mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for FABP1
Gene summary
Basic gene Info.Gene symbolFABP1
Gene namefatty acid binding protein 1, liver
SynonymsFABPL|L-FABP
CytomapUCSC genome browser: 2p11
Type of geneprotein-coding
RefGenesNM_001443.2,
Descriptionfatty acid-binding protein 1fatty acid-binding protein, liverliver-type fatty acid-binding protein
Modification date20141207
dbXrefs MIM : 134650
HGNC : HGNC
Ensembl : ENSG00000163586
HPRD : 00612
Vega : OTTHUMG00000130312
ProteinUniProt: P07148
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FABP1
BioGPS: 2168
PathwayNCI Pathway Interaction Database: FABP1
KEGG: FABP1
REACTOME: FABP1
Pathway Commons: FABP1
ContextiHOP: FABP1
ligand binding site mutation search in PubMed: FABP1
UCL Cancer Institute: FABP1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0043066negative regulation of apoptotic process16175609
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process16175609
GO:0070301cellular response to hydrogen peroxide16175609
GO:0071456cellular response to hypoxia16175609


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Ligand binding site mutations for FABP1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F63E62KSKCM3
T75G76EBRCA1
V65E67DCOAD1
S39S39LGBM1
Q60Q60EKIRC1
I22,L24G23SLUSC1
L24,L28E26KSKCM1
G32G32ESKCM1
L24L24MUCEC1
D107D107NUCEC1
I98I98TUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for FABP1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
S39S39L0.51559037
I98I98T-1.3641891
D107D107N-1.2896974
V65E67D-1.1360709
L24L24M-1.0852012
F63E62K-0.95390431
I22G23S-0.69843345
L24G23S-0.69843345
G32G32E-0.55131461
Q60Q60E-0.47520558
T75G76E-0.45993758
L24E26K-0.43249083
L28E26K-0.43249083
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for FABP1 from PDB
PDB IDPDB titlePDB structure
2F73Crystal structure of human fatty acid binding protein 1 (FABP1)

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Differential gene expression and gene-gene network for FABP1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of FABP1 and the right PPI network was created from samples without mutations in the LBS of FABP1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for FABP1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0023794Lipidoses2Biomarker
umls:C0022661Kidney Failure, Chronic1Biomarker
umls:C0022672Kidney Tubular Necrosis, Acute1Therapeutic

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for FABP1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of FABP1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IODIODIDE3b2hAD107
IODIODIDE3b2hAI22 I98
IODIODIDE3b2hAI22 I98
IODIODIDE3b2kAI22 I98
IODIODIDE3vg6AI22 I98
IODIODIDE3vg6AI22 I98
IODIODIDE3b2iAI22 T75
IODIODIDE3b2jAI22 T75
OLAOLEIC ACID2lkkAL24 L28 G32
IODIODIDE3b2jAQ60
IODIODIDE3vg2AQ60
PLMPALMITIC ACID3stmXS39
OLAOLEIC ACID2lkkAS39 F63
PLMPALMITIC ACID3stkAS39 F63
IODIODIDE3b2hAV65


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Conservation information for LBS of FABP1
Multiple alignments for P07148 in multiple species
LBSAA sequence# speciesSpecies
A54KFTITAGSKVI1Homo sapiens
A54KVTVTAGTKVI1Danio rerio
A54KFIITAGSKVI1Bos taurus
A54KLTITYGPKVV1Mus musculus
A54KLTITYGSKVI1Rattus norvegicus
D107TELNGDIITNT1Homo sapiens
D107TELDGDTISNT1Danio rerio
D107TEFNGDTVTST1Bos taurus
D107TELNGDTITNT1Mus musculus
D107TEFNGDTITNT1Rattus norvegicus
E13QLQSQENFEAF1Homo sapiens
E13QLESHENFEAF1Danio rerio
E13QVQTQENYEAF1Bos taurus
E13QLQSQENFEPF1Mus musculus
E13QVQSQENFEPF1Rattus norvegicus
E40IKGVSEIVQNG2Homo sapiens, Bos taurus
E40IKGVSEIVHEG2Mus musculus, Rattus norvegicus
E40IKSISEIHQDG1Danio rerio
E72EECELETMTGE3Homo sapiens, Mus musculus, Rattus norvegicus
E72EECELETFTGD1Danio rerio
E72EECEMEFMTGE1Bos taurus
F120LGDIVYKRVSK2Mus musculus, Rattus norvegicus
F120LGDIVFKRISK1Homo sapiens
F120FNGIVYKRISR1Danio rerio
F120KGDVVFKRVSK1Bos taurus
F15QSQENFEPFMK2Mus musculus, Rattus norvegicus
F15QSQENFEAFMK1Homo sapiens
F15ESHENFEAFMK1Danio rerio
F15QTQENYEAFMK1Bos taurus
F18ENFEAFMKAIG1Homo sapiens
F18ENFEAFMKAVG1Danio rerio
F18ENYEAFMKAVG1Bos taurus
F18ENFEPFMKAIG1Mus musculus
F18ENFEPFMKAMG1Rattus norvegicus
F50GKHFKFTITAG1Homo sapiens
F50GKDFKVTVTAG1Danio rerio
F50GKHFKFIITAG1Bos taurus
F50GKKIKLTITYG1Mus musculus
F50GKKVKLTITYG1Rattus norvegicus
F63VIQNEFTVGEE1Homo sapiens
F63VILYSFTVGEE1Danio rerio
F63VIQNEFTLGEE1Bos taurus
F63VVRNEFTLGEE1Mus musculus
F63VIHNEFTLGEE1Rattus norvegicus
F95KMVTTFKGIKS2Mus musculus, Rattus norvegicus
F95KLVTTFKNIKS1Homo sapiens
F95KLTAFVKGIES1Danio rerio
F95KLVTTFKGIKS1Bos taurus
G32DLIQKGKDIKG2Mus musculus, Rattus norvegicus
G32ELIQKGKDIKG1Homo sapiens
G32DEVEKGKDIKS1Danio rerio
G32DIIQKGKDIKG1Bos taurus
G55FTITAGSKVIQ1Homo sapiens
G55VTVTAGTKVIL1Danio rerio
G55FIITAGSKVIQ1Bos taurus
G55LTITYGPKVVR1Mus musculus
G55LTITYGSKVIH1Rattus norvegicus
I109LNGDIITNTMT1Homo sapiens
I109LDGDTISNTLS1Danio rerio
I109FNGDTVTSTMT1Bos taurus
I109LNGDTITNTMT1Mus musculus
I109FNGDTITNTMT1Rattus norvegicus
I123IVYKRVSKRI-2Mus musculus, Rattus norvegicus
I123IVFKRISKRI-1Homo sapiens
I123IVYKRISRRIS1Danio rerio
I123VVFKRVSKRI-1Bos taurus
I22AFMKAIGLPEE1Homo sapiens
I22AFMKAVGVPDD1Danio rerio
I22AFMKAVGMPDD1Bos taurus
I22PFMKAIGLPED1Mus musculus
I22PFMKAMGLPED1Rattus norvegicus
I35QKGKDIKGVSE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I35EKGKDIKSISE1Danio rerio
I41KGVSEIVQNGK2Homo sapiens, Bos taurus
I41KGVSEIVHEGK2Mus musculus, Rattus norvegicus
I41KSISEIHQDGK1Danio rerio
I52HFKFTITAGSK1Homo sapiens
I52DFKVTVTAGTK1Danio rerio
I52HFKFIITAGSK1Bos taurus
I52KIKLTITYGPK1Mus musculus
I52KVKLTITYGSK1Rattus norvegicus
I98TTFKGIKSVTE3Bos taurus, Mus musculus, Rattus norvegicus
I98TTFKNIKSVTE1Homo sapiens
I98AFVKGIESVTE1Danio rerio
K121GDIVYKRVSKR2Mus musculus, Rattus norvegicus
K121GDIVFKRISKR1Homo sapiens
K121NGIVYKRISRR1Danio rerio
K121GDVVFKRVSKR1Bos taurus
K31EDLIQKGKDIK2Mus musculus, Rattus norvegicus
K31EELIQKGKDIK1Homo sapiens
K31DDEVEKGKDIK1Danio rerio
K31DDIIQKGKDIK1Bos taurus
K36KGKDIKGVSEI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K36KGKDIKSISEI1Danio rerio
K49NGKHFKFTITA1Homo sapiens
K49DGKDFKVTVTA1Danio rerio
K49NGKHFKFIITA1Bos taurus
K49EGKKIKLTITY1Mus musculus
K49EGKKVKLTITY1Rattus norvegicus
K96MVTTFKGIKSV2Mus musculus, Rattus norvegicus
K96LVTTFKNIKSV1Homo sapiens
K96LTAFVKGIESV1Danio rerio
K96LVTTFKGIKSV1Bos taurus
L115TNTMTLGDIVY2Mus musculus, Rattus norvegicus
L115TNTMTLGDIVF1Homo sapiens
L115SNTLSFNGIVY1Danio rerio
L115TSTMTKGDVVF1Bos taurus
L24MKAIGLPEELI1Homo sapiens
L24MKAVGVPDDEV1Danio rerio
L24MKAVGMPDDII1Bos taurus
L24MKAIGLPEDLI1Mus musculus
L24MKAMGLPEDLI1Rattus norvegicus
L28GLPEDLIQKGK2Mus musculus, Rattus norvegicus
L28GLPEELIQKGK1Homo sapiens
L28GVPDDEVEKGK1Danio rerio
L28GMPDDIIQKGK1Bos taurus
L71GEECELETMTG3Homo sapiens, Mus musculus, Rattus norvegicus
L71GEECELETFTG1Danio rerio
L71GEECEMEFMTG1Bos taurus
L85KTVVQLEGDNK1Homo sapiens
L85KTVVQMDG-NK1Danio rerio
L85KAVVQQEGDNK1Bos taurus
L85KAVVKLEGDNK1Mus musculus
L85KAVVKMEGDNK1Rattus norvegicus
M113TITNTMTLGDI2Mus musculus, Rattus norvegicus
M113IITNTMTLGDI1Homo sapiens
M113TISNTLSFNGI1Danio rerio
M113TVTSTMTKGDV1Bos taurus
M19NFEAFMKAIGL1Homo sapiens
M19NFEAFMKAVGV1Danio rerio
M19NYEAFMKAVGM1Bos taurus
M19NFEPFMKAIGL1Mus musculus
M19NFEPFMKAMGL1Rattus norvegicus
M74CELETMTGEKV3Homo sapiens, Mus musculus, Rattus norvegicus
M74CELETFTGDRA1Danio rerio
M74CEMEFMTGEKI1Bos taurus
N111GDTITNTMTLG2Mus musculus, Rattus norvegicus
N111GDIITNTMTLG1Homo sapiens
N111GDTISNTLSFN1Danio rerio
N111GDTVTSTMTKG1Bos taurus
Q12YQLQSQENFEA1Homo sapiens
Q12YQLESHENFEA1Danio rerio
Q12YQVQTQENYEA1Bos taurus
Q12YQLQSQENFEP1Mus musculus
Q12YQVQSQENFEP1Rattus norvegicus
Q60GSKVIQNEFTV1Homo sapiens
Q60GTKVILYSFTV1Danio rerio
Q60GSKVIQNEFTL1Bos taurus
Q60GPKVVRNEFTL1Mus musculus
Q60GSKVIHNEFTL1Rattus norvegicus
Q84VKTVVQLEGDN1Homo sapiens
Q84AKTVVQMDG-N1Danio rerio
Q84IKAVVQQEGDN1Bos taurus
Q84VKAVVKLEGDN1Mus musculus
Q84VKAVVKMEGDN1Rattus norvegicus
R122DIVYKRVSKRI2Mus musculus, Rattus norvegicus
R122DIVFKRISKRI1Homo sapiens
R122GIVYKRISRRI1Danio rerio
R122DVVFKRVSKRI1Bos taurus
S100FKGIKSVTEFN2Bos taurus, Rattus norvegicus
S100FKNIKSVTELN1Homo sapiens
S100VKGIESVTELD1Danio rerio
S100FKGIKSVTELN1Mus musculus
S11KYQLQSQENFE2Homo sapiens, Mus musculus
S11KYQLESHENFE1Danio rerio
S11KYQVQTQENYE1Bos taurus
S11KYQVQSQENFE1Rattus norvegicus
S124VYKRVSKRI-2Mus musculus, Rattus norvegicus
S124VFKRISKRI-1Homo sapiens
S124VYKRISRRIS1Danio rerio
S124VFKRVSKRI-1Bos taurus
S39DIKGVSEIVQN2Homo sapiens, Bos taurus
S39DIKGVSEIVHE2Mus musculus, Rattus norvegicus
S39DIKSISEIHQD1Danio rerio
S56TITAGSKVIQN1Homo sapiens
S56TVTAGTKVILY1Danio rerio
S56IITAGSKVIQN1Bos taurus
S56TITYGPKVVRN1Mus musculus
S56TITYGSKVIHN1Rattus norvegicus
T102GIKSVTEFNGD2Bos taurus, Rattus norvegicus
T102NIKSVTELNGD1Homo sapiens
T102GIESVTELDGD1Danio rerio
T102GIKSVTELNGD1Mus musculus
T51KHFKFTITAGS1Homo sapiens
T51KDFKVTVTAGT1Danio rerio
T51KHFKFIITAGS1Bos taurus
T51KKIKLTITYGP1Mus musculus
T51KKVKLTITYGS1Rattus norvegicus
T73ECELETMTGEK3Homo sapiens, Mus musculus, Rattus norvegicus
T73ECELETFTGDR1Danio rerio
T73ECEMEFMTGEK1Bos taurus
T75ELETMTGEKVK3Homo sapiens, Mus musculus, Rattus norvegicus
T75ELETFTGDRAK1Danio rerio
T75EMEFMTGEKIK1Bos taurus
T93DNKMVTTFKGI2Mus musculus, Rattus norvegicus
T93DNKLVTTFKNI1Homo sapiens
T93-NKLTAFVKGI1Danio rerio
T93DNKLVTTFKGI1Bos taurus
V42GVSEIVQNGKH2Homo sapiens, Bos taurus
V42GVSEIVHEGKK2Mus musculus, Rattus norvegicus
V42SISEIHQDGKD1Danio rerio
V65QNEFTVGEECE1Homo sapiens
V65LYSFTVGEECE1Danio rerio
V65QNEFTLGEECE1Bos taurus
V65RNEFTLGEECE1Mus musculus
V65HNEFTLGEECE1Rattus norvegicus


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