|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for FKBP3 |
 Gene summary |
| Basic gene Info. | Gene symbol | FKBP3 |
| Gene name | FK506 binding protein 3, 25kDa | |
| Synonyms | FKBP-25|FKBP-3|FKBP25|PPIase | |
| Cytomap | UCSC genome browser: 14q21.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002013.3, | |
| Description | 25 kDa FK506-binding protein25 kDa FKBPFK506-binding protein 25, T-cellFK506-binding protein 3 (25kD)PPIase FKBP3immunophilin FKBP25peptidyl-prolyl cis-trans isomerase FKBP3rapamycin binding proteinrapamycin-selective 25 kDa immunophilinrotamase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 186947 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000100442 | ||
| HPRD : 01743 | ||
| Protein | UniProt: Q00688 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FKBP3 | |
| BioGPS: 2287 | ||
| Pathway | NCI Pathway Interaction Database: FKBP3 | |
| KEGG: FKBP3 | ||
| REACTOME: FKBP3 | ||
| Pathway Commons: FKBP3 | ||
| Context | iHOP: FKBP3 | |
| ligand binding site mutation search in PubMed: FKBP3 | ||
| UCL Cancer Institute: FKBP3 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
| Top |
| Ligand binding site mutations for FKBP3 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | L162 | K160R | COAD | 1 | Y198 | G199R | GBM | 1 | G169 | G167A | HNSC | 1 | W175 | E177K | LUSC | 1 | D146 | T147A | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for FKBP3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D146 | T147A | -0.98226029 | G169 | G167A | -0.74559131 | L162 | K160R | -0.71511164 | W175 | E177K | -0.22503658 | Y198 | G199R | -0.16138399 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for FKBP3 from PDB |
| Top |
| Differential gene expression and gene-gene network for FKBP3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for FKBP3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for FKBP3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of FKBP3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | RAP | RAPAMYCIN IMMUNOSUPPRESSANT DRUG | 1pbk | A | D146 L162 G169 W175 Y198 |
| Top |
| Conservation information for LBS of FKBP3 |
| Multiple alignments for Q00688 in multiple species |
| LBS | AA sequence | # species | Species | D146 | DGTVFDTNIQT | 3 | Homo sapiens, Mus musculus, Bos taurus | F145 | QDGTVFDTNIQ | 2 | Homo sapiens, Bos taurus | F145 | PDGTVFDTNIQ | 1 | Mus musculus | G169 | FKVGVGKVIRG | 2 | Homo sapiens, Mus musculus | G169 | FKVGIGKVIRG | 1 | Bos taurus | I172 | GVGKVIRGWDE | 2 | Homo sapiens, Mus musculus | I172 | GIGKVIRGWDE | 1 | Bos taurus | I208 | QPDAKIPPNAK | 2 | Homo sapiens, Bos taurus | I208 | QPDAKIPPNTK | 1 | Mus musculus | K170 | KVGVGKVIRGW | 2 | Homo sapiens, Mus musculus | K170 | KVGIGKVIRGW | 1 | Bos taurus | L162 | KNAKPLSFKVG | 3 | Homo sapiens, Mus musculus, Bos taurus | V171 | VGVGKVIRGWD | 2 | Homo sapiens, Mus musculus | V171 | VGIGKVIRGWD | 1 | Bos taurus | W175 | KVIRGWDEALL | 3 | Homo sapiens, Mus musculus, Bos taurus | Y135 | VVHCWYTGTLQ | 2 | Homo sapiens, Bos taurus | Y135 | VVHCWYTGTLP | 1 | Mus musculus | Y198 | EPEWAYGKKGQ | 3 | Homo sapiens, Mus musculus, Bos taurus |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |