mutLBSgeneDB |
Gene summary for FGF9 |
Gene summary |
Basic gene Info. | Gene symbol | FGF9 |
Gene name | fibroblast growth factor 9 | |
Synonyms | FGF-9|GAF|HBFG-9|HBGF-9|SYNS3 | |
Cytomap | UCSC genome browser: 13q11-q12 | |
Type of gene | protein-coding | |
RefGenes | NM_002010.2, | |
Description | fibroblast growth factor 9 (glia-activating factor)heparin-binding growth factor 9 | |
Modification date | 20141207 | |
dbXrefs | MIM : 600921 | |
HGNC : HGNC | ||
Ensembl : ENSG00000102678 | ||
HPRD : 02951 | ||
Vega : OTTHUMG00000017412 | ||
Protein | UniProt: P31371 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FGF9 | |
BioGPS: 2254 | ||
Pathway | NCI Pathway Interaction Database: FGF9 | |
KEGG: FGF9 | ||
REACTOME: FGF9 | ||
Pathway Commons: FGF9 | ||
Context | iHOP: FGF9 | |
ligand binding site mutation search in PubMed: FGF9 | ||
UCL Cancer Institute: FGF9 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0008284 | positive regulation of cell proliferation | 8321227 |
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Ligand binding site mutations for FGF9 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | P78 | G80D | STAD | 1 | F92 | G93D | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for FGF9 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | P78 | G80D | -0.44424003 | F92 | G93D | -0.34642579 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for FGF9 from PDB |
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Differential gene expression and gene-gene network for FGF9 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for FGF9 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0007131 | Carcinoma, Non-Small-Cell Lung | 4 | Biomarker |
umls:C0001418 | Adenocarcinoma | 2 | Biomarker |
umls:C2751826 | Multiple Synostoses Syndrome 3 | 1 | Biomarker, GeneticVariation |
umls:C0008924 | Cleft Lip | 1 | Biomarker |
umls:C0008925 | Cleft Palate | 1 | Biomarker |
umls:C0024121 | Lung Neoplasms | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for FGF9 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of FGF9 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | FUC | ALPHA-L-FUCOPYRANOSE | 1g82 | A | P78 F92 |
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Conservation information for LBS of FGF9 |
Multiple alignments for P31371 in multiple species |
LBS | AA sequence | # species | Species | F92 | KDHSRFGILEF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P78 | HLEIFPNGTIQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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