mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for FGF9
Gene summary
Basic gene Info.Gene symbolFGF9
Gene namefibroblast growth factor 9
CytomapUCSC genome browser: 13q11-q12
Type of geneprotein-coding
Descriptionfibroblast growth factor 9 (glia-activating factor)heparin-binding growth factor 9
Modification date20141207
dbXrefs MIM : 600921
Ensembl : ENSG00000102678
HPRD : 02951
Vega : OTTHUMG00000017412
ProteinUniProt: P31371
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FGF9
BioGPS: 2254
PathwayNCI Pathway Interaction Database: FGF9
Pathway Commons: FGF9
ContextiHOP: FGF9
ligand binding site mutation search in PubMed: FGF9
UCL Cancer Institute: FGF9
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0008284positive regulation of cell proliferation8321227

Ligand binding site mutations for FGF9
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for FGF9
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for FGF9 from PDB

Differential gene expression and gene-gene network for FGF9
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of FGF9 and the right PPI network was created from samples without mutations in the LBS of FGF9. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for FGF9
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0007131Carcinoma, Non-Small-Cell Lung4Biomarker
umls:C2751826Multiple Synostoses Syndrome 31Biomarker, GeneticVariation
umls:C0008924Cleft Lip1Biomarker
umls:C0008925Cleft Palate1Biomarker
umls:C0024121Lung Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for FGF9
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of FGF9 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of FGF9
Multiple alignments for P31371 in multiple species
LBSAA sequence# speciesSpecies
F92KDHSRFGILEF3Homo sapiens, Mus musculus, Rattus norvegicus
P78HLEIFPNGTIQ3Homo sapiens, Mus musculus, Rattus norvegicus

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