mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for ETF1

Gene summary

Basic gene Info.	Gene symbol	ETF1
	Gene name	eukaryotic translation termination factor 1
	Synonyms	D5S1995\|ERF\|ERF1\|RF1\|SUP45L1\|TB3-1
	Cytomap	UCSC genome browser: 5q31.1
	Type of gene	protein-coding
	RefGenes	NM_001256302.1, NM_001282185.1,NM_001291974.1,NM_001291975.1,NM_004730.3,
	Description	eukaryotic peptide chain release factor subunit 1polypeptide chain release factor 1protein Cl1sup45 (yeast omnipotent suppressor 45) homolog-like 1
	Modification date	20141207
dbXrefs	MIM : 600285
	HGNC : HGNC
	Ensembl : ENSG00000120705
	HPRD : 02616
	Vega : OTTHUMG00000129199
Protein	UniProt: P62495 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_ETF1
	BioGPS: 2107
Pathway	NCI Pathway Interaction Database: ETF1
	KEGG: ETF1
	REACTOME: ETF1
	Pathway Commons: ETF1
Context	iHOP: ETF1
	ligand binding site mutation search in PubMed: ETF1
	UCL Cancer Institute: ETF1
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0006479	protein methylation	18539146

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Ligand binding site mutations for ETF1

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
K83,R81	L82P	COAD	4
L126	L126S	COAD	2
K118	P119L	COAD	1
L126	L126F	OV	1
D435	L434F	SKCM	1
R192	R192C	STAD	1
V71,L69	S70L	STAD	1
R414	R414W	UCEC	1
S77	S77F	UCEC	1
F232	F232V	UCEC	1
T122	T122M	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for ETF1

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
L126	L126S	-1.6096529
L126	L126F	-1.3082985
D435	L434F	-1.2699294
R414	R414W	-1.1141188
R81	L82P	-1.0506607
K83	L82P	-1.0506607
F232	F232V	-0.89060708
R192	R192C	-0.64447821
K118	P119L	-0.48770111
V71	S70L	-0.11428976
L69	S70L	-0.11428976
S77	S77F	-0.10874014
T122	T122M	-0.09423824

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ETF1 from PDB

PDB ID	PDB title	PDB structure
1DT9	THE CRYSTAL STRUCTURE OF HUMAN EUKARYOTIC RELEASE FACTOR ERF1-MECHANISM OF STOP CODON RECOGNITION AND PEPTIDYL-TRNA HYDROLYSIS

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Differential gene expression and gene-gene network for ETF1

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of ETF1 and the right PPI network was created from samples without mutations in the LBS of ETF1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for ETF1

Gene level disease information (DisGeNet)

Disease ID

Disease name

# PubMed

Association type

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for ETF1

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Drug information targeting mutLBSgene (Approved drugs only)

Drug status

DrugBank ID

Name

Type

Drug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ETF1 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
ATP		ATP	3e1y	A	K118
ATP		ATP	3e1y	B	K118
NUC		Nucleic Acids	3j5y	A	K83
NUC		Nucleic Acids	5a8l	Q	L69 S77 R81 L126
NUC		Nucleic Acids	5a8l	Q	T122 R192 F232 R414 D435
NUC		Nucleic Acids	5a8l	Q	V71

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Conservation information for LBS of ETF1

