|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for FARSA |
 Gene summary |
| Basic gene Info. | Gene symbol | FARSA |
| Gene name | phenylalanyl-tRNA synthetase, alpha subunit | |
| Synonyms | CML33|FARSL|FARSLA|FRSA|PheHA | |
| Cytomap | UCSC genome browser: 19p13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004461.2, | |
| Description | pheRSphenylalanine tRNA ligase 1, alpha, cytoplasmicphenylalanine--tRNA ligase alpha chainphenylalanine--tRNA ligase alpha subunitphenylalanine-tRNA synthetase alpha-subunitphenylalanine-tRNA synthetase-like, alpha subunitphenylalanyl-tRNA synthetas | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602918 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000179115 | ||
| HPRD : 04227 | ||
| Vega : OTTHUMG00000180569 | ||
| Protein | UniProt: Q9Y285 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FARSA | |
| BioGPS: 2193 | ||
| Pathway | NCI Pathway Interaction Database: FARSA | |
| KEGG: FARSA | ||
| REACTOME: FARSA | ||
| Pathway Commons: FARSA | ||
| Context | iHOP: FARSA | |
| ligand binding site mutation search in PubMed: FARSA | ||
| UCL Cancer Institute: FARSA | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
| Top |
| Ligand binding site mutations for FARSA |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | S435 | S435L | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for FARSA |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | S435 | S435L | 0.48850644 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for FARSA from PDB |
| Top |
| Differential gene expression and gene-gene network for FARSA |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for FARSA |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for FARSA |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Gene-centered drug-gene interaction network |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|nutraceutical | DB00120 | L-Phenylalanine | Small molecule |  |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of FARSA go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | PHE | L-PHENYLALANINE | 3l4g | A | S435 | PHE | L-PHENYLALANINE | 3l4g | C | S435 | PHE | L-PHENYLALANINE | 3l4g | G | S435 | PHE | L-PHENYLALANINE | 3l4g | I | S435 | PHE | L-PHENYLALANINE | 3l4g | K | S435 | PHE | L-PHENYLALANINE | 3l4g | M | S435 | PHE | L-PHENYLALANINE | 3l4g | O | S435 |
| Top |
| Conservation information for LBS of FARSA |
| Multiple alignments for Q9Y285 in multiple species |
| LBS | AA sequence | # species | Species | A456 | NVSVIAWGLSL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A456 | DVRVIAWGLSL | 1 | Arabidopsis thaliana | A456 | NVNVIAWGLSL | 1 | Drosophila melanogaster | A456 | ----------- | 1 | Gallus gallus | A456 | GVSVIAWGLSL | 1 | Danio rerio | A456 | DLRVLGWGLSL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A456 | DVRCLGFGLSL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E374 | EFHQIEGVVAD | 2 | Homo sapiens, Danio rerio | E374 | EFHQIEGVIAD | 2 | Mus musculus, Rattus norvegicus | E374 | EFHQIEGLICD | 1 | Arabidopsis thaliana | E374 | EFHQVEGVIAD | 1 | Drosophila melanogaster | E374 | EFHQVEGVVAD | 1 | Gallus gallus | E374 | EFHQVEGVLAD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E374 | EFHQVEGVICD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F438 | GNSGVFRPEML | 5 | Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus | F438 | GNSGMFRPEML | 3 | Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F438 | GNSGVFRS--- | 1 | Gallus gallus | G436 | EVGNSGVFRPE | 5 | Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus | G436 | EIGNSGMFRPE | 2 | Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G436 | EVGNSGVFRS- | 1 | Gallus gallus | G436 | EVGNSGMFRPE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G458 | SVIAWGLSLER | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | G458 | RVIAWGLSLER | 1 | Arabidopsis thaliana | G458 | NVIAWGLSLER | 1 | Drosophila melanogaster | G458 | ----------- | 1 | Gallus gallus | G458 | RVLGWGLSLER | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G458 | RCLGFGLSLER | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H327 | NLLRTHTTAVS | 3 | Arabidopsis thaliana, Drosophila melanogaster, Danio rerio | H327 | NLLRTHTTSAS | 2 | Homo sapiens, Gallus gallus | H327 | NLLRTHTTAAS | 2 | Mus musculus, Rattus norvegicus | H327 | LVLRTHSTAIS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H327 | LVLRTHTTAVS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L459 | VIAWGLSLERP | 6 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus | L459 | ----------- | 1 | Gallus gallus | L459 | VLGWGLSLERP | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L459 | CLGFGLSLERP | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N410 | FKPAYNPYTEP | 8 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Danio rerio, Mus musculus, Rattus norvegicus, Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N410 | FKPTYNPYTEP | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N434 | WVEVGNSGVFR | 5 | Homo sapiens, Gallus gallus, Danio rerio, Mus musculus, Rattus norvegicus | N434 | WVEIGNSGMFR | 2 | Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N434 | WIEVGNSGVFR | 1 | Drosophila melanogaster | N434 | WVEVGNSGMFR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Q372 | LAEFHQIEGVV | 2 | Homo sapiens, Danio rerio | Q372 | LAEFHQVEGVI | 2 | Drosophila melanogaster, Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Q372 | LAEFHQIEGVI | 2 | Mus musculus, Rattus norvegicus | Q372 | LAEFHQIEGLI | 1 | Arabidopsis thaliana | Q372 | LAEFHQVEGVV | 1 | Gallus gallus | Q372 | LAEFHQVEGVL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S435 | VEVGNSGVFRP | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | S435 | VEIGNSGMFRP | 2 | Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S435 | IEVGNSGVFRP | 1 | Drosophila melanogaster | S435 | VEVGNSGVFRS | 1 | Gallus gallus | S435 | VEVGNSGMFRP | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T329 | LRTHTTSASAR | 2 | Homo sapiens, Gallus gallus | T329 | LRTHTTAVSAR | 2 | Drosophila melanogaster, Danio rerio | T329 | LRTHTTAASAR | 2 | Mus musculus, Rattus norvegicus | T329 | LRTHTTAVSSR | 1 | Arabidopsis thaliana | T329 | LRTHSTAISAR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T329 | LRTHTTAVSAN | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T413 | AYNPYTEPSME | 7 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Danio rerio, Mus musculus, Rattus norvegicus | T413 | TYNPYTEPSME | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T413 | AYNPYTEPSLE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | W457 | VSVIAWGLSLE | 4 | Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus | W457 | VRVIAWGLSLE | 1 | Arabidopsis thaliana | W457 | VNVIAWGLSLE | 1 | Drosophila melanogaster | W457 | ----------- | 1 | Gallus gallus | W457 | LRVLGWGLSLE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | W457 | VRCLGFGLSLE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y412 | PAYNPYTEPSM | 7 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Danio rerio, Mus musculus, Rattus norvegicus | Y412 | PTYNPYTEPSM | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y412 | PAYNPYTEPSL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |