mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SIRT2
Gene summary
Basic gene Info.Gene symbolSIRT2
Gene namesirtuin 2
SynonymsSIR2|SIR2L|SIR2L2
CytomapUCSC genome browser: 19q13
Type of geneprotein-coding
RefGenesNM_001193286.1,
NM_012237.3,NM_030593.2,NR_034146.1,
DescriptionNAD-dependent deacetylase sirtuin-2NAD-dependent protein deacetylase sirtuin-2SIR2-like protein 2regulatory protein SIR2 homolog 2silent information regulator 2sir2-related protein type 2sirtuin type 2sirtuin-2
Modification date20141207
dbXrefs MIM : 604480
HGNC : HGNC
Ensembl : ENSG00000068903
HPRD : 10377
Vega : OTTHUMG00000150480
ProteinUniProt: Q8IXJ6
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SIRT2
BioGPS: 22933
PathwayNCI Pathway Interaction Database: SIRT2
KEGG: SIRT2
REACTOME: SIRT2
Pathway Commons: SIRT2
ContextiHOP: SIRT2
ligand binding site mutation search in PubMed: SIRT2
UCL Cancer Institute: SIRT2
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoter18722353
GO:0006476protein deacetylation17172643
GO:0006476protein deacetylation24177535
GO:0016575histone deacetylation24177535
GO:0016575histone deacetylation24177535
GO:0034983peptidyl-lysine deacetylation23932781
GO:0035729cellular response to hepatocyte growth factor stimulus23908241
GO:0045843negative regulation of striated muscle tissue development12887892
GO:0045892negative regulation of transcription, DNA-templated12887892
GO:0048012hepatocyte growth factor receptor signaling pathway23908241
GO:0070933histone H4 deacetylation16648462
GO:0071219cellular response to molecule of bacterial origin23908241
GO:0071456cellular response to hypoxia24681946
GO:0090042tubulin deacetylation18722353
GO:0090042tubulin deacetylation24177535


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Ligand binding site mutations for SIRT2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F131P130HCOAD1
F190F190VCOAD1
F235F235LGBM1
K287K287NLUAD1
C221K220NLUAD1
L134L134ILUAD1
L134A133TSTAD1
H187A186VUCEC1
P140P140HUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for SIRT2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
F131P130H-1.5090996
C221K220N-1.1735247
H187A186V-1.1696498
L134L134I-0.95682123
P140P140H-0.94984255
F190F190V-0.78407456
K287K287N-0.72418792
L134A133T-0.60117251
F235F235L-0.068337963
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SIRT2 from PDB

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Differential gene expression and gene-gene network for SIRT2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SIRT2 and the right PPI network was created from samples without mutations in the LBS of SIRT2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for SIRT2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for SIRT2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SIRT2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)1j8fAC221
ZNZINC(2+)1j8fBC221
ZNZINC(2+)1j8fCC221
ZNZINC(2+)3zgvAC221
ZNZINC(2+)3zgvBC221
ZNZINC(2+)3zgoAC221
ZNZINC(2+)3zgoBC221
ZNZINC(2+)3zgoCC221
ZNZINC(2+)4l3oAC221
ZNZINC(2+)4l3oBC221
ZNZINC(2+)4l3oCC221
ZNZINC(2+)4l3oDC221
ZNZINC(2+)4rmgAC221
ZNZINC(2+)4rmhAC221
ZNZINC(2+)4rmiAC221
ZNZINC(2+)4rmjAC221
ZNZINC(2+)4rmjBC221
ZNZINC(2+)4r8mAC221
ZNZINC(2+)4r8mBC221
ZNZINC(2+)5d7oAC221
