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mutLBSgeneDB |
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| Gene summary for FABP7 |
 Gene summary |
| Basic gene Info. | Gene symbol | FABP7 |
| Gene name | fatty acid binding protein 7, brain | |
| Synonyms | B-FABP|BLBP|FABPB|LTR2-FABP7|MRG | |
| Cytomap | UCSC genome browser: 6q22-q23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001446.3, | |
| Description | Hypothetical protein DKFZp547J2313brain lipid binding proteinbrain lipid-binding proteinbrain-type fatty acid-binding proteinfatty acid-binding protein 7fatty acid-binding protein, brainmammary-derived growth inhibitor relatedmammary-derived growth | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602965 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000164434 | ||
| HPRD : 04271 | ||
| Vega : OTTHUMG00000015489 | ||
| Protein | UniProt: O15540 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FABP7 | |
| BioGPS: 2173 | ||
| Pathway | NCI Pathway Interaction Database: FABP7 | |
| KEGG: FABP7 | ||
| REACTOME: FABP7 | ||
| Pathway Commons: FABP7 | ||
| Context | iHOP: FABP7 | |
| ligand binding site mutation search in PubMed: FABP7 | ||
| UCL Cancer Institute: FABP7 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for FABP7 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R127 | R127H | COAD | 1 | D77 | D78Y | HNSC | 1 | F105 | F105Y | OV | 1 | R127 | R127H | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for FABP7 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R127 | R127H | -0.792869 | F105 | F105Y | -0.74439454 | D77 | D78Y | -0.37978956 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for FABP7 from PDB |
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| Differential gene expression and gene-gene network for FABP7 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for FABP7 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C1458155 | Breast Neoplasms | 1 | Biomarker |
| umls:C0023893 | Liver Cirrhosis, Experimental | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for FABP7 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of FABP7 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of FABP7 |
| Multiple alignments for O15540 in multiple species |
| LBS | AA sequence | # species | Species | A76 | FDETTADDRNC | 2 | Homo sapiens, Bos taurus | A76 | FEETSIDDRNC | 2 | Mus musculus, Rattus norvegicus | A76 | FDETTPDDRNC | 1 | Gallus gallus | D77 | DETTADDRNCK | 2 | Homo sapiens, Bos taurus | D77 | EETSIDDRNCK | 2 | Mus musculus, Rattus norvegicus | D77 | DETTPDDRNCK | 1 | Gallus gallus | E73 | GEEFDETTADD | 2 | Homo sapiens, Bos taurus | E73 | GEEFEETSIDD | 2 | Mus musculus, Rattus norvegicus | E73 | GEEFDETTPDD | 1 | Gallus gallus | F105 | GKETNFVREIK | 3 | Homo sapiens, Gallus gallus, Bos taurus | F105 | GKETNCTREIK | 1 | Mus musculus | F105 | GKETNCVREIK | 1 | Rattus norvegicus | F17 | TDSQNFDEYMK | 2 | Mus musculus, Rattus norvegicus | F17 | TNSQNFDEYMK | 1 | Homo sapiens | F17 | ADSHNFDEYMK | 1 | Gallus gallus | F17 | TESQNFDEYMK | 1 | Bos taurus | F58 | RTQCTFKNTEI | 2 | Mus musculus, Rattus norvegicus | F58 | RTQSTFKNTEI | 2 | Gallus gallus, Bos taurus | F58 | RTLSTFKNTEI | 1 | Homo sapiens | G34 | ATRQVGNVTKP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G34 | AMRQVGNVTKP | 1 | Gallus gallus | I63 | FKNTEISFQLG | 2 | Homo sapiens, Rattus norvegicus | I63 | FKNTEINFQLG | 1 | Mus musculus | I63 | FKNTEISFKLG | 1 | Gallus gallus | I63 | FKNTEISFHLG | 1 | Bos taurus | K59 | TQSTFKNTEIS | 2 | Gallus gallus, Bos taurus | K59 | TLSTFKNTEIS | 1 | Homo sapiens | K59 | TQCTFKNTEIN | 1 | Mus musculus | K59 | TQCTFKNTEIS | 1 | Rattus norvegicus | L118 | KMVMTLTFGDV | 1 | Homo sapiens | L118 | KMVVTLTFGDI | 1 | Mus musculus | L118 | KMVVTLTFGDV | 1 | Rattus norvegicus | L118 | RMVMTLTFGDV | 1 | Gallus gallus | L118 | KMIMTLTFGDV | 1 | Bos taurus | M116 | DGKMVVTLTFG | 2 | Mus musculus, Rattus norvegicus | M116 | DGKMVMTLTFG | 1 | Homo sapiens | M116 | DGRMVMTLTFG | 1 | Gallus gallus | M116 | DGKMIMTLTFG | 1 | Bos taurus | M21 | NFDEYMKALGV | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus | P39 | GNVTKPTVIIS | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Bos taurus | R127 | DVVAVRHYEKA | 3 | Homo sapiens, Gallus gallus, Bos taurus | R127 | DIVAVRCYEKA | 1 | Mus musculus | R127 | DVVAVRCYEKA | 1 | Rattus norvegicus | S56 | VIRTQCTFKNT | 2 | Mus musculus, Rattus norvegicus | S56 | VIRTQSTFKNT | 2 | Gallus gallus, Bos taurus | S56 | VIRTLSTFKNT | 1 | Homo sapiens | T30 | GVGFATRQVGN | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | T30 | GVGFAMRQVGN | 1 | Gallus gallus | T54 | KVVIRTQCTFK | 2 | Mus musculus, Rattus norvegicus | T54 | KVVIRTLSTFK | 1 | Homo sapiens | T54 | KVVIRTQSTFK | 1 | Gallus gallus | T54 | RVVIRTQSTFK | 1 | Bos taurus | T61 | STFKNTEISFQ | 1 | Homo sapiens | T61 | CTFKNTEINFQ | 1 | Mus musculus | T61 | CTFKNTEISFQ | 1 | Rattus norvegicus | T61 | STFKNTEISFK | 1 | Gallus gallus | T61 | STFKNTEISFH | 1 | Bos taurus | T75 | EFDETTADDRN | 2 | Homo sapiens, Bos taurus | T75 | EFEETSIDDRN | 2 | Mus musculus, Rattus norvegicus | T75 | EFDETTPDDRN | 1 | Gallus gallus | V41 | VTKPTVIISQE | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | V41 | VTKPTVIISSE | 1 | Gallus gallus | Y129 | VAVRHYEKA | 3 | Homo sapiens, Gallus gallus, Bos taurus | Y129 | VAVRCYEKA | 2 | Mus musculus, Rattus norvegicus |
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