mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for FGFR2
Gene summary
Basic gene Info.Gene symbolFGFR2
Gene namefibroblast growth factor receptor 2
SynonymsBBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25
CytomapUCSC genome browser: 10q26
Type of geneprotein-coding
RefGenesNM_000141.4,
NM_001144913.1,NM_001144914.1,NM_001144915.1,NM_001144916.1,
NM_001144917.1,NM_001144918.1,NM_001144919.1,NM_022970.3,
NM_023029.2,NR_073009.1,NM_022971.1,NM_022972.1,
NM_022973.1,NM_022974.1,NM_022975.2,NM_022976.1,
NM_023028.1,NM_023030.1,
DescriptionBEK fibroblast growth factor receptorFGF receptorFGFR-2FGFR2-AHCYL1 fusion kinase proteinbacteria-expressed kinasehydroxyaryl-protein kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14soluble FGFR4 variant 4
Modification date20141222
dbXrefs MIM : 176943
HGNC : HGNC
Ensembl : ENSG00000066468
HPRD : 01492
Vega : OTTHUMG00000019175
ProteinUniProt: P21802
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FGFR2
BioGPS: 2263
PathwayNCI Pathway Interaction Database: FGFR2
KEGG: FGFR2
REACTOME: FGFR2
Pathway Commons: FGFR2
ContextiHOP: FGFR2
ligand binding site mutation search in PubMed: FGFR2
UCL Cancer Institute: FGFR2
Assigned class in mutLBSgeneDBA: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for FGFR2.1. "Wilkie AO, Oldridge M, Tang Z, Maxson RE Jr. Craniosynostosis and related limb anomalies. Novartis Found Symp. 2001;232:122-33; discussion 133-43. Review. PubMed PMID: 11277076. " 11277076
2. "Lew ED, Bae JH, Rohmann E, Wollnik B, Schlessinger J. Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19802-7. Epub 2007 Dec 3. PubMed PMID: 18056630; PubMed Central PMCID: PMC2148379. " 18056630
3. "Martin LA, Assif N, Gilbert M, Wijewarnasuriya D, Seandel M. Enhanced fitness of adult spermatogonial stem cells bearing a paternal age-associated FGFR2 mutation. Stem Cell Reports. 2014 Aug 12;3(2):219-26. doi:10.1016/j.stemcr.2014.06.007. Epub 2014 Jul 17. PubMed PMID: 25254335; PubMed Central PMCID: PMC4176532. " 25254335

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0008284positive regulation of cell proliferation8663044
GO:0008543fibroblast growth factor receptor signaling pathway15629145
GO:0018108peptidyl-tyrosine phosphorylation15629145
GO:0046777protein autophosphorylation15629145


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Ligand binding site mutations for FGFR2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R251S252WUCEC9
I548N549KBRCA4
I548N549KUCEC4
I548I547TCOAD2
R251R251LCOAD2
G646A648TCOAD2
K164E163KSKCM2
I548N549HUCEC2
N631,L633V632IBRCA1
H254P253SCOAD1
I548L550ICOAD1
D644I642TCOAD1
R664R664WCOAD1
R210R210QCOAD1
V495M497ICOAD1
D644I642VCOAD1
I217E219GCOAD1
D644I642MCOAD1
G646A648DCOAD1
H213Q212KGBM1
T174T174NHNSC1
K164R165LLUAD1
H254P253LLUAD1
D626R625QSKCM1
R251R251QSKCM1
V709P708SSKCM1
R210R210QSKCM1
G570G570RSTAD1
K164R165WUCEC1
M538M537IUCEC1
R664R664WUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for FGFR2 from My Cancer Genome.
The fibroblast growth factor receptor 2 gene (FGFR2) encodes one member of the FGFR tyrosine kinase (TK) family, which includes four kinases: FGFR1, 2, 3, and 4. FGFR TKs play crucial roles in development and have been shown in cancers to be deregulated by amplification, point mutation, or translocation (Turner and Grose 2010). Amplification or activation of FGFR2 has been reported in breast cancer and gastric cancer (Jain and Turner 2012). FGFR2 mutations have been observed in endometrial cancer and breast cancer (Dutt et al. 2008; Jain and Turner 2012;Reintjes et al. 2013).Turner, N. 2015. FGFR2. My Cancer Genomehttps://www.mycancergenome.org/content/gene/fgfr2/ (Updated December 2015)

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Protein structure related information for FGFR2
Protein structure of wild type (WT) and mutant type (MT) of FGFR2
Wild type FGFR2
Mutant type FGFR2

Free energy of binding of drugs to wild type and mutant tpye of FGFR2
Gene symbolDrug nameFree energy of binding (kcal/mol) of wild typeFree energy of binding (kcal/mol) of mutant type
FGFR2Ponatinib-9.5-9.4
FGFR2Regorafenib-8.1-8.1

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
G570G570R0.18475134
I217E219G-1.3843316
M538M537I-1.3495591
I548I547T-1.2713025
R664R664W-1.2174143
R251R251Q-1.2108418
D644I642T-1.1459779
H213Q212K-1.0862754
I548L550I-1.0452371
R210R210Q-1.0410815
H254P253S-1.015026
K164E163K-0.89351539
D644I642V-0.86954299
N631V632I-0.85241959
L633V632I-0.85241959
D644I642M-0.83491218
V709P708S-0.76431207
I548N549H-0.71820678
D626R625Q-0.7002287
I548N549K-0.63012981
T174T174N-0.61386992
R251R251L-0.58065701
R251S252W-0.51009314
G646A648T-0.45183309
G646A648D-0.44179852
K164R165W-0.44173214
H254P253L-0.42749447
V495M497I-0.23277115
K164R165L-0.18696067
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for FGFR2 from PDB
PDB IDPDB titlePDB structure
1GJOTHE FGFR2 TYROSINE KINASE DOMAIN

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Differential gene expression and gene-gene network for FGFR2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types
FGFR2_COAD_DE

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of FGFR2 and the right PPI network was created from samples without mutations in the LBS of FGFR2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

* In COAD


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Phenotype information for FGFR2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0010278Craniosynostoses78Biomarker, GeneticVariation
umls:C0001193apert syndrome51Biomarker, GeneticVariation
umls:C0010273Craniofacial Dysostosis41Biomarker, GeneticVariation
umls:C0220658PFEIFFER SYNDROME31Biomarker, GeneticVariation
umls:C1458155Breast Neoplasms20AlteredExpression, Biomarker, GeneticVariation
umls:C1510455Acrocephalosyndactylia12Biomarker, GeneticVariation
umls:C2936791antley-bixler syndrome7Biomarker, GeneticVariation
umls:C1852406Cutis Gyrata Syndrome of Beare And Stevenson6Biomarker, GeneticVariation
umls:C0376634Craniofacial Abnormalities5AlteredExpression, Biomarker
umls:C0795998Jackson-Weiss syndrome4Biomarker, GeneticVariation
umls:C0038356Stomach Neoplasms4AlteredExpression, Biomarker, PostTranslationalModification
umls:C0008925Cleft Palate4Biomarker
umls:C0175699Saethre-Chotzen Syndrome3Biomarker, GeneticVariation
umls:C0023890Liver Cirrhosis2AlteredExpression, Biomarker
umls:C3714756Intellectual Disability2Biomarker
umls:C0000772Abnormalities, Multiple1Biomarker
umls:C0003090Ankylosis1Biomarker
umls:C2350233Antley-Bixler Syndrome Phenotype1Biomarker
umls:C0006435Burns, Chemical1Biomarker
umls:C0008924Cleft Lip1Biomarker
umls:C0014170Endometrial Neoplasms1Biomarker
umls:C0018553Hamartoma Syndrome, Multiple1Biomarker
umls:C0206762Limb Deformities, Congenital1Biomarker
umls:C0024121Lung Neoplasms1Biomarker
umls:C0026613Motor Skills Disorders1Biomarker
umls:C1450010Plagiocephaly, Nonsynostotic1Biomarker
umls:C0037268Skin Abnormalities1Biomarker
umls:C0037274Skin Diseases1Biomarker
umls:C0080178Spinal Dysraphism1Biomarker
umls:C0040427Tooth Abnormalities1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs
28311S252WPathogenicGermline;somatic;unknownGeneReviews:NBK1455
MedGen:C0001193
OMIM:101200
Orphanet:ORPHA87
SNOMED CT:205258009
MedGen:C0476089
OMIM:608089
SNOMED CT:254878006
28335A648TPathogenicGermline-

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Pharmacological information for FGFR2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00039PaliferminBiotech
Approved|investigational|withdrawnDB01041ThalidomideSmall molecule
ExperimentalDB02058SU4984Small molecule
ExperimentalDB024914-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-AmineSmall molecule
ApprovedDB08896RegorafenibSmall molecule
ApprovedDB08901PonatinibSmall molecule
ApprovedDB09078LenvatinibSmall molecule
ApprovedDB09079NintedanibSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of FGFR2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (GLU,GLU,TYR,LEU)2pvfAD626 R664 V709
MGMAGNESIUM(2+)4j96BD644
MGMAGNESIUM(2+)4j99DD644 G646
SO4SULFATE1djsAH254
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4j98BI548 G570 D626 N631 L633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4j96BI548 L633 D644
SGNN,O6-DISULFO-GLUCOSAMINE1e0oBK164
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2pvyAL633
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2pvyCL633
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2pvyDL633
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2pzrBL633
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2q0bBL633
M335'-O-[(S)-HYDROXY{[(S)-HYDROXY(METHYL)PHOSPHORYL]OXY}PHOSPHORYL]ADENOSINE3b2tAL633
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4j97AL633
AA24-[4-(1-AMINO-1-METHYLETHYL)PHENYL]-5-CHLORO-N-[4-(2-MORPHOLIN-4-YLETHYL)PHENYL]PYRIMIDIN-2-AMINE1oecAL633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4j97DL633 D644
MGMAGNESIUM(2+)2pvfAN631 D644
MGMAGNESIUM(2+)2py3AN631 D644
MGMAGNESIUM(2+)2py3BN631 D644
MGMAGNESIUM(2+)2pz5AN631 D644
MGMAGNESIUM(2+)2pz5BN631 D644
MGMAGNESIUM(2+)2pzpAN631 D644
MGMAGNESIUM(2+)2pzpBN631 D644
MGMAGNESIUM(2+)4j99CN631 D644
MGMAGNESIUM(2+)4j99DN631 D644
SCRSUCROSE OCTASULFATE3cu1CR210 H213
SCRSUCROSE OCTASULFATE3cu1AR210 H213 I217
SO4SULFATE1djsAR210 I217
SO4SULFATE1e0oDR251 H254
IDS2-O-SULFO-ALPHA-L-IDOPYRANURONIC ACID1e0oBT174
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4j97BV495 G570 N631 L633
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4j99AV495 I548 D626 N631 L633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4j99BV495 I548 D626 N631 L633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2q0bAV495 I548 L633
M335'-O-[(S)-HYDROXY{[(S)-HYDROXY(METHYL)PHOSPHORYL]OXY}PHOSPHORYL]ADENOSINE3b2tBV495 I548 N631 L633
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4j99DV495 I548 N631 L633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4j99CV495 I548 N631 L633 D644 G646
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2pvyBV495 L633
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2pzrAV495 L633
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2pwlAV495 L633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2pwlBV495 L633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4j95CV495 L633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4j95DV495 L633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4j97CV495 L633 D644
3RH(6S)-6-PHENYL-5,6-DIHYDROBENZO[H]QUINAZOLIN-2-AMINE3ri1AV495 M538 I548 L633
3RH(6S)-6-PHENYL-5,6-DIHYDROBENZO[H]QUINAZOLIN-2-AMINE3ri1BV495 M538 L633
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2pvfAV495 N631 L633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2py3AV495 N631 L633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2py3BV495 N631 L633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2pz5AV495 N631 L633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2pz5BV495 N631 L633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2pzpAV495 N631 L633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE2pzpBV495 N631 L633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4j95AV495 N631 L633 D644
ACPADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE4j95BV495 N631 L633 D644


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Conservation information for LBS of FGFR2
Multiple alignments for P21802 in multiple species
LBSAA sequence# speciesSpecies
A355ISFHSAWLTV-2Homo sapiens, Mus musculus
A355RSNSSVYLRVV1Drosophila melanogaster
A355ISFHTAWLTV-1Gallus gallus
A515EAVTVAVKMLK3Homo sapiens, Gallus gallus, Mus musculus
A515AETIVAVKMVK1Drosophila melanogaster
A567VIVEYASKGNL3Homo sapiens, Gallus gallus, Mus musculus
A567VIVEYAPHGNL1Drosophila melanogaster
D626KCIHRDLAARN3Homo sapiens, Gallus gallus, Mus musculus
D626RCIHRDLAARN1Drosophila melanogaster
D644VMKIADFGLAR4Homo sapiens, Drosophila melanogaster, Gallus gallus, Mus musculus
E339FEDAGEYTCLA3Homo sapiens, Gallus gallus, Mus musculus
E339FDQEGWYTCLA1Drosophila melanogaster
E489GKPLGEGCFGQ3Homo sapiens, Gallus gallus, Mus musculus
E489GSILGEGAFGR1Drosophila melanogaster
E534SDLVSEMEMMK3Homo sapiens, Gallus gallus, Mus musculus
E534ASLVREMEVMK1Drosophila melanogaster
E565LYVIVEYASKG3Homo sapiens, Gallus gallus, Mus musculus
E565LWVIVEYAPHG1Drosophila melanogaster
F492LGEGCFGQVVM3Homo sapiens, Gallus gallus, Mus musculus
F492LGEGAFGRVVM1Drosophila melanogaster
G488LGKPLGEGCFG3Homo sapiens, Gallus gallus, Mus musculus
G488LGSILGEGAFG1Drosophila melanogaster
G490KPLGEGCFGQV3Homo sapiens, Gallus gallus, Mus musculus
G490SILGEGAFGRV1Drosophila melanogaster
G493GEGCFGQVVMA3Homo sapiens, Gallus gallus, Mus musculus
G493GEGAFGRVVMA1Drosophila melanogaster
G570EYASKGNLREY3Homo sapiens, Gallus gallus, Mus musculus
G570EYAPHGNLKDF1Drosophila melanogaster
G646KIADFGLARDI4Homo sapiens, Drosophila melanogaster, Gallus gallus, Mus musculus
H167MEKRLHAVPAA2Homo sapiens, Gallus gallus
H167ELKRLQHSLSG1Drosophila melanogaster
H167MEKRLHACPAA1Mus musculus
H213KVRNQHWSLIM3Homo sapiens, Gallus gallus, Mus musculus
H213VQKN--WTLRF1Drosophila melanogaster
H254VERSPHRPILQ3Homo sapiens, Gallus gallus, Mus musculus
H254NDRTRSAPIIV1Drosophila melanogaster
I217QHWSLIMESVV3Homo sapiens, Gallus gallus, Mus musculus
I217--WTLRFVEAT1Drosophila melanogaster
I348LAGNSIGISFH3Homo sapiens, Gallus gallus, Mus musculus
I348LASSGLGRSNS1Drosophila melanogaster
I548KHKNIINLLGA3Homo sapiens, Gallus gallus, Mus musculus
I548KHINIINLLGC1Drosophila melanogaster
K161WTNTEKMEKRL2Homo sapiens, Mus musculus
K161FR---KELKRL1Drosophila melanogaster
K161WTHTDKMEKRL1Gallus gallus
K164TEKMEKRLHAV1Homo sapiens
K164--KELKRLQHS1Drosophila melanogaster
K164TDKMEKRLHAV1Gallus gallus
K164TEKMEKRLHAC1Mus musculus
K176AANTVKFRCPA3Homo sapiens, Gallus gallus, Mus musculus
K176SGNTVNLACPV1Drosophila melanogaster
K517VTVAVKMLKDD3Homo sapiens, Gallus gallus, Mus musculus
