAEPPMIYSE	1	Mus musculus
P325	LDAEPPLIYSE	1	Rattus norvegicus
P325	LEAEPPIIYSE	1	Bos taurus
P406	KLLFAPNLLLD	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
P406	KLIFAQDLILD	1	Danio rerio
Q238	RRKSCQACRLR	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
Q375	LTLHDQVHLLE	2	Homo sapiens, Gallus gallus
Q375	LNLHDQVHLLE	2	Mus musculus, Rattus norvegicus
Q375	LSLHDQVQLLE	1	Danio rerio
Q375	LALHDQVHLLE	1	Bos taurus
Q441	RMMNLQGEEFV	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
Q441	RSLKLKLEEFV	1	Danio rerio
R211	KAFFKRSIQGH	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
R234	IDKNRRKSCQA	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
R234	IDRNRRKSCQA	1	Danio rerio
R241	SCQACRLRKCY	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
R352	TNLADRELVHM	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
R352	TNMADKELVHM	1	Danio rerio
R363	INWAKRVPGFV	3	Homo sapiens, Gallus gallus, Bos taurus
R363	INWAKRVPGFG	2	Mus musculus, Rattus norvegicus
R363	IAWAKKVPGFQ	1	Danio rerio
R394	IGLVWRSMEHP	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
R394	IGLIWRSIHSP	1	Danio rerio
T334	SEYDPTRPFSE	2	Homo sapiens, Bos taurus
T334	SEYDPSRPFSE	2	Mus musculus, Rattus norvegicus
T334	SRQKHSRPYTE	1	Danio rerio
T334	SEYDPNRPFNE	1	Gallus gallus
T347	MMGLLTNLADR	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T347	MMSLLTNMADK	1	Danio rerio
T347	MMTLLTNLADR	1	Gallus gallus
V355	ADRELVHMINW	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
V355	ADKELVHMIAW	1	Danio rerio
V376	TLHDQVHLLEC	2	Homo sapiens, Gallus gallus
V376	NLHDQVHLLEC	2	Mus musculus, Rattus norvegicus
V376	SLHDQVQLLES	1	Danio rerio
V376	ALHDQVHLLEC	1	Bos taurus
V418	NQGKCVEGMVE	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
V418	SEGECVEGMAE	1	Danio rerio
V533	MKCKNVVPLYD	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
V533	MKCKNRVPLYD	1	Danio rerio
W383	LLECAWLEILM	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
W383	LLESSWLEVLM	1	Danio rerio
W393	MIGLVWRSMEH	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
W393	MIGLIWRSIHS	1	Danio rerio
Y195	DYASGYHYGVW	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
Y197	ASGYHYGVWSC	6	Homo sapiens, Danio rerio, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
Y328	EPPILYSEYDP	1	Homo sapiens
Y328	EPPAVCSRQKH	1	Danio rerio
Y328	EPPIVYSEYDP	1	Gallus gallus
Y328	EPPMIYSEYDP	1	Mus musculus
Y328	EPPLIYSEYDP	1	Rattus norvegicus
Y328	EPPIIYSEYDP	1	Bos taurus
Y537	NVVPLYDLLLE	5	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus, Bos taurus
Y537	NRVPLYDLLLE	1	Danio rerio