mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for FABP7
Gene summary
Basic gene Info.Gene symbolFABP7
Gene namefatty acid binding protein 7, brain
CytomapUCSC genome browser: 6q22-q23
Type of geneprotein-coding
DescriptionHypothetical protein DKFZp547J2313brain lipid binding proteinbrain lipid-binding proteinbrain-type fatty acid-binding proteinfatty acid-binding protein 7fatty acid-binding protein, brainmammary-derived growth inhibitor relatedmammary-derived growth
Modification date20141207
dbXrefs MIM : 602965
Ensembl : ENSG00000164434
HPRD : 04271
Vega : OTTHUMG00000015489
ProteinUniProt: O15540
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FABP7
BioGPS: 2173
PathwayNCI Pathway Interaction Database: FABP7
Pathway Commons: FABP7
ContextiHOP: FABP7
ligand binding site mutation search in PubMed: FABP7
UCL Cancer Institute: FABP7
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for FABP7
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for FABP7
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for FABP7 from PDB

Differential gene expression and gene-gene network for FABP7
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of FABP7 and the right PPI network was created from samples without mutations in the LBS of FABP7. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for FABP7
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1458155Breast Neoplasms1Biomarker
umls:C0023893Liver Cirrhosis, Experimental1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for FABP7
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of FABP7 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of FABP7
Multiple alignments for O15540 in multiple species
LBSAA sequence# speciesSpecies
A76FDETTADDRNC2Homo sapiens, Bos taurus
A76FEETSIDDRNC2Mus musculus, Rattus norvegicus
A76FDETTPDDRNC1Gallus gallus
D77DETTADDRNCK2Homo sapiens, Bos taurus
D77EETSIDDRNCK2Mus musculus, Rattus norvegicus
D77DETTPDDRNCK1Gallus gallus
E73GEEFDETTADD2Homo sapiens, Bos taurus
E73GEEFEETSIDD2Mus musculus, Rattus norvegicus
E73GEEFDETTPDD1Gallus gallus
F105GKETNFVREIK3Homo sapiens, Gallus gallus, Bos taurus
F105GKETNCTREIK1Mus musculus
F105GKETNCVREIK1Rattus norvegicus
F17TDSQNFDEYMK2Mus musculus, Rattus norvegicus
F17TNSQNFDEYMK1Homo sapiens
F17ADSHNFDEYMK1Gallus gallus
F58RTQCTFKNTEI2Mus musculus, Rattus norvegicus
F58RTQSTFKNTEI2Gallus gallus, Bos taurus
F58RTLSTFKNTEI1Homo sapiens
G34ATRQVGNVTKP4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G34AMRQVGNVTKP1Gallus gallus
I63FKNTEISFQLG2Homo sapiens, Rattus norvegicus
I63FKNTEINFQLG1Mus musculus
I63FKNTEISFKLG1Gallus gallus
K59TQSTFKNTEIS2Gallus gallus, Bos taurus
K59TLSTFKNTEIS1Homo sapiens
K59TQCTFKNTEIN1Mus musculus
K59TQCTFKNTEIS1Rattus norvegicus
L118KMVMTLTFGDV1Homo sapiens
L118KMVVTLTFGDI1Mus musculus
L118KMVVTLTFGDV1Rattus norvegicus
L118RMVMTLTFGDV1Gallus gallus
L118KMIMTLTFGDV1Bos taurus
M116DGKMVVTLTFG2Mus musculus, Rattus norvegicus
M116DGKMVMTLTFG1Homo sapiens
M116DGRMVMTLTFG1Gallus gallus
M116DGKMIMTLTFG1Bos taurus
M21NFDEYMKALGV5Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus
P39GNVTKPTVIIS5Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus
R127DVVAVRHYEKA3Homo sapiens, Gallus gallus, Bos taurus
R127DIVAVRCYEKA1Mus musculus
R127DVVAVRCYEKA1Rattus norvegicus
S56VIRTQCTFKNT2Mus musculus, Rattus norvegicus
S56VIRTQSTFKNT2Gallus gallus, Bos taurus
S56VIRTLSTFKNT1Homo sapiens
T30GVGFATRQVGN4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T30GVGFAMRQVGN1Gallus gallus
T54KVVIRTQCTFK2Mus musculus, Rattus norvegicus
T54KVVIRTLSTFK1Homo sapiens
T54KVVIRTQSTFK1Gallus gallus
T61STFKNTEISFQ1Homo sapiens
T61CTFKNTEINFQ1Mus musculus
T61CTFKNTEISFQ1Rattus norvegicus
T61STFKNTEISFK1Gallus gallus
T75EFDETTADDRN2Homo sapiens, Bos taurus
T75EFEETSIDDRN2Mus musculus, Rattus norvegicus
T75EFDETTPDDRN1Gallus gallus
V41VTKPTVIISQE4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V41VTKPTVIISSE1Gallus gallus
Y129VAVRHYEKA3Homo sapiens, Gallus gallus, Bos taurus
Y129VAVRCYEKA2Mus musculus, Rattus norvegicus

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