mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for FGG
Gene summary
Basic gene Info.Gene symbolFGG
Gene namefibrinogen gamma chain
Synonyms-
CytomapUCSC genome browser: 4q28
Type of geneprotein-coding
RefGenesNM_000509.4,
NM_021870.2,
Descriptionfibrinogen, gamma polypeptide
Modification date20141222
dbXrefs MIM : 134850
HGNC : HGNC
Ensembl : ENSG00000171557
HPRD : 00621
Vega : OTTHUMG00000150329
ProteinUniProt: P02679
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FGG
BioGPS: 2266
PathwayNCI Pathway Interaction Database: FGG
KEGG: FGG
REACTOME: FGG
Pathway Commons: FGG
ContextiHOP: FGG
ligand binding site mutation search in PubMed: FGG
UCL Cancer Institute: FGG
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0007160cell-matrix adhesion10903502
GO:0034116positive regulation of heterotypic cell-cell adhesion8100742
GO:0043623cellular protein complex assembly8910396
GO:0045907positive regulation of vasoconstriction15739255
GO:0045921positive regulation of exocytosis19193866
GO:0050714positive regulation of protein secretion19193866
GO:0051592response to calcium ion6777381
GO:0070374positive regulation of ERK1 and ERK2 cascade10903502
GO:0070527platelet aggregation6281794
GO:0090277positive regulation of peptide hormone secretion19193866
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors10903502
GO:2000352negative regulation of endothelial cell apoptotic process10903502


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Ligand binding site mutations for FGG

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Q162E163KCOAD2
D323D323NGBM1
E349E349VLUAD1
K364N363SSKCM1
N351C352RSTAD1
D346D346HUCEC1
D320G318DUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for FGG
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
N351C352R0.10833317
Q162E163K-1.3668645
D346D346H-1.2427545
D323D323N-0.96788155
K364N363S-0.73165152
D320G318D-0.66072388
E349E349V-0.5151234
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for FGG from PDB
PDB IDPDB titlePDB structure
1FIBRECOMBINANT HUMAN GAMMA-FIBRINOGEN CARBOXYL TERMINAL FRAGMENT (RESIDUES 143-411) BOUND TO CALCIUM AT PH 6.0

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Differential gene expression and gene-gene network for FGG
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of FGG and the right PPI network was created from samples without mutations in the LBS of FGG. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for FGG
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0019250Afibrinogenemia congenital4Biomarker, GeneticVariation
umls:C0022548Keloid1Biomarker
umls:C0038356Stomach Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for FGG
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00364SucralfateSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of FGG go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)1fibAD320
CACALCIUM(2+)1ficAD320
CACALCIUM(2+)1ficBD320
CACALCIUM(2+)1fidAD320
CACALCIUM(2+)1fzaCD320
CACALCIUM(2+)1fzaFD320
CACALCIUM(2+)1fzbCD320
CACALCIUM(2+)1fzbFD320
CACALCIUM(2+)1fzcCD320
CACALCIUM(2+)1fzcFD320
CACALCIUM(2+)1fzeCD320
CACALCIUM(2+)1fzeFD320
CACALCIUM(2+)1fzfCD320
CACALCIUM(2+)1fzfFD320
CACALCIUM(2+)1fzgCD320
CACALCIUM(2+)1fzgFD320
CACALCIUM(2+)1lt9CD320
CACALCIUM(2+)1lt9FD320
CACALCIUM(2+)1ltjCD320
CACALCIUM(2+)1ltjFD320
CACALCIUM(2+)1n86CD320
CACALCIUM(2+)1n86FD320
CACALCIUM(2+)1re3CD320
CACALCIUM(2+)1re3FD320
CACALCIUM(2+)1re4CD320
CACALCIUM(2+)1re4FD320
CACALCIUM(2+)1rf0CD320
CACALCIUM(2+)1rf0FD320
CACALCIUM(2+)1rf1CD320
CACALCIUM(2+)1rf1FD320
CACALCIUM(2+)2ffdCD320
CACALCIUM(2+)2ffdFD320
CACALCIUM(2+)2fibAD320
CACALCIUM(2+)2h43CD320
CACALCIUM(2+)2h43FD320
CACALCIUM(2+)2hloCD320
CACALCIUM(2+)2hloFD320
CACALCIUM(2+)2hodCD320
CACALCIUM(2+)2hodFD320
CACALCIUM(2+)2hodID320
CACALCIUM(2+)2hodLD320
CACALCIUM(2+)2hpcCD320
CACALCIUM(2+)2hpcFD320
CACALCIUM(2+)2hpcID320
CACALCIUM(2+)2hpcLD320
CACALCIUM(2+)2oyhCD320
CACALCIUM(2+)2oyhFD320
CACALCIUM(2+)2oyiCD320
CACALCIUM(2+)2oyiFD320
CACALCIUM(2+)2q9iCD320
CACALCIUM(2+)2q9iFD320
CACALCIUM(2+)2z4eCD320
CACALCIUM(2+)2z4eFD320
CACALCIUM(2+)3bvhCD320
CACALCIUM(2+)3bvhFD320
CACALCIUM(2+)3e1iCD320
CACALCIUM(2+)3e1iFD320
CACALCIUM(2+)3fibAD320
CACALCIUM(2+)3ghgCD320
CACALCIUM(2+)3ghgFD320
CACALCIUM(2+)3ghgID320
CACALCIUM(2+)3ghgLD320
CACALCIUM(2+)3h32CD320
CACALCIUM(2+)3husCD320
CACALCIUM(2+)3husFD320


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Conservation information for LBS of FGG
Multiple alignments for P02679 in multiple species
LBSAA sequence# speciesSpecies
C365WWMNKCHAGHL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D320AFDGYDFGDDP2Mus musculus, Rattus norvegicus
D320AFDGFDFGDDP1Homo sapiens
D320AFDGYDFGDDS1Bos taurus
D323GYDFGDDPSDK2Mus musculus, Rattus norvegicus
D323GFDFGDDPSDK1Homo sapiens
D323GYDFGDDSSDK1Bos taurus
D324YDFGDDPSDKF2Mus musculus, Rattus norvegicus
D324FDFGDDPSDKF1Homo sapiens
D324YDFGDDSSDKF1Bos taurus
D327GDDPSDKFFTS3Homo sapiens, Mus musculus, Rattus norvegicus
D327GDDSSDKFFTS1Bos taurus
D344STWDNDNDKFE3Homo sapiens, Mus musculus, Rattus norvegicus
D344STWDSDNDKYD1Bos taurus
D346WDNDNDKFEGN3Homo sapiens, Mus musculus, Rattus norvegicus
D346WDSDNDKYDGN1Bos taurus
D356NCAEQDGSGWW3Homo sapiens, Mus musculus, Rattus norvegicus
D356NCAEQVGIGWW1Bos taurus
D390TPNGYDNGIIW3Homo sapiens, Bos taurus, Rattus norvegicus
D390TTNGFDDGIIW1Mus musculus
E158KVAQLEAQCQE3Homo sapiens, Mus musculus, Rattus norvegicus
E158KVVQLEANCQE1Bos taurus
E349DNDKFEGNCAE3Homo sapiens, Mus musculus, Rattus norvegicus
E349DNDKYDGNCAE1Bos taurus
F321FDGYDFGDDPS2Mus musculus, Rattus norvegicus
F321FDGFDFGDDPS1Homo sapiens
F321FDGYDFGDDSS1Bos taurus
F330PSDKFFTSHNG3Homo sapiens, Mus musculus, Rattus norvegicus
F330SSDKFFTSHNG1Bos taurus
F348NDNDKFEGNCA3Homo sapiens, Mus musculus, Rattus norvegicus
F348SDNDKYDGNCA1Bos taurus
G322DGYDFGDDPSD2Mus musculus, Rattus norvegicus
G322DGFDFGDDPSD1Homo sapiens
G322DGYDFGDDSSD1Bos taurus
G350NDKFEGNCAEQ3Homo sapiens, Mus musculus, Rattus norvegicus
G350NDKYDGNCAEQ1Bos taurus
H366WMNKCHAGHLN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I394YDNGIIWATWK3Homo sapiens, Bos taurus, Rattus norvegicus
I394FDDGIIWATWK1Mus musculus
K328DDPSDKFFTSH3Homo sapiens, Mus musculus, Rattus norvegicus
K328DDSSDKFFTSH1Bos taurus
K364GWWMNKCHAGH4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N351DKFEGNCAEQD3Homo sapiens, Mus musculus, Rattus norvegicus
N351DKYDGNCAEQV1Bos taurus
P325DFGDDPSDKFF3Homo sapiens, Mus musculus, Rattus norvegicus
P325DFGDDSSDKFF1Bos taurus
Q162LEAQCQEPCKD3Homo sapiens, Mus musculus, Rattus norvegicus
Q162LEANCQEPCQD1Bos taurus
Q355GNCAEQDGSGW3Homo sapiens, Mus musculus, Rattus norvegicus
Q355GNCAEQVGIGW1Bos taurus
R401ATWKTRWYSMK2Homo sapiens, Rattus norvegicus
R401ATWKSRWYSMK2Bos taurus, Mus musculus
T331SDKFFTSHNGM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y389STPNGYDNGII3Homo sapiens, Bos taurus, Rattus norvegicus
Y389STTNGFDDGII1Mus musculus


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