ZNZINC(2+)5d7oBC221
ZNZINC(2+)5d7pAC221
ZNZINC(2+)5d7pBC221
ZNZINC(2+)5d7qAC221
ZNZINC(2+)5d7qBC221
ZNZINC(2+)4y6lAC221
ZNZINC(2+)4y6lBC221
ZNZINC(2+)4y6oAC221
ZNZINC(2+)4y6oBC221
ZNZINC(2+)4y6qAC221
ZNZINC(2+)4y6qBC221
ZNZINC(2+)4y6qCC221
ZNZINC(2+)4y6qDC221
ZNZINC(2+)4x3oAC221
ZNZINC(2+)4x3pAC221
ZNZINC(2+)5dy4AC221
4I5(6S)-2-CHLORO-5,6,7,8,9,10- HEXAHYDROCYCLOHEPTA[B]INDOLE-6-CARBOXAMIDE5d7qAF131
OCZ(1S)-6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1- CARBOXAMIDE5d7pBF131 F190
4I5(6S)-2-CHLORO-5,6,7,8,9,10- HEXAHYDROCYCLOHEPTA[B]INDOLE-6-CARBOXAMIDE5d7qBF131 F190
3LXTRIDECANETHIAL4r8mBF131 H187 F190
IIIPeptide ligand (THR,ALA,ARG,MYK,SER,THR,GLY)4y6lBF131 H187 F190 F235
IIIPeptide ligand (LEU,PRO,LYS,MYK,THR,GLY,GLY)4y6oBF131 H187 F190 F235
3TKN-(5-BENZYL-1,3-THIAZOL-2-YL)-2-[(4,6- DIMETHYLPYRIMIDIN-2-YL)SULFANYL]ACETAMIDE4rmiAF131 L134 P140 F190
3TE2-[(4,6-DIMETHYLPYRIMIDIN-2-YL)SULFANYL]-N-[5- (NAPHTHALEN-1-YLMETHYL)-1,3-THIAZOL-2-YL]ACETAMIDE4rmgAF131 P140 F190
3TE2-[(4,6-DIMETHYLPYRIMIDIN-2-YL)SULFANYL]-N-[5- (NAPHTHALEN-1-YLMETHYL)-1,3-THIAZOL-2-YL]ACETAMIDE4rmhAF131 P140 F190
OCZ(1S)-6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1- CARBOXAMIDE5d7pAF131 P140 F190
5GNN-{5-[(7-BROMONAPHTHALEN-1-YL)METHYL]-1,3-THIAZOL-2- YL}-2-[(4,6-DIMETHYLPYRIMIDIN-2-YL)SULFANYL]ACETAMIDE5dy4AF131 P140 F190
IIIPeptide ligand (THR,ALA,ARG,MYK,SER,THR,GLY)4y6lAF131 P140 H187 F190 F235
3LXTRIDECANETHIAL4x3pAF190 F235
LYSLYSINE4rmhAF235
IIIPeptide ligand (PRO,LYS,LYS,THR,GLY)4x3oAF235
IIIPeptide ligand (PRO,LYS,LYS,THR,GLY)4x3pAF235
OCZ(1S)-6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1- CARBOXAMIDE5d7pBH187
4I5(6S)-2-CHLORO-5,6,7,8,9,10- HEXAHYDROCYCLOHEPTA[B]INDOLE-6-CARBOXAMIDE5d7qAH187
4I5(6S)-2-CHLORO-5,6,7,8,9,10- HEXAHYDROCYCLOHEPTA[B]INDOLE-6-CARBOXAMIDE5d7qBH187
3LXTRIDECANETHIAL4r8mAH187 F190
IIIPeptide ligand (LEU,PRO,LYS,MYK,THR,GLY,GLY)4y6oAH187 F190 F235
3Y0[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4- BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL] [(2R,3R,4R,5R)-3-OXIDANYL-5-SULFANYL-4-TRIDECOXY- OXOLAN-2-YL]METHYL HYDROGEN PHOSPHATE4x3oAH187 F190 F235 K287
OMR[(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9- YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANYL- PHOSPHORYL]OXY-OXIDANYL-PHOSPHORYL]OXYMETHYL]-2,4- BIS(OXIDANYL)OXOLAN-3-YL] TETRADECANOATE4y6qDH187 F190 K287
IIIPeptide ligand (ACY,TYR,HIS,THR,TYR,HIS,VAL,LYS,ARG,ARG,THR,ASN,TYR,TYR,CYS,NH2)4l3oAH187 F235
IIIPeptide ligand (ACY,TYR,HIS,THR,TYR,HIS,VAL,LYS,ARG,ARG,THR,ASN,TYR,TYR,CYS,NH2)4l3oBH187 F235
IIIPeptide ligand (ACY,TYR,HIS,THR,TYR,HIS,VAL,LYS,ARG,ARG,THR,ASN,TYR,TYR,CYS,NH2)4l3oCH187 F235
IIIPeptide ligand (ACY,TYR,HIS,THR,TYR,HIS,VAL,LYS,ARG,ARG,THR,ASN,TYR,TYR,CYS,NH2)4l3oDH187 F235
IIIPeptide ligand (GLU,LYS,ARG)4rmiAH187 F235
IIIPeptide ligand (PRO,LYS,LYS,THR,GLY)4r8mAH187 F235
IIIPeptide ligand (PRO,LYS,LYS,THR,GLY)4r8mBH187 F235
AR6[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE3zgvAH187 F235 K287
AR6[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE3zgvBH187 F235 K287
AR6[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE4rmjAH187 F235 K287
AR6[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE4rmjBH187 F235 K287
