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mutLBSgeneDB |
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| Gene summary for FGB |
 Gene summary |
| Basic gene Info. | Gene symbol | FGB |
| Gene name | fibrinogen beta chain | |
| Synonyms | HEL-S-78p | |
| Cytomap | UCSC genome browser: 4q28 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001184741.1, NM_005141.4, | |
| Description | epididymis secretory sperm binding protein Li 78pfibrinogen, B beta polypeptide | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 134830 | |
| HGNC : HGNC | ||
| HPRD : 00620 | ||
| Protein | UniProt: P02675 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FGB | |
| BioGPS: 2244 | ||
| Pathway | NCI Pathway Interaction Database: FGB | |
| KEGG: FGB | ||
| REACTOME: FGB | ||
| Pathway Commons: FGB | ||
| Context | iHOP: FGB | |
| ligand binding site mutation search in PubMed: FGB | ||
| UCL Cancer Institute: FGB | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0007160 | cell-matrix adhesion | 10903502 | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 8100742 | GO:0043623 | cellular protein complex assembly | 8910396 | GO:0045907 | positive regulation of vasoconstriction | 15739255 | GO:0045921 | positive regulation of exocytosis | 19193866 | GO:0050714 | positive regulation of protein secretion | 19193866 | GO:0051258 | protein polymerization | 12706644 | GO:0051592 | response to calcium ion | 6777381 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10903502 | GO:0070527 | platelet aggregation | 6281794 | GO:0090277 | positive regulation of peptide hormone secretion | 19193866 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 10903502 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 10903502 |
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| Ligand binding site mutations for FGB |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | T398 | A398T | KIRC | 1 | D291 | G290E | LUAD | 1 | L390 | G391E | LUAD | 1 | D413 | G413E | OV | 1 | Y408 | M409I | SKCM | 1 | D413,D411 | K412R | SKCM | 1 | D413,D411 | K412N | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for FGB |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for FGB from PDB |
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| Differential gene expression and gene-gene network for FGB |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for FGB |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0019250 | Afibrinogenemia congenital | 6 | Biomarker, GeneticVariation |
| umls:C0029456 | Osteoporosis | 1 | Biomarker |
| umls:C0030567 | Parkinson Disease | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for FGB |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved | DB00364 | Sucralfate | Small molecule |  |
| Investigational | DB04919 | Alfimeprase | Biotech |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of FGB go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of FGB |
| Multiple alignments for P02675 in multiple species |
| LBS | AA sequence | # species | Species | C437 | WWYNRCHAANP | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | D291 | QDGSVDFGRKW | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D291 | QDGSVNFGRAW | 1 | Gallus gallus | D411 | STYDRDNDGWL | 2 | Homo sapiens, Gallus gallus | D411 | STYDRDNDGWV | 2 | Mus musculus, Rattus norvegicus | D413 | YDRDNDGWVTT | 2 | Mus musculus, Rattus norvegicus | D413 | YDRDNDGWLTS | 1 | Homo sapiens | D413 | YDRDNDGWLTT | 1 | Gallus gallus | D428 | QCSKEDGGGWW | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | D462 | SKHGTDDGVVW | 2 | Mus musculus, Rattus norvegicus | D462 | AKHGTDDGVVW | 1 | Homo sapiens | D462 | AKHGTDDGIVW | 1 | Gallus gallus | E393 | SQLVGENRTMT | 2 | Mus musculus, Rattus norvegicus | E393 | SQLMGENRTMT | 1 | Homo sapiens | E393 | SQLYGENRTMT | 1 | Gallus gallus | E427 | KQCSKEDGGGW | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | G293 | GSVDFGRKWDP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G293 | GSVNFGRAWDE | 1 | Gallus gallus | H438 | WYNRCHAANPN | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | K422 | TTDPRKQCSKE | 3 | Gallus gallus, Mus musculus, Rattus norvegicus | K422 | TSDPRKQCSKE | 1 | Homo sapiens | L390 | DGASQLMGENR | 1 | Homo sapiens | L390 | EGASQLYGENR | 1 | Gallus gallus | L390 | DGASQLVGENR | 1 | Mus musculus | L390 | EGASQLVGENR | 1 | Rattus norvegicus | L416 | DNDGWVTTDPR | 2 | Mus musculus, Rattus norvegicus | L416 | DNDGWLTSDPR | 1 | Homo sapiens | L416 | DNDGWLTTDPR | 1 | Gallus gallus | M397 | GENRTMTIHNG | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | M468 | DGVVWMNWKGS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M468 | DGIVWMNWKGS | 1 | Gallus gallus | N394 | QLVGENRTMTI | 2 | Mus musculus, Rattus norvegicus | N394 | QLMGENRTMTI | 1 | Homo sapiens | N394 | QLYGENRTMTI | 1 | Gallus gallus | R294 | SVDFGRKWDPY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R294 | SVNFGRAWDEY | 1 | Gallus gallus | R436 | GWWYNRCHAAN | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | T398 | ENRTMTIHNGM | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | T417 | NDGWVTTDPRK | 2 | Mus musculus, Rattus norvegicus | T417 | NDGWLTSDPRK | 1 | Homo sapiens | T417 | NDGWLTTDPRK | 1 | Gallus gallus | T461 | MSKHGTDDGVV | 2 | Mus musculus, Rattus norvegicus | T461 | MAKHGTDDGVV | 1 | Homo sapiens | T461 | MAKHGTDDGIV | 1 | Gallus gallus | W415 | RDNDGWVTTDP | 2 | Mus musculus, Rattus norvegicus | W415 | RDNDGWLTSDP | 1 | Homo sapiens | W415 | RDNDGWLTTDP | 1 | Gallus gallus | W474 | NWKGSWYSMRR | 2 | Mus musculus, Rattus norvegicus | W474 | NWKGSWYSMRK | 1 | Homo sapiens | W474 | NWKGSWYSMKK | 1 | Gallus gallus | Y408 | MFFSTYDRDND | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y408 | MYFSTYDRDND | 1 | Gallus gallus |
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