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mutLBSgeneDB |
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| Gene summary for FABP6 |
 Gene summary |
| Basic gene Info. | Gene symbol | FABP6 |
| Gene name | fatty acid binding protein 6, ileal | |
| Synonyms | I-15P|I-BABP|I-BALB|I-BAP|ILBP|ILBP3|ILLBP | |
| Cytomap | UCSC genome browser: 5q33.3-q34 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001040442.1, NM_001130958.1,NM_001445.2, | |
| Description | GTgastrotropinileal bile acid binding proteinileal lipid-binding proteinilleal lipid-binding proteinintestinal 15 kDa protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600422 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000170231 | ||
| HPRD : 02689 | ||
| Vega : OTTHUMG00000130329 | ||
| Protein | UniProt: P51161 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FABP6 | |
| BioGPS: 2172 | ||
| Pathway | NCI Pathway Interaction Database: FABP6 | |
| KEGG: FABP6 | ||
| REACTOME: FABP6 | ||
| Pathway Commons: FABP6 | ||
| Context | iHOP: FABP6 | |
| ligand binding site mutation search in PubMed: FABP6 | ||
| UCL Cancer Institute: FABP6 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for FABP6 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | M19 | M19L | BRCA | 1 | F3,F7 | G5D | GBM | 1 | Q52,W50 | S51Y | HNSC | 1 | F3,F7 | G5D | KIRC | 1 | A32 | R33H | STAD | 1 | E103 | E103D | STAD | 1 | Y54 | G56R | STAD | 1 | A32,V28 | E30K | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for FABP6 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | A32 | R33H | -1.4332177 | V28 | E30K | -1.2483629 | A32 | E30K | -1.2483629 | E103 | E103D | -1.0425788 | F3 | G5D | -0.6726704 | F7 | G5D | -0.6726704 | W50 | S51Y | -0.24777642 | Q52 | S51Y | -0.24777642 | M19 | M19L | -0.22683268 | Y54 | G56R | -0.16358156 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for FABP6 from PDB |
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| Differential gene expression and gene-gene network for FABP6 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for FABP6 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for FABP6 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved | DB02659 | Cholic Acid | Small molecule |  |
| Experimental | DB02691 | N-Cholylglycine | Small molecule |  |
| Experimental | DB04348 | Taurocholic Acid | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of FABP6 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of FABP6 |
| Multiple alignments for P51161 in multiple species |
| LBS | AA sequence | # species | Species | A32 | DVIEKARNFKI | 1 | Homo sapiens | A32 | DRIEKGRNFKV | 1 | Bos taurus | A32 | DVIERGRNFKI | 1 | Mus musculus | A32 | EVIERGRNFKI | 1 | Rattus norvegicus | E103 | YHQTSEVVGDK | 2 | Mus musculus, Rattus norvegicus | E103 | YHQTSEIVGDK | 1 | Homo sapiens | E103 | YHHTVEIVDGK | 1 | Bos taurus | E111 | GDKLVEISTIG | 2 | Mus musculus, Rattus norvegicus | E111 | GDKLVEVSTIG | 1 | Homo sapiens | E111 | DGKLVEVSTFG | 1 | Bos taurus | F18 | KNYDEFMKRLG | 3 | Bos taurus, Mus musculus, Rattus norvegicus | F18 | KNYDEFMKLLG | 1 | Homo sapiens | F3 | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | F48 | QDGQDFTWSQH | 1 | Homo sapiens | F48 | QDGQNFTWSQH | 1 | Bos taurus | F48 | QDGQDFTWSQS | 1 | Mus musculus | F48 | QDGENFTWSQS | 1 | Rattus norvegicus | F64 | IMSNKFTIGKE | 2 | Mus musculus, Rattus norvegicus | F64 | TMTNKFTVGKE | 1 | Homo sapiens | F64 | SISNNFTIGKE | 1 | Bos taurus | F7 | AFTGKFEMESE | 1 | Homo sapiens | F7 | AFTGKYETESE | 1 | Bos taurus | F7 | AFSGKYEFESE | 1 | Mus musculus | F7 | AFTGKYEFESE | 1 | Rattus norvegicus | F80 | MGGKKFKATVK | 2 | Mus musculus, Rattus norvegicus | F80 | MGGKTFKATVQ | 1 | Homo sapiens | F80 | VGNKKFKVTVK | 1 | Bos taurus | F95 | KLVVNFPNYHQ | 1 | Homo sapiens | F95 | KVVVDSANYHH | 1 | Bos taurus | F95 | KVVAEFPNYHQ | 1 | Mus musculus | F95 | KVVADFPNYHQ | 1 | Rattus norvegicus | G23 | FMKLLGISSDV | 1 | Homo sapiens | G23 | FMKRLGLSSDR | 1 | Bos taurus | G23 | FMKRLGLPGDV | 1 | Mus musculus | G23 | FMKRLGLPDEV | 1 | Rattus norvegicus | G76 | EMQTMGGKKFK | 2 | Mus musculus, Rattus norvegicus | G76 | NIQTMGGKTFK | 1 | Homo sapiens | G76 | EMETVGNKKFK | 1 | Bos taurus | I24 | MKLLGISSDVI | 1 | Homo sapiens | I24 | MKRLGLSSDRI | 1 | Bos taurus | I24 | MKRLGLPGDVI | 1 | Mus musculus | I24 | MKRLGLPDEVI | 1 | Rattus norvegicus | I37 | GRNFKIITEVQ | 2 | Mus musculus, Rattus norvegicus | I37 | ARNFKIVTEVQ | 1 | Homo sapiens | I37 | GRNFKVISEIQ | 1 | Bos taurus | I72 | GKECEMQTMGG | 2 | Mus musculus, Rattus norvegicus | I72 | GKESNIQTMGG | 1 | Homo sapiens | I72 | GKETEMETVGN | 1 | Bos taurus | L109 | VVGDKLVEIST | 2 | Mus musculus, Rattus norvegicus | L109 | IVGDKLVEVST | 1 | Homo sapiens | L109 | IVDGKLVEVST | 1 | Bos taurus | L22 | EFMKLLGISSD | 1 | Homo sapiens | L22 | EFMKRLGLSSD | 1 | Bos taurus | L22 | EFMKRLGLPGD | 1 | Mus musculus | L22 | EFMKRLGLPDE | 1 | Rattus norvegicus | L91 | MEGGKLVVNFP | 1 | Homo sapiens | L91 | MEGGKVVVDSA | 1 | Bos taurus | L91 | MEGGKVVAEFP | 1 | Mus musculus | L91 | MEGGKVVADFP | 1 | Rattus norvegicus | M19 | NYDEFMKRLGL | 3 | Bos taurus, Mus musculus, Rattus norvegicus | M19 | NYDEFMKLLGI | 1 | Homo sapiens | M60 | SGGNIMSNKFT | 2 | Mus musculus, Rattus norvegicus | M60 | SGGHTMTNKFT | 1 | Homo sapiens | M60 | PGGHSISNNFT | 1 | Bos taurus | M75 | CEMQTMGGKKF | 2 | Mus musculus, Rattus norvegicus | M75 | SNIQTMGGKTF | 1 | Homo sapiens | M75 | TEMETVGNKKF | 1 | Bos taurus | M9 | TGKFEMESEKN | 1 | Homo sapiens | M9 | TGKYETESEKN | 1 | Bos taurus | M9 | SGKYEFESEKN | 1 | Mus musculus | M9 | TGKYEFESEKN | 1 | Rattus norvegicus | N62 | GNIMSNKFTIG | 2 | Mus musculus, Rattus norvegicus | N62 | GHTMTNKFTVG | 1 | Homo sapiens | N62 | GHSISNNFTIG | 1 | Bos taurus | Q100 | FPNYHQTSEVV | 2 | Mus musculus, Rattus norvegicus | Q100 | FPNYHQTSEIV | 1 | Homo sapiens | Q100 | SANYHHTVEIV | 1 | Bos taurus | Q52 | DFTWSQHYSGG | 1 | Homo sapiens | Q52 | NFTWSQHYPGG | 1 | Bos taurus | Q52 | DFTWSQSYSGG | 1 | Mus musculus | Q52 | NFTWSQSYSGG | 1 | Rattus norvegicus | Q73 | KECEMQTMGGK | 2 | Mus musculus, Rattus norvegicus | Q73 | KESNIQTMGGK | 1 | Homo sapiens | Q73 | KETEMETVGNK | 1 | Bos taurus | R122 | GVTYERVSKRL | 1 | Homo sapiens | R122 | GVIYERVSKKV | 1 | Bos taurus | R122 | DVTYERVSKRL | 1 | Mus musculus | R122 | DVTYERVSKRV | 1 | Rattus norvegicus | S102 | NYHQTSEVVGD | 2 | Mus musculus, Rattus norvegicus | S102 | NYHQTSEIVGD | 1 | Homo sapiens | S102 | NYHHTVEIVDG | 1 | Bos taurus | S124 | TYERVSKRLA | 2 | Homo sapiens, Mus musculus | S124 | IYERVSKKVA | 1 | Bos taurus | S124 | TYERVSKRVA | 1 | Rattus norvegicus | T39 | NFKIITEVQQD | 2 | Mus musculus, Rattus norvegicus | T39 | NFKIVTEVQQD | 1 | Homo sapiens | T39 | NFKVISEIQQD | 1 | Bos taurus | T74 | ECEMQTMGGKK | 2 | Mus musculus, Rattus norvegicus | T74 | ESNIQTMGGKT | 1 | Homo sapiens | T74 | ETEMETVGNKK | 1 | Bos taurus | V28 | GISSDVIEKAR | 1 | Homo sapiens | V28 | GLSSDRIEKGR | 1 | Bos taurus | V28 | GLPGDVIERGR | 1 | Mus musculus | V28 | GLPDEVIERGR | 1 | Rattus norvegicus | V38 | RNFKIITEVQQ | 2 | Mus musculus, Rattus norvegicus | V38 | RNFKIVTEVQQ | 1 | Homo sapiens | V38 | RNFKVISEIQQ | 1 | Bos taurus | V41 | KIVTEVQQDGQ | 1 | Homo sapiens | V41 | KVISEIQQDGQ | 1 | Bos taurus | V41 | KIITEVQQDGQ | 1 | Mus musculus | V41 | KIITEVQQDGE | 1 | Rattus norvegicus | V84 | KFKATVKMEGG | 2 | Mus musculus, Rattus norvegicus | V84 | TFKATVQMEGG | 1 | Homo sapiens | V84 | KFKVTVKMEGG | 1 | Bos taurus | V93 | GGKLVVNFPNY | 1 | Homo sapiens | V93 | GGKVVVDSANY | 1 | Bos taurus | V93 | GGKVVAEFPNY | 1 | Mus musculus | V93 | GGKVVADFPNY | 1 | Rattus norvegicus | W50 | GQDFTWSQHYS | 1 | Homo sapiens | W50 | GQNFTWSQHYP | 1 | Bos taurus | W50 | GQDFTWSQSYS | 1 | Mus musculus | W50 | GENFTWSQSYS | 1 | Rattus norvegicus | Y120 | IGDVTYERVSK | 2 | Mus musculus, Rattus norvegicus | Y120 | IGGVTYERVSK | 1 | Homo sapiens | Y120 | FGGVIYERVSK | 1 | Bos taurus | Y15 | ESEKNYDEFMK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y54 | TWSQSYSGGNI | 2 | Mus musculus, Rattus norvegicus | Y54 | TWSQHYSGGHT | 1 | Homo sapiens | Y54 | TWSQHYPGGHS | 1 | Bos taurus | Y98 | VNFPNYHQTSE | 1 | Homo sapiens | Y98 | VDSANYHHTVE | 1 | Bos taurus | Y98 | AEFPNYHQTSE | 1 | Mus musculus | Y98 | ADFPNYHQTSE | 1 | Rattus norvegicus |
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