mutLBSgeneDB |
Gene summary for FCER1A |
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Basic gene Info. | Gene symbol | FCER1A |
Gene name | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | |
Synonyms | FCE1A|FcERI | |
Cytomap | UCSC genome browser: 1q23 | |
Type of gene | protein-coding | |
RefGenes | NM_002001.3, | |
Description | Fc IgE receptor, alpha polypeptideFc epsilon RI alpha-chainFc-epsilon RI-alphahigh affinity immunoglobulin epsilon receptor alpha-subunithigh affinity immunoglobulin epsilon receptor subunit alphaigE Fc receptor subunit alphaimmunoglobulin E recepto | |
Modification date | 20141207 | |
dbXrefs | MIM : 147140 | |
HGNC : HGNC | ||
Ensembl : ENSG00000179639 | ||
HPRD : 00917 | ||
Vega : OTTHUMG00000037176 | ||
Protein | UniProt: P12319 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FCER1A | |
BioGPS: 2205 | ||
Pathway | NCI Pathway Interaction Database: FCER1A | |
KEGG: FCER1A | ||
REACTOME: FCER1A | ||
Pathway Commons: FCER1A | ||
Context | iHOP: FCER1A | |
ligand binding site mutation search in PubMed: FCER1A | ||
UCL Cancer Institute: FCER1A | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for FCER1A |
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LBS | AAchange of nsSNV | Cancer type | # samples | F85 | E86K | BRCA | 1 | W135 | G134S | GBM | 1 | R136 | R136S | LUAD | 1 | W181 | W181L | LUSC | 1 | W181 | W181C | LUSC | 1 | W135 | G134C | SKCM | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for FCER1A |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | W181 | W181L | 0.047890927 | R136 | R136S | -1.0612652 | F85 | E86K | -1.0069337 | W135 | G134S | -0.4997907 | W181 | W181C | -0.41370781 | W135 | G134C | -0.27119586 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for FCER1A |
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Phenotype information for FCER1A |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0042109 | Urticaria | 3 | Biomarker |
umls:C0013182 | Drug Hypersensitivity | 2 | Biomarker |
umls:C0011609 | Drug Eruptions | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for FCER1A |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
Approved|investigational | DB00043 | Omalizumab | Biotech | ![]() |
Approved | DB00895 | Benzylpenicilloyl Polylysine | Small molecule | ![]() |
Investigational | DB05797 | TNX-901 | Small molecule | ![]() |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of FCER1A |
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LBS | AA sequence | # species | Species | D111 | LEVFSDWLLLQ | 1 | Homo sapiens | D111 | LNVTQDWLLLQ | 1 | Mus musculus | D111 | LNVMQEWLLLQ | 1 | Rattus norvegicus | F85 | IVNAKFEDSGE | 1 | Homo sapiens | F85 | IVSATVQDSGK | 1 | Mus musculus | F85 | IVSATIQDSGK | 1 | Rattus norvegicus | L183 | GKVWQLDYESE | 1 | Homo sapiens | L183 | GYLRQVKYESD | 1 | Mus musculus | L183 | GYLNKVECKSD | 1 | Rattus norvegicus | N82 | SLNIVNAKFED | 1 | Homo sapiens | N82 | HLVIVSATVQD | 1 | Mus musculus | N82 | HWVIVSATIQD | 1 | Rattus norvegicus | R136 | RCHGWRNWDVY | 1 | Homo sapiens | R136 | RCHGWKNWNVR | 1 | Mus musculus | R136 | RCRSWKKWKVH | 1 | Rattus norvegicus | S110 | YLEVFSDWLLL | 1 | Homo sapiens | S110 | YLNVTQDWLLL | 1 | Mus musculus | S110 | YLNVMQEWLLL | 1 | Rattus norvegicus | W112 | EVFSDWLLLQA | 1 | Homo sapiens | W112 | NVTQDWLLLQT | 1 | Mus musculus | W112 | NVMQEWLLLQS | 1 | Rattus norvegicus | W135 | LRCHGWRNWDV | 1 | Homo sapiens | W135 | IRCHGWKNWNV | 1 | Mus musculus | W135 | IRCRSWKKWKV | 1 | Rattus norvegicus | W138 | HGWRNWDVYKV | 1 | Homo sapiens | W138 | HGWKNWNVRKV | 1 | Mus musculus | W138 | RSWKKWKVHKV | 1 | Rattus norvegicus | W181 | CTGKVWQLDYE | 1 | Homo sapiens | W181 | CKGYLRQVKYE | 1 | Mus musculus | W181 | CTGYLNKVECK | 1 | Rattus norvegicus | Y185 | VWQLDYESEPL | 1 | Homo sapiens | Y185 | LRQVKYESDKF | 1 | Mus musculus | Y185 | LNKVECKSDKF | 1 | Rattus norvegicus |
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