AR6[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE5d7oAH187 F235 K287
AR6[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE5d7oBH187 F235 K287
AR6[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE5d7pAH187 F235 K287
AR6[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE5d7pBH187 F235 K287
AR6[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE5d7qAH187 F235 K287
AR6[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE5d7qBH187 F235 K287
NADNAD ZWITTERION4rmgAH187 K287
CNACARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE4x3pAH187 K287
NADNAD ZWITTERION5dy4AH187 K287
OMR[(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9- YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANYL- PHOSPHORYL]OXY-OXIDANYL-PHOSPHORYL]OXYMETHYL]-2,4- BIS(OXIDANYL)OXOLAN-3-YL] TETRADECANOATE4y6qAP140 H187 F190 F235 K287
OMR[(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9- YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANYL- PHOSPHORYL]OXY-OXIDANYL-PHOSPHORYL]OXYMETHYL]-2,4- BIS(OXIDANYL)OXOLAN-3-YL] TETRADECANOATE4y6qBP140 H187 F190 F235 K287
OMR[(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9- YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANYL- PHOSPHORYL]OXY-OXIDANYL-PHOSPHORYL]OXYMETHYL]-2,4- BIS(OXIDANYL)OXOLAN-3-YL] TETRADECANOATE4y6qCP140 H187 F190 F235 K287


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Conservation information for LBS of SIRT2
Multiple alignments for Q8IXJ6 in multiple species
LBSAA sequence# speciesSpecies
A135PFFALAKELYP4Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus
A135PFYTLAKELYP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A135PFYELAHELMP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A135PFFALARELYP1Danio rerio
A241GESLPARFFSC1Homo sapiens
A241GEDLPDSFSET1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A241GEGLPMRFFEH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A241GENLPKRFYSS1Drosophila melanogaster
A241GESLPSRFFTS1Danio rerio
A241GENLPSRFFSC1Mus musculus
A241GENLPPRFFSC1Rattus norvegicus
A85ICLVGAGISTS3Homo sapiens, Mus musculus, Rattus norvegicus
A85IFMVGAGISTS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A85CVMVGAGISTA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A85VTMVGAGISTS1Drosophila melanogaster
A85ICMVGAGISTS1Danio rerio
C195FYTSHCVNTSC2Mus musculus, Rattus norvegicus
C195FYTSHCVSASC1Homo sapiens
C195FAHCHCIG--C1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C195FQYSRCIE--C1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C195FHTNHCIK--C1Drosophila melanogaster
C195FHTSHCVSFLC1Danio rerio
C200CVSASCRHEYP1Homo sapiens
C200CIG--CGKVYP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C200CIE--CYEMAE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C200CIK--CRKEYD1Drosophila melanogaster
C200CVSFLCRKEYS1Danio rerio
C200CVNTSCRKEYT1Mus musculus
C200CVNTSCGKEYT1Rattus norvegicus
C221P---KCEDCQS1Homo sapiens
C221KDFVKCDVCGE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C221P---KCNSCKG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C221P---KCQKCQG1Drosophila melanogaster
C221P---KCDSCGS1Danio rerio
C221P---RCEQCQS1Mus musculus
C221P---KCEKCQN1Rattus norvegicus
C224-KCEDCQSLVK1Homo sapiens
C224VKCDVCGELVK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C224-KCNSCKGLIK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C224-KCQKCQGVVK1Drosophila melanogaster
C224-KCDSCGSLVK1Danio rerio
C224-RCEQCQSVVK1Mus musculus
C224-KCEKCQNVVK1Rattus norvegicus
C324AWLGDCDQGCL2Mus musculus, Rattus norvegicus
C324AWLGECDQGCL1Homo sapiens
C324IVHQYSDEFAE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C324MILGDCDSQVR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C324AFLGDCDAGVM1Drosophila melanogaster
C324AHLSTCDDGCM1Danio rerio
D170YTQNIDTLERV2Mus musculus, Rattus norvegicus
D170YTQNIDTLERI1Homo sapiens
D170YTQNIDTLERQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D170YTQNIDTLERL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D170YTQNIDTLDRL1Drosophila melanogaster
D170YSQNIDTLERV1Danio rerio
D294KTGQTDPFLGM2Mus musculus, Rattus norvegicus
D294KAGQSDPFLGM1Homo sapiens
D294TVG--------1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D294PAG--------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D294AVGQASCVLFM1Drosophila melanogaster
D294KTGQSEFGMGL1Danio rerio
D95SAGIPDFRSPS3Homo sapiens, Mus musculus, Rattus norvegicus
D95SAGIPDFRSPG2Drosophila melanogaster, Danio rerio
D95SCGIPDFRSPG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D95AAGIPDFRSPE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E116HLPYPEAIFEI3Homo sapiens, Mus musculus, Rattus norvegicus
E116KLPYPEAVFDV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E116NLPYAEAVFDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E116ELPHPTAIFDL1Drosophila melanogaster
E116NLPYPEAIFQI1Danio rerio
E120PEAIFEISYFK3Homo sapiens, Mus musculus, Rattus norvegicus
E120PEAVFDVDFFQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E120AEAVFDLSYFR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E120PTAIFDLDYFE1Drosophila melanogaster
E120PEAIFQIDYFK1Danio rerio
E237IVFFGESLPAR1Homo sapiens
E237IVFFGEDLPDS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E237IVFYGEGLPMR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E237IVFFGENLPKR1Drosophila melanogaster
E237IVFFGESLPSR1Danio rerio
E237IVFFGENLPSR1Mus musculus
E237IVFFGENLPPR1Rattus norvegicus
E288LLINKEKTGQT2Mus musculus, Rattus norvegicus
E288LLINKEKAGQS1Homo sapiens
E288VLCNLETVG--1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E288VLINREPAG--1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E288LLINRDAVGQA1Drosophila melanogaster
E288LLINMEKTGQS1Danio rerio
E323VAWLGDCDQGC2Mus musculus, Rattus norvegicus
E323VAWLGECDQGC1Homo sapiens
E323LIVHQYSDEFA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E323IMILGDCDSQV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E323VAFLGDCDAGV1Drosophila melanogaster
E323VAHLSTCDDGC1Danio rerio
F119YPEAIFEISYF3Homo sapiens, Mus musculus, Rattus norvegicus
F119YPEAVFDVDFF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F119YAEAVFDLSYF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F119HPTAIFDLDYF1Drosophila melanogaster
F119YPEAIFQIDYF1Danio rerio
F131KHPEPFFALAK3Homo sapiens, Mus musculus, Rattus norvegicus
F131SDPLPFYTLAK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F131KNPRPFYELAH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F131KNPAPFFALAK1Drosophila melanogaster
F131KHPEPFