mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for FECH
Gene summary
Basic gene Info.Gene symbolFECH
Gene nameferrochelatase
SynonymsEPP|FCE
CytomapUCSC genome browser: 18q21.3
Type of geneprotein-coding
RefGenesNM_000140.3,
NM_001012515.2,
Descriptionferrochelatase, mitochondrialheme synthaseheme synthetaseprotoheme ferro-lyaseprotoporphyria
Modification date20141219
dbXrefs MIM : 612386
HGNC : HGNC
HPRD : 01509
ProteinUniProt: P22830
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FECH
BioGPS: 2235
PathwayNCI Pathway Interaction Database: FECH
KEGG: FECH
REACTOME: FECH
Pathway Commons: FECH
ContextiHOP: FECH
ligand binding site mutation search in PubMed: FECH
UCL Cancer Institute: FECH
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0046501protoporphyrinogen IX metabolic process15123683


Top
Ligand binding site mutations for FECH

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
H341D340EBLCA1
S281A282TCOAD1
I132K133NCOAD1
R115R115QGBM1
L89L89FSKCM1
Y165V166ASTAD1
Y191Y191HSTAD1
L98D97YSTAD1
P79P79HSTAD1
I111A112SSTAD1
R115R115QUCEC1
M76N75SUCEC1
H263H263RUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for FECH
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Y191Y191H-1.3410846
M76N75S-1.3151234
Y165V166A-1.2533325
I132K133N-1.1979664
L89L89F-1.1331942
I111A112S-0.91954089
L98D97Y-0.90828491
R115R115Q-0.77616849
S281A282T-0.45271395
H263H263R-0.39329968
P79P79H-0.33493893
H341D340E-0.27830545
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for FECH from PDB

Top
Differential gene expression and gene-gene network for FECH
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of FECH and the right PPI network was created from samples without mutations in the LBS of FECH. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for FECH
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0162568Protoporphyria, Erythropoietic101Biomarker, GeneticVariation, Therapeutic
umls:C0005395Bile Duct Diseases1Biomarker
umls:C0016059Fibrosis1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for FECH
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB02659Cholic AcidSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of FECH go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
PP9PROTOPORPHYRIN2hreBI111
PP9PROTOPORPHYRIN2qd1DI111
PP9PROTOPORPHYRIN2hreDI111 R115
HEMHEME B4kmmBL98 R115 H263 H341
PP9PROTOPORPHYRIN4klaBL98 R115 Y191 H263 H341
HEMHEME B4klcBL98 R115 Y191 H263 H341
BCTHYDROGENCARBONATE3hcoAL98 Y165
FDEFE(III) DEUTEROPORPHYRIN IX3hcrAM76 L89 L98 R115 H263 H341
HEMHEME B4klrAM76 L89 L98 R115 H263 H341
PP9PROTOPORPHYRIN2qd1CM76 L89 L98 R115 I132 Y191 H263 H341
PP9PROTOPORPHYRIN2hreAM76 L89 L98 R115 Y191 H263 H341
PP9PROTOPORPHYRIN2hreCM76 L89 L98 R115 Y191 H263 H341
PP9PROTOPORPHYRIN2qd1AM76 L89 L98 R115 Y191 H263 H341
PP9PROTOPORPHYRIN2qd1BM76 L89 L98 R115 Y191 H263 H341
PP9PROTOPORPHYRIN2qd1DM76 L89 L98 R115 Y191 H263 H341
HEMHEME B3hcnAM76 L89 L98 R115 Y191 H263 H341
HEMHEME B3hcoAM76 L89 L98 R115 Y191 H263 H341
HEMHEME B4klrBM76 L89 L98 R115 Y191 H263 H341
FDEFE(III) DEUTEROPORPHYRIN IX3hcpAM76 L98 R115 H263
PP9PROTOPORPHYRIN2qd5AM76 L98 R115 H263 H341
PP9PROTOPORPHYRIN2hreBM76 L98 R115 I132 Y191 H263 H341
PP9PROTOPORPHYRIN2hreDM76 L98 R115 I132 Y191 H263 H341
HEMHEME B2qd2AM76 L98 R115 Y191 H263 H341
HEMHEME B2qd2BM76 L98 R115 Y191 H263 H341
BCTHYDROGENCARBONATE2qd2AM76 L98 Y165
BCTHYDROGENCARBONATE4klrAM76 L98 Y165
BCTHYDROGENCARBONATE4klrBM76 L98 Y165
BCTHYDROGENCARBONATE2qd2BM76 L98 Y165 Y191
BCTHYDROGENCARBONATE3hcnAM76 L98 Y165 Y191
HEMHEME B4klcAM76 P79 L98 H263 H341
HEMHEME B4kmmAR115 Y191 H263 H341
SALSALICYLIC ACID3w1wAS281
SALSALICYLIC ACID3w1wBS281


Top
Conservation information for LBS of FECH
Multiple alignments for P22830 in multiple species
LBSAA sequence# speciesSpecies
A336LLVPIAFTSDH4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
A336LAVPISFVSEH1Oryza sativa subsp. japonica
A336ILVPIAFTSDH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A336MFIPIAFTSDH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A336ILVPIAFVNEH1Drosophila melanogaster
C196YPQYSCSTTGS4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
C196YPQFSISTSGS1Oryza sativa subsp. japonica
C196YPQWSCATSGA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C196YPHFSYSTTGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C196YPQYSCATSGS1Drosophila melanogaster
C403QLTLSCPLC-V3Homo sapiens, Bos taurus, Pan troglodytes
C403NLEARQPLV-P1Oryza sativa subsp. japonica
C403QFTQRCPGC-T1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C403QLPLDFALGKS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C403KFLMRCPMC-S1Drosophila melanogaster
C403QLTLCCPLC-V1Gallus gallus
C406LSCPLC-VNPV2Homo sapiens, Pan troglodytes
C406ARQPLV-PLGS1Oryza sativa subsp. japonica
C406QRCPGC-TSES1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C406LDFALGKSNDP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C406MRCPMC-SNPK1Drosophila melanogaster
C406LCCPLC-VNPV1Gallus gallus
C406LSCPLC-VNPT1Bos taurus
C411-VNPVCRETKS2Homo sapiens, Pan troglodytes
C411-PLGSVEELLA1Oryza sativa subsp. japonica
C411-TSESCAERIN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C411KSNDPVKDLSL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C411-SNPKCRESKS1Drosophila melanogaster
C411-VNPVCRETKA1Gallus gallus
C411-VNPTCRETKS1Bos taurus
E343TSDHIETLYEL4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
E343VSEHIETLEEI1Oryza sativa subsp. japonica
E343TSDHIETLKEL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E343TSDHIETLHEI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E343VNEHIETLHEL1Drosophila melanogaster
F110NKLAPFIAKRR3Homo sapiens, Gallus gallus, Pan troglodytes
F110KPLAQFISVVR1Oryza sativa subsp. japonica
F110NSLGKFIAKRR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F110KTIAKYIAKFR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F110SRLGPWIAQRR1Drosophila melanogaster
F110DKLGPFIAKRR1Bos taurus
F337LVPIAFTSDHI5Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Gallus gallus, Bos taurus, Pan troglodytes
F337AVPISFVSEHI1Oryza sativa subsp. japonica
F337FIPIAFTSDHI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F337LVPIAFVNEHI1Drosophila melanogaster
F88GDVHDFLLRLF2Homo sapiens, Pan troglodytes
F88DDVQPFLFNLF1Oryza sativa subsp. japonica
F88DEVGPFLERLF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F88EETYDFLYQLF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F88DQVHDYLLRIM1Drosophila melanogaster
F88DDVHDFLLRLF1Gallus gallus
F88EEVQDFLQRLF1Bos taurus
F93FLLRLFLDRDL3Homo sapiens, Gallus gallus, Pan troglodytes
F93FLFNLFADPDI1Oryza sativa subsp. japonica
F93FLERLFTDGDI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F93FLYQLFADNDL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F93YLLRIMTDRDM1Drosophila melanogaster
F93FLQRLFLDQDL1Bos taurus
G306WQSKVGPMPWL4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
G306YQSRVGPVEWL1Oryza sativa subsp. japonica
G306WQSKVGPLPWM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G306WQSQVGPKPWL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G306WQSKVGPLPWL1Drosophila melanogaster
G77LMLNMGGPETL2Homo sapiens, Pan troglodytes
G77LLLNLGGPETL1Oryza sativa subsp. japonica
G77VMMNMGGPSNL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G77VLMNMGGPSKV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G77LMLNMGGPTHT1Drosophila melanogaster
G77LMLNMGGPERL1Gallus gallus
G77LMLNMGGPETV1Bos taurus
G78MLNMGGPETLG2Homo sapiens, Pan troglodytes
G78LLNLGGPETLD1Oryza sativa subsp. japonica
G78MMNMGGPSNLD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G78LMNMGGPSKVE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G78MLNMGGPTHTD1Drosophila melanogaster
G78MLNMGGPERLD1Gallus gallus
G78MLNMGGPETVE1Bos taurus
H263ILFSAHSLPMS4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
H263IFFSAHGVPLA1Oryza sativa subsp. japonica
H263IVFSAHSLPMS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H263LLFSAHSLPMD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H263ILFTAHSLPLK1Drosophila melanogaster
H341AFTSDHIETLY4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
H341SFVSEHIETLE1Oryza sativa subsp. japonica
H341AFTSDHIETLK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H341AFTSDHIETLH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H341AFVNEHIETLH1Drosophila melanogaster
I111KLAPFIAKRRT3Homo sapiens, Gallus gallus, Pan troglodytes
I111PLAQFISVVRA1Oryza sativa subsp. japonica
I111SLGKFIAKRRT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I111TIAKYIAKFRT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I111RLGPWIAQRRT1Drosophila melanogaster
I111KLGPFIAKRRT1Bos taurus
I119RRTPKIQEQYR3Homo sapiens, Bos taurus, Pan troglodytes
I119VRAPKSKEGYA1Oryza sativa subsp. japonica
I119RRTPKVQNHYS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I119FRTPKIEKQYR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I119RRTPEVQKKYK1Drosophila melanogaster
I119RRTPRIQEQYS1Gallus gallus
I132GGGSPIKIWTS2Homo sapiens, Pan troglodytes
I132GGGSPLRQITD1Oryza sativa subsp. japonica
I132GGGSPILHWTR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I132GGGSPIRKWSE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I132GGGSPILKWTE1Drosophila melanogaster
I132GGGSPIKKWTA1Gallus gallus
I132GGGSPIKMWTS1Bos taurus
I342FTSDHIETLYE4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
I342FVSEHIETLEE1Oryza sativa subsp. japonica
I342FTSDHIETLKE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I342FTSDHIETLHE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I342FVNEHIETLHE1Drosophila melanogaster
L265FSAHSLPMSVV4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
L265FSAHGVPLAYV1Oryza sativa subsp. japonica
L265FSAHSLPMSQV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L265FSAHSLPMDVV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L265FTAHSLPLKAV1Drosophila melanogaster
L311GPMPWLGPQTD3Homo sapiens, Bos taurus, Pan troglodytes
L311GPVEWLRPYTD1Oryza sativa subsp. japonica
L311GPLPWMSPATD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L311GPKPWLGAQTA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L311GPLPWLAPATD1Drosophila melanogaster
L311GPMPWLVPQTD1Gallus gallus
L89DVHDFLLRLFL3Homo sapiens, Gallus gallus, Pan troglodytes
L89DVQPFLFNLFA1Oryza sativa subsp. japonica
L89EVGPFLERLFT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L89ETYDFLYQLFA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L89QVHDYLLRIMT1Drosophila melanogaster
L89EVQDFLQRLFL1Bos taurus
L92DFLLRLFLDRD3Homo sapiens, Gallus gallus, Pan troglodytes
L92PFLFNLFADPD1Oryza sativa subsp. japonica
L92PFLERLFTDGD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L92DFLYQLFADND1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L92DYLLRIMTDRD1Drosophila melanogaster
L92DFLQRLFLDQD1Bos taurus
L98FLDRDLMTLP-3Homo sapiens, Gallus gallus, Pan troglodytes
L98FADPDIIRLPR1Oryza sativa subsp. japonica
L98FTDGDIIPLG-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L98FADNDLIPIS-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L98MTDRDMIQLP-1Drosophila melanogaster
L98FLDQDLMTLP-1Bos taurus
M308SKVGPMPWLGP3Homo sapiens, Bos taurus, Pan troglodytes
M308SRVGPVEWLRP1Oryza sativa subsp. japonica
M308SKVGPLPWMSP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M308SQVGPKPWLGA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M308SKVGPLPWLAP1Drosophila melanogaster
M308SKVGPMPWLVP1Gallus gallus
M76ILMLNMGGPET3Homo sapiens, Bos taurus, Pan troglodytes
M76VLLLNLGGPET1Oryza sativa subsp. japonica
M76VVMMNMGGPSN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M76IVLMNMGGPSK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M76ILMLNMGGPTH1Drosophila melanogaster
M76ILMLNMGGPER1Gallus gallus
M99LDRDLMTLP--3Homo sapiens, Gallus gallus, Pan troglodytes
M99ADPDIIRLPRL1Oryza sativa subsp. japonica
M99TDGDIIPLG--1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M99ADNDLIPIS--1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M99TDRDMIQLP--1Drosophila melanogaster
M99LDQDLMTLP--1Bos taurus
N408PLC-VNPVCRE3Homo sapiens, Gallus gallus, Pan troglodytes
N408PLV-PLGSVEE1Oryza sativa subsp. japonica
N408PGC-TSESCAE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N408ALGKSNDPVKD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N408PMC-SNPKCRE1Drosophila melanogaster
N408PLC-VNPTCRE1Bos taurus
P102DLMTLP-----4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
P102DIIRLPRLFRF1Oryza sativa subsp. japonica
P102DIIPLG----Y1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P102DLIPIS---AK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P102DMIQLP-----1Drosophila melanogaster
P266SAHSLPMSVVN4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
P266SAHGVPLAYVE1Oryza sativa subsp. japonica
P266SAHSLPMSQVA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P266SAHSLPMDVVN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P266TAHSLPLKAVN1Drosophila melanogaster
P277-GDPYPQEVSA2Homo sapiens, Pan troglodytes
P277-GDPYPQEVGA2Gallus gallus, Bos taurus
P277AGDPYKAEMEE1Oryza sativa subsp. japonica
P277-GDPYVYEIAA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P277-GDAYPAEVAA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P277-GDAYPSEIGA1Drosophila melanogaster
P307QSKVGPMPWLG3Homo sapiens, Bos taurus, Pan troglodytes
P307QSRVGPVEWLR1Oryza sativa subsp. japonica
P307QSKVGPLPWMS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P307QSQVGPKPWLG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P307QSKVGPLPWLA1Drosophila melanogaster
P307QSKVGPMPWLV1Gallus gallus
P79LNMGGPETLGD2Homo sapiens, Pan troglodytes
P79LNLGGPETLDD1Oryza sativa subsp. japonica
P79MNMGGPSNLDE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P79MNMGGPSKVEE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P79LNMGGPTHTDQ1Drosophila melanogaster
P79LNMGGPERLDD1Gallus gallus
P79LNMGGPETVEE1Bos taurus
Q122PKIQEQYRRIG3Homo sapiens, Bos taurus, Pan troglodytes
Q122PKSKEGYASIG1Oryza sativa subsp. japonica
Q122PKVQNHYSDIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q122PKIEKQYREIG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q122PEVQKKYKEIG1Drosophila melanogaster
Q122PRIQEQYSRIG1Gallus gallus
Q278GDPYPQEVSAT2Homo sapiens, Pan troglodytes
Q278GDPYPQEVGAT2Gallus gallus, Bos taurus
Q278GDPYKAEMEEC1Oryza sativa subsp. japonica
Q278GDPYVYEIAAT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q278GDAYPAEVAAT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q278GDAYPSEIGAS1Drosophila melanogaster
R114PFIAKRRTPKI3Homo sapiens, Bos taurus, Pan troglodytes
R114QFISVVRAPKS1Oryza sativa subsp. japonica
R114KFIAKRRTPKV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R114KYIAKFRTPKI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R114PWIAQRRTPEV1Drosophila melanogaster
R114PFIAKRRTPRI1Gallus gallus
R115FIAKRRTPKIQ3Homo sapiens, Bos taurus, Pan troglodytes
R115FISVVRAPKSK1Oryza sativa subsp. japonica
R115FIAKRRTPKVQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R115YIAKFRTPKIE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R115WIAQRRTPEVQ1Drosophila melanogaster
R115FIAKRRTPRIQ1Gallus gallus
R272MSVVNR-GDPY4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
R272LAYVEEAGDPY1Oryza sativa subsp. japonica
R272MSQVAK-GDPY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R272MDVVNT-GDAY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R272LKAVNR-GDAY1Drosophila melanogaster
S130RIGGGSPIKIW2Homo sapiens, Pan troglodytes
S130SIGGGSPLRQI1Oryza sativa subsp. japonica
S130DIGGGSPILHW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S130EIGGGSPIRKW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S130EIGGGSPILKW1Drosophila melanogaster
S130RIGGGSPIKKW1Gallus gallus
S130RIGGGSPIKMW1Bos taurus
S195QYPQYSCSTTG4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
S195LYPQFSISTSG1Oryza sativa subsp. japonica
S195QYPQWSCATSG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S195QYPHFSYSTTG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S195QYPQYSCATSG1Drosophila melanogaster
