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mutLBSgeneDB |
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| Gene summary for FHL2 |
 Gene summary |
| Basic gene Info. | Gene symbol | FHL2 |
| Gene name | four and a half LIM domains 2 | |
| Synonyms | AAG11|DRAL|FHL-2|SLIM-3|SLIM3 | |
| Cytomap | UCSC genome browser: 2q12.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001039492.2, NM_001450.3,NM_201555.1,NM_201557.3,NM_201556.1, | |
| Description | LIM domain protein DRALaging-associated gene 11down-regulated in rhabdomyosarcoma LIM proteinfour and a half LIM domains protein 2skeletal muscle LIM-protein 3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602633 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000115641 | ||
| HPRD : 04026 | ||
| Vega : OTTHUMG00000153120 | ||
| Protein | UniProt: Q14192 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FHL2 | |
| BioGPS: 2274 | ||
| Pathway | NCI Pathway Interaction Database: FHL2 | |
| KEGG: FHL2 | ||
| REACTOME: FHL2 | ||
| Pathway Commons: FHL2 | ||
| Context | iHOP: FHL2 | |
| ligand binding site mutation search in PubMed: FHL2 | ||
| UCL Cancer Institute: FHL2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 15692560 | GO:0043066 | negative regulation of apoptotic process | 15692560 |
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| Ligand binding site mutations for FHL2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C132 | R131S | STAD | 1 | C10 | E12K | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for FHL2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | C132 | R131S | -0.58492364 | C10 | E12K | -0.35625869 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for FHL2 from PDB |
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| Differential gene expression and gene-gene network for FHL2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for FHL2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C1458155 | Breast Neoplasms | 2 | AlteredExpression, Biomarker |
| umls:C0023467 | Leukemia, Myeloid, Acute | 2 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for FHL2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of FHL2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 2miu | A | C10 |
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| Conservation information for LBS of FHL2 |
| Multiple alignments for Q14192 in multiple species |
| LBS | AA sequence | # species | Species | C10 | FDCHHCNESLY | 2 | Mus musculus, Rattus norvegicus | C10 | FDCHHCNESLF | 1 | Homo sapiens | C10 | FDCHHCEDSLF | 1 | Bos taurus | C101 | EYSSKCQECKK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C101 | EYSSRCQECKK | 1 | Bos taurus | C104 | SKCQECKKTIM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C104 | SRCQECKKSIM | 1 | Bos taurus | C126 | SWHETCFICHR | 2 | Homo sapiens, Bos taurus | C126 | SWHETCFTCQR | 2 | Mus musculus, Rattus norvegicus | C129 | ETCFICHRCQQ | 2 | Homo sapiens, Bos taurus | C129 | ETCFTCQRCQQ | 2 | Mus musculus, Rattus norvegicus | C132 | FICHRCQQPIG | 2 | Homo sapiens, Bos taurus | C132 | FTCQRCQQPIG | 2 | Mus musculus, Rattus norvegicus | C150 | ENQNFCVPCYE | 2 | Mus musculus, Rattus norvegicus | C150 | DNQNFCVPCYE | 1 | Homo sapiens | C150 | DSENFCVPCYE | 1 | Bos taurus | C153 | NFCVPCYEKQY | 2 | Mus musculus, Rattus norvegicus | C153 | NFCVPCYEKQH | 1 | Homo sapiens | C153 | NFCVPCYERQY | 1 | Bos taurus | C162 | QYALQCVQCKK | 3 | Bos taurus, Mus musculus, Rattus norvegicus | C162 | QHAMQCVQCKK | 1 | Homo sapiens | C165 | LQCVQCKKPIT | 3 | Bos taurus, Mus musculus, Rattus norvegicus | C165 | MQCVQCKKPIT | 1 | Homo sapiens | C185 | PWHKECFVCTA | 2 | Homo sapiens, Mus musculus | C185 | PWHRECFVCTA | 2 | Bos taurus, Rattus norvegicus | C188 | RECFVCTACKK | 2 | Bos taurus, Rattus norvegicus | C188 | KECFVCTACRK | 1 | Homo sapiens | C188 | KECFVCTACKK | 1 | Mus musculus | C191 | FVCTACKKQLS | 2 | Mus musculus, Rattus norvegicus | C191 | FVCTACRKQLS | 1 | Homo sapiens | C191 | FVCTACKKPLS | 1 | Bos taurus | C209 | DEFPYCLTCFC | 2 | Mus musculus, Rattus norvegicus | C209 | DDFAYCLNCFC | 1 | Homo sapiens | C209 | DEFAYCLGCFC | 1 | Bos taurus | C212 | PYCLTCFCDLY | 2 | Mus musculus, Rattus norvegicus | C212 | AYCLNCFCDLY | 1 | Homo sapiens | C212 | AYCLGCFCDLY | 1 | Bos taurus | C221 | LYAKKCAGCTN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C221 | LYAKKCAGCAN | 1 | Bos taurus | C224 | KKCAGCTNPIS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C224 | KKCAGCANPIS | 1 | Bos taurus | C248 | QWHNDCFNCKK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C251 | NDCFNCKKCSL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C254 | FNCKKCSLSLV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C272 | RDDILCPDCGK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C275 | ILCPDCGKDI | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C28 | EENPHCVACFE | 2 | Mus musculus, Rattus norvegicus | C28 | EESPYCVVCFE | 1 | Homo sapiens | C28 | EEQPYCVACFE | 1 | Bos taurus | C31 | PHCVACFEELY | 2 | Mus musculus, Rattus norvegicus | C31 | PYCVVCFETLF | 1 | Homo sapiens | C31 | PYCVACFEALF | 1 | Bos taurus | C40 | LYANTCEECGT | 2 | Mus musculus, Rattus norvegicus | C40 | LFANTCEECGK | 1 | Homo sapiens | C40 | LFASTCEECGK | 1 | Bos taurus | C43 | NTCEECGTPIG | 2 | Mus musculus, Rattus norvegicus | C43 | NTCEECGKPIG | 1 | Homo sapiens | C43 | STCEECGKLIG | 1 | Bos taurus | C65 | HWHEGCFHCSR | 2 | Mus musculus, Rattus norvegicus | C65 | HWHEACFHCSQ | 1 | Homo sapiens | C65 | HWHEACFHCSR | 1 | Bos taurus | C7 | TERFDCHHCNE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C7 | TERFDCHHCED | 1 | Bos taurus | H123 | KGSSWHETCFI | 2 | Homo sapiens, Bos taurus | H123 | KGSSWHETCFT | 2 | Mus musculus, Rattus norvegicus | H182 | REQPWHKECFV | 2 | Homo sapiens, Mus musculus | H182 | REQPWHRECFV | 1 | Bos taurus | H182 | RDQPWHRECFV | 1 | Rattus norvegicus | H245 | EERQWHNDCFN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H62 | KDRHWHEACFH | 2 | Homo sapiens, Bos taurus | H62 | KDRHWHEGCFH | 2 | Mus musculus, Rattus norvegicus |
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