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mutLBSgeneDB |
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| Gene summary for MARCH8 |
 Gene summary |
| Basic gene Info. | Gene symbol | MARCH8 |
| Gene name | membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase | |
| Synonyms | MARCH-VIII|MIR|RNF178|c-MIR | |
| Cytomap | UCSC genome browser: 10q11.21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001002265.1, NM_001002266.2,NM_001282866.1,NM_145021.5, | |
| Description | E3 ubiquitin-protein ligase MARCH8RING finger protein 178c-mir, cellular modulator of immune recognitioncellular modulator of immune recognition (c-MIR)membrane-associated RING finger protein 8membrane-associated RING-CH protein VIII | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 613335 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000165406 | ||
| HPRD : 17466 | ||
| Vega : OTTHUMG00000019345 | ||
| Protein | UniProt: Q5T0T0 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MARCH8 | |
| BioGPS: 220972 | ||
| Pathway | NCI Pathway Interaction Database: MARCH8 | |
| KEGG: MARCH8 | ||
| REACTOME: MARCH8 | ||
| Pathway Commons: MARCH8 | ||
| Context | iHOP: MARCH8 | |
| ligand binding site mutation search in PubMed: MARCH8 | ||
| UCL Cancer Institute: MARCH8 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0000209 | protein polyubiquitination | 19117940 |
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| Ligand binding site mutations for MARCH8 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C123 | E124K | COAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MARCH8 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | C123 | E124K | -0.90838774 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MARCH8 from PDB |
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| Differential gene expression and gene-gene network for MARCH8 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MARCH8 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0014859 | Esophageal Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MARCH8 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MARCH8 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of MARCH8 |
| Multiple alignments for Q5T0T0 in multiple species |
| LBS | AA sequence | # species | Species | C110 | FVHQACLQQWI | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | C110 | FVHQTCLQQWI | 1 | Bos taurus | C123 | SDTRCCELCKY | 3 | Homo sapiens, Mus musculus, Bos taurus | C123 | SDTRCCELCKF | 1 | Xenopus tropicalis | C126 | RCCELCKYEFI | 3 | Homo sapiens, Mus musculus, Bos taurus | C126 | RCCELCKFEFI | 1 | Xenopus tropicalis | C80 | SSQDICRICHC | 2 | Homo sapiens, Xenopus tropicalis | C80 | SNQDICRICHC | 2 | Mus musculus, Bos taurus | C83 | DICRICHCEGD | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Bos taurus | C97 | PLITPCHCTGS | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | C97 | PLITPCRCTGS | 1 | Bos taurus | C99 | ITPCHCTGSLH | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | C99 | ITPCRCTGSLH | 1 | Bos taurus | H107 | SLHFVHQACLQ | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | H107 | SLHFVHQTCLQ | 1 | Bos taurus |
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