mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for F7
Gene summary
Basic gene Info.Gene symbolF7
Gene namecoagulation factor VII (serum prothrombin conversion accelerator)
SynonymsSPCA
CytomapUCSC genome browser: 13q34
Type of geneprotein-coding
RefGenesNM_000131.4,
NM_001267554.1,NM_019616.3,NR_051961.1,
DescriptionFVII coagulation proteincoagulation factor VIIeptacog alfaproconvertin
Modification date20141207
dbXrefs MIM : 613878
HGNC : HGNC
Ensembl : ENSG00000057593
HPRD : 01965
Vega : OTTHUMG00000017373
ProteinUniProt: P08709
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_F7
BioGPS: 2155
PathwayNCI Pathway Interaction Database: F7
KEGG: F7
REACTOME: F7
Pathway Commons: F7
ContextiHOP: F7
ligand binding site mutation search in PubMed: F7
UCL Cancer Institute: F7
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0002690positive regulation of leukocyte chemotaxis17991872
GO:0010641positive regulation of platelet-derived growth factor receptor signaling pathway17991872
GO:0050927positive regulation of positive chemotaxis17991872
GO:0051897positive regulation of protein kinase B signaling18612547


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Ligand binding site mutations for F7

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
M366R364WCOAD2
I265,V267A266TCOAD1
R69R69WCOAD1
Y178G177WHNSC1
H317D316HHNSC1
T367Q368KLUAD1
D398S396ILUAD1
A252A251ELUAD1
R462R462PLUSC1
K221G222ESKCM1
V377V377MSKCM1
G234G234RSKCM1
I290P291RSKCM1
L273L273FSKCM1
A252A251VSTAD1
I265,V267A266VSTAD1
D277D277NSTAD1
I265,V267A266TUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for F7
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
A252A251V0.080945932
D277D277N0.031193024
H317D316H-1.3173929
L273L273F-1.220777
I290P291R-1.1468681
R69R69W-1.039259
T367Q368K-1.0314383
Y178G177W-0.90410152
M366R364W-0.88392273
R462R462P-0.86462664
D398S396I-0.78157833
V377V377M-0.71421859
K221G222E-0.7030451
V267A266T-0.66762651
I265A266T-0.66762651
I265A266V-0.43358024
V267A266V-0.43358024
G234G234R-0.032503456
A252A251E-0.023346366
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for F7 from PDB
PDB IDPDB titlePDB structure
1CVWCrystal structure of active site-inhibited human coagulation factor VIIA (DES-GLA)

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Differential gene expression and gene-gene network for F7
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of F7 and the right PPI network was created from samples without mutations in the LBS of F7. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for F7
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0015503Factor VII Deficiency44Biomarker, GeneticVariation
umls:C0019080Hemorrhage6AlteredExpression, GeneticVariation, Therapeutic
umls:C0151699Intracranial Hemorrhages5Therapeutic
umls:C0042487Venous Thrombosis4Biomarker, GeneticVariation
umls:C2937358Cerebral Hemorrhage3GeneticVariation, Therapeutic
umls:C0019087Hemorrhagic Disorders3Biomarker, GeneticVariation
umls:C0040038Thromboembolism3Biomarker, GeneticVariation
umls:C0012644Disease Models, Animal1Therapeutic
umls:C0012739Disseminated Intravascular Coagulation1Biomarker
umls:C0749098Hematoma, Subdural, Acute1Therapeutic
umls:C0018965Hematuria1Therapeutic
umls:C0273058Intracranial Hemorrhage, Traumatic1Therapeutic
umls:C0032787Postoperative Complications1Therapeutic

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for F7
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00036Coagulation factor VIIa Recombinant HumanBiotech
ApprovedDB00100Coagulation Factor IXBiotech
Approved|nutraceuticalDB00170MenadioneSmall molecule
ExperimentalDB04590(2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACIDSmall molecule
ExperimentalDB045933-({1-[3-CARBAMIMIDOYL-1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-PROPYLCARBAMOYL]-2-METHYL-BUTYLSULFAMOYL}-METHYL)-BENZOIC ACIDSmall molecule
ExperimentalDB046062-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE)Small molecule
ExperimentalDB047582-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE)Small molecule
ExperimentalDB04767N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMIDSmall molecule
ExperimentalDB072072-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINESmall molecule
ExperimentalDB07247[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREASmall molecule
ExperimentalDB073765-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)Small molecule
ExperimentalDB08232{5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3'-NITRO-BIPHENYL-3-YL]-ACETIC ACIDSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of F7 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of F7
Multiple alignments for P08709 in multiple species
LBSAA sequence# speciesSpecies
A235LLVNGAQLCGG1Homo sapiens
A235LKINGLLLCGA1Mus musculus
A235LKFNEALLCGA1Rattus norvegicus
A235LKLNGALLCGG1Bos taurus
A252WVVSAAHCFDK1Homo sapiens
A252WIVTAAHCFDN1Mus musculus
A252WIVTAAHCFDK1Rattus norvegicus
A252WVVSAAHCFER1Bos taurus
A429WGEGCAAIGHI2Mus musculus, Rattus norvegicus
A429WGQGCATVGHF1Homo sapiens
A429WGEGCAAAGHF1Bos taurus
A463GVLLRAPFP1Homo sapiens
A463GVFRLPLL-1Mus musculus
A463GISRVSLL-1Rattus norvegicus
A463GFFQVPLLP1Bos taurus
A61HRQRRANSLLE2Mus musculus, Rattus norvegicus
A61HRRRRANAFLE1Homo sapiens
A61HRPRRANGFLE1Bos taurus
C132SYICFCLPAFE1Homo sapiens
C132SYVCFCLLDFE1Mus musculus
C132SYVCFCPLDFE1Rattus norvegicus
C132SYICFCPDGFE1Bos taurus
C174KRSCRCHEGYS1Homo sapiens
C174KRTCSCHEDYT1Mus musculus
C174KRTCSCHEDYV1Rattus norvegicus
C174GRFCWCHEGYA1Bos taurus
C238NGAQLCGGTLI1Homo sapiens
C238NGLLLCGAVLL1Mus musculus
C238NEALLCGAVLL1Rattus norvegicus
C238NGALLCGGTLV1Bos taurus
C254VSAAHCFDKIK1Homo sapiens
C254VTAAHCFDNIR1Mus musculus
C254VTAAHCFDKFG1Rattus norvegicus
C254VSAAHCFERLR1Bos taurus
C400GTKDACKGDSG2Mus musculus, Rattus norvegicus
C400GSKDSCKGDSG1Homo sapiens
C400GSKDACKGDSG1Bos taurus
C428SWGEGCAAIGH2Mus musculus, Rattus norvegicus
C428SWGQGCATVGH1Homo sapiens
C428SWGEGCAAAGH1Bos taurus
C82CKEEQCSFEEA1Homo sapiens
C82CNEEQCSFEEA1Mus musculus
C82CNEERCSFEEA1Rattus norvegicus
C82CREELCSFEEA1Bos taurus
D106WISYSDGDQCA1Homo sapiens
D106WIVYSDGDQCA1Mus musculus
D106WTIYSDGDQCA1Rattus norvegicus
D106WVSYNDGDQCA1Bos taurus
D108SYSDGDQCASS1Homo sapiens
D108VYSDGDQCASN1Mus musculus
D108IYSDGDQCASN1Rattus norvegicus
D108SYNDGDQCASS1Bos taurus
D123GGTCQDHLKSY2Mus musculus, Rattus norvegicus
D123GGSCKDQLQSY1Homo sapiens
D123GGSCEDQLRSY1Bos taurus
D256AAHCFDKIKNW1Homo sapiens
D256AAHCFDNIRYW1Mus musculus
D256AAHCFDKFGKL1Rattus norvegicus
D256AAHCFERLRSR1Bos taurus
D272VLGEHDLSEHD1Homo sapiens
D272VMGEHDFSEKD1Mus musculus
D272VLGEHDFSEKE1Rattus norvegicus
D272VLGEHDLSRVE1Bos taurus
D277DLSEHDGDEQS1Homo sapiens
D277DFSEKDGDEQV1Mus musculus
D277DFSEKEGTEQV1Rattus norvegicus
D277DLSRVEGPEQE1Bos taurus
D302GTTNHDIALLR1Homo sapiens
D302GKINHDIALLR1Mus musculus
D302GRTDHDIALVR1Rattus norvegicus
D302GQTDHDVALLQ1Bos taurus
D349WGQLLDRGATA3Homo sapiens, Mus musculus, Rattus norvegicus
D349WGQLLERGVTA1Bos taurus
D379SRKVGDSPNIT1Homo sapiens
D379AKHSSNTPKIT1Mus musculus
D379AKHSANTPRIT1Rattus norvegicus
D379SRQRPGGPVVT1Bos taurus
D398MDGTKDACKGD2Mus musculus, Rattus norvegicus
D398SDGSKDSCKGD1Homo sapiens
D398SDGSKDACKGD1Bos taurus
D403DACKGDSGGPH3Mus musculus, Rattus norvegicus, Bos taurus
D403DSCKGDSGGPH1Homo sapiens
E270IAVLGEHDLSE1Homo sapiens
E270TVVMGEHDFSE1Mus musculus
E270TVVLGEHDFSE1Rattus norvegicus
E270TAVLGEHDLSR1Bos taurus
E275EHDLSEHDGDE1Homo sapiens
E275EHDFSEKDGDE1Mus musculus
E275EHDFSEKEGTE1Rattus norvegicus
E275EHDLSRVEGPE1Bos taurus
E280EHDGDEQSRRV1Homo sapiens
E280EKDGDEQVRRV1Mus musculus
E280EKEGTEQVRLV1Rattus norvegicus
E280RVEGPEQERRV1Bos taurus
E66ANAFLEELRPG1Homo sapiens
E66ANSLLEELWPG1Mus musculus
E66ANSLLEELWSS1Rattus norvegicus
E66ANGFLEELLPG1Bos taurus
E67NAFLEELRPGS1Homo sapiens
E67NSLLEELWPGS1Mus musculus
E67NSLLEELWSSS1Rattus norvegicus
E67NGFLEELLPGS1Bos taurus
E74RPGSLERECKE1Homo sapiens
E74WPGSLERECNE1Mus musculus
E74WSSSLERECNE1Rattus norvegicus
E74LPGSLERECRE1Bos taurus
E76GSLERECKEEQ1Homo sapiens
E76GSLERECNEEQ1Mus musculus
E76SSLERECNEER1Rattus norvegicus
E76GSLERECREEL1Bos taurus
E79ERECKEEQCSF1Homo sapiens
E79ERECNEEQCSF1Mus musculus
E79ERECNEERCSF1Rattus norvegicus
E79ERECREELCSF1Bos taurus
E80RECKEEQCSFE1Homo sapiens
E80RECNEEQCSFE1Mus musculus
E80RECNEERCSFE1Rattus norvegicus
E80RECREELCSFE1Bos taurus
E85EQCSFEEAREI2Homo sapiens, Mus musculus
E85ERCSFEEAREI1Rattus norvegicus
E85ELCSFEEAHEI1Bos taurus
E86QCSFEEAREIF2Homo sapiens, Mus musculus
E86RCSFEEAREIF1Rattus norvegicus
E86LCSFEEAHEIF1Bos taurus
E89FEEAREIFKSP2Mus musculus, Rattus norvegicus
E89FEEAREIFKDA1Homo sapiens
E89FEEAHEIFRNE1Bos taurus
F131QSYICFCLPAF1Homo sapiens
F131KSYVCFCLLDF1Mus musculus
F131KSYVCFCPLDF1Rattus norvegicus
F131RSYICFCPDGF1Bos taurus
F255SAAHCFDKIKN1Homo sapiens
F255TAAHCFDNIRY1Mus musculus
F255TAAHCFDKFGK1Rattus norvegicus
F255SAAHCFERLRS1Bos taurus
F434AAIGHIGVYTR2Mus musculus, Rattus norvegicus
F434ATVGHFGVYTR1Homo sapiens
F434AAAGHFGIYTR1Bos taurus
G107ISYSDGDQCAS1Homo sapiens
G107IVYSDGDQCAS1Mus musculus
G107TIYSDGDQCAS1Rattus norvegicus
G107VSYNDGDQCAS1Bos taurus
G118NPCQNGGTCQD2Mus musculus, Rattus norvegicus
G118SPCQNGGSCKD1Homo sapiens
G118SPCQNGGSCED1Bos taurus
G119PCQNGGTCQDH2Mus musculus, Rattus norvegicus
G119PCQNGGSCKDQ1Homo sapiens
G119PCQNGGSCEDQ1Bos taurus
G234LLLVNGAQLCG1Homo sapiens
G234VLKINGLLLCG1Mus musculus
G234VLKFNEALLCG1Rattus norvegicus
G234MLKLNGALLCG1Bos taurus
G269LIAVLGEHDLS1Homo sapiens
G269ITVVMGEHDFS1Mus musculus
G269ITVVLGEHDFS1Rattus norvegicus
G269LTAVLGEHDLS1Bos taurus
G297STYVPGTTNHD1Homo sapiens
G297DKYIRGKINHD1Mus musculus
G297NKYTRGRTDHD1Rattus norvegicus
G297KQYVPGQTDHD1Bos taurus
G402KDACKGDSGGP3Mus musculus, Rattus norvegicus, Bos taurus
G402KDSCKGDSGGP1Homo sapiens
G425GVVSWGEGCAA3Mus musculus, Rattus norvegicus, Bos taurus
G425GIVSWGQGCAT1Homo sapiens
G427VSWGEGCAAIG2Mus musculus, Rattus norvegicus
G427VSWGQGCATVG1Homo sapiens
G427VSWGEGCAAAG1Bos taurus
G435AIGHIGVYTRV2Mus musculus, Rattus norvegicus
G435TVGHFGVYTRV1Homo sapiens
G435AAGHFGIYTRV1Bos taurus
G458EP-RPGVLLRA1Homo sapiens
G458KL-QVGVFRLP1Mus musculus
G458KL-RVGISRVS1Rattus norvegicus
G458PPSRQGFFQVP1Bos taurus
H175RSCRCHEGYSL1Homo sapiens
H175RTCSCHEDYTL1Mus musculus
H175RTCSCHEDYVL1Rattus norvegicus
H175RFCWCHEGYAL1Bos taurus
H253VVSAAHCFDKI1Homo sapiens
H253IVTAAHCFDNI1Mus musculus
H253IVTAAHCFDKF1Rattus norvegicus
H253VVSAAHCFERL1Bos taurus
H276HDLSEHDGDEQ1Homo sapiens
H276HDFSEKDGDEQ1Mus musculus
H276HDFSEKEGTEQ1Rattus norvegicus
H276HDLSRVEGPEQ1Bos taurus
H309ALLRLHQPVVL1Homo sapiens
H309ALLRLHRPVTF1Mus musculus
H309ALVRLHRPVTF1Rattus norvegicus
H309ALLQLAQPVAL1Bos taurus
H317VTFTDYVVPLC2Mus musculus, Rattus norvegicus
H317VVLTDHVVPLC1Homo sapiens
H317VALGDHVAPLC1Bos taurus
H433CAAIGHIGVYT2Mus musculus, Rattus norvegicus
H433CATVGHFGVYT1Homo sapiens
H433CAAAGHFGIYT1Bos taurus
I258HCFDKIKNWRN1Homo sapiens
I258HCFDNIRYWGN1Mus musculus
