mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ETS2
Gene summary
Basic gene Info.Gene symbolETS2
Gene namev-ets avian erythroblastosis virus E26 oncogene homolog 2
SynonymsETS2IT1
CytomapUCSC genome browser: 21q22.2
Type of geneprotein-coding
RefGenesNM_001256295.1,
NM_005239.5,
Descriptiononcogene ETS-2protein C-ets-2v-ets avian erythroblastosis virus E2 oncogene homolog 2v-ets erythroblastosis virus E26 oncogene homolog 2
Modification date20141207
dbXrefs MIM : 164740
HGNC : HGNC
Ensembl : ENSG00000157557
HPRD : 01263
Vega : OTTHUMG00000090769
ProteinUniProt: P15036
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ETS2
BioGPS: 2114
PathwayNCI Pathway Interaction Database: ETS2
KEGG: ETS2
REACTOME: ETS2
Pathway Commons: ETS2
ContextiHOP: ETS2
ligand binding site mutation search in PubMed: ETS2
UCL Cancer Institute: ETS2
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoter12637547
GO:0045893positive regulation of transcription, DNA-templated11909962


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Ligand binding site mutations for ETS2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
M412M412IBRCA1
I167I167FBRCA1
R437R437HCOAD1
W403R401CCOAD1
K416,Y414E415KHNSC1
I167M166ILUAD1
K432K432NLUAD1
M412K411TLUAD1
R419G420DSKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ETS2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
M412K411T-1.3099355
I167I167F-1.1617421
R437R437H-1.1341114
I167M166I-0.9046649
W403R401C-0.8813818
Y414E415K-0.87907859
K416E415K-0.87907859
M412M412I-0.78657986
R419G420D-0.710634
K432K432N-0.41534978
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ETS2 from PDB

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Differential gene expression and gene-gene network for ETS2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ETS2 and the right PPI network was created from samples without mutations in the LBS of ETS2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ETS2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1458155Breast Neoplasms8AlteredExpression, Biomarker
umls:C0376634Craniofacial Abnormalities1Biomarker
umls:C0162820Dermatitis, Allergic Contact1Biomarker
umls:C0027746Nerve Degeneration1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ETS2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ETS2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids4bqaAW403 M412 K416 R419
NUCNucleic Acids4bqaDW403 M412 K416 R419
NUCNucleic Acids4bqaGW403 M412 R419
NUCNucleic Acids4bqaAY414 R419 K432 R437
NUCNucleic Acids4bqaDY414 R419 K432 R437
NUCNucleic Acids4bqaGY414 R419 K432 R437


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Conservation information for LBS of ETS2
Multiple alignments for P15036 in multiple species
LBSAA sequence# speciesSpecies


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