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mutLBSgeneDB |
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| Gene summary for HS3ST5 |
 Gene summary |
| Basic gene Info. | Gene symbol | HS3ST5 |
| Gene name | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | |
| Synonyms | 3-OST-5|3OST5|HS3OST5|NBLA04021 | |
| Cytomap | UCSC genome browser: 6q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_153612.3, | |
| Description | h3-OST-5heparan sulfate 3-O-sulfotransferase 5heparan sulfate 3-OST-5heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5heparan sulfate glucosamine 3-O-sulfotransferase 5 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609407 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000249853 | ||
| HPRD : 13674 | ||
| Protein | UniProt: Q8IZT8 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HS3ST5 | |
| BioGPS: 222537 | ||
| Pathway | NCI Pathway Interaction Database: HS3ST5 | |
| KEGG: HS3ST5 | ||
| REACTOME: HS3ST5 | ||
| Pathway Commons: HS3ST5 | ||
| Context | iHOP: HS3ST5 | |
| ligand binding site mutation search in PubMed: HS3ST5 | ||
| UCL Cancer Institute: HS3ST5 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006477 | protein sulfation | 12138164 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification | 12138164 | GO:0046596 | regulation of viral entry into host cell | 12138164 | GO:0050819 | negative regulation of coagulation | 12138164 |
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| Ligand binding site mutations for HS3ST5 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R311 | R311S | LUAD | 1 | F292 | R290T | LUAD | 1 | I259 | R257C | SKCM | 1 | H313 | P314Q | SKCM | 1 | I259 | R257H | UCEC | 1 | F292 | F292L | UCEC | 1 | H313,R311 | I312T | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for HS3ST5 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R311 | R311S | -1.3155065 | F292 | F292L | -1.1287242 | R311 | I312T | -0.99517408 | H313 | I312T | -0.99517408 | I259 | R257H | -0.80982116 | H313 | P314Q | -0.80857652 | F292 | R290T | -0.6023947 | I259 | R257C | -0.59599461 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for HS3ST5 from PDB |
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| Differential gene expression and gene-gene network for HS3ST5 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for HS3ST5 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0025202 | Melanoma | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for HS3ST5 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of HS3ST5 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | A3P | ADENOSINE 3',5'-BISPHOSPHATE | 3bd9 | A | I259 F292 R311 H313 |
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| Conservation information for LBS of HS3ST5 |
| Multiple alignments for Q8IZT8 in multiple species |
| LBS | AA sequence | # species | Species |
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