I258HCFDKFGKLVN1Rattus norvegicus
I258HCFERLRSRGN1Bos taurus
I265NWRNLIAVLGE1Homo sapiens
I265YWGNITVVMGE1Mus musculus
I265KLVNITVVLGE1Rattus norvegicus
I265SRGNLTAVLGE1Bos taurus
I289RVAQVIIPSTY1Homo sapiens
I289RVTQVIMPDKY1Mus musculus
I289LVEQVIMPNKY1Rattus norvegicus
I289RVAQIIVPKQY1Bos taurus
I290VAQVIIPSTYV1Homo sapiens
I290VTQVIMPDKYI1Mus musculus
I290VEQVIMPNKYT1Rattus norvegicus
I290VAQIIVPKQYV1Bos taurus
K221GKVCPKGECPW1Homo sapiens
K221GNVCPKGECPW1Mus musculus
K221GYVCPKGECPW1Rattus norvegicus
K221GHVCPKGECPW1Bos taurus
K257AHCFDKIKNWR1Homo sapiens
K257AHCFDNIRYWG1Mus musculus
K257AHCFDKFGKLV1Rattus norvegicus
K257AHCFERLRSRG1Bos taurus
K401TKDACKGDSGG2Mus musculus, Rattus norvegicus
K401SKDSCKGDSGG1Homo sapiens
K401SKDACKGDSGG1Bos taurus
K449IEWLQKLMRSE1Homo sapiens
K449IDWLVRHMDSK1Mus musculus
K449IDWLVKYMDSK1Rattus norvegicus
K449TAWLRQLMGHP1Bos taurus
L125TCQDHLKSYVC2Mus musculus, Rattus norvegicus
L125SCKDQLQSYIC1Homo sapiens
L125SCEDQLRSYIC1Bos taurus
L133YICFCLPAFEG1Homo sapiens
L133YVCFCLLDFEG1Mus musculus
L133YVCFCPLDFEG1Rattus norvegicus
L133YICFCPDGFEG1Bos taurus
L231WQVLLLVNGAQ1Homo sapiens
L231WQAVLKINGLL1Mus musculus
L231WQAVLKFNEAL1Rattus norvegicus
L231WQAMLKLNGAL1Bos taurus
L237VNGAQLCGGTL1Homo sapiens
L237INGLLLCGAVL1Mus musculus
L237FNEALLCGAVL1Rattus norvegicus
L237LNGALLCGGTL1Bos taurus
L264KNWRNLIAVLG1Homo sapiens
L264RYWGNITVVMG1Mus musculus
L264GKLVNITVVLG1Rattus norvegicus
L264RSRGNLTAVLG1Bos taurus
L273LGEHDLSEHDG1Homo sapiens
L273MGEHDFSEKDG1Mus musculus
L273LGEHDFSEKEG1Rattus norvegicus
L273LGEHDLSRVEG1Bos taurus
L347SGWGQLLDRGA3Homo sapiens, Mus musculus, Rattus norvegicus
L347SGWGQLLERGV1Bos taurus
L348GWGQLLDRGAT3Homo sapiens, Mus musculus, Rattus norvegicus
L348GWGQLLERGVT1Bos taurus
L355RGATALELMVL1Homo sapiens
L355RGATALELMSI1Mus musculus
L355RGATALELMVI1Rattus norvegicus
L355RGVTARKLMVV1Bos taurus
L450EWLQKLMRSEP1Homo sapiens
L450DWLVRHMDSKL1Mus musculus
L450DWLVKYMDSKL1Rattus norvegicus
L450AWLRQLMGHPP1Bos taurus
L460-RPGVLLRAPF1Homo sapiens
L460-QVGVFRLPLL1Mus musculus
L460-RVGISRVSLL1Rattus norvegicus
L460SRQGFFQVPLL1Bos taurus
L461RPGVLLRAPFP1Homo sapiens
L461QVGVFRLPLL-1Mus musculus
L461RVGISRVSLL-1Rattus norvegicus
L461RQGFFQVPLLP1Bos taurus
M366EVPRLMTQDCL2Mus musculus, Rattus norvegicus
M366NVPRLMTQDCL1Homo sapiens
M366LVPRLLTQDCL1Bos taurus
N62RQRRANSLLEE2Mus musculus, Rattus norvegicus
N62RRRRANAFLEE1Homo sapiens
N62RPRRANGFLEE1Bos taurus
P114QCASSPCQNGG2Homo sapiens, Bos taurus
P114QCASNPCQNGG2Mus musculus, Rattus norvegicus
P311LRLHQPVVLTD1Homo sapiens
P311LRLHRPVTFTD1Mus musculus
P311VRLHRPVTFTD1Rattus norvegicus
P311LQLAQPVALGD1Bos taurus
P381KVGDSPNITEY1Homo sapiens
P381HSSNTPKITEN1Mus musculus
P381HSANTPRITEN1Rattus norvegicus
P381QRPGGPVVTDN1Bos taurus
P464VLLRAPFP1Homo sapiens
P464VFRLPLL-1Mus musculus
P464ISRVSLL-1Rattus norvegicus
P464FFQVPLLP1Bos taurus
Q109YSDGDQCASNP2Mus musculus, Rattus norvegicus
Q109YSDGDQCASSP1Homo sapiens
Q109YNDGDQCASSP1Bos taurus
Q124GTCQDHLKSYV2Mus musculus, Rattus norvegicus
Q124GSCKDQLQSYI1Homo sapiens
Q124GSCEDQLRSYI1Bos taurus
Q126CQDHLKSYVCF2Mus musculus, Rattus norvegicus
Q126CKDQLQSYICF1Homo sapiens
Q126CEDQLRSYICF1Bos taurus
Q236LVNGAQLCGGT1Homo sapiens
Q236KINGLLLCGAV1Mus musculus
Q236KFNEALLCGAV1Rattus norvegicus
Q236KLNGALLCGGT1Bos taurus
Q310LLRLHQPVVLT1Homo sapiens
Q310LLRLHRPVTFT1Mus musculus
Q310LVRLHRPVTFT1Rattus norvegicus
Q310LLQLAQPVALG1Bos taurus
Q346VSGWGQLLDRG3Homo sapiens, Mus musculus, Rattus norvegicus
Q346VSGWGQLLERG1Bos taurus
Q426VVSWGEGCAAI2Mus musculus, Rattus norvegicus
Q426IVSWGQGCATV1Homo sapiens
Q426VVSWGEGCAAA1Bos taurus
Q81ECKEEQCSFEE1Homo sapiens
Q81ECNEEQCSFEE1Mus musculus
Q81ECNEERCSFEE1Rattus norvegicus
Q81ECREELCSFEE1Bos taurus
R139PAFEGRNCETH1Homo sapiens
R139LDFEGRNCEKS1Mus musculus
R139LDFEGRNCEKN1Rattus norvegicus
R139DGFEGRNCETD1Bos taurus
R283GDEQSRRVAQV1Homo sapiens
R283GDEQVRRVTQV1Mus musculus
R283GTEQVRLVEQV1Rattus norvegicus
R283GPEQERRVAQI1Bos taurus
R284DEQSRRVAQVI1Homo sapiens
R284DEQVRRVTQVI1Mus musculus
R284TEQVRLVEQVI1Rattus norvegicus
R284PEQERRVAQII1Bos taurus
R350GQLLDRGATAL3Homo sapiens, Mus musculus, Rattus norvegicus
R350GQLLERGVTAR1Bos taurus
R439IGVYTRVSQYI2Mus musculus, Rattus norvegicus
R439FGVYTRVSQYI1Homo sapiens
R439FGIYTRVSRYT1Bos taurus
R456RSEP-RPGVLL1Homo sapiens
R456DSKL-QVGVFR1Mus musculus
R456DSKL-RVGISR1Rattus norvegicus
R456GHPPSRQGFFQ1Bos taurus
R462PGVLLRAPFP1Homo sapiens
R462VGVFRLPLL-1Mus musculus
R462VGISRVSLL-1Rattus norvegicus
R462QGFFQVPLLP1Bos taurus
R69FLEELRPGSLE1Homo sapiens
R69LLEELWPGSLE1Mus musculus
R69LLEELWSSSLE1Rattus norvegicus
R69FLEELLPGSLE1Bos taurus
R75PGSLERECKEE1Homo sapiens
R75PGSLERECNEE1Mus musculus
R75SSSLERECNEE1Rattus norvegicus
R75PGSLERECREE1Bos taurus
R88SFEEAREIFKS2Mus musculus, Rattus norvegicus
R88SFEEAREIFKD1Homo sapiens
R88SFEEAHEIFRN1Bos taurus
S112GDQCASSPCQN2Homo sapiens, Bos taurus
S112GDQCASNPCQN2Mus musculus, Rattus norvegicus
S120CQNGGTCQDHL2Mus musculus, Rattus norvegicus
S120CQNGGSCKDQL1Homo sapiens
S120CQNGGSCEDQL1Bos taurus
S127QDHLKSYVCFC2Mus musculus, Rattus norvegicus
S127KDQLQSYICFC1Homo sapiens
S127EDQLRSYICFC1Bos taurus
S274GEHDLSEHDGD1Homo sapiens
S274GEHDFSEKDGD1Mus musculus
S274GEHDFSEKEGT1Rattus norvegicus
S274GEHDLSRVEGP1Bos taurus
S282DGDEQSRRVAQ1Homo sapiens
S282DGDEQVRRVTQ1Mus musculus
S282EGTEQVRLVEQ1Rattus norvegicus
S282EGPEQERRVAQ1Bos taurus
S374DCLQQSRKVGD1Homo sapiens
S374DCLEHAKHSSN1Mus musculus
