mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for ESR2

Gene summary

Basic gene Info.	Gene symbol	ESR2
	Gene name	estrogen receptor 2 (ER beta)
	Synonyms	ER-BETA\|ESR-BETA\|ESRB\|ESTRB\|Erb\|NR3A2
	Cytomap	UCSC genome browser: 14q23.2
	Type of gene	protein-coding
	RefGenes	NM_001040275.1, NM_001214902.1,NM_001271876.1,NM_001271877.1,NM_001291712.1, NM_001291723.1,NM_001437.2,NR_073496.1,NR_073497.1, NR_073505.1,NM_001040276.1,NM_001214903.1,
	Description	estrogen receptor betaestrogen receptor beta 4nuclear receptor subfamily 3 group A member 2
	Modification date	20141222
dbXrefs	MIM : 601663
	HGNC : HGNC
	Ensembl : ENSG00000140009
	HPRD : 03390
	Vega : OTTHUMG00000141306
Protein	UniProt: Q92731 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_ESR2
	BioGPS: 2100
Pathway	NCI Pathway Interaction Database: ESR2
	KEGG: ESR2
	REACTOME: ESR2
	Pathway Commons: ESR2
Context	iHOP: ESR2
	ligand binding site mutation search in PubMed: ESR2
	UCL Cancer Institute: ESR2
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	15345745
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	10681512

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Ligand binding site mutations for ESR2

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
V78	W80R	COAD	2
K314	I316N	GBM	1
D303	D303N	KICH	1
V499	R501C	LUAD	1
Q327	D326H	LUSC	1
F319	E321K	SKCM	1
A45	M46R	STAD	1
I373	L374R	STAD	1
Q327	D326G	STAD	1
I373	G372E	UCEC	1
V499	V499M	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for ESR2

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
K314	I316N	-1.6510595
A45	M46R	-1.1842458
D303	D303N	-1.1317561
Q327	D326G	-1.061349
V78	W80R	-1.0316438
Q327	D326H	-0.96410595
V499	R501C	-0.72039812
I373	L374R	-0.61903224
F319	E321K	-0.42435792
I373	G372E	-0.40396148
V499	V499M	-0.3511879

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ESR2 from PDB

PDB ID	PDB title	PDB structure
1NDE	Estrogen Receptor beta with Selective Triazine Modulator

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Differential gene expression and gene-gene network for ESR2

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of ESR2 and the right PPI network was created from samples without mutations in the LBS of ESR2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for ESR2

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C1458155	Breast Neoplasms	50	AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification, Therapeutic
umls:C0014175	Endometriosis	21	AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0033578	Prostatic Neoplasms	17	AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0007097	Carcinoma	14	AlteredExpression, Biomarker, GeneticVariation
umls:C0001418	Adenocarcinoma	14	AlteredExpression, Biomarker
umls:C1956346	Coronary Artery Disease	5	AlteredExpression, Biomarker, GeneticVariation
umls:C0009404	Colorectal Neoplasms	4	Biomarker, GeneticVariation
umls:C0025149	Medulloblastoma	4	Biomarker, Therapeutic
umls:C0010068	Coronary Disease	3	Biomarker, GeneticVariation
umls:C0024668	Mammary Neoplasms, Experimental	2	Biomarker, Therapeutic
umls:C0282612	Prostatic Intraepithelial Neoplasia	2	Biomarker, Therapeutic
umls:C0021361	Infertility, Female	2	Biomarker, GeneticVariation
umls:C0024667	Mammary Neoplasms, Animal	2	Biomarker, GeneticVariation
umls:C0005695	Urinary Bladder Neoplasms	1	AlteredExpression, Biomarker
umls:C0003811	Arrhythmias, Cardiac	1	Biomarker
umls:C0007138	Carcinoma, Transitional Cell	1	Biomarker
umls:C0236736	Cocaine-Related Disorders	1	Biomarker
umls:C0023869	Lithiasis	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for ESR2

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Approved	DB00255	Diethylstilbestrol	Small molecule
Approved\|investigational	DB00481	Raloxifene	Small molecule
Approved	DB00675	Tamoxifen	Small molecule
Approved\|investigational\|vet_approved	DB00783	Estradiol	Small molecule
Approved\|investigational\|vet_approved\|withdrawn	DB01108	Trilostane	Small molecule
Approved	DB01196	Estramustine	Small molecule
Investigational	DB01645	Genistein	Small molecule
Nutraceutical	DB01708	Dehydroepiandrosterone	Small molecule
Experimental	DB02983	Para-Mercury-Benzenesulfonic Acid	Small molecule
Experimental	DB03860	N-Butyl-11-[(7r,8r,9s,13s,14s,17s)-3,17-Dihydroxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-Decahydro-6h-Cyclopenta[a]Phenanthren-7-Yl]-N-Methylundecanamide	Small molecule
Experimental	DB03882	5-Alpha-Androstane-3-Beta,17beta-Diol	Small molecule
Experimental	DB04020	4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol	Small molecule
Investigational	DB04468	Afimoxifene	Small molecule
Approved\|vet_approved	DB04573	Estriol	Small molecule
Approved	DB04574	Estrone sulfate	Small molecule
Investigational	DB05052	MF101	Small molecule
Investigational	DB05882	CHF 4227	Small molecule
Experimental	DB06832	2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL	Small molecule
Experimental	DB06875	3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE	Small molecule
Experimental	DB06927	[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE	Small molecule
Experimental	DB06937	4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL	Small molecule
Experimental	DB07009	2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL	Small molecule
Experimental	DB07032	2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL	Small molecule
Experimental	DB07036	(3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol	Small molecule
Experimental	DB07119	1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL	Small molecule
Experimental	DB07150	4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME	Small molecule
Experimental	DB07198	5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE	Small molecule
Experimental	DB07230	3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE	Small molecule
Experimental	DB07236	3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL	Small molecule
Experimental	DB07638	(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	Small molecule
Experimental	DB07702	(16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL	Small molecule
Experimental	DB07757	(9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one	Small molecule
Experimental	DB07933	(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	Small molecule
Experimental	DB08020	(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ESR2 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
MON		4-(2-{[4-{[3-(4-CHLOROPHENYL)PROPYL]SULFANYL}-6-(1-PIPERAZINYL)-1,3,5-TRIAZIN-2-YL]AMINO}ETHYL)PHENOL	1nde	A	D303 I373
OHT		AFIMOXIFENE	2fsz	A	D303 I373
OHT		AFIMOXIFENE	2fsz	B	D303 I373
GEN		GENISTEIN	1qkm	A	I373
272		BENZISOXAZOLE	1u3q	A	I373
338		2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL	1u3r	A	I373
797		3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL	1u3s	A	I373
797		3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL	1u3s	B	I373
697		5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE	1x76	A	I373
697		5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE	1x76	B	I373
244		[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE	1x78	A	I373
041		PRINABEREL	1x7b	A	I373
GEN		GENISTEIN	1x7j	A	I373
4NA		1-CHLORO-6-(4-HYDROXYPHENYL)NAPHTHALEN-2-OL	1yy4	A	I373
4NA		1-CHLORO-6-(4-HYDROXYPHENYL)NAPHTHALEN-2-OL	1yy4	B	I373
196		3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE	1yye	B	I373
789		3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE	1zaf	B	I373
FBR		(9AS)-4-BROMO-9A-BUTYL-7-HYDROXY-1,2,9,9A-TETRAHYDRO-3H-FLUOREN-3-ONE	2giu	A	I373
JJ3		(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	2jj3	A	I373
JJ3		(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	2jj3	B	I373
555		4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME	2nv7	A	I373
555		4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME	2nv7	B	I373
3AS		(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	2qtu	A	I373
3AS		(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	2qtu	B	I373
YJD		4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL	2yjd	A	I373
YJD		4-(2-PROPAN-2-YLOXYBENZIMIDAZOL-1-YL)PHENOL	2yjd	B	I373
SU4	HYDROXYBENZENESULFONAMIDE	N-CYCLOPROPYL-4-OXIDANYL-N-[(2R)-2-OXIDANYL- 2-PHENYL-PROPYL]BENZENESULFONAMIDE	2yly	A	I373
