mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for FDFT1

Gene summary

Basic gene Info.	Gene symbol	FDFT1
	Gene name	farnesyl-diphosphate farnesyltransferase 1
	Synonyms	DGPT\|ERG9\|SQS\|SS
	Cytomap	UCSC genome browser: 8p23.1-p22
	Type of gene	protein-coding
	RefGenes	NM_001287742.1, NM_001287743.1,NM_001287744.1,NM_001287745.1,NM_001287747.1, NM_001287748.1,NM_001287749.1,NM_001287750.1,NM_001287751.1, NM_001287756.1,NM_004462.4,
	Description	FPP:FPP farnesyltransferasepresqualene-di-diphosphate synthasesqualene synthasesqualene synthetase
	Modification date	20141207
dbXrefs	MIM : 184420
	HGNC : HGNC
	Ensembl : ENSG00000079459
	HPRD : 01694
	Vega : OTTHUMG00000090801
Protein	UniProt: P37268 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_FDFT1
	BioGPS: 2222
Pathway	NCI Pathway Interaction Database: FDFT1
	KEGG: FDFT1
	REACTOME: FDFT1
	Pathway Commons: FDFT1
Context	iHOP: FDFT1
	ligand binding site mutation search in PubMed: FDFT1
	UCL Cancer Institute: FDFT1
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO Term

PubMed ID

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Ligand binding site mutations for FDFT1

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
V175	Y174C	COAD	1
N215	N215S	COAD	1
M150	R149I	COAD	1
M150	R148Q	HNSC	1
F54	A55T	HNSC	1
S184	R185H	LUAD	1
M325	M325I	LUSC	1
F230	F230L	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for FDFT1

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
S184	R185H	-1.1401371
F54	A55T	-1.121974
M150	R148Q	-1.0739375
M325	M325I	-1.0295101
M150	R149I	-0.97614245
N215	N215S	-0.82207556
F230	F230L	-0.81530889
V175	Y174C	-0.44887739

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for FDFT1 from PDB

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Differential gene expression and gene-gene network for FDFT1

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of FDFT1 and the right PPI network was created from samples without mutations in the LBS of FDFT1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for FDFT1

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C2239176	Carcinoma, Hepatocellular	1	Biomarker
umls:C0236736	Cocaine-Related Disorders	1	Biomarker
umls:C0024809	Marijuana Abuse	1	Biomarker
umls:C0031391	Phencyclidine Abuse	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for FDFT1

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Investigational	DB05317	TAK-475	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of FDFT1 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
IN0		N-{2-[TRANS-7-CHLORO-1-(2,2-DIMETHYL-PROPYL) -5-NAPHTHALEN-1-YL-2-OXO-1,2,3,5-TETRAHYDRO-BENZO[E] [1,4]OXAZEPIN-3-YL]-ACETYL}-ASPARTIC ACID	1ezf	A	F54
IN0		N-{2-[TRANS-7-CHLORO-1-(2,2-DIMETHYL-PROPYL) -5-NAPHTHALEN-1-YL-2-OXO-1,2,3,5-TETRAHYDRO-BENZO[E] [1,4]OXAZEPIN-3-YL]-ACETYL}-ASPARTIC ACID	1ezf	B	F54
IN0		N-{2-[TRANS-7-CHLORO-1-(2,2-DIMETHYL-PROPYL) -5-NAPHTHALEN-1-YL-2-OXO-1,2,3,5-TETRAHYDRO-BENZO[E] [1,4]OXAZEPIN-3-YL]-ACETYL}-ASPARTIC ACID	1ezf	C	F54
D99		(3R)-1-{4-[{4-CHLORO-2-[(S)-(2-CHLOROPHENYL)(HYDROXY)METHYL]PHENYL}(2,2-DIMETHYLPROPYL)AMINO]-4-OXOBUTANOYL}PIPERIDINE-3-CARBOXYLIC ACID	3asx	A	F54
B65		BPH-652	3lee	F	F54
D9A		N-{[(3R,5S)-7-CHLORO-5-(2,3-DIMETHOXYPHENYL)-1-(2,2-DIMETHYLPROPYL)-2-OXO-1,2,3,5-TETRAHYDRO-4,1-BENZOXAZEPIN-3-YL]ACETYL}-L-ASPARTIC ACID	3q2z	A	F54
FPS		FARNESYL THIOPYROPHOSPHATE	3wef	B	F54
FPS		FARNESYL THIOPYROPHOSPHATE	3wc9	A	F54
FPS		FARNESYL THIOPYROPHOSPHATE	3wc9	C	F54
FPS		FARNESYL THIOPYROPHOSPHATE	3wc9	D	F54
FPS		FARNESYL THIOPYROPHOSPHATE	3wc9	D	F54
RWY		2-(4-PHENOXYPHENOXY)ETHYL THIOCYANATE	3wcd	B	F54
BH8		HYDROGEN [(1S)-2-(3-DECYL-1H-IMIDAZOL-3-IUM-1-YL)-1- PHOSPHONOETHYL]PHOSPHONATE	3wcf	D	F54
8PH		HYDROGEN [(1R)-2-(3-DECYL-1H-IMIDAZOL-3-IUM-1-YL)-1- HYDROXY-1-PHOSPHONOETHYL]PHOSPHONATE	3wch	A	F54
8PH		HYDROGEN [(1R)-2-(3-DECYL-1H-IMIDAZOL-3-IUM-1-YL)-1- HYDROXY-1-PHOSPHONOETHYL]PHOSPHONATE	3wch	B	F54
8PH		HYDROGEN [(1R)-2-(3-DECYL-1H-IMIDAZOL-3-IUM-1-YL)-1- HYDROXY-1-PHOSPHONOETHYL]PHOSPHONATE	3wch	F	F54
BH5		HYDROGEN [(1R)-1-HYDROXY-2-(3-PENTADECYL-1H-IMIDAZOL-3- IUM-1-YL)-1-PHOSPHONOETHYL]PHOSPHONATE	3wci	B	F54
ER4		(3R)-3-{[2-BENZYL-6-(3-METHOXYPROPOXY)PYRIDIN-3- YL]ETHYNYL}-1-AZABICYCLO[2.2.2]OCTAN-3-OL	3wcm	A	F54
ER4		(3R)-3-{[2-BENZYL-6-(3-METHOXYPROPOXY)PYRIDIN-3- YL]ETHYNYL}-1-AZABICYCLO[2.2.2]OCTAN-3-OL	3wcm	B	F54
ER4		(3R)-3-{[2-BENZYL-6-(3-METHOXYPROPOXY)PYRIDIN-3- YL]ETHYNYL}-1-AZABICYCLO[2.2.2]OCTAN-3-OL	3wcm	C	F54
ER4		(3R)-3-{[2-BENZYL-6-(3-METHOXYPROPOXY)PYRIDIN-3- YL]ETHYNYL}-1-AZABICYCLO[2.2.2]OCTAN-3-OL	3wcm	D	F54
ER4		(3R)-3-{[2-BENZYL-6-(3-METHOXYPROPOXY)PYRIDIN-3- YL]ETHYNYL}-1-AZABICYCLO[2.2.2]OCTAN-3-OL	3wcm	E	F54
RWZ		N-[(2Z)-3,7-DIMETHYLOCTA-2,6-DIEN-1-YL]-N'-[(1R,3S,5R,7R)-TRICYCLO[3.3.1.1~3,7~]DEC-2-YL]ETHANE-1,2-DIAMINE	3wsa	B	F54
RWZ		N-[(2Z)-3,7-DIMETHYLOCTA-2,6-DIEN-1-YL]-N'-[(1R,3S,5R,7R)-TRICYCLO[3.3.1.1~3,7~]DEC-2-YL]ETHANE-1,2-DIAMINE	3wsa	E	F54
ZGA		ZARAGOZIC ACID A	3vjc	A	F54 M150 V175
FPS		FARNESYL THIOPYROPHOSPHATE	3wef	B	F54 M150 V175
ZGA		ZARAGOZIC ACID A	3vjc	B	F54 M150 V175 N215
ZGA		ZARAGOZIC ACID A	3vjc	C	F54 M150 V175 N215
ZGA		ZARAGOZIC ACID A	3vjc	D	F54 M150 V175 N215
ZGA		ZARAGOZIC ACID A	3vjc	E	F54 M150 V175 N215
D3A	(1-{[(4R,6S)-8-CHLORO-6-(2,3-DIMETHOXYPHENYL)-4H,6H- PYRROLO[1,2-A][4,1]BENZOXAZEPIN-4-YL]ACETYL}PIPERIDIN- 4-YL)ACETIC ACID	2-(1-{2-[(4R,6S)-8-CHLORO-6-(2,3-DIMETHOXYPHENYL)-4H, 6H-PYRROLO[1,2-A][4,1]BENZOXAZEPIN-4-YL]ACETYL}-4- PIPERIDINYL)ACETIC ACID	3v66	A	F54 M325
FPS		FARNESYL THIOPYROPHOSPHATE	3wef	A	F54 N215
FPS		FARNESYL THIOPYROPHOSPHATE	3wef	C	F54 N215
FPS		FARNESYL THIOPYROPHOSPHATE	3wef	D	F54 N215
FPS		FARNESYL THIOPYROPHOSPHATE	3wef	E	F54 N215
FPS		FARNESYL THIOPYROPHOSPHATE	3weg	A	F54 N215
PS7		{(1R,2R,3R)-2-[(3E)-4,8-DIMETHYLNONA-3,7-DIEN-1-YL]-2-METHYL-3-[(1E,5E)-2,6,10-TRIMETHYLUNDECA-1,5,9-TRIEN-1-YL]CYCLOPROPYL}METHYL TRIHYDROGEN DIPHOSPHATE	3wej	A	F54 N215
FPS		FARNESYL THIOPYROPHOSPHATE	3wc9	B	F54 N215
FPS		FARNESYL THIOPYROPHOSPHATE	3wc9	E	F54 N215
FPS		FARNESYL THIOPYROPHOSPHATE	3wc9	F	F54 N215
BH8		HYDROGEN [(1S)-2-(3-DECYL-1H-IMIDAZOL-3-IUM-1-YL)-1- PHOSPHONOETHYL]PHOSPHONATE	3wcf	B	F54 N215
BH8		HYDROGEN [(1S)-2-(3-DECYL-1H-IMIDAZOL-3-IUM-1-YL)-1- PHOSPHONOETHYL]PHOSPHONATE	3wcf	E	F54 N215
BH8		HYDROGEN [(1S)-2-(3-DECYL-1H-IMIDAZOL-3-IUM-1-YL)-1- PHOSPHONOETHYL]PHOSPHONATE	3wcf	F	F54 N215
8PH		HYDROGEN [(1R)-2-(3-DECYL-1H-IMIDAZOL-3-IUM-1-YL)-1- HYDROXY-1-PHOSPHONOETHYL]PHOSPHONATE	3wch	E	F54 N215
B65		BPH-652	3lee	B	F54 V175
B65		BPH-652	3lee	C	F54 V175
B65		BPH-652	3lee	E	F54 V175
FPS		FARNESYL THIOPYROPHOSPHATE	3wef	A	F54 V175
FPS		FARNESYL THIOPYROPHOSPHATE	3weg	A	F54 V175
E5S		(3R)-3-({2-BENZYL-6-[(3R,4S)-3-HYDROXY-4- METHOXYPYRROLIDIN-1-YL]PYRIDIN-3-YL}ETHYNYL)-1- AZABICYCLO[2.2.2]OCTAN-3-OL	3wcj	A	F54 V175
E5S		(3R)-3-({2-BENZYL-6-[(3R,4S)-3-HYDROXY-4- METHOXYPYRROLIDIN-1-YL]PYRIDIN-3-YL}ETHYNYL)-1- AZABICYCLO[2.2.2]OCTAN-3-OL	3wcj	B	F54 V175
E5S		(3R)-3-({2-BENZYL-6-[(3R,4S)-3-HYDROXY-4- METHOXYPYRROLIDIN-1-YL]PYRIDIN-3-YL}ETHYNYL)-1- AZABICYCLO[2.2.2]OCTAN-3-OL	3wcj	C	F54 V175
E5S		(3R)-3-({2-BENZYL-6-[(3R,4S)-3-HYDROXY-4- METHOXYPYRROLIDIN-1-YL]PYRIDIN-3-YL}ETHYNYL)-1- AZABICYCLO[2.2.2]OCTAN-3-OL	3wcj	D	F54 V175
E5S		(3R)-3-({2-BENZYL-6-[(3R,4S)-3-HYDROXY-4- METHOXYPYRROLIDIN-1-YL]PYRIDIN-3-YL}ETHYNYL)-1- AZABICYCLO[2.2.2]OCTAN-3-OL	3wcj	E	F54 V175
E5S		(3R)-3-({2-BENZYL-6-[(3R,4S)-3-HYDROXY-4- METHOXYPYRROLIDIN-1-YL]PYRIDIN-3-YL}ETHYNYL)-1- AZABICYCLO[2.2.2]OCTAN-3-OL	3wcj	F	F54 V175
BH3		HYDROGEN [(1R)-2-(3-PENTADECYL-1H-IMIDAZOL-3-IUM-1-YL)- 1-PHOSPHONOETHYL]PHOSPHONATE	3wcl	A	F54 V175
ZGA		ZARAGOZIC ACID A	3vjc	F	F54 V175 N215
PS7		{(1R,2R,3R)-2-[(3E)-4,8-DIMETHYLNONA-3,7-DIEN-1-YL]-2-METHYL-3-[(1E,5E)-2,6,10-TRIMETHYLUNDECA-1,5,9-TRIEN-1-YL]CYCLOPROPYL}METHYL TRIHYDROGEN DIPHOSPHATE	3weh	A	F54 V175 N215
PS7		{(1R,2R,3R)-2-[(3E)-4,8-DIMETHYLNONA-3,7-DIEN-1-YL]-2-METHYL-3-[(1E,5E)-2,6,10-TRIMETHYLUNDECA-1,5,9-TRIEN-1-YL]CYCLOPROPYL}METHYL TRIHYDROGEN DIPHOSPHATE	3wei	A	F54 V175 S184 N215
PS7		{(1R,2R,3R)-2-[(3E)-4,8-DIMETHYLNONA-3,7-DIEN-1-YL]-2-METHYL-3-[(1E,5E)-2,6,10-TRIMETHYLUNDECA-1,5,9-TRIEN-1-YL]CYCLOPROPYL}METHYL TRIHYDROGEN DIPHOSPHATE	3wek	A	F54 V175 S184 N215
D61		(2R,3R)-2-(CARBOXYMETHOXY)-4-{[5-(NAPHTHALEN-2-YL)PENTYL]AMINO}-3-{[5-(NAPHTHALEN-2-YL)PENTYL]OXY}-4-OXOBUTANOIC ACID	3q30	A	M150 V175
FPS		FARNESYL THIOPYROPHOSPHATE	3wef	E	M150 V175 F230
MN		MANGANESE(2+)	3wei	A	N215
BH8		HYDROGEN [(1S)-2-(3-DECYL-1H-IMIDAZOL-3-IUM-1-YL)-1- PHOSPHONOETHYL]PHOSPHONATE	3wcf	A	N215
BH8		HYDROGEN [(1S)-2-(3-DECYL-1H-IMIDAZOL-3-IUM-1-YL)-1- PHOSPHONOETHYL]PHOSPHONATE	3wcf	C	N215
8PH		HYDROGEN [(1R)-2-(3-DECYL-1H-IMIDAZOL-3-IUM-1-YL)-1- HYDROXY-1-PHOSPHONOETHYL]PHOSPHONATE	3wch	A	N215
ER4		(3R)-3-{[2-BENZYL-6-(3-METHOXYPROPOXY)PYRIDIN-3- YL]ETHYNYL}-1-AZABICYCLO[2.2.2]OCTAN-3-OL	3wcm	F	S184
B65		BPH-652	3lee	A	V175
B65		BPH-652	3lee	D	V175
MG		MAGNESIUM(2+)	3lee	E	V175
RWY		2-(4-PHENOXYPHENOXY)ETHYL THIOCYANATE	3wcd	A	V175
8PH		HYDROGEN [(1R)-2-(3-DECYL-1H-IMIDAZOL-3-IUM-1-YL)-1- HYDROXY-1-PHOSPHONOETHYL]PHOSPHONATE	3wch	A	V175
8PH		HYDROGEN [(1R)-2-(3-DECYL-1H-IMIDAZOL-3-IUM-1-YL)-1- HYDROXY-1-PHOSPHONOETHYL]PHOSPHONATE	3wch	C	V175
8PH		HYDROGEN [(1R)-2-(3-DECYL-1H-IMIDAZOL-3-IUM-1-YL)-1- HYDROXY-1-PHOSPHONOETHYL]PHOSPHONATE	3wch	D	V175
BH5		HYDROGEN [(1R)-1-HYDROXY-2-(3-PENTADECYL-1H-IMIDAZOL-3- IUM-1-YL)-1-PHOSPHONOETHYL]PHOSPHONATE	3wci	A	V175
BH5		HYDROGEN [(1R)-1-HYDROXY-2-(3-PENTADECYL-1H-IMIDAZOL-3- IUM-1-YL)-1-PHOSPHONOETHYL]PHOSPHONATE	3wci	D	V175
BH5		HYDROGEN [(1R)-1-HYDROXY-2-(3-PENTADECYL-1H-IMIDAZOL-3- IUM-1-YL)-1-PHOSPHONOETHYL]PHOSPHONATE	3wci	F	V175
8PH		HYDROGEN [(1R)-2-(3-DECYL-1H-IMIDAZOL-3-IUM-1-YL)-1- HYDROXY-1-PHOSPHONOETHYL]PHOSPHONATE	3wch	B	V175 N215

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Conservation information for LBS of FDFT1

Multiple alignments for P37268 in multiple species

LBS	AA sequence	# species	Species
A176	YCHYVAGLVGI	4	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus
A176	YCHYVAGLVGD	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A176	YCHYVAGLVGL	1	Arabidopsis thaliana
A296	IPQVMAIATLA	6	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A296	IPQIMAIGTLA	1	Arabidopsis thaliana
C289	SVFNFCAIPQV	3	Homo sapiens, Mus musculus, Rattus norvegicus
C289	EIFNFCAIPQV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C289	SIFRFCAIPQI	1	Arabidopsis thaliana
C289	STFQFCAIPQV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C289	SSFQFCAIPQV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D219	TNIIRDYLEDQ	3	Homo sapiens, Mus musculus, Rattus norvegicus
D219	VNIIRDYREDF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D219	TNIIRDYLEDI	1	Arabidopsis thaliana
D219	TNIIRDYNEDL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D219	TNIIRDYAEDL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D80	VLRALDTVEDD	2	Arabidopsis thaliana, Mus musculus
D80	VLRALDTLEDD	1	Homo sapiens
D80	VLRGLDTVEDD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D80	ILRAMDTVEDD	1	Rattus norvegicus
D80	ILRALDTIEDD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D80	ILRALDTVEDD	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D84	LDTLEDDMTIS	1	Homo sapiens
D84	LDTVEDDMTLP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D84	LDTVEDDTSIP	1	Arabidopsis thaliana
D84	LDTVEDDMSIS	1	Mus musculus
D84	MDTVEDDMAIS	1	Rattus norvegicus
D84	LDTIEDDMSIE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D84	LDTVEDDMTIS	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E222	IRDYLEDQQE-	2	Mus musculus, Rattus norvegicus
E222	IRDYLEDQQG-	1	Homo sapiens
E222	IRDYREDFDD-	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E222	IRDYLEDINEI	1	Arabidopsis thaliana
E222	IRDYNEDLVD-	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E222	IRDYAEDLAD-	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E83	ALDTLEDDMTI	1	Homo sapiens
E83	GLDTVEDDMTL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E83	ALDTVEDDTSI	1	Arabidopsis thaliana
E83	ALDTVEDDMSI	1	Mus musculus
E83	AMDTVEDDMAI	1	Rattus norvegicus
E83	ALDTIEDDMSI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E83	ALDTVEDDMTI	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F187	GLSRLFSASEF	3	Homo sapiens, Mus musculus, Rattus norvegicus
F187	GLSRLFAQSKL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F187	GLSKLFLAA--	1	Arabidopsis thaliana
F187	GLTRLIVIAKF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F187	GLTHLIMLAKF	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F230	--GRSFWPKEI	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F230	--GREFWPQEV	1	Homo sapiens
F230	--NRHFWPREI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F230	PKSRMFWPREI	1	Arabidopsis thaliana
F230	--GRKFWPQEV	1	Mus musculus
F230	--GRQFWPQEV	1	Rattus norvegicus
F288	QSVFNFCAIPQ	3	Homo sapiens, Mus musculus, Rattus norvegicus
F288	QEIFNFCAIPQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F288	PSIFRFCAIPQ	1	Arabidopsis thaliana
F288	QSTFQFCAIPQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F288	QSSFQFCAIPQ	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F54	QTSRSFAAVIQ	3	Homo sapiens, Mus musculus, Rattus norvegicus
F54	MTSRSFAVVIK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F54	KVSRSFSLVIQ	1	Arabidopsis thaliana
F54	LTSRSFAAVIR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F54	RTSRSFAAVIM	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F72	NAVCIFYLVLR	1	Homo sapiens
F72	EAVMIFYLVLR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F72	NAVCVFYLVLR	1	Arabidopsis thaliana
F72	HAICVFYLVLR	1	Mus musculus
F72	HAVCVFYLILR	1	Rattus norvegicus
F72	NCVTLFYLILR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F72	NAVMLFYLILR	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G180	VAGLVGIGLSR	4	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus
G180	VAGLVGLGLSK	1	Arabidopsis thaliana
G180	VAGLVGDGLTR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G180	VAGLVGDGLTH	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G208	CANSMGLFLQK	2	Mus musculus, Rattus norvegicus
G208	LYESMGLFLQK	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G208	RANSMGLFLQK	1	Homo sapiens
G208	ISNSLGLFLQK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G208	ISNSMGLFLQK	1	Arabidopsis thaliana
I58	SFAAVIQALDG	3	Homo sapiens, Mus musculus, Rattus norvegicus
I58	SFAVVIKELPN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I58	SFSLVIQQLNT	1	Arabidopsis thaliana
I58	SFAAVIRELHP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I58	SFAAVIMELHP	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K117	MESKEKDRQVL	1	Homo sapiens
K117	SGPNEKDRQLL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K117	SCGTKEYKILM	1	Arabidopsis thaliana
K117	TESKEKDRQVL	1	Mus musculus
K117	TESKEKHRVVL	1	Rattus norvegicus
K117	NAPDVKDRAVL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K117	NAKTEKDRDVL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L183	LVGIGLSRLFS	3	Homo sapiens, Mus musculus, Rattus norvegicus
L183	LVGIGLSRLFA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L183	LVGLGLSKLFL	1	Arabidopsis thaliana
L183	LVGDGLTRLIV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L183	LVGDGLTHLIM	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L211	SMGLFLQKTNI	6	Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L211	SLGLFLQKVNI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L76	VFYLVLRALDT	2	Arabidopsis thaliana, Mus musculus
L76	LFYLILRALDT	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L76	IFYLVLRALDT	1	Homo sapiens
L76	IFYLVLRGLDT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L76	VFYLILRAMDT	1	Rattus norvegicus
M150	DICHRMGCGMA	2	Mus musculus, Rattus norvegicus
M150	DICRRMGIGMA	1	Homo sapiens
M150	NITKEMGDGMA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M150	EITRRMGAGMA	1	Arabidopsis thaliana
M150	EITEKMGNGMA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M150	DITHKMGNGMA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M154	KMGNGMADYI-	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M154	RMGIGMAEFL-	1	Homo sapiens
M154	EMGDGMAYYAS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M154	RMGAGMAKFI-	1	Arabidopsis thaliana
M154	RMGCGMAEFV-	1	Mus musculus
M154	RMGCGMAEFL-	1	Rattus norvegicus
M207	ECANSMGLFLQ	2	Mus musculus, Rattus norvegicus
M207	ERANSMGLFLQ	1	Homo sapiens
M207	AISNSLGLFLQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M207	AISNSMGLFLQ	1	Arabidopsis thaliana
M207	QLYESMGLFLQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M207	DLYESMGLFLQ	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M295	AIPQVMAIATL	6	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M295	AIPQIMAIGTL	1	Arabidopsis thaliana
M325	QAVTLMMDATN	3	Homo sapiens, Mus musculus, Rattus norvegicus
M325	TTCYLILKSRT	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M325	QAVQIILHSVN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M325	LTAKVIDRTKT	1	Arabidopsis thaliana
N215	FLQKTNIIRDY	6	Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N215	FLQKVNIIRDY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P292	NFCAIPQVMAI	4	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus
P292	QFCAIPQVMAI	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P292	RFCAIPQIMAI	1	Arabidopsis thaliana
Q212	MGLFLQKTNII	6	Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Q212	LGLFLQKVNII	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q293	FCAIPQVMAIA	6	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Q293	FCAIPQIMAIG	1	Arabidopsis thaliana
R218	KTNIIRDYLED	4	Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus
R218	KVNIIRDYRED	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R218	KTNIIRDYNED	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R218	KTNIIRDYAED	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R228	D---GRSFWPK	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R228	G---GREFWPQ	1	Homo sapiens
R228	D---NRHFWPR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R228	EIPKSRMFWPR	1	Arabidopsis thaliana
R228	E---GRKFWPQ	1	Mus musculus
R228	E---GRQFWPQ	1	Rattus norvegicus
R52	LNQTSRSFAAV	2	Homo sapiens, Mus musculus
R52	LDMTSRSFAVV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R52	LHKVSRSFSLV	1	Arabidopsis thaliana
R52	LDQTSRSFAAV	1	Rattus norvegicus
R52	LNLTSRSFAAV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R52	LQRTSRSFAAV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R77	FYLVLRALDTV	2	Arabidopsis thaliana, Mus musculus
R77	FYLVLRALDTL	1	Homo sapiens
R77	FYLVLRGLDTV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R77	FYLILRAMDTV	1	Rattus norvegicus
R77	FYLILRALDTI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R77	FYLILRALDTV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S184	VGIGLSRLFSA	3	Homo sapiens, Mus musculus, Rattus norvegicus
S184	VGIGLSRLFAQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S184	VGLGLSKLFLA	1	Arabidopsis thaliana
S184	VGDGLTRLIVI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S184	VGDGLTHLIML	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S51	YLNQTSRSFAA	2	Homo sapiens, Mus musculus
S51	LLDMTSRSFAV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S51	MLHKVSRSFSL	1	Arabidopsis thaliana
S51	YLDQTSRSFAA	1	Rattus norvegicus
S51	LLNLTSRSFAA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S51	LLQRTSRSFAA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S53	NQTSRSFAAVI	2	Homo sapiens, Mus musculus
S53	DMTSRSFAVVI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S53	HKVSRSFSLVI	1	Arabidopsis thaliana
S53	DQTSRSFAAVI	1	Rattus norvegicus
S53	NLTSRSFAAVI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S53	QRTSRSFAAVI	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T214	LFLQKTNIIRD	6	Homo sapiens, Arabidopsis thaliana, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T214	LFLQKVNIIRD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T299	VMAIATLAACY	3	Homo sapiens, Mus musculus, Rattus norvegicus
T299	VMAIATLALVF	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T299	VMAIATLAAVF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T299	IMAIGTLALCY	1	Arabidopsis thaliana
T50	KYLNQTSRSFA	2	Homo sapiens, Mus musculus
T50	QLLDMTSRSFA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T50	SMLHKVSRSFS	1	Arabidopsis thaliana
T50	KYLDQTSRSFA	1	Rattus norvegicus
T50	ELLNLTSRSFA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T50	QLLQRTSRSFA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V175	KYCHYVAGLVG	4	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus
V175	EYCHYVAGLVG	1	Arabidopsis thaliana
V175	VYCHYVAGLVG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V175	RYCHYVAGLVG	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V179	YVAGLVGIGLS	4	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus
V179	YVAGLVGDGLT	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V179	YVAGLVGLGLS	1	Arabidopsis thaliana
V69	EMRNAVCIFYL	1	Homo sapiens
V69	GIREAVMIFYL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V69	ELRNAVCVFYL	1	Arabidopsis thaliana
V69	DIRHAICVFYL	1	Mus musculus
V69	DIRHAVCVFYL	1	Rattus norvegicus
V69	ELRNCVTLFYL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V69	ELRNAVMLFYL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y171	QDWDKYCHYVA	2	Mus musculus, Rattus norvegicus
Y171	QEWDKYCHYVA	1	Homo sapiens
Y171	EDFNKYCHYVA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y171	DDYDEYCHYVA	1	Arabidopsis thaliana
Y171	HDYDVYCHYVA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y171	QDYDRYCHYVA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y276	PDVITYLSRLR	2	Homo sapiens, Rattus norvegicus
Y276	TDALVYLSQLK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y276	EDCLKYMVSLR	1	Arabidopsis thaliana
Y276	PDVLTYLSRLR	1	Mus musculus
Y276	IDVLTYLAGIH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y276	QHVLTYLASLR	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y73	AVCIFYLVLRA	1	Homo sapiens
Y73	AVMIFYLVLRG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y73	AVCVFYLVLRA	1	Arabidopsis thaliana
Y73	AICVFYLVLRA	1	Mus musculus
Y73	AVCVFYLILRA	1	Rattus norvegicus
Y73	CVTLFYLILRA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y73	AVMLFYLILRA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)