S197PQYSCSTTGSS4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
S197PQFSISTSGSS1Oryza sativa subsp. japonica
S197PQWSCATSGAS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S197PHFSYSTTGSS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S197PQYSCATSGSS1Drosophila melanogaster
S281YPQEVSATVQK2Homo sapiens, Pan troglodytes
S281YPQEVGATVQR2Gallus gallus, Bos taurus
S281YKAEMEECVDL1Oryza sativa subsp. japonica
S281YVYEIAATSQA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S281YPAEVAATVYN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S281YPSEIGASVHM1Drosophila melanogaster
S402KQLTLSCPLC-2Homo sapiens, Pan troglodytes
S402SNLEARQPLV-1Oryza sativa subsp. japonica
S402RQFTQRCPGC-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S402NQLPLDFALGK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S402PKFLMRCPMC-1Drosophila melanogaster
S402KQLTLCCPLC-1Gallus gallus
S402TQLTLSCPLC-1Bos taurus
T198QYSCSTTGSSL4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
T198QFSISTSGSSL1Oryza sativa subsp. japonica
T198QWSCATSGASL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T198HFSYSTTGSSI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T198QYSCATSGSSF1Drosophila melanogaster
V269SLPMSVVNR-G4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
V269GVPLAYVEEAG1Oryza sativa subsp. japonica
V269SLPMSQVAK-G1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V269SLPMDVVNT-G1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V269SLPLKAVNR-G1Drosophila melanogaster
V305VWQSKVGPMPW4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
V305AWQSKVGPLPW2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
V305AYQSRVGPVEW1Oryza sativa subsp. japonica
V305VWQSQVGPKPW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V407CPLC-VNPVCR3Homo sapiens, Gallus gallus, Pan troglodytes
V407QPLV-PLGSVE1Oryza sativa subsp. japonica
V407CPGC-TSESCA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V407FALGKSNDPVK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V407CPMC-SNPKCR1Drosophila melanogaster
V407CPLC-VNPTCR1Bos taurus
W301PYRLVWQSKVG4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
W301SCTLAYQSRVG1Oryza sativa subsp. japonica
W301KFVNAWQSKVG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W301PYRLVWQSQVG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W301PYSLAWQSKVG1Drosophila melanogaster
W310VGPMPWLGPQT3Homo sapiens, Bos taurus, Pan troglodytes
W310VGPVEWLRPYT1Oryza sativa subsp. japonica
W310VGPLPWMSPAT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W310VGPKPWLGAQT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W310VGPLPWLAPAT1Drosophila melanogaster
W310VGPMPWLVPQT1Gallus gallus
Y123KIQEQYRRIGG3Homo sapiens, Bos taurus, Pan troglodytes
Y123KSKEGYASIGG1Oryza sativa subsp. japonica
Y123KVQNHYSDIGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y123KIEKQYREIGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y123EVQKKYKEIGG1Drosophila melanogaster
Y123RIQEQYSRIGG1Gallus gallus
Y165YIGFRYVHPLT4Homo sapiens, Gallus gallus, Bos taurus, Pan troglodytes
Y165YVGMRYWHPFT1Oryza sativa subsp. japonica
Y165FVAFRYAPPLT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y165YVAFRYAKPLT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y165YVGFRYVNPLT1Drosophila melanogaster
Y191IAFTQYPQYSC3Homo sapiens, Gallus gallus, Pan troglodytes
Y191VVLPLYPQFSI1Oryza sativa subsp. japonica
Y191VAFSQYPQWSC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y191VAFSQYPHFSY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y191VLFSQYPQYSC1Drosophila melanogaster
Y191VAFTQYPQYSC1Bos taurus
Y276R-GDPYPQEVS2Homo sapiens, Pan troglodytes
Y276R-GDPYPQEVG2Gallus gallus, Bos taurus
Y276EAGDPYKAEME1Oryza sativa subsp. japonica
Y276K-GDPYVYEIA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y276T-GDAYPAEVA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y276R-GDAYPSEIG1Drosophila melanogaster


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas