mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for NAPEPLD
Gene summary
Basic gene Info.Gene symbolNAPEPLD
Gene nameN-acyl phosphatidylethanolamine phospholipase D
CytomapUCSC genome browser: 7q22.1
Type of geneprotein-coding
DescriptionN-acyl-phosphatidylethanolamine-hydrolyzing phospholipase DNAPE-hydrolyzing phospholipase D
Modification date20141207
dbXrefs MIM : 612334
Ensembl : ENSG00000161048
HPRD : 14809
Vega : OTTHUMG00000157204
ProteinUniProt: Q6IQ20
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NAPEPLD
BioGPS: 222236
PathwayNCI Pathway Interaction Database: NAPEPLD
Pathway Commons: NAPEPLD
ligand binding site mutation search in PubMed: NAPEPLD
UCL Cancer Institute: NAPEPLD
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for NAPEPLD

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for NAPEPLD
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for NAPEPLD from PDB

Differential gene expression and gene-gene network for NAPEPLD
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of NAPEPLD and the right PPI network was created from samples without mutations in the LBS of NAPEPLD. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for NAPEPLD
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for NAPEPLD
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of NAPEPLD go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of NAPEPLD
Multiple alignments for Q6IQ20 in multiple species
LBSAA sequence# speciesSpecies
A348HWGTFALANEH4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
C222DWMQKCGCENV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D189SHNHYDHLDYG2Mus musculus, Rattus norvegicus
D189SHNHYDHLDYN1Homo sapiens
D189SHNHYDHLDCN1Bos taurus
D284FFFAGDTGYCP3Homo sapiens, Mus musculus, Rattus norvegicus
D284FFFAGDTGYCS1Bos taurus
G161PSQYMGPKRFR3Homo sapiens, Mus musculus, Rattus norvegicus
G161PSQRMGPKRFR1Bos taurus
H185AVLISHNHYDH3Homo sapiens, Mus musculus, Rattus norvegicus
H185AVLVSHNHYDH1Bos taurus
H187LISHNHYDHLD3Homo sapiens, Mus musculus, Rattus norvegicus
H187LVSHNHYDHLD1Bos taurus
H190HNHYDHLDYGS2Mus musculus, Rattus norvegicus
H190HNHYDHLDYNS1Homo sapiens
H190HNHYDHLDCNS1Bos taurus
H253FTPSQHWCKRT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H343RSVAIHWGTFA2Mus musculus, Rattus norvegicus
H343KSMAIHWGTFA1Homo sapiens
H343KSVAIHWGTFA1Bos taurus
K221LDWMQKCGCEN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K256SQHWCKRTLMD2Homo sapiens, Bos taurus
K256SQHWCKRTLLD2Mus musculus, Rattus norvegicus
L259WCKRTLMDDNK2Homo sapiens, Bos taurus
L259WCKRTLLDDNK2Mus musculus, Rattus norvegicus
M160SPSQYMGPKRF3Homo sapiens, Mus musculus, Rattus norvegicus
M160SPSQRMGPKRF1Bos taurus
M260CKRTLMDDNKV2Homo sapiens, Bos taurus
M260CKRTLLDDNKV2Mus musculus, Rattus norvegicus
P162SQYMGPKRFRR3Homo sapiens, Mus musculus, Rattus norvegicus
P162SQRMGPKRFRR1Bos taurus
R257QHWCKRTLMDD2Homo sapiens, Bos taurus
R257QHWCKRTLLDD2Mus musculus, Rattus norvegicus
T258HWCKRTLMDDN2Homo sapiens, Bos taurus
T258HWCKRTLLDDN2Mus musculus, Rattus norvegicus
W218LGLLDWMQKCG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y159ASPSQYMGPKR3Homo sapiens, Mus musculus, Rattus norvegicus
Y159ASPSQRMGPKR1Bos taurus
Y188ISHNHYDHLDY3Homo sapiens, Mus musculus, Rattus norvegicus
Y188VSHNHYDHLDC1Bos taurus
Y193YDHLDYGSVLA2Mus musculus, Rattus norvegicus
Y193YDHLDYNSVIA1Homo sapiens
Y193YDHLDCNSVIA1Bos taurus

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