mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for FARSA
Gene summary
Basic gene Info.Gene symbolFARSA
Gene namephenylalanyl-tRNA synthetase, alpha subunit
CytomapUCSC genome browser: 19p13.2
Type of geneprotein-coding
DescriptionpheRSphenylalanine tRNA ligase 1, alpha, cytoplasmicphenylalanine--tRNA ligase alpha chainphenylalanine--tRNA ligase alpha subunitphenylalanine-tRNA synthetase alpha-subunitphenylalanine-tRNA synthetase-like, alpha subunitphenylalanyl-tRNA synthetas
Modification date20141207
dbXrefs MIM : 602918
Ensembl : ENSG00000179115
HPRD : 04227
Vega : OTTHUMG00000180569
ProteinUniProt: Q9Y285
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FARSA
BioGPS: 2193
PathwayNCI Pathway Interaction Database: FARSA
Pathway Commons: FARSA
ContextiHOP: FARSA
ligand binding site mutation search in PubMed: FARSA
UCL Cancer Institute: FARSA
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for FARSA

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for FARSA
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for FARSA from PDB

Differential gene expression and gene-gene network for FARSA
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of FARSA and the right PPI network was created from samples without mutations in the LBS of FARSA. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for FARSA
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for FARSA
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00120L-PhenylalanineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of FARSA go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of FARSA
Multiple alignments for Q9Y285 in multiple species
LBSAA sequence# speciesSpecies
A456NVSVIAWGLSL3Homo sapiens, Mus musculus, Rattus norvegicus
A456DVRVIAWGLSL1Arabidopsis thaliana
A456NVNVIAWGLSL1Drosophila melanogaster
A456-----------1Gallus gallus
A456GVSVIAWGLSL1Danio rerio
A456DLRVLGWGLSL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A456DVRCLGFGLSL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E374EFHQIEGVVAD2Homo sapiens, Danio rerio
E374EFHQIEGVIAD2Mus musculus, Rattus norvegicus
E374EFHQIEGLICD1Arabidopsis thaliana
E374EFHQVEGVIAD1Drosophila melanogaster
E374EFHQVEGVVAD1Gallus gallus
E374EFHQVEGVLAD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E374EFHQVEGVICD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F438GNSGVFRPEML5Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
F438GNSGMFRPEML3Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F438GNSGVFRS---1Gallus gallus
G436EVGNSGVFRPE5Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
G436EIGNSGMFRPE2Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G436EVGNSGVFRS-1Gallus gallus
G436EVGNSGMFRPE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G458SVIAWGLSLER4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
G458RVIAWGLSLER1Arabidopsis thaliana
G458NVIAWGLSLER1Drosophila melanogaster
G458-----------1Gallus gallus
G458RVLGWGLSLER1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G458RCLGFGLSLER1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H327NLLRTHTTAVS3Arabidopsis thaliana, Drosophila melanogaster, Danio rerio
H327NLLRTHTTSAS2Homo sapiens, Gallus gallus
H327NLLRTHTTAAS2Mus musculus, Rattus norvegicus
H327LVLRTHSTAIS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H327LVLRTHTTAVS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L459VIAWGLSLERP6Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
L459-----------1Gallus gallus
L459VLGWGLSLERP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L459CLGFGLSLERP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N410FKPAYNPYTEP8Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Danio rerio, Mus musculus, Rattus norvegicus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N410FKPTYNPYTEP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N434WVEVGNSGVFR5Homo sapiens, Gallus gallus, Danio rerio, Mus musculus, Rattus norvegicus
N434WVEIGNSGMFR2Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N434WIEVGNSGVFR1Drosophila melanogaster
N434WVEVGNSGMFR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q372LAEFHQIEGVV2Homo sapiens, Danio rerio
Q372LAEFHQVEGVI2Drosophila melanogaster, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q372LAEFHQIEGVI2Mus musculus, Rattus norvegicus
Q372LAEFHQIEGLI1Arabidopsis thaliana
Q372LAEFHQVEGVV1Gallus gallus
Q372LAEFHQVEGVL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S435VEVGNSGVFRP4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
S435VEIGNSGMFRP2Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S435IEVGNSGVFRP1Drosophila melanogaster
S435VEVGNSGVFRS1Gallus gallus
S435VEVGNSGMFRP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T329LRTHTTSASAR2Homo sapiens, Gallus gallus
T329LRTHTTAVSAR2Drosophila melanogaster, Danio rerio
T329LRTHTTAASAR2Mus musculus, Rattus norvegicus
T329LRTHTTAVSSR1Arabidopsis thaliana
T329LRTHSTAISAR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T329LRTHTTAVSAN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T413AYNPYTEPSME7Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Danio rerio, Mus musculus, Rattus norvegicus
T413TYNPYTEPSME1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T413AYNPYTEPSLE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W457VSVIAWGLSLE4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
W457VRVIAWGLSLE1Arabidopsis thaliana
W457VNVIAWGLSLE1Drosophila melanogaster
W457-----------1Gallus gallus
W457LRVLGWGLSLE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W457VRCLGFGLSLE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y412PAYNPYTEPSM7Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Danio rerio, Mus musculus, Rattus norvegicus
Y412PTYNPYTEPSM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y412PAYNPYTEPSL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)

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