mutLBSgeneDB |
Gene summary for FABP7 |
Gene summary |
Basic gene Info. | Gene symbol | FABP7 |
Gene name | fatty acid binding protein 7, brain | |
Synonyms | B-FABP|BLBP|FABPB|LTR2-FABP7|MRG | |
Cytomap | UCSC genome browser: 6q22-q23 | |
Type of gene | protein-coding | |
RefGenes | NM_001446.3, | |
Description | Hypothetical protein DKFZp547J2313brain lipid binding proteinbrain lipid-binding proteinbrain-type fatty acid-binding proteinfatty acid-binding protein 7fatty acid-binding protein, brainmammary-derived growth inhibitor relatedmammary-derived growth | |
Modification date | 20141207 | |
dbXrefs | MIM : 602965 | |
HGNC : HGNC | ||
Ensembl : ENSG00000164434 | ||
HPRD : 04271 | ||
Vega : OTTHUMG00000015489 | ||
Protein | UniProt: O15540 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FABP7 | |
BioGPS: 2173 | ||
Pathway | NCI Pathway Interaction Database: FABP7 | |
KEGG: FABP7 | ||
REACTOME: FABP7 | ||
Pathway Commons: FABP7 | ||
Context | iHOP: FABP7 | |
ligand binding site mutation search in PubMed: FABP7 | ||
UCL Cancer Institute: FABP7 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for FABP7 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | R127 | R127H | COAD | 1 | D77 | D78Y | HNSC | 1 | F105 | F105Y | OV | 1 | R127 | R127H | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for FABP7 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R127 | R127H | -0.792869 | F105 | F105Y | -0.74439454 | D77 | D78Y | -0.37978956 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for FABP7 from PDB |
Top |
Differential gene expression and gene-gene network for FABP7 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for FABP7 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C1458155 | Breast Neoplasms | 1 | Biomarker |
umls:C0023893 | Liver Cirrhosis, Experimental | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for FABP7 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of FABP7 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
Top |
Conservation information for LBS of FABP7 |
Multiple alignments for O15540 in multiple species |
LBS | AA sequence | # species | Species | A76 | FDETTADDRNC | 2 | Homo sapiens, Bos taurus | A76 | FEETSIDDRNC | 2 | Mus musculus, Rattus norvegicus | A76 | FDETTPDDRNC | 1 | Gallus gallus | D77 | DETTADDRNCK | 2 | Homo sapiens, Bos taurus | D77 | EETSIDDRNCK | 2 | Mus musculus, Rattus norvegicus | D77 | DETTPDDRNCK | 1 | Gallus gallus | E73 | GEEFDETTADD | 2 | Homo sapiens, Bos taurus | E73 | GEEFEETSIDD | 2 | Mus musculus, Rattus norvegicus | E73 | GEEFDETTPDD | 1 | Gallus gallus | F105 | GKETNFVREIK | 3 | Homo sapiens, Gallus gallus, Bos taurus | F105 | GKETNCTREIK | 1 | Mus musculus | F105 | GKETNCVREIK | 1 | Rattus norvegicus | F17 | TDSQNFDEYMK | 2 | Mus musculus, Rattus norvegicus | F17 | TNSQNFDEYMK | 1 | Homo sapiens | F17 | ADSHNFDEYMK | 1 | Gallus gallus | F17 | TESQNFDEYMK | 1 | Bos taurus | F58 | RTQCTFKNTEI | 2 | Mus musculus, Rattus norvegicus | F58 | RTQSTFKNTEI | 2 | Gallus gallus, Bos taurus | F58 | RTLSTFKNTEI | 1 | Homo sapiens | G34 | ATRQVGNVTKP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G34 | AMRQVGNVTKP | 1 | Gallus gallus | I63 | FKNTEISFQLG | 2 | Homo sapiens, Rattus norvegicus | I63 | FKNTEINFQLG | 1 | Mus musculus | I63 | FKNTEISFKLG | 1 | Gallus gallus | I63 | FKNTEISFHLG | 1 | Bos taurus | K59 | TQSTFKNTEIS | 2 | Gallus gallus, Bos taurus | K59 | TLSTFKNTEIS | 1 | Homo sapiens | K59 | TQCTFKNTEIN | 1 | Mus musculus | K59 | TQCTFKNTEIS | 1 | Rattus norvegicus | L118 | KMVMTLTFGDV | 1 | Homo sapiens | L118 | KMVVTLTFGDI | 1 | Mus musculus | L118 | KMVVTLTFGDV | 1 | Rattus norvegicus | L118 | RMVMTLTFGDV | 1 | Gallus gallus | L118 | KMIMTLTFGDV | 1 | Bos taurus | M116 | DGKMVVTLTFG | 2 | Mus musculus, Rattus norvegicus | M116 | DGKMVMTLTFG | 1 | Homo sapiens | M116 | DGRMVMTLTFG | 1 | Gallus gallus | M116 | DGKMIMTLTFG | 1 | Bos taurus | M21 | NFDEYMKALGV | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus | P39 | GNVTKPTVIIS | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus | R127 | DVVAVRHYEKA | 3 | Homo sapiens, Gallus gallus, Bos taurus | R127 | DIVAVRCYEKA | 1 | Mus musculus | R127 | DVVAVRCYEKA | 1 | Rattus norvegicus | S56 | VIRTQCTFKNT | 2 | Mus musculus, Rattus norvegicus | S56 | VIRTQSTFKNT | 2 | Gallus gallus, Bos taurus | S56 | VIRTLSTFKNT | 1 | Homo sapiens | T30 | GVGFATRQVGN | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | T30 | GVGFAMRQVGN | 1 | Gallus gallus | T54 | KVVIRTQCTFK | 2 | Mus musculus, Rattus norvegicus | T54 | KVVIRTLSTFK | 1 | Homo sapiens | T54 | KVVIRTQSTFK | 1 | Gallus gallus | T54 | RVVIRTQSTFK | 1 | Bos taurus | T61 | STFKNTEISFQ | 1 | Homo sapiens | T61 | CTFKNTEINFQ | 1 | Mus musculus | T61 | CTFKNTEISFQ | 1 | Rattus norvegicus | T61 | STFKNTEISFK | 1 | Gallus gallus | T61 | STFKNTEISFH | 1 | Bos taurus | T75 | EFDETTADDRN | 2 | Homo sapiens, Bos taurus | T75 | EFEETSIDDRN | 2 | Mus musculus, Rattus norvegicus | T75 | EFDETTPDDRN | 1 | Gallus gallus | V41 | VTKPTVIISQE | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | V41 | VTKPTVIISSE | 1 | Gallus gallus | Y129 | VAVRHYEKA | 3 | Homo sapiens, Gallus gallus, Bos taurus | Y129 | VAVRCYEKA | 2 | Mus musculus, Rattus norvegicus |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |