mutLBSgeneDB |
Gene summary for FES |
Gene summary |
Basic gene Info. | Gene symbol | FES |
Gene name | FES proto-oncogene, tyrosine kinase | |
Synonyms | FPS | |
Cytomap | UCSC genome browser: 15q26.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001143783.1, NM_001143784.1,NM_001143785.1,NM_002005.3, | |
Description | Oncogene FES, feline sarcoma virusfeline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homologfeline sarcoma oncogenefeline sarcoma/Fujinami avian sarcoma oncogene homologp93c-fesproto-oncogene c-Fespro | |
Modification date | 20141207 | |
dbXrefs | MIM : 190030 | |
HGNC : HGNC | ||
Ensembl : ENSG00000182511 | ||
HPRD : 01814 | ||
Vega : OTTHUMG00000044456 | ||
Protein | UniProt: P07332 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FES | |
BioGPS: 2242 | ||
Pathway | NCI Pathway Interaction Database: FES | |
KEGG: FES | ||
REACTOME: FES | ||
Pathway Commons: FES | ||
Context | iHOP: FES | |
ligand binding site mutation search in PubMed: FES | ||
UCL Cancer Institute: FES | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0018108 | peptidyl-tyrosine phosphorylation | 11509660 | GO:0046777 | protein autophosphorylation | 7687763 |
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Ligand binding site mutations for FES |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | A588 | A588V | UCEC | 2 | I623 | V625F | BRCA | 1 | D683 | D683E | BRCA | 1 | D583,R581 | A582V | SKCM | 1 | R621 | R621H | STAD | 1 | L580 | R579C | STAD | 1 | R770 | F772L | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for FES |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | I623 | V625F | -1.3028543 | R621 | R621H | -1.1551207 | R770 | F772L | -0.96850659 | L580 | R579C | -0.81414284 | R581 | A582V | -0.7526059 | D583 | A582V | -0.7526059 | A588 | A588V | -0.48406414 | D683 | D683E | -0.11604934 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for FES from PDB |
PDB ID | PDB title | PDB structure | 3BKB | Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES) |
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Differential gene expression and gene-gene network for FES |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for FES |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for FES |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of FES go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | STU | STAUROSPORINE | 3bkb | A | A588 | STU | STAUROSPORINE | 3cbl | A | A588 | STU | STAUROSPORINE | 3cd3 | A | A588 | GUI | S1108_SELLECK | 4e93 | A | A588 | STU | STAUROSPORINE | 3cd3 | A | D583 R621 I623 | III | Peptide ligand (ACE,ILE,TYR,GLU,SER,LEU) | 3cbl | A | D683 | III | Peptide ligand (ACE,ILE,TYR,GLU,SER,LEU) | 3cd3 | A | D683 R770 | STU | STAUROSPORINE | 3cbl | A | L580 D583 R621 I623 | STU | STAUROSPORINE | 3cbl | A | R581 | STU | STAUROSPORINE | 3cd3 | A | R581 |
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Conservation information for LBS of FES |
Multiple alignments for P07332 in multiple species |
LBS | AA sequence | # species | Species |
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