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mutLBSgeneDB |
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| Gene summary for OARD1 |
 Gene summary |
| Basic gene Info. | Gene symbol | OARD1 |
| Gene name | O-acyl-ADP-ribose deacylase 1 | |
| Synonyms | C6orf130|TARG1|dJ34B21.3 | |
| Cytomap | UCSC genome browser: 6p21.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_145063.2, | |
| Description | O-acetyl-ADP-ribose deacetylase 1O-acetyl-ADP-ribose deacetylase C6orf130terminal ADP-ribose protein glycohydrolase 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 614393 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000124596 | ||
| HPRD : 12849 | ||
| Vega : OTTHUMG00000014667 | ||
| Protein | UniProt: Q9Y530 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_OARD1 | |
| BioGPS: 221443 | ||
| Pathway | NCI Pathway Interaction Database: OARD1 | |
| KEGG: OARD1 | ||
| REACTOME: OARD1 | ||
| Pathway Commons: OARD1 | ||
| Context | iHOP: OARD1 | |
| ligand binding site mutation search in PubMed: OARD1 | ||
| UCL Cancer Institute: OARD1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0042278 | purine nucleoside metabolic process | 21849506 |
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| Ligand binding site mutations for OARD1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D125 | R126C | COAD | 1 | Y150 | V149M | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for OARD1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D125 | R126C | -1.3279949 | Y150 | V149M | -1.1134983 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for OARD1 from PDB |
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| Differential gene expression and gene-gene network for OARD1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for OARD1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for OARD1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of OARD1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | A1R | [(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHYL-ADP | 4j5r | A | D125 | APR | ADP-RIBOSE | 2l8r | A | D125 Y150 | A1R | [(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHYL-ADP | 4j5r | B | D125 Y150 |
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| Conservation information for LBS of OARD1 |
| Multiple alignments for Q9Y530 in multiple species |
| LBS | AA sequence | # species | Species | A42 | DCRMGAGIAVL | 3 | Homo sapiens, Bos taurus, Mus musculus | A45 | MGAGIAVLFKK | 3 | Homo sapiens, Bos taurus, Mus musculus | A87 | ITKKRASHKPT | 3 | Homo sapiens, Bos taurus, Mus musculus | C122 | MPRIGCGLDRL | 3 | Homo sapiens, Bos taurus, Mus musculus | C33 | DSLAHCISEDC | 2 | Homo sapiens, Mus musculus | C33 | DSLVHCISEDC | 1 | Bos taurus | D125 | IGCGLDRLQWE | 3 | Homo sapiens, Bos taurus, Mus musculus | D20 | TYVKGDLFACP | 3 | Homo sapiens, Bos taurus, Mus musculus | F22 | VKGDLFACPKT | 2 | Homo sapiens, Mus musculus | F22 | VKGDLFACPQT | 1 | Bos taurus | G121 | SMPRIGCGLDR | 3 | Homo sapiens, Bos taurus, Mus musculus | G123 | PRIGCGLDRLQ | 3 | Homo sapiens, Bos taurus, Mus musculus | G19 | ITYVKGDLFAC | 3 | Homo sapiens, Bos taurus, Mus musculus | G43 | CRMGAGIAVLF | 3 | Homo sapiens, Bos taurus, Mus musculus | H32 | TDSLAHCISED | 2 | Homo sapiens, Mus musculus | H32 | TDSLVHCISED | 1 | Bos taurus | I120 | LSMPRIGCGLD | 3 | Homo sapiens, Bos taurus, Mus musculus | I34 | SLAHCISEDCR | 2 | Homo sapiens, Mus musculus | I34 | SLVHCISEDCR | 1 | Bos taurus | I44 | RMGAGIAVLFK | 3 | Homo sapiens, Bos taurus, Mus musculus | K84 | YYLITKKRASH | 3 | Homo sapiens, Bos taurus, Mus musculus | L124 | RIGCGLDRLQW | 3 | Homo sapiens, Bos taurus, Mus musculus | L21 | YVKGDLFACPK | 2 | Homo sapiens, Mus musculus | L21 | YVKGDLFACPQ | 1 | Bos taurus | L47 | AGIAVLFKKKF | 2 | Homo sapiens, Bos taurus | L47 | AGIAVLFKKRF | 1 | Mus musculus | L5 | 3 | Homo sapiens, Bos taurus, Mus musculus | M40 | SEDCRMGAGIA | 3 | Homo sapiens, Bos taurus, Mus musculus | P118 | TDLSMPRIGCG | 3 | Homo sapiens, Bos taurus, Mus musculus | R119 | DLSMPRIGCGL | 3 | Homo sapiens, Bos taurus, Mus musculus | R39 | ISEDCRMGAGI | 3 | Homo sapiens, Bos taurus, Mus musculus | S35 | LAHCISEDCRM | 2 | Homo sapiens, Mus musculus | S35 | LVHCISEDCRM | 1 | Bos taurus | Y150 | IKITVYTL | 2 | Homo sapiens, Mus musculus | Y150 | IRITVYTL | 1 | Bos taurus |
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