mutLBSgeneDB |
Gene summary for FGA |
Gene summary |
Basic gene Info. | Gene symbol | FGA |
Gene name | fibrinogen alpha chain | |
Synonyms | Fib2 | |
Cytomap | UCSC genome browser: 4q28 | |
Type of gene | protein-coding | |
RefGenes | NM_000508.3, NM_021871.2, | |
Description | fibrinogen, A alpha polypeptide | |
Modification date | 20141207 | |
dbXrefs | MIM : 134820 | |
HGNC : HGNC | ||
Ensembl : ENSG00000171560 | ||
HPRD : 00619 | ||
Vega : OTTHUMG00000150330 | ||
Protein | UniProt: P02671 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FGA | |
BioGPS: 2243 | ||
Pathway | NCI Pathway Interaction Database: FGA | |
KEGG: FGA | ||
REACTOME: FGA | ||
Pathway Commons: FGA | ||
Context | iHOP: FGA | |
ligand binding site mutation search in PubMed: FGA | ||
UCL Cancer Institute: FGA | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0007160 | cell-matrix adhesion | 10903502 | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 8100742 | GO:0043623 | cellular protein complex assembly | 8910396 | GO:0045907 | positive regulation of vasoconstriction | 15739255 | GO:0045921 | positive regulation of exocytosis | 19193866 | GO:0050714 | positive regulation of protein secretion | 19193866 | GO:0051258 | protein polymerization | 12706644 | GO:0051592 | response to calcium ion | 6777381 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10903502 | GO:0070527 | platelet aggregation | 6281794 | GO:0090277 | positive regulation of peptide hormone secretion | 19193866 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 10903502 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 10903502 |
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Ligand binding site mutations for FGA |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | D791 | D789E | OV | 1 | D791,D793 | A792T | SKCM | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for FGA |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | D793 | A792T | -1.2816097 | D791 | A792T | -1.2816097 | D791 | D789E | -0.2997526 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for FGA from PDB |
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Differential gene expression and gene-gene network for FGA |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for FGA |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0019250 | Afibrinogenemia congenital | 12 | Biomarker, GeneticVariation |
umls:C0040053 | Thrombosis | 5 | Biomarker, GeneticVariation |
umls:C0001733 | Afibrinogenemia | 5 | Biomarker, GeneticVariation |
umls:C1861172 | Venous Thromboembolism | 4 | Biomarker, GeneticVariation |
umls:C0034065 | Pulmonary Embolism | 2 | Biomarker |
umls:C0740340 | Amyloidosis, Familial | 2 | Biomarker |
umls:C0022658 | Kidney Diseases | 2 | Biomarker |
umls:C1260903 | Dysfibrinogenemia | 2 | GeneticVariation |
umls:C0268389 | Amyloidosis, familial visceral | 1 | Biomarker, GeneticVariation |
umls:C0008370 | Cholestasis | 1 | Biomarker |
umls:C0860207 | Drug-Induced Liver Injury | 1 | Biomarker |
umls:C3658338 | Drug-Related Side Effects and Adverse Reactions | 1 | Biomarker |
umls:C0026640 | Mouth Neoplasms | 1 | Biomarker |
umls:C0029456 | Osteoporosis | 1 | Biomarker |
umls:C0398623 | Thrombophilia | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for FGA |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Approved | DB00009 | Alteplase | Biotech | |
Approved | DB00015 | Reteplase | Biotech | |
Approved | DB00029 | Anistreplase | Biotech | |
Approved | DB00031 | Tenecteplase | Biotech | |
Approved | DB00364 | Sucralfate | Small molecule | |
Investigational | DB04919 | Alfimeprase | Biotech | |
Investigational | DB05099 | Ancrod | Small molecule | |
Investigational | DB05675 | EP-2104R | Biotech |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of FGA go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of FGA |
Multiple alignments for P02671 in multiple species |
LBS | AA sequence | # species | Species |
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