SU4	HYDROXYBENZENESULFONAMIDE	N-CYCLOPROPYL-4-OXIDANYL-N-[(2R)-2-OXIDANYL- 2-PHENYL-PROPYL]BENZENESULFONAMIDE	2yly	B	I373
DC8		(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	2z4b	A	I373
DC8		(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	2z4b	B	I373
EST		ESTRADIOL	3ols	B	I373
WV7		2-(TRIFLUOROACETYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-6-OL	3omo	A	I373
WV7		2-(TRIFLUOROACETYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-6-OL	3omo	B	I373
W14		2-(TRIFLUOROACETYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-7-OL	3omp	A	I373
W14		2-(TRIFLUOROACETYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-7-OL	3omp	B	I373
W23		2-[(TRIFLUOROMETHYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLIN-6-OL	3omq	A	I373
W23		2-[(TRIFLUOROMETHYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLIN-6-OL	3omq	B	I373
III		Peptide ligand (LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1u3r	A	K314
III		Peptide ligand (LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1u3s	A	K314
III		Peptide ligand (LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1u3s	B	K314
III		Peptide ligand (LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1u9e	A	K314
III		Peptide ligand (LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1x76	A	K314
III		Peptide ligand (LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1x78	A	K314
III		Peptide ligand (LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1x78	B	K314
III		Peptide ligand (HIS,LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1x7b	A	K314
III		Peptide ligand (HIS,LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1x7j	A	K314
III		Peptide ligand (LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1yy4	B	K314
III		Peptide ligand (HIS,LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1yye	A	K314
III		Peptide ligand (HIS,LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1yye	B	K314
III		Peptide ligand (SER,GLY,SER,HIS,LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1zaf	A	K314
III		Peptide ligand (HIS,LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	2nv7	B	K314
III		Peptide ligand (HIS,LEU,ILE,LEU,HIS,LEU,LEU,LEU,GLN,ASP,SER)	2yjd	B	K314
III		Peptide ligand (ARG,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN)	3oll	A	K314
III		Peptide ligand (ARG,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN)	3oll	B	K314
III		Peptide ligand (ARG,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN)	3omo	A	K314 F319 Q327
III		Peptide ligand (LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1x76	B	K314 Q327
III		Peptide ligand (HIS,LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1x7b	B	K314 Q327
III		Peptide ligand (HIS,LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1x7j	B	K314 Q327
III		Peptide ligand (LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1yy4	A	K314 Q327
OHT		AFIMOXIFENE	2fsz	A	K314 Q327
III		Peptide ligand (HIS,LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	2nv7	A	K314 Q327
III		Peptide ligand (HIS,LEU,ILE,LEU,HIS,LEU,LEU,LEU,GLN,ASP,SER)	2yjd	A	K314 Q327
III		Peptide ligand (ARG,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN)	3ols	A	K314 Q327
III		Peptide ligand (ARG,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN)	3ols	B	K314 Q327
III		Peptide ligand (ARG,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN)	3omo	B	K314 Q327
III		Peptide ligand (ARG,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN)	3omp	A	K314 Q327
III		Peptide ligand (ARG,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN)	3omp	B	K314 Q327
III		Peptide ligand (ARG,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN)	3omq	A	K314 Q327
III		Peptide ligand (ARG,HIS,LYS,ILE,LEU,HIS,ARG,LEU,LEU,GLN)	3omq	B	K314 Q327
III		Peptide ligand (ARG,HIS,PRO,LEU,LEU,LEU,ARG,HIS,LEU,LEU,GLN,ASN)	4j24	A	K314 Q327
III		Peptide ligand (ARG,HIS,PRO,LEU,LEU,LEU,ARG,HIS,LEU,LEU,GLN)	4j24	B	K314 Q327
III		Peptide ligand (ARG,HIS,PRO,LEU,LEU,LEU,ARG,HIS,LEU,LEU,GLN,ASN)	4j24	C	K314 Q327
III		Peptide ligand (ARG,HIS,PRO,LEU,LEU,LEU,ARG,HIS,LEU,LEU)	4j24	D	K314 Q327
III		Peptide ligand (HIS,PRO,LEU,LEU,MET,ARG,LEU,LEU,HIS,HIS,PRO,SER)	4j26	A	K314 Q327
III		Peptide ligand (HIS,PRO,LEU,LEU,MET,ARG,LEU,LEU,HIS,HIS)	4j26	B	K314 Q327
III		Peptide ligand (LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1u3r	B	K314 V499
III		Peptide ligand (LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1u9e	B	K314 V499
III		Peptide ligand (SER,GLY,SER,HIS,LYS,LEU,VAL,GLN,LEU,LEU,THR,THR,THR)	1zaf	B	K314 V499
OHT		AFIMOXIFENE	2fsz	B	Q327

