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mutLBSgeneDB |
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| Gene summary for FCGR2A |
 Gene summary |
| Basic gene Info. | Gene symbol | FCGR2A |
| Gene name | Fc fragment of IgG, low affinity IIa, receptor (CD32) | |
| Synonyms | CD32|CD32A|CDw32|FCG2|FCGR2|FCGR2A1|FcGR|IGFR2 | |
| Cytomap | UCSC genome browser: 1q23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001136219.1, NM_021642.3, | |
| Description | Immunoglobulin G Fc receptor IIfc-gamma RII-afc-gamma-RIIafcRII-aigG Fc receptor II-alow affinity immunoglobulin gamma Fc region receptor II-a | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 146790 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000143226 | ||
| HPRD : 00906 | ||
| Vega : OTTHUMG00000034469 | ||
| Protein | UniProt: P12318 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FCGR2A | |
| BioGPS: 2212 | ||
| Pathway | NCI Pathway Interaction Database: FCGR2A | |
| KEGG: FCGR2A | ||
| REACTOME: FCGR2A | ||
| Pathway Commons: FCGR2A | ||
| Context | iHOP: FCGR2A | |
| ligand binding site mutation search in PubMed: FCGR2A | ||
| UCL Cancer Institute: FCGR2A | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for FCGR2A |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | K161 | G160R | LUAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for FCGR2A |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K161 | G160R | -0.064707806 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for FCGR2A from PDB |
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| Differential gene expression and gene-gene network for FCGR2A |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for FCGR2A |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0024141 | Lupus Erythematosus, Systemic | 45 | Biomarker, GeneticVariation |
| umls:C0003873 | Arthritis, Rheumatoid | 22 | Biomarker, GeneticVariation |
| umls:C0009324 | Colitis, Ulcerative | 6 | Biomarker, GeneticVariation |
| umls:C0026691 | Mucocutaneous Lymph Node Syndrome | 5 | Biomarker, GeneticVariation |
| umls:C0040053 | Thrombosis | 2 | AlteredExpression, Biomarker |
| umls:C0040034 | Thrombocytopenia | 2 | Biomarker, GeneticVariation |
| umls:C1527336 | Sjogren's Syndrome | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for FCGR2A |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved | DB00002 | Cetuximab | Biotech |  |
| Approved|investigational | DB00005 | Etanercept | Biotech |  |
| Approved|investigational | DB00028 | Immune Globulin Human | Biotech |  |
| Approved | DB00051 | Adalimumab | Biotech |  |
| Approved | DB00054 | Abciximab | Biotech |  |
| Approved|investigational|withdrawn | DB00056 | Gemtuzumab ozogamicin | Biotech |  |
| Approved|investigational | DB00072 | Trastuzumab | Biotech |  |
| Approved | DB00073 | Rituximab | Biotech |  |
| Approved|investigational | DB00074 | Basiliximab | Biotech |  |
| Approved|investigational | DB00075 | Muromonab | Biotech |  |
| Approved | DB00078 | Ibritumomab tiuxetan | Biotech |  |
| Approved | DB00081 | Tositumomab | Biotech |  |
| Approved|investigational | DB00087 | Alemtuzumab | Biotech |  |
| Approved|withdrawn | DB00092 | Alefacept | Biotech |  |
| Approved|investigational | DB00095 | Efalizumab | Biotech |  |
| Approved|investigational | DB00108 | Natalizumab | Biotech |  |
| Approved|investigational | DB00110 | Palivizumab | Biotech |  |
| Approved|investigational | DB00111 | Daclizumab | Biotech |  |
| Approved|investigational | DB00112 | Bevacizumab | Biotech |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of FCGR2A go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of FCGR2A |
| Multiple alignments for P12318 in multiple species |
| LBS | AA sequence | # species | Species | K161 | FFQNGKSQKFS | 2 | Homo sapiens, Pan troglodytes | K161 | LFQNGKPVRYY | 2 | Rattus norvegicus, Rattus norvegicus | S162 | FQNGKSQKFSH | 2 | Homo sapiens, Pan troglodytes | S162 | FQNGKPVRYYY | 2 | Rattus norvegicus, Rattus norvegicus |
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