mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for F10
Gene summary
Basic gene Info.Gene symbolF10
Gene namecoagulation factor X
SynonymsFX|FXA
CytomapUCSC genome browser: 13q34
Type of geneprotein-coding
RefGenesNM_000504.3,
DescriptionStuart-Prower factorfactor Xaprothrombinase
Modification date20141207
dbXrefs MIM : 613872
HGNC : HGNC
Ensembl : ENSG00000126218
HPRD : 01966
Vega : OTTHUMG00000017374
ProteinUniProt: P00742
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_F10
BioGPS: 2159
PathwayNCI Pathway Interaction Database: F10
KEGG: F10
REACTOME: F10
Pathway Commons: F10
ContextiHOP: F10
ligand binding site mutation search in PubMed: F10
UCL Cancer Institute: F10
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0051897positive regulation of protein kinase B signaling18612547


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Ligand binding site mutations for F10

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
E66E65KSKCM2
F427R426CCOAD1
R445R445CGBM1
Q89D88HHNSC1
Q416G417VLUAD1
G371Q373KLUSC1
S419G420ROV1
E317E317KSKCM1
E300G299SSTAD1
P340A339VSTAD1
E66R68HSTAD1
E300G299STHCA1
R366G365RUCEC1
L343L343PUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for F10
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
S419G420R0.062443732
F427R426C-1.1275778
E66E65K-1.1103781
Q89D88H-1.0987529
R445R445C-1.0572229
E66R68H-1.0310224
E317E317K-0.88190441
L343L343P-0.86789988
E300G299S-0.58617322
P340A339V-0.48112709
G371Q373K-0.41197676
Q416G417V-0.24835345
R366G365R-0.046693457
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for F10 from PDB
PDB IDPDB titlePDB structure
1EZQCRYSTAL STRUCTURE OF HUMAN COAGULATION FACTOR XA COMPLEXED WITH RPR128515

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Differential gene expression and gene-gene network for F10
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of F10 and the right PPI network was created from samples without mutations in the LBS of F10. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for F10
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1414497COAGULATION FACTOR X13Biomarker, GeneticVariation
umls:C0005779Blood Coagulation Disorders6Biomarker
umls:C0015519Factor X Deficiency5Biomarker, GeneticVariation
umls:C0040053Thrombosis1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for F10
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00025Antihemophilic Factor (Recombinant)Biotech
ApprovedDB00036Coagulation factor VIIa Recombinant HumanBiotech
ApprovedDB00100Coagulation Factor IXBiotech
Approved|nutraceuticalDB00170MenadioneSmall molecule
Approved|investigationalDB00569Fondaparinux sodiumSmall molecule
Approved|investigationalDB01109HeparinSmall molecule
ApprovedDB01225EnoxaparinSmall molecule
ExperimentalDB03847Gamma-Carboxy-Glutamic AcidSmall molecule
ExperimentalDB046734-[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL)PYRIMIDIN-2-YL]CARBONYL]PIPERAZINESmall molecule
InvestigationalDB05362SSR-126517ESmall molecule
InvestigationalDB05713LY-517717Small molecule
ApprovedDB06228RivaroxabanSmall molecule
ApprovedDB06605ApixabanSmall molecule
ExperimentalDB06920(2R,4R)-N~1~-(4-CHLOROPHENYL)-N~2~-[2-FLUORO-4-(2-OXOPYRIDIN-1(2H)-YL)PHENYL]-4-METHOXYPYRROLIDINE-1,2-DICARBOXAMIDESmall molecule
ExperimentalDB07211(2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDESmall molecule
ExperimentalDB07261THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDESmall molecule
ExperimentalDB072772-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDESmall molecule
ExperimentalDB072782-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHENESULFONAMIDESmall molecule
ExperimentalDB076052-({4-[(5-CHLORO-1H-INDOL-2-YL)SULFONYL]PIPERAZIN-1-YL}CARBONYL)THIENO[3,2-B]PYRIDINE 4-OXIDESmall molecule
ExperimentalDB07629N-((1R,2S)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDESmall molecule
ExperimentalDB07630N-((1R,2R)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDESmall molecule
ExperimentalDB07800N-(2-(((5-CHLORO-2-PYRIDINYL)AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)-PYRIDINYL)BENZAMIDESmall molecule
ExperimentalDB078045-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1H-1,2,4-TRIAZOLE-3-SULFONAMIDESmall molecule
ExperimentalDB078435-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDESmall molecule
ExperimentalDB078446-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDESmall molecule
ExperimentalDB078476-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-(4-MORPHOLINYL)-2-OXO ETHYL]-2-OXO-3-PYRROLIDINYL}-2-NAPHTHALENESULFONAMIDESmall molecule
ExperimentalDB078485-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-5-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-SULFONAMIDESmall molecule
ExperimentalDB078725-chloro-N-[(3R)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)pyrrolidin-3-yl]thiophene-2-carboxamideSmall molecule
ExperimentalDB078755-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amideSmall molecule
ExperimentalDB07973N-(1-ISOPROPYLPIPERIDIN-4-YL)-1-(3-METHOXYBENZYL)-1H-INDOLE-2-CARBOXAMIDESmall molecule
ExperimentalDB079741-{2-[(4-CHLOROPHENYL)AMINO]-2-OXOETHYL}-N-(1-ISOPROPYLPIPERIDIN-4-YL)-1H-INDOLE-2-CARBOXAMIDESmall molecule
ExperimentalDB081435-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3S,4S)-4-FLUORO- 1-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-PYRROLIDIN-3-YL)-AMIDESmall molecule
ExperimentalDB081735-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDESmall molecule
ExperimentalDB081745-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO) CYCLOPENTYL)THIOPHENE-2-CARBOXAMIDESmall molecule
ExperimentalDB08426THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [2-OXO-1-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)-PYRROLIDIN-3-YL]-AMIDESmall molecule
ExperimentalDB084775-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamideSmall molecule
ExperimentalDB084873-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDESmall molecule
ExperimentalDB084884-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1H-PYRROLO[3,2-C]PYRIDIN-2-YLMETHYL)PIPERAZIN-2-ONESmall molecule
ExperimentalDB084954-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDESmall molecule
ExperimentalDB087454-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONESmall molecule
ExperimentalDB087461-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINESmall molecule
ApprovedDB09075EdoxabanSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of F10 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of F10
Multiple alignments for P00742 in multiple species
LBSAA sequence# speciesSpecies
A414TKQEDACQGDS1Homo sapiens
A414TEQKDACQGDS1Gallus gallus
A414TQPEDACQGDS1Bos taurus
A414AKLEDACQGDS1Mus musculus
A414AKQEDACQGDS1Rattus norvegicus
A444WGEGCARKGKY4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
A444WGEGCARKGKF1Bos taurus
C342NVAPACLPQKD2Mus musculus, Rattus norvegicus
C342NVAPACLPERD1Homo sapiens
C342YVVPACLPQAD1Gallus gallus
C342NVAPACLPEKD1Bos taurus
C415KQEDACQGDSG2Homo sapiens, Rattus norvegicus
C415EQKDACQGDSG1Gallus gallus
C415QPEDACQGDSG1Bos taurus
C415KLEDACQGDSG1Mus musculus
C443SWGEGCARKGK5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
D103QGKCKDGLGEY1Homo sapiens
D103GGQCKDGLGSY1Gallus gallus
D103QGHCKDGIGDY1Bos taurus
D103QGACRDGIGGY1Mus musculus
D103QGECRDGLGSY1Rattus norvegicus
D290KVRVGDRNTEQ1Homo sapiens
D290KVVVGEVDREK1Gallus gallus
D290TVRVGDRNTEQ1Bos taurus
D290KVRVGDRNTEK1Mus musculus
D290KVRVGDLNTEQ1Rattus norvegicus
D347CLPERDWAEST1Homo sapiens
D347CLPQADFANEV1Gallus gallus
D347CLPEKDWAEAT1Bos taurus
D347CLPQKDWAEST1Mus musculus
D347CLPQKDWAEAT1Rattus norvegicus
D408FCAGYDTKQED1Homo sapiens
D408FCAGYETEQKD1Gallus gallus
D408FCAGYDTQPED1Bos taurus
D408FCAGYEAKLED1Mus musculus
D408FCAGYDAKQED1Rattus norvegicus
D413DTKQEDACQGD1Homo sapiens
D413ETEQKDACQGD1Gallus gallus
D413DTQPEDACQGD1Bos taurus
D413EAKLEDACQGD1Mus musculus
D413DAKQEDACQGD1Rattus norvegicus
D429VTRFKDTYFVT3Homo sapiens, Bos taurus, Rattus norvegicus
D429VTRYKDTYFVT1Gallus gallus
D429VTRFKNTYYVT1Mus musculus
E107KDGLGEYTCTC1Homo sapiens
E107KDGLGSYTCSC1Gallus gallus
E107KDGIGDYTCTC1Bos taurus
E107RDGIGGYTCTC1Mus musculus
E107RDGLGSYTCTC1Rattus norvegicus
E245ECKDGECPWQA2Homo sapiens, Mus musculus
E245ECRPGECPWQA1Gallus gallus
E245DCAEGECPWQA1Bos taurus
E245ECKRGECPWQA1Rattus norvegicus
E296RNTEQEEGGEA1Homo sapiens
E296VDREKEEHSET1Gallus gallus
E296RNTEQEEGNEM1Bos taurus
E296RNTEKEEGNEM1Mus musculus
E296LNTEQEDGGEM1Rattus norvegicus
E297NTEQEEGGEAV1Homo sapiens
E297DREKEEHSETT1Gallus gallus
E297NTEQEEGNEMA1Bos taurus
E297NTEKEEGNEMV1Mus musculus
E297NTEQEDGGEMV1Rattus norvegicus
E300QEEGGEAVHEV1Homo sapiens
E300KEEHSETTHTA1Gallus gallus
E300QEEGNEMAHEV1Bos taurus
E300KEEGNEMVHEV1Mus musculus
E300QEDGGEMVHEV1Rattus norvegicus
E317NRFTKETYDFD1Homo sapiens
E317SKYIAETYDND1Gallus gallus
E317SRFVKETYDFD1Bos taurus
E317NKFQRDTYDYD1Mus musculus
E317NKFQRDTYDFD1Rattus norvegicus
E345PACLPQKDWAE2Mus musculus, Rattus norvegicus
E345PACLPERDWAE1Homo sapiens
E345PACLPQADFAN1Gallus gallus
E345PACLPEKDWAE1Bos taurus
E369FGRTHEKGRQS3Homo sapiens, Mus musculus, Rattus norvegicus
E369FGREFEAGRLS1Gallus gallus
E369FGRTHEKGRLS1Bos taurus
E441IVSWGEGCARK5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
E56GHLERECMEET1Homo sapiens
E56GNIERECNEER1Gallus gallus
E56GNLERECLEEA1Bos taurus
E56GNLERECMEEI1Mus musculus
E56GNLERECVEEI1Rattus norvegicus
E66TCSYEEAREVF1Homo sapiens
E66RCSKEEAREAF1Gallus gallus
E66ACSLEEAREVF1Bos taurus
E66ICSYEEVREIF1Mus musculus