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Conservation information for LBS of ESR2

Multiple alignments for Q92731 in multiple species

LBS	AA sequence	# species	Species
A146	GSKRDAHFCAV	2	Homo sapiens, Gallus gallus
A146	SSKRDAHFCAV	1	Bos taurus
A146	SAKRDAHFCAV	1	Mus musculus
A146	NAKRDAHFCPV	1	Rattus norvegicus
A302	SLTKLADKELV	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
A45	RHEYSAMTFYS	2	Mus musculus, Rattus norvegicus
A45	HHEYPAMTFYS	1	Homo sapiens
A45	------MAFCS	1	Gallus gallus
A45	RHEYSAVTFYS	1	Bos taurus
D303	LTKLADKELVH	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
D489	VVPVYDLLLEM	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
E305	KLADKELVHMI	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
E332	QVRLLESCWME	4	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
E332	QVRLLESCWLE	1	Bos taurus
E493	YDLLLEMLNAH	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
F319	KKIPGFVELSL	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F319	KKIPGFIDLSL	1	Gallus gallus
F356	PGKLIFAPDLV	4	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
F356	PGKLIFAPDLI	1	Bos taurus
F377	GILEIFDMLLA	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
G472	HASNKGMEHLL	3	Homo sapiens, Gallus gallus, Bos taurus
G472	HISNKGMEHLL	2	Mus musculus, Rattus norvegicus
H475	NKGMEHLLSMK	3	Gallus gallus, Mus musculus, Rattus norvegicus
H475	NKGMEHLLNMK	2	Homo sapiens, Bos taurus
I310	ELVHMIGWAKK	3	Gallus gallus, Mus musculus, Rattus norvegicus
I310	ELVHMISWAKK	2	Homo sapiens, Bos taurus
I373	KCVEGILEIFD	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
I376	EGILEIFDMLL	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
K314	MIGWAKKIPGF	3	Gallus gallus, Mus musculus, Rattus norvegicus
K314	MISWAKKIPGF	2	Homo sapiens, Bos taurus
L298	SMMMSLTKLAD	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
L301	MSLTKLADKEL	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
L306	LADKELVHMIG	3	Gallus gallus, Mus musculus, Rattus norvegicus
L306	LADKELVHMIS	2	Homo sapiens, Bos taurus
L324	FVELSLLDQVR	2	Mus musculus, Rattus norvegicus
L324	FVELSLFDQVR	1	Homo sapiens
L324	FIDLSLYDQVR	1	Gallus gallus
L324	FVELSLYDQVR	1	Bos taurus
L331	DQVRLLESCWM	4	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
L331	DQVRLLESCWL	1	Bos taurus
L339	CWMEVLMVGLM	2	Mus musculus, Rattus norvegicus
L339	CWMEVLMMGLM	1	Homo sapiens
L339	CWMEVLMIGLM	1	Gallus gallus
L339	CWLEVLMVGLM	1	Bos taurus
L343	VLMVGLMWRSI	3	Bos taurus, Mus musculus, Rattus norvegicus
L343	VLMMGLMWRSI	1	Homo sapiens
L343	VLMIGLMWRSI	1	Gallus gallus
L380	EIFDMLLATTS	3	Homo sapiens, Bos taurus, Rattus norvegicus
L380	EIFDMLLAMTS	1	Gallus gallus
L380	EIFDMLLATTA	1	Mus musculus
L476	KGMEHLLSMKC	3	Gallus gallus, Mus musculus, Rattus norvegicus
L476	KGMEHLLNMKC	2	Homo sapiens, Bos taurus
L490	VPVYDLLLEML	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
L491	PVYDLLLEMLN	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
M295	TEASMMMSLTK	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
M309	KELVHMIGWAK	3	Gallus gallus, Mus musculus, Rattus norvegicus
M309	KELVHMISWAK	2	Homo sapiens, Bos taurus
M336	LESCWMEVLMV	2	Mus musculus, Rattus norvegicus
M336	LESCWMEVLMM	1	Homo sapiens
M336	LESCWMEVLMI	1	Gallus gallus
M336	LESCWLEVLMV	1	Bos taurus
M340	WMEVLMVGLMW	2	Mus musculus, Rattus norvegicus
M340	WMEVLMMGLMW	1	Homo sapiens
M340	WMEVLMIGLMW	1	Gallus gallus
M340	WLEVLMVGLMW	1	Bos taurus
M379	LEIFDMLLATT	4	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M379	LEIFDMLLAMT	1	Gallus gallus
M479	EHLLSMKCKNV	3	Gallus gallus, Mus musculus, Rattus norvegicus
M479	EHLLNMKCKNV	2	Homo sapiens, Bos taurus
M494	DLLLEMLNAHT	4	Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
M494	DLLLEMLNAHV	1	Homo sapiens
Q327	LSLYDQVRLLE	2	Gallus gallus, Bos taurus
Q327	LSLLDQVRLLE	2	Mus musculus, Rattus norvegicus
Q327	LSLFDQVRLLE	1	Homo sapiens
R346	VGLMWRSIDHP	3	Bos taurus, Mus musculus, Rattus norvegicus
R346	MGLMWRSIDHP	1	Homo sapiens
R346	IGLMWRSIDHP	1	Gallus gallus
T299	MMMSLTKLADK	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
V328	SLYDQVRLLES	2	Gallus gallus, Bos taurus
V328	SLLDQVRLLES	2	Mus musculus, Rattus norvegicus
V328	SLFDQVRLLES	1	Homo sapiens
V487	KNVVPVYDLLL	5	Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
V499	MLNAHTLRG-Y	2	Mus musculus, Rattus norvegicus
V499	MLNAHVLRG-C	1	Homo sapiens
V499	MLNAHTLRGQR	1	Gallus gallus
V499	MLNAHTLRG-N	1	Bos taurus
V78	TTSPNVLWPTP	2	Homo sapiens, Bos taurus
V78	TSSPSVLWSAP	1	Gallus gallus
V78	TASPNVLWPTS	1	Mus musculus
V78	STSPNVLWPTS	1	Rattus norvegicus
W335	LLESCWMEVLM	4	Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
W335	LLESCWLEVLM	1	Bos taurus