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mutLBSgeneDB |
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| Gene summary for FABP5 |
 Gene summary |
| Basic gene Info. | Gene symbol | FABP5 |
| Gene name | fatty acid binding protein 5 (psoriasis-associated) | |
| Synonyms | E-FABP|EFABP|KFABP|PA-FABP|PAFABP | |
| Cytomap | UCSC genome browser: 8q21.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001444.2, | |
| Description | epidermal-type fatty acid-binding proteinfatty acid-binding protein, epidermalpsoriasis-associated fatty acid-binding protein homolog | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605168 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000164687 | ||
| HPRD : 05524 | ||
| Vega : OTTHUMG00000134313 | ||
| Protein | UniProt: Q01469 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FABP5 | |
| BioGPS: 2171 | ||
| Pathway | NCI Pathway Interaction Database: FABP5 | |
| KEGG: FABP5 | ||
| REACTOME: FABP5 | ||
| Pathway Commons: FABP5 | ||
| Context | iHOP: FABP5 | |
| ligand binding site mutation search in PubMed: FABP5 | ||
| UCL Cancer Institute: FABP5 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for FABP5 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | T56,I54 | K55N | COAD | 1 | C43 | I44V | HNSC | 1 | I107 | S105I | LUSC | 1 | R129,Y131 | I130V | STAD | 1 | V118 | L116I | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for FABP5 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y131 | I130V | -1.3953264 | R129 | I130V | -1.3953264 | C43 | I44V | -1.3586054 | I54 | K55N | -1.0238089 | T56 | K55N | -1.0238089 | V118 | L116I | -0.566182 | I107 | S105I | -0.51096896 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for FABP5 from PDB |
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| Differential gene expression and gene-gene network for FABP5 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for FABP5 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C2239176 | Carcinoma, Hepatocellular | 1 | Biomarker |
| umls:C0151744 | Myocardial Ischemia | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for FABP5 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of FABP5 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | A9M | N-(2-HYDROXYETHYL)ICOSANAMIDE | 4azr | B | C43 | T4B | ((2'-(5-ETHYL-3,4-DIPHENYL-1H-PYRAZOL-1-YL)-3-BIPHENYLYL)OXY)ACETIC ACID | 4azm | A | C43 T56 | A9M | N-(2-HYDROXYETHYL)ICOSANAMIDE | 4azr | A | C43 T56 | PLM | PALMITIC ACID | 1b56 | A | I107 V118 R129 Y131 | T4B | ((2'-(5-ETHYL-3,4-DIPHENYL-1H-PYRAZOL-1-YL)-3-BIPHENYLYL)OXY)ACETIC ACID | 4azm | B | I54 T56 | A9M | N-(2-HYDROXYETHYL)ICOSANAMIDE | 4azr | B | R129 Y131 | EIC | LINOLEIC ACID | 4lkt | A | R129 Y131 | EIC | LINOLEIC ACID | 4lkt | B | R129 Y131 | EIC | LINOLEIC ACID | 4lkt | D | T56 I107 V118 R129 Y131 | EIC | LINOLEIC ACID | 4lkt | C | T56 V118 R129 Y131 | T4B | ((2'-(5-ETHYL-3,4-DIPHENYL-1H-PYRAZOL-1-YL)-3-BIPHENYLYL)OXY)ACETIC ACID | 4azm | A | V118 R129 Y131 | T4B | ((2'-(5-ETHYL-3,4-DIPHENYL-1H-PYRAZOL-1-YL)-3-BIPHENYLYL)OXY)ACETIC ACID | 4azm | B | V118 R129 Y131 | A9M | N-(2-HYDROXYETHYL)ICOSANAMIDE | 4azr | A | V118 R129 Y131 |
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| Conservation information for LBS of FABP5 |
| Multiple alignments for Q01469 in multiple species |