S374DCLEHAKHSAN1Rattus norvegicus
S374DCLQQSRQRPG1Bos taurus
S380RKVGDSPNITE1Homo sapiens
S380KHSSNTPKITE1Mus musculus
S380KHSANTPRITE1Rattus norvegicus
S380RQRPGGPVVTD1Bos taurus
S399DGTKDACKGDS2Mus musculus, Rattus norvegicus
S399DGSKDSCKGDS1Homo sapiens
S399DGSKDACKGDS1Bos taurus
S404ACKGDSGGPHA3Mus musculus, Rattus norvegicus, Bos taurus
S404SCKGDSGGPHA1Homo sapiens
S423LTGVVSWGEGC3Mus musculus, Rattus norvegicus, Bos taurus
S423LTGIVSWGQGC1Homo sapiens
S453QKLMRSEP-RP1Homo sapiens
S453VRHMDSKL-QV1Mus musculus
S453VKYMDSKL-RV1Rattus norvegicus
S453RQLMGHPPSRQ1Bos taurus
T298TYVPGTTNHDI1Homo sapiens
T298KYIRGKINHDI1Mus musculus
T298KYTRGRTDHDI1Rattus norvegicus
T298QYVPGQTDHDV1Bos taurus
T299YVPGTTNHDIA1Homo sapiens
T299YIRGKINHDIA1Mus musculus
T299YTRGRTDHDIA1Rattus norvegicus
T299YVPGQTDHDVA1Bos taurus
T353LDRGATALELM3Homo sapiens, Mus musculus, Rattus norvegicus
T353LERGVTARKLM1Bos taurus
T367VPRLMTQDCLE2Mus musculus, Rattus norvegicus
T367VPRLMTQDCLQ1Homo sapiens
T367VPRLLTQDCLQ1Bos taurus
T430GEGCAAIGHIG2Mus musculus, Rattus norvegicus
T430GQGCATVGHFG1Homo sapiens
T430GEGCAAAGHFG1Bos taurus
V267RNLIAVLGEHD1Homo sapiens
V267GNITVVMGEHD1Mus musculus
V267VNITVVLGEHD1Rattus norvegicus
V267GNLTAVLGEHD1Bos taurus
V285EQSRRVAQVII1Homo sapiens
V285EQVRRVTQVIM1Mus musculus
V285EQVRLVEQVIM1Rattus norvegicus
V285EQERRVAQIIV1Bos taurus
V288RRVAQVIIPST1Homo sapiens
V288RRVTQVIMPDK1Mus musculus
V288RLVEQVIMPNK1Rattus norvegicus
V288RRVAQIIVPKQ1Bos taurus
V313LHRPVTFTDYV2Mus musculus, Rattus norvegicus
V313LHQPVVLTDHV1Homo sapiens
V313LAQPVALGDHV1Bos taurus
V377QQSRKVGDSPN1Homo sapiens
V377EHAKHSSNTPK1Mus musculus
V377EHAKHSANTPR1Rattus norvegicus
V377QQSRQRPGGPV1Bos taurus
V422YLTGVVSWGEG2Mus musculus, Rattus norvegicus
V422YLTGIVSWGQG1Homo sapiens
V422FLTGVVSWGEG1Bos taurus
V436IGHIGVYTRVS2Mus musculus, Rattus norvegicus
V436VGHFGVYTRVS1Homo sapiens
V436AGHFGIYTRVS1Bos taurus
V459P-RPGVLLRAP1Homo sapiens
V459L-QVGVFRLPL1Mus musculus
V459L-RVGISRVSL1Rattus norvegicus
V459PSRQGFFQVPL1Bos taurus
W261DKIKNWRNLIA1Homo sapiens
W261DNIRYWGNITV1Mus musculus
W261DKFGKLVNITV1Rattus norvegicus
W261ERLRSRGNLTA1Bos taurus
W424TGVVSWGEGCA3Mus musculus, Rattus norvegicus, Bos taurus
W424TGIVSWGQGCA1Homo sapiens
Y128DQLQSYICFCL1Homo sapiens
Y128DHLKSYVCFCL1Mus musculus
Y128DHLKSYVCFCP1Rattus norvegicus
Y128DQLRSYICFCP1Bos taurus
Y178RCHEGYSLLAD1Homo sapiens
Y178SCHEDYTLQPD1Mus musculus
Y178SCHEDYVLQPD1Rattus norvegicus
Y178WCHEGYALQAD1Bos taurus
Y294IIPSTYVPGTT1Homo sapiens
Y294IMPDKYIRGKI1Mus musculus
Y294IMPNKYTRGRT1Rattus norvegicus
Y294IVPKQYVPGQT1Bos taurus
Y437GHIGVYTRVSQ2Mus musculus, Rattus norvegicus
Y437GHFGVYTRVSQ1Homo sapiens
Y437GHFGIYTRVSR1Bos taurus


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