Multiple alignments for P62495 in multiple species

LBS	AA sequence	# species	Species
A230	VLAGSADFKTE	6	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
A230	ILAGSADFKTE	3	Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster
A230	ILAGSADFKTD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A316	ALEMGAVEILI	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
A316	ALQEGAVETLL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A316	ALDLGAVEKLI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A316	ALESGAIETLI	1	Arabidopsis thaliana
A316	ALEMGAIETLI	1	Caenorhabditis elegans
A316	ALELGSVETLI	1	Drosophila melanogaster
A59	DEFGTASNIKS	6	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
A59	EEYGTASNIKS	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans
A59	DEYGTASNIKS	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana
C127	TSLYLCDNKFH	8	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
C127	TSQYLCDNKFH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C127	ASLYLCDNKFH	1	Arabidopsis thaliana
D128	SLYLCDNKFHT	9	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
D128	SQYLCDNKFHT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D255	VLKLVDISYGG	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
D255	IIKTVDVSYGG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D255	VISIVDVSYGG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D255	ILNVVDVSYGG	1	Arabidopsis thaliana
D255	MIKTVDIAYGG	1	Caenorhabditis elegans
D255	VIKLVDVSYGG	1	Drosophila melanogaster
D297	DEISQDTGKYC	6	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
D297	DEISLDSGKYC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D297	DEISQDTGKFC	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D297	EEISQDTGKYV	1	Arabidopsis thaliana
D297	DEISQDTGKYV	1	Caenorhabditis elegans
D43	IIPPKDQISRV	6	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
D43	IIPPGEQISRY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D43	VIPPKGQIPLY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D43	IMPPRDQVSRV	1	Arabidopsis thaliana
D43	IIPPKDQVARI	1	Caenorhabditis elegans
D435	---DLD---DY	6	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
D435	---DSD-----	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D435	---DEDEGSDY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D435	---DDD---SE	1	Arabidopsis thaliana
D435	STRNSN---DF	1	Caenorhabditis elegans
D436	LD---DY---	6	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
D436	SD--------	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D436	EDEGSDYDFI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D436	DD---SE---	1	Arabidopsis thaliana
D436	SN---DF---	1	Caenorhabditis elegans
D54	AKMLADEFGTA	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
D54	SNMLAEEYGTA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D54	QKMLTDEYGTA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D54	TKMLGDEYGTA	1	Arabidopsis thaliana
D54	QRMLAEEYGTA	1	Caenorhabditis elegans
D54	SKMLADEFGTA	1	Drosophila melanogaster
E196	ARLRMEKRHNY	7	Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
E196	ARLRDEKRHNY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E196	ARLREEKRHNY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E196	ARLRNEKRHNY	1	Caenorhabditis elegans
E55	KMLADEFGTAS	6	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
E55	NMLAEEYGTAS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E55	KMLTDEYGTAS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E55	KMLGDEYGTAS	1	Arabidopsis thaliana
E55	RMLAEEYGTAS	1	Caenorhabditis elegans
F190	QSALRFARLRM	7	Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
F190	QSALRFARLRD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F190	QSALRFARLRE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F190	QSAVRFARLRN	1	Caenorhabditis elegans
F232	AGSADFKTELS	7	Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
F232	AGSADFKTELG	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans
F232	AGSADFKTDLA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F385	NNYKKFGATLE	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
F385	EHYKDYGANLE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F385	ANYKNFGATLE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F385	NEYRRFGCALE	1	Arabidopsis thaliana
F385	NNYKNFGAALE	1	Caenorhabditis elegans
F385	NNYKMFGATLE	1	Drosophila melanogaster
F432	GDDEFF-----	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
F432	ESDEFYS----	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F432	SEDEYY-----	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F432	EDGEAL-----	1	Arabidopsis thaliana
F432	TEKETFHARNE	1	Caenorhabditis elegans
F432	LDNDGF-----	1	Drosophila melanogaster
G153	FIVIDGSGALF	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
G153	FIVMDGHQTLY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G153	FIVMDGQGTLF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G153	FIVMDGNGTLF	1	Arabidopsis thaliana
G153	FIIMDGNGCLF	1	Caenorhabditis elegans
G153	FIVMDGNGALF	1	Drosophila melanogaster
G181	LPKKHGRGGQS	10	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicali
G183	KKHGRGGQSAL	9	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
G183	KKHGRGGQSAV	1	Caenorhabditis elegans
G184	KHGRGGQSALR	9	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
G184	KHGRGGQSAVR	1	Caenorhabditis elegans
G315	KALEMGAVEIL	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
G315	NALQEGAVETL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G315	KALDLGAVEKL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G315	NALESGAIETL	1	Arabidopsis thaliana
G315	AALEMGAIETL	1	Caenorhabditis elegans
G315	RALELGSVETL	1	Drosophila melanogaster
G386	NYKKFGATLEI	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
G386	HYKDYGANLEF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G386	NYKNFGATLEF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G386	EYRRFGCALEF	1	Arabidopsis thaliana
G386	NYKNFGAALEI	1	Caenorhabditis elegans
G386	NYKMFGATLEI	1	Drosophila melanogaster
H180	DLPKKHGRGGQ	10	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicali
H199	RMEKRHNYVRK	7	Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
H199	RDEKRHNYVRK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H199	REEKRHNYVRK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H199	RNEKRHNYVRK	1	Caenorhabditis elegans
I62	GTASNIKSRVN	10	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicali
K118	DFEPFKPINTS	7	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
K118	DIEPYKPINTS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K118	DFEPFRPINAS	1	Arabidopsis thaliana
K118	DFEPFKAINTS	1	Caenorhabditis elegans
K178	TVDLPKKHGRG	9	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
K178	SVDLPKKHGRG	1	Arabidopsis thaliana
K179	VDLPKKHGRGG	10	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicali
K383	FANNYKKFGAT	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
K383	LAEHYKDYGAN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K383	LAANYKNFGAT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K383	LANEYRRFGCA	1	Arabidopsis thaliana
K383	FANNYKNFGAA	1	Caenorhabditis elegans
K383	LANNYKMFGAT	1	Drosophila melanogaster
K384	ANNYKKFGATL	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
K384	AEHYKDYGANL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K384	AANYKNFGATL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K384	ANEYRRFGCAL	1	Arabidopsis thaliana
K384	ANNYKNFGAAL	1	Caenorhabditis elegans
K384	ANNYKMFGATL	1	Drosophila melanogaster
K50	ISRVAKMLADE	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
K50	ISRYSNMLAEE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K50	IPLYQKMLTDE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K50	VSRVTKMLGDE	1	Arabidopsis thaliana
K50	VARIQRMLAEE	1	Caenorhabditis elegans
K50	ISRVSKMLADE	1	Drosophila melanogaster
K63	TASNIKSRVNR	10	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicali
K83	VQQRLKLYNKV	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
K83	TRERLKLYNKV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K83	TQQKLKLYNTL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K83	AQQRLKLYNRV	1	Arabidopsis thaliana
K83	VQGRLKLYNKV	1	Caenorhabditis elegans
K83	VQHRLKLYTKV	1	Drosophila melanogaster
L126	NTSLYLCDNKF	8	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
L126	NTSQYLCDNKF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L126	NASLYLCDNKF	1	Arabidopsis thaliana
L176	KFTVDLPKKHG	8	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
L176	RFTVDLPKKHG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L176	KFSVDLPKKHG	1	Arabidopsis thaliana
L188	GGQSALRFARL	9	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
L188	GGQSAVRFARL	1	Caenorhabditis elegans
L193	LRFARLRMEKR	7	Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
L193	LRFARLRDEKR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L193	LRFARLREEKR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L193	VRFARLRNEKR	1	Caenorhabditis elegans
L69	SRVNRLSVLGA	7	Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
L69	SRVNRLSVLSA	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L69	SRVNRQSVLGA	1	Arabidopsis thaliana
M51	SRVAKMLADEF	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
M51	SRYSNMLAEEY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M51	PLYQKMLTDEY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M51	SRVTKMLGDEY	1	Arabidopsis thaliana
M51	ARIQRMLAEEY	1	Caenorhabditis elegans
M51	SRVSKMLADEF	1	Drosophila melanogaster
N121	PFKPINTSLYL	6	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
N121	PFKPINTSQYL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N121	PYKPINTSLYL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N121	PFRPINASLYL	1	Arabidopsis thaliana
N121	PFKAINTSLYL	1	Caenorhabditis elegans
N164	GTLQGNTREVL	7	Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
N164	GVVSGSAREVL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N164	GSVSGNTRTVL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N164	GTLSGNTREVL	1	Arabidopsis thaliana
N265	GENGFNQAIEL	9	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
N265	GDAGFNQAIEL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N61	FGTASNIKSRV	6	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
N61	YGTASNIKSRV	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Caenorhabditis elegans
Q185	HGRGGQSALRF	9	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
Q185	HGRGGQSAVRF	1	Caenorhabditis elegans
Q80	ITSVQQRLKLY	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
Q80	ITSTRERLKLY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q80	ITSTQQKLKLY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q80	ITSAQQRLKLY	1	Arabidopsis thaliana
Q80	ITSVQGRLKLY	1	Caenorhabditis elegans
Q80	ITSVQHRLKLY	1	Drosophila melanogaster
R182	PKKHGRGGQSA	10	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicali
R189	GQSALRFARLR	9	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
R189	GQSAVRFARLR	1	Caenorhabditis elegans
R192	ALRFARLRMEK	7	Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
R192	ALRFARLRDEK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R192	ALRFARLREEK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R192	AVRFARLRNEK	1	Caenorhabditis elegans
R203	RHNYVRKVAET	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
R203	RHNYVRKVAEV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Drosophila melanogaster
R203	RHNYVRKVAEG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R203	RHNYVRKTAEL	1	Arabidopsis thaliana
R203	RHNYVRKVAEN	1	Caenorhabditis elegans
R245	DMFDQRLQSKV	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
R245	DLFDQRLQSRI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R245	ELFDPRLACKV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R245	DMFDPRLAAKI	1	Arabidopsis thaliana
R245	DMFDQRLQAKM	1	Caenorhabditis elegans
R245	DMFDPRLQSKV	1	Drosophila melanogaster
R414	IGGILRYRVD-	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
R414	IGAVMRYQLD-	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R414	IGAMLRYKVN-	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R414	IGGILRYQLD-	1	Arabidopsis thaliana
R414	IGGLLRYRVDL	1	Caenorhabditis elegans
R414	IGGILRYKVD-	1	Drosophila melanogaster
R47	KDQISRVAKML	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
R47	GEQISRYSNML	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R47	KGQIPLYQKML	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R47	RDQVSRVTKML	1	Arabidopsis thaliana
R47	KDQVARIQRML	1	Caenorhabditis elegans
R47	KDQISRVSKML	1	Drosophila melanogaster
R65	SNIKSRVNRLS	9	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
R65	SNIKSRVNRQS	1	Arabidopsis thaliana
R68	KSRVNRLSVLG	7	Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
R68	KSRVNRLSVLS	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R68	KSRVNRQSVLG	1	Arabidopsis thaliana
R81	TSVQQRLKLYN	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
R81	TSTRERLKLYN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R81	TSTQQKLKLYN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R81	TSAQQRLKLYN	1	Arabidopsis thaliana
R81	TSVQGRLKLYN	1	Caenorhabditis elegans
R81	TSVQHRLKLYT	1	Drosophila melanogaster
S123	KPINTSLYLCD	7	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
S123	KPINTSQYLCD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S123	RPINASLYLCD	1	Arabidopsis thaliana
S123	KAINTSLYLCD	1	Caenorhabditis elegans
S186	GRGGQSALRFA	9	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
S186	GRGGQSAVRFA	1	Caenorhabditis elegans
S229	LVLAGSADFKT	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
S229	LILAGSADFKT	4	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster
S229	IVLAGSADFKT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S257	KLVDISYGGEN	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
S257	KTVDVSYGGDA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S257	SIVDVSYGGEN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S257	NVVDVSYGGEN	1	Arabidopsis thaliana
S257	KTVDIAYGGEN	1	Caenorhabditis elegans
S257	KLVDVSYGGEN	1	Drosophila melanogaster
S295	YFDEISQDTGK	8	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
S295	FFDEISLDSGK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S295	YFEEISQDTGK	1	Arabidopsis thaliana
S46	PKDQISRVAKM	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
S46	PGEQISRYSNM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S46	PKGQIPLYQKM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S46	PRDQVSRVTKM	1	Arabidopsis thaliana
S46	PKDQVARIQRM	1	Caenorhabditis elegans
S46	PKDQISRVSKM	1	Drosophila melanogaster
S64	ASNIKSRVNRL	9	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
S64	ASNIKSRVNRQ	1	Arabidopsis thaliana
S77	LGAITSVQQRL	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
S77	LSAITSTRERL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S77	LSAITSTQQKL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S77	LGAITSAQQRL	1	Arabidopsis thaliana
S77	LGAITSVQGRL	1	Caenorhabditis elegans
S77	LGAITSVQHRL	1	Drosophila melanogaster
T122	FKPINTSLYLC	6	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
T122	FKPINTSQYLC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T122	YKPINTSLYLC	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T122	FRPINASLYLC	1	Arabidopsis thaliana
T122	FKAINTSLYLC	1	Caenorhabditis elegans
T32	ARGNGTSMISL	9	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
T32	CHGNGTSMITL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T58	ADEFGTASNIK	6	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
T58	AEEYGTASNIK	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans
T58	TDEYGTASNIK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T58	GDEYGTASNIK	1	Arabidopsis thaliana
T76	VLGAITSVQQR	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
T76	VLSAITSTRER	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T76	VLSAITSTQQK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T76	VLGAITSAQQR	1	Arabidopsis thaliana
T76	VLGAITSVQGR	1	Caenorhabditis elegans
T76	VLGAITSVQHR	1	Drosophila melanogaster
V66	NIKSRVNRLSV	9	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
V66	NIKSRVNRQSV	1	Arabidopsis thaliana
V71	VNRLSVLGAIT	7	Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
V71	VNRLSVLSAIT	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V71	VNRQSVLGAIT	1	Arabidopsis thaliana
Y415	GGILRYRVD--	5	Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Xenopus tropicalis
Y415	GAVMRYQLD--	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y415	GAMLRYKVN--	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y415	GGILRYQLD--	1	Arabidopsis thaliana
Y415	GGLLRYRVDLA	1	Caenorhabditis elegans
Y415	GGILRYKVD--	1	Drosophila melanogaster