K517TIVAVKMVKEE1Drosophila melanogaster
L487TLGKPLGEGCF3Homo sapiens, Gallus gallus, Mus musculus
L487SLGSILGEGAF1Drosophila melanogaster
L633AARNVLVTENN3Homo sapiens, Gallus gallus, Mus musculus
L633AARNVLVSDGY1Drosophila melanogaster
L665TTNGRLPVKWM3Homo sapiens, Gallus gallus, Mus musculus
L665NTNGRLPIKWM1Drosophila melanogaster
M538SEMEMMKMIGK3Homo sapiens, Gallus gallus, Mus musculus
M538REMEVMKMIGK1Drosophila melanogaster
N571YASKGNLREYL3Homo sapiens, Gallus gallus, Mus musculus
N571YAPHGNLKDFL1Drosophila melanogaster
N631DLAARNVLVTE3Homo sapiens, Gallus gallus, Mus musculus
N631DLAARNVLVSD1Drosophila melanogaster
P666TNGRLPVKWMA3Homo sapiens, Gallus gallus, Mus musculus
P666TNGRLPIKWMA1Drosophila melanogaster
Q494EGCFGQVVMAE3Homo sapiens, Gallus gallus, Mus musculus
Q494EGAFGRVVMAE1Drosophila melanogaster
R178NTVKFRCPAGG2Homo sapiens, Mus musculus
R178NTVNLACPVYG1Drosophila melanogaster
R178NTVKFRCPAMG1Gallus gallus
R210GGYKVRNQHWS3Homo sapiens, Gallus gallus, Mus musculus
R210GVYVQKN--WT1Drosophila melanogaster
R251LDVVERSPHRP3Homo sapiens, Gallus gallus, Mus musculus
R251VQINDRTRSAP1Drosophila melanogaster
R255ERSPHRPILQA3Homo sapiens, Gallus gallus, Mus musculus
R255DRTRSAPIIV-1Drosophila melanogaster
R630RDLAARNVLVT3Homo sapiens, Gallus gallus, Mus musculus
R630RDLAARNVLVS1Drosophila melanogaster
R664KTTNGRLPVKW3Homo sapiens, Gallus gallus, Mus musculus
R664KNTNGRLPIKW1Drosophila melanogaster
S215RNQHWSLIMES3Homo sapiens, Gallus gallus, Mus musculus
S215KN--WTLRFVE1Drosophila melanogaster
S354GISFHSAWLTV2Homo sapiens, Mus musculus
S354GRSNSSVYLRV1Drosophila melanogaster
S354GISFHTAWLTV1Gallus gallus
T174VPAANTVKFRC2Homo sapiens, Gallus gallus
T174SLSGNTVNLAC1Drosophila melanogaster
T174CPAANTVKFRC1Mus musculus
V175PAANTVKFRCP3Homo sapiens, Gallus gallus, Mus musculus
V175LSGNTVNLACP1Drosophila melanogaster
V495GCFGQVVMAEA3Homo sapiens, Gallus gallus, Mus musculus
V495GAFGRVVMAEA1Drosophila melanogaster
V564PLYVIVEYASK3Homo sapiens, Gallus gallus, Mus musculus
V564PLWVIVEYAPH1Drosophila melanogaster
V667NGRLPVKWMAP3Homo sapiens, Gallus gallus, Mus musculus
V667NGRLPIKWMAP1Drosophila melanogaster
V709PGI-PVEELFK3Homo sapiens, Gallus gallus, Mus musculus
V709PHILSAEELYS1Drosophila melanogaster
W356SFHSAWLTV--2Homo sapiens, Mus musculus
W356SNSSVYLRVVS1Drosophila melanogaster
W356SFHTAWLTV--1Gallus gallus
W669RLPVKWMAPEA3Homo sapiens, Gallus gallus, Mus musculus
W669RLPIKWMAPES1Drosophila melanogaster
Y566YVIVEYASKGN3Homo sapiens, Gallus gallus, Mus musculus
Y566WVIVEYAPHGN1Drosophila melanogaster


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