mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for FKBP4
Gene summary
Basic gene Info.Gene symbolFKBP4
Gene nameFK506 binding protein 4, 59kDa
SynonymsFKBP51|FKBP52|FKBP59|HBI|Hsp56|PPIase|p52
CytomapUCSC genome browser: 12p13.33
Type of geneprotein-coding
RefGenesNM_002014.3,
Description51 kDa FK506-binding proteinFK506-binding protein 4 (59kD)HSP binding immunophilinT-cell FK506-binding protein, 59kDpeptidyl-prolyl cis-trans isomerase FKBP4peptidylprolyl cis-trans isomeraserotamase
Modification date20141207
dbXrefs MIM : 600611
HGNC : HGNC
Ensembl : ENSG00000004478
HPRD : 11794
Vega : OTTHUMG00000090429
ProteinUniProt: Q02790
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FKBP4
BioGPS: 2288
PathwayNCI Pathway Interaction Database: FKBP4
KEGG: FKBP4
REACTOME: FKBP4
Pathway Commons: FKBP4
ContextiHOP: FKBP4
ligand binding site mutation search in PubMed: FKBP4
UCL Cancer Institute: FKBP4
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0000413protein peptidyl-prolyl isomerization11350175
GO:0061077chaperone-mediated protein folding11350175


Top
Ligand binding site mutations for FKBP4
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F130E131QHNSC1
G84G82RSKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for FKBP4
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
G84G82R-1.0257245
F130E131Q-1.0044499
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for FKBP4 from PDB

Top
Differential gene expression and gene-gene network for FKBP4
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of FKBP4 and the right PPI network was created from samples without mutations in the LBS of FKBP4. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for FKBP4
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for FKBP4
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of FKBP4 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
FK5TACROLIMUS (ANHYDROUS)4laxAF130
RAPRAPAMYCIN IMMUNOSUPPRESSANT DRUG4drjAG84 F130
I63{3-[(1R)-3-(3,4-DIMETHOXYPHENYL)-1-({[(2S)-1-(3,3-DIMETHYL-2-OXOPENTANOYL)PIPERIDIN-2-YL]CARBONYL}OXY)PROPYL]PHENOXY}ACETIC ACID4layAG84 F130
37M2-(5-{[({3-[(1R)-1-[({(2S)-1-[(2S)-2-[(1S)-CYCLOHEX-2- EN-1-YL]-2-(3,4,5-TRIMETHOXYPHENYL)ACETYL]PIPERIDIN-2- YL}CARBONYL)OXY]-3-(3,4-DIMETHOXYPHENYL) PROPYL]PHENOXY}ACETYL)AMINO]METHYL}-6-HYDROXY-3-OXO- 3H-XANTHEN-9-YL)BENZOIC ACID4tw8AG84 F130
37M2-(5-{[({3-[(1R)-1-[({(2S)-1-[(2S)-2-[(1S)-CYCLOHEX-2- EN-1-YL]-2-(3,4,5-TRIMETHOXYPHENYL)ACETYL]PIPERIDIN-2- YL}CARBONYL)OXY]-3-(3,4-DIMETHOXYPHENYL) PROPYL]PHENOXY}ACETYL)AMINO]METHYL}-6-HYDROXY-3-OXO- 3H-XANTHEN-9-YL)BENZOIC ACID4tw8BG84 F130


Top
Conservation information for LBS of FKBP4
Multiple alignments for Q02790 in multiple species
LBSAA sequence# speciesSpecies
A112CKPEYAYGSAG2Homo sapiens, Rattus norvegicus
A112IPAELAYGESG1Arabidopsis thaliana
A112CAPNYAYGAAG1Drosophila melanogaster
A112CKPEYAYGLAG1Bos taurus
A112CKPEYAYGAAG1Mus musculus
D68DGTKFDSSLDR4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D68DGTKFDSSRDR1Arabidopsis thaliana
D68DGTEFDSSLSR1Drosophila melanogaster
E353LDSNNEKGLFR4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E353LESTNVKALYR1Arabidopsis thaliana
E353LDKNNVKALYR1Drosophila melanogaster
E85DLGKGEVIKAW4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E85TLGQGQVIKGW1Arabidopsis thaliana
E85SLGKGNVIKAF1Drosophila melanogaster
F130NATLVFEVELF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F130NATLQFDVELL1Arabidopsis thaliana
F130DATLIFELEML1Drosophila melanogaster
F67LDGTKFDSSLD4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F67LDGTKFDSSRD1Arabidopsis thaliana
F67VDGTEFDSSLS1Drosophila melanogaster
F77DRKDKFSFDLG3Homo sapiens, Mus musculus, Rattus norvegicus
F77DRATPFKFTLG1Arabidopsis thaliana
F77SRNEPFEFSLG1Drosophila melanogaster
F77DRKDRFSFDLG1Bos taurus
G59FVHYTGWLLDG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G59EVHYTGTLLDG1Arabidopsis thaliana
G59SLHYTGRLVDG1Drosophila melanogaster
G84FDLGKGEVIKA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G84FTLGQGQVIKG1Arabidopsis thaliana
G84FSLGKGNVIKA1Drosophila melanogaster
I122GSPPKIPPNAT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I122GSPPTIPANAT1Arabidopsis thaliana
I122GSPPAIPPDAT1Drosophila melanogaster
I87GKGEVIKAWDI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I87GQGQVIKGWDI1Arabidopsis thaliana
I87GKGNVIKAFDM1Drosophila melanogaster
K121AGSPPKIPPNA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K121SGSPPTIPANA1Arabidopsis thaliana
K121AGSPPAIPPDA1Drosophila melanogaster
K282GTVYFKEGKYK3Homo sapiens, Bos taurus, Rattus norvegicus
K282GNSKFKGGKYS1Arabidopsis thaliana
K282GTNYFKKENWA1Drosophila melanogaster
K282GTAYFKEGKYK1Mus musculus
K354DSNNEKGLFRR4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K354ESTNVKALYRR1Arabidopsis thaliana
K354DKNNVKALYRR1Drosophila melanogaster
K387LYPSNKAAKTQ2Mus musculus, Rattus norvegicus
K387LYPNNKAAKTQ1Homo sapiens
K387IDPNNREVKLE1Arabidopsis thaliana
K387LEPGNKAAANQ1Drosophila melanogaster
K387LYPSNKAAKAQ1Bos taurus
M327HLNLAMCHLKL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M327NLNDAACKLKL1Arabidopsis thaliana
M327HSNIALCHQKS1Drosophila melanogaster
N324LASHLNLAMCH4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N324VACNLNDAACK1Arabidopsis thaliana
N324VATHSNIALCH1Drosophila melanogaster
R358EKGLFRRGEAH4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R358VKALYRRAQAY1Arabidopsis thaliana
R358VKALYRRGQCN1Drosophila melanogaster
V86LGKGEVIKAWD4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
V86LGQGQVIKGWD1Arabidopsis thaliana
V86LGKGNVIKAFD1Drosophila melanogaster
W60VHYTGWLLDGT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
W60VHYTGTLLDGT1Arabidopsis thaliana
W60LHYTGRLVDGT1Drosophila melanogaster
W90EVIKAWDIAVA3Bos taurus, Mus musculus, Rattus norvegicus
W90EVIKAWDIAIA1Homo sapiens
W90QVIKGWDIGIK1Arabidopsis thaliana
W90NVIKAFDMGVA1Drosophila melanogaster
Y113KPEYAYGSAGS2Homo sapiens, Rattus norvegicus
Y113PAELAYGESGS1Arabidopsis thaliana
Y113APNYAYGAAGS1Drosophila melanogaster
Y113KPEYAYGLAGS1Bos taurus
Y113KPEYAYGAAGS1Mus musculus
Y57RVFVHYTGWLL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y57EVEVHYTGTLL1Arabidopsis thaliana
Y57TVSLHYTGRLV1Drosophila melanogaster


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas