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mutLBSgeneDB |
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| Gene summary for FGF1 |
 Gene summary |
| Basic gene Info. | Gene symbol | FGF1 |
| Gene name | fibroblast growth factor 1 (acidic) | |
| Synonyms | AFGF|ECGF|ECGF-beta|ECGFA|ECGFB|FGF-1|FGF-alpha|FGFA|GLIO703|HBGF-1|HBGF1 | |
| Cytomap | UCSC genome browser: 5q31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000800.4, NM_001144892.2,NM_001144934.1,NM_001144935.1,NM_001257205.1, NM_001257206.1,NM_001257207.1,NM_001257208.1,NM_001257209.1, NM_001257210.1,NM_001257211.1,NM_001257212.1,NM_033136.3, NM_033137.2, | |
| Description | beta-endothelial cell growth factorendothelial cell growth factor, alphaendothelial cell growth factor, betafibroblast growth factor 1heparin-binding growth factor 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 131220 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000113578 | ||
| HPRD : 00567 | ||
| Vega : OTTHUMG00000059703 | ||
| Protein | UniProt: P05230 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FGF1 | |
| BioGPS: 2246 | ||
| Pathway | NCI Pathway Interaction Database: FGF1 | |
| KEGG: FGF1 | ||
| REACTOME: FGF1 | ||
| Pathway Commons: FGF1 | ||
| Context | iHOP: FGF1 | |
| ligand binding site mutation search in PubMed: FGF1 | ||
| UCL Cancer Institute: FGF1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0008543 | fibroblast growth factor receptor signaling pathway | 20145243 | GO:0030335 | positive regulation of cell migration | 20145243 | GO:0034605 | cellular response to heat | 12746488 | GO:0045542 | positive regulation of cholesterol biosynthetic process | 19229075 | GO:0045766 | positive regulation of angiogenesis | 20145243 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 19229075 | GO:0051781 | positive regulation of cell division | 20145243 | GO:0060681 | branch elongation involved in ureteric bud branching | 11731227 | GO:0072163 | mesonephric epithelium development | 11731227 | GO:1902533 | positive regulation of intracellular signal transduction | 19229075 |
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| Ligand binding site mutations for FGF1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | P149 | L148F | BLCA | 1 | L101 | F100L | COAD | 1 | G34 | G35D | COAD | 1 | Y109 | N110T | COAD | 1 | R137 | R137W | HNSC | 1 | Y109 | T111P | STAD | 1 | K27 | L29I | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for FGF1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K27 | L29I | -1.619585 | Y109 | T111P | -1.0755595 | P149 | L148F | -1.0239865 | G34 | G35D | -0.96350033 | Y109 | N110T | -0.86940262 | L101 | F100L | -0.62161943 | R137 | R137W | -0.072217329 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for FGF1 from PDB |
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| Differential gene expression and gene-gene network for FGF1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for FGF1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0023418 | Leukemia | 2 | Biomarker |
| umls:C0025500 | Mesothelioma | 2 | Biomarker |
| umls:C0151744 | Myocardial Ischemia | 2 | Biomarker |
| umls:C0034069 | Pulmonary Fibrosis | 2 | Biomarker |
| umls:C0020649 | Hypotension | 1 | Biomarker |
| umls:C0043094 | Weight Gain | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for FGF1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved | DB00686 | Pentosan Polysulfate | Small molecule |  |
| Approved|investigational | DB01025 | Amlexanox | Small molecule |  |
| Experimental | DB01901 | Sucrosofate | Small molecule |  |
| Experimental | DB01942 | Formic Acid | Small molecule |  |
| Experimental | DB02264 | O2-Sulfo-Glucuronic Acid | Small molecule |  |
| Experimental | DB03959 | N,O6-Disulfo-Glucosamine | Small molecule |  |
| Experimental | DB04409 | Naphthalene Trisulfonate | Small molecule |  |
| Approved | DB06589 | Pazopanib | Small molecule |  |
| Experimental | DB08238 | 5-AMINO-NAPHTALENE-2-MONOSULFONATE | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of FGF1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of FGF1 |
| Multiple alignments for P05230 in multiple species |
| LBS | AA sequence | # species | Species | A118 | TSKKHAEKNWF | 2 | Mus musculus, Rattus norvegicus | A118 | ISKKHAEKNWF | 1 | Homo sapiens | A118 | ISKKHADKNWF | 1 | Gallus gallus | A118 | ISKKHAEKHWF | 1 | Bos taurus | A144 | HYGQKAILFLP | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | A144 | HFGQKAILFLP | 1 | Bos taurus | G125 | KNWFVGLKKNG | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | G125 | KHWFVGLKKNG | 1 | Bos taurus | G141 | PRTHYGQKAIL | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | G141 | PRTHFGQKAIL | 1 | Bos taurus | G21 | FNLPLGNYKKP | 3 | Bos taurus, Mus musculus, Rattus norvegicus | G21 | FNLPPGNYKKP | 1 | Homo sapiens | G21 | FGLPLGNYKKP | 1 | Gallus gallus | G34 | LYCSNGGHFLR | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | G34 | LYCSNGGYFLR | 1 | Bos taurus | H139 | RGPRTHYGQKA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H139 | LGPRTHYGQKA | 1 | Gallus gallus | H139 | LGPRTHFGQKA | 1 | Bos taurus | I145 | YGQKAILFLPL | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | I145 | FGQKAILFLPL | 1 | Bos taurus | K120 | KKHAEKNWFVG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K120 | KKHADKNWFVG | 1 | Gallus gallus | K120 | KKHAEKHWFVG | 1 | Bos taurus | K127 | WFVGLKKNGSC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K127 | WFVGLKKNGNS | 1 | Gallus gallus | K127 | WFVGLKKNGRS | 1 | Bos taurus | K128 | FVGLKKNGSCK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K128 | FVGLKKNGNSK | 1 | Gallus gallus | K128 | FVGLKKNGRSK | 1 | Bos taurus | K133 | KNGSCKRGPRT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K133 | KNGNSKLGPRT | 1 | Gallus gallus | K133 | KNGRSKLGPRT | 1 | Bos taurus | K143 | THYGQKAILFL | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | K143 | THFGQKAILFL | 1 | Bos taurus | K27 | NYKKPKLLYCS | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | L101 | EECLFLERLEE | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | L146 | GQKAILFLPLP | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | L150 | ILFLPLPVSSD | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L150 | ILFLPLPVSAD | 1 | Gallus gallus | N107 | ERLEENHYNTY | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | N129 | VGLKKNGSCKR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N129 | VGLKKNGNSKL | 1 | Gallus gallus | N129 | VGLKKNGRSKL | 1 | Bos taurus | N33 | LLYCSNGGHFL | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | N33 | LLYCSNGGYFL | 1 | Bos taurus | P136 | SCKRGPRTHYG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P136 | NSKLGPRTHYG | 1 | Gallus gallus | P136 | RSKLGPRTHFG | 1 | Bos taurus | P149 | AILFLPLPVSS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | P149 | AILFLPLPVSA | 1 | Gallus gallus | P151 | LFLPLPVSSD | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | P151 | LFLPLPVSAD | 1 | Gallus gallus | Q142 | RTHYGQKAILF | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | Q142 | RTHFGQKAILF | 1 | Bos taurus | R134 | NGSCKRGPRTH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R134 | NGNSKLGPRTH | 1 | Gallus gallus | R134 | NGRSKLGPRTH | 1 | Bos taurus | R137 | CKRGPRTHYGQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R137 | SKLGPRTHYGQ | 1 | Gallus gallus | R137 | SKLGPRTHFGQ | 1 | Bos taurus | S32 | KLLYCSNGGHF | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | S32 | KLLYCSNGGYF | 1 | Bos taurus | T138 | KRGPRTHYGQK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T138 | KLGPRTHYGQK | 1 | Gallus gallus | T138 | KLGPRTHFGQK | 1 | Bos taurus | W122 | HAEKNWFVGLK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W122 | HADKNWFVGLK | 1 | Gallus gallus | W122 | HAEKHWFVGLK | 1 | Bos taurus | Y109 | LEENHYNTYIS | 3 | Homo sapiens, Gallus gallus, Bos taurus | Y109 | LEENHYNTYTS | 2 | Mus musculus, Rattus norvegicus | Y140 | GPRTHYGQKAI | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | Y140 | GPRTHFGQKAI | 1 | Bos taurus |
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