| LBS | AA sequence | # species | Species | A39 | KMGAMAKPDCI | 2 | Homo sapiens, Rattus norvegicus | A39 | KVGAMAKPDCI | 1 | Bos taurus | A39 | KMAAMAKPDCI | 1 | Mus musculus | A78 | FEETTADGRKT | 2 | Homo sapiens, Bos taurus | A78 | FDETTADGRKT | 2 | Mus musculus, Rattus norvegicus | C120 | KLVVECVMNNV | 1 | Homo sapiens | C120 | KLVVVCVMNNV | 1 | Bos taurus | C120 | KMIVECVMNNA | 1 | Mus musculus | C120 | KMVVECVMNNA | 1 | Rattus norvegicus | C127 | MNNVTCTRIYE | 1 | Homo sapiens | C127 | MNNVTCTRVYE | 1 | Bos taurus | C127 | MNNATCTRVYE | 1 | Mus musculus | C127 | MNNAICTRVYE | 1 | Rattus norvegicus | C43 | MAKPDCIITCD | 2 | Homo sapiens, Mus musculus | C43 | MAKPDCIITSD | 1 | Bos taurus | C43 | MAKPDCIITLD | 1 | Rattus norvegicus | D79 | EETTADGRKTQ | 2 | Homo sapiens, Bos taurus | D79 | DETTADGRKTE | 2 | Mus musculus, Rattus norvegicus | F19 | VDSKGFDEYMK | 1 | Homo sapiens | F19 | VESKGFDEYMK | 1 | Bos taurus | F19 | MESHGFEEYMK | 1 | Mus musculus | F19 | VESHGFEDYMK | 1 | Rattus norvegicus | G36 | ALRKMGAMAKP | 2 | Homo sapiens, Rattus norvegicus | G36 | ALRKVGAMAKP | 1 | Bos taurus | G36 | ALRKMAAMAKP | 1 | Mus musculus | I107 | GKESTITRKLK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I107 | GKESTITRKLE | 1 | Bos taurus | I54 | GKNLTIKTEST | 1 | Homo sapiens | I54 | GKNLSIKTEST | 1 | Bos taurus | I54 | GNNITVKTEST | 1 | Mus musculus | I54 | GNNLTVKTEST | 1 | Rattus norvegicus | K61 | TESTLKTTQFS | 2 | Homo sapiens, Bos taurus | K61 | TESTVKTTVFS | 2 | Mus musculus, Rattus norvegicus | L26 | EYMKELGVGIA | 1 | Homo sapiens | L26 | EYMKEVGVGMA | 1 | Bos taurus | L26 | EYMKELGVGLA | 1 | Mus musculus | L26 | DYMKELGVGLA | 1 | Rattus norvegicus | L32 | GVGIALRKMGA | 1 | Homo sapiens | L32 | GVGMALRKVGA | 1 | Bos taurus | L32 | GVGLALRKMAA | 1 | Mus musculus | L32 | GVGLALRKMGA | 1 | Rattus norvegicus | L60 | KTESTLKTTQF | 2 | Homo sapiens, Bos taurus | L60 | KTESTVKTTVF | 2 | Mus musculus, Rattus norvegicus | M23 | GFDEYMKELGV | 1 | Homo sapiens | M23 | GFDEYMKEVGV | 1 | Bos taurus | M23 | GFEEYMKELGV | 1 | Mus musculus | M23 | GFEDYMKELGV | 1 | Rattus norvegicus | M35 | IALRKMGAMAK | 1 | Homo sapiens | M35 | MALRKVGAMAK | 1 | Bos taurus | M35 | LALRKMAAMAK | 1 | Mus musculus | M35 | LALRKMGAMAK | 1 | Rattus norvegicus | P41 | GAMAKPDCIIT | 3 | Homo sapiens, Bos taurus, Rattus norvegicus | P41 | AAMAKPDCIIT | 1 | Mus musculus | Q64 | TLKTTQFSCTL | 1 | Homo sapiens | Q64 | TLKTTQFSCKL | 1 | Bos taurus | Q64 | TVKTTVFSCNL | 1 | Mus musculus | Q64 | TVKTTVFSCTL | 1 | Rattus norvegicus | R109 | ESTITRKLKDG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R109 | ESTITRKLEDG | 1 | Bos taurus | R129 | NVTCTRIYEKV | 1 | Homo sapiens | R129 | NVTCTRVYEKV | 1 | Bos taurus | R129 | NATCTRVYEKV | 1 | Mus musculus | R129 | NAICTRVYEKV | 1 | Rattus norvegicus | R81 | TTADGRKTQTV | 2 | Homo sapiens, Bos taurus | R81 | TTADGRKTETV | 2 | Mus musculus, Rattus norvegicus | T56 | NLTIKTESTLK | 1 | Homo sapiens | T56 | NLSIKTESTLK | 1 | Bos taurus | T56 | NITVKTESTVK | 1 | Mus musculus | T56 | NLTVKTESTVK | 1 | Rattus norvegicus | V118 | DGKLVVECVMN | 1 | Homo sapiens | V118 | DGKLVVVCVMN | 1 | Bos taurus | V118 | DGKMIVECVMN | 1 | Mus musculus | V118 | DGKMVVECVMN | 1 | Rattus norvegicus | Y131 | TCTRIYEKVE | 1 | Homo sapiens | Y131 | TCTRVYEKVE | 1 | Bos taurus | Y131 | TCTRVYEKVQ | 1 | Mus musculus | Y131 | ICTRVYEKVQ | 1 | Rattus norvegicus | Y22 | KGFDEYMKELG | 1 | Homo sapiens | Y22 | KGFDEYMKEVG | 1 | Bos taurus | Y22 | HGFEEYMKELG | 1 | Mus musculus | Y22 | HGFEDYMKELG | 1 | Rattus norvegicus |
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