E66ICSFEEAREVF1Rattus norvegicus
F334KTPITFRMNVA2Homo sapiens, Mus musculus
F334KEPIQFSEYVV1Gallus gallus
F334KTPIRFRRNVA1Bos taurus
F334KTPITFRENVA1Rattus norvegicus
F396KLSSSFIITQN1Homo sapiens
F396KQSTNFAITEN1Gallus gallus
F396KLSSSFTITPN1Bos taurus
F396KLSTSFSITQN1Mus musculus
F396RLSTSFSITQN1Rattus norvegicus
F427PHVTRFKDTYF3Homo sapiens, Bos taurus, Rattus norvegicus
F427PHVTRYKDTYF1Gallus gallus
F427PHVTRFKNTYY1Mus musculus
F432FKDTYFVTGIV3Homo sapiens, Bos taurus, Rattus norvegicus
F432YKDTYFVTGIV1Gallus gallus
F432FKNTYYVTGIV1Mus musculus
G104GKCKDGLGEYT1Homo sapiens
G104GQCKDGLGSYT1Gallus gallus
G104GHCKDGIGDYT1Bos taurus
G104GACRDGIGGYT1Mus musculus
G104GECRDGLGSYT1Rattus norvegicus
G106CKDGLGEYTCT1Homo sapiens
G106CKDGLGSYTCS1Gallus gallus
G106CKDGIGDYTCT1Bos taurus
G106CRDGIGGYTCT1Mus musculus
G106CRDGLGSYTCT1Rattus norvegicus
G244QECKDGECPWQ1Homo sapiens
G244DECRPGECPWQ1Gallus gallus
G244RDCAEGECPWQ1Bos taurus
G244RECKDGECPWQ1Mus musculus
G244QECKRGECPWQ1Rattus norvegicus
G371RTHEKGRQSTR1Homo sapiens
G371REFEAGRLSKR1Gallus gallus
G371RTHEKGRLSST1Bos taurus
G371RTHEKGRQSNI1Mus musculus
G371RTHEKGRQSKV1Rattus norvegicus
G440GIVSWGEGCAR5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
G442VSWGEGCARKG5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
G447GCARKGKYGIY3Homo sapiens, Mus musculus, Rattus norvegicus
G447GCARKGKYGVY1Gallus gallus
G447GCARKGKFGVY1Bos taurus
G450RKGKYGIYTKV3Homo sapiens, Mus musculus, Rattus norvegicus
G450RKGKYGVYTKL1Gallus gallus
G450RKGKFGVYTKV1Bos taurus
H276ILTAAHCLHQA2Mus musculus, Rattus norvegicus
H276ILTAAHCLYQA1Homo sapiens
H276ILTAAHCINQS1Gallus gallus
H276VLTAAHCLHQA1Bos taurus
I451KGKYGIYTKVT3Homo sapiens, Mus musculus, Rattus norvegicus
I451KGKYGVYTKLS1Gallus gallus
I451KGKFGVYTKVS1Bos taurus
K316HNRFTKETYDF1Homo sapiens
K316HSKYIAETYDN1Gallus gallus
K316HSRFVKETYDF1Bos taurus
K316HNKFQRDTYDY1Mus musculus
K316HNKFQRDTYDF1Rattus norvegicus
K370GRTHEKGRQST1Homo sapiens
K370GREFEAGRLSK1Gallus gallus
K370GRTHEKGRLSS1Bos taurus
K370GRTHEKGRQSN1Mus musculus
K370GRTHEKGRQSK1Rattus norvegicus
K428HVTRFKDTYFV3Homo sapiens, Bos taurus, Rattus norvegicus
K428HVTRYKDTYFV1Gallus gallus
K428HVTRFKNTYYV1Mus musculus
K446EGCARKGKYGI3Homo sapiens, Mus musculus, Rattus norvegicus
K446EGCARKGKYGV1Gallus gallus
K446EGCARKGKFGV1Bos taurus
K448CARKGKYGIYT3Homo sapiens, Mus musculus, Rattus norvegicus
K448CARKGKYGVYT1Gallus gallus
K448CARKGKFGVYT1Bos taurus
L105KCKDGLGEYTC1Homo sapiens
L105QCKDGLGSYTC1Gallus gallus
L105HCKDGIGDYTC1Bos taurus
L105ACRDGIGGYTC1Mus musculus
L105ECRDGLGSYTC1Rattus norvegicus
L343VAPACLPQKDW2Mus musculus, Rattus norvegicus
L343VAPACLPERDW1Homo sapiens
L343VVPACLPQADF1Gallus gallus
L343VAPACLPEKDW1Bos taurus
M336PITFRMNVAPA2Homo sapiens, Mus musculus
M336PIQFSEYVVPA1Gallus gallus
M336PIRFRRNVAPA1Bos taurus
M336PITFRENVAPA1Rattus norvegicus
N292RVGDRNTEQEE2Homo sapiens, Bos taurus
N292VVGEVDREKEE1Gallus gallus
N292RVGDRNTEKEE1Mus musculus
N292RVGDLNTEQED1Rattus norvegicus
N337ITFRMNVAPAC2Homo sapiens, Mus musculus
N337IQFSEYVVPAC1Gallus gallus
N337IRFRRNVAPAC1Bos taurus
N337ITFRENVAPAC1Rattus norvegicus
P340RMNVAPACLPE1Homo sapiens
P340SEYVVPACLPQ1Gallus gallus
P340RRNVAPACLPE1Bos taurus
P340RMNVAPACLPQ1Mus musculus
P340RENVAPACLPQ1Rattus norvegicus
P344APACLPQKDWA2Mus musculus, Rattus norvegicus
P344APACLPERDWA1Homo sapiens
P344VPACLPQADFA1Gallus gallus
P344APACLPEKDWA1Bos taurus
Q280AHCLYQAKRFK1Homo sapiens
Q280AHCINQSKEIK1Gallus gallus
Q280AHCLHQAKRFT1Bos taurus
Q280AHCLHQARRFK1Mus musculus
Q280AHCLHQAKRFK1Rattus norvegicus
Q295DRNTEQEEGGE1Homo sapiens
Q295EVDREKEEHSE1Gallus gallus
Q295DRNTEQEEGNE1Bos taurus
Q295DRNTEKEEGNE1Mus musculus
Q295DLNTEQEDGGE1Rattus norvegicus
Q416QEDACQGDSGG2Homo sapiens, Rattus norvegicus
Q416QKDACQGDSGG1Gallus gallus
Q416PEDACQGDSGG1Bos taurus
Q416LEDACQGDSGG1Mus musculus
Q89YKDGDQCETSP1Homo sapiens
Q89YVDGDQCSSNP1Gallus gallus
Q89YKDGDQCEGHP1Bos taurus
Q89YKDGDQCESSP1Mus musculus
Q89YEDGDQCESSP1Rattus norvegicus
R287KRFKVRVGDRN1Homo sapiens
R287KEIKVVVGEVD1Gallus gallus
R287KRFTVRVGDRN1Bos taurus
R287RRFKVRVGDRN1Mus musculus
R287KRFKVRVGDLN1Rattus norvegicus
R291VRVGDRNTEQE2Homo sapiens, Bos taurus
R291VVVGEVDREKE1Gallus gallus
R291VRVGDRNTEKE1Mus musculus
R291VRVGDLNTEQE1Rattus norvegicus
R335TPITFRMNVAP2Homo sapiens, Mus musculus
R335EPIQFSEYVVP1Gallus gallus
R335TPIRFRRNVAP1Bos taurus
R335TPITFRENVAP1Rattus norvegicus
R366VSGFGRTHEKG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R366VSGFGREFEAG1Gallus gallus
R445GEGCARKGKYG4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
R445GEGCARKGKFG1Bos taurus
S419ACQGDSGGPHV5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
S438VTGIVSWGEGC5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
T293VGDRNTEQEEG2Homo sapiens, Bos taurus
T293VGEVDREKEEH1Gallus gallus
T293VGDRNTEKEEG1Mus musculus
T293VGDLNTEQEDG1Rattus norvegicus
T318RFTKETYDFDI1Homo sapiens
T318KYIAETYDNDI1Gallus gallus
T318RFVKETYDFDI1Bos taurus
T318KFQRDTYDYDI1Mus musculus
T318KFQRDTYDFDI1Rattus norvegicus
T409CAGYDTKQEDA1Homo sapiens
T409CAGYETEQKDA1Gallus gallus
T409CAGYDTQPEDA1Bos taurus
T409CAGYEAKLEDA1Mus musculus
T409CAGYDAKQEDA1Rattus norvegicus
T430TRFKDTYFVTG3Homo sapiens, Bos taurus, Rattus norvegicus
T430TRYKDTYFVTG1Gallus gallus
T430TRFKNTYYVTG1Mus musculus
V437FVTGIVSWGEG4Homo sapiens, Gallus gallus, Bos taurus, Rattus norvegicus
V437YVTGIVSWGEG1Mus musculus
W248DGECPWQALLI2Homo sapiens, Mus musculus
W248PGECPWQAVLI1Gallus gallus
W248EGECPWQALLV1Bos taurus
W248RGECPWQALLF1Rattus norvegicus
W348LPERDWAESTL1Homo sapiens
W348LPQADFANEVL1Gallus gallus
W348LPEKDWAEATL1Bos taurus
W348LPQKDWAESTL1Mus musculus
W348LPQKDWAEATL1Rattus norvegicus
W439TGIVSWGEGCA5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
Y319FTKETYDFDIA1Homo sapiens
Y319YIAETYDNDIA1Gallus gallus
Y319FVKETYDFDIA1Bos taurus
Y319FQRDTYDYDIA1Mus musculus
Y319FQRDTYDFDIA1Rattus norvegicus
Y407MFCAGYDTKQE1Homo sapiens
Y407MFCAGYETEQK1Gallus gallus
Y407MFCAGYDTQPE1Bos taurus
Y407MFCAGYEAKLE1Mus musculus
Y407MFCAGYDAKQE1Rattus norvegicus
Y431RFKDTYFVTGI3Homo sapiens, Bos taurus, Rattus norvegicus
Y431RYKDTYFVTGI1Gallus gallus
Y431RFKNTYYVTGI1Mus musculus
Y452GKYGIYTKVTA2Homo sapiens, Rattus norvegicus
Y452GKYGVYTKLSR1Gallus gallus
Y452GKFGVYTKVSN1Bos taurus
Y452GKYGIYTKVTT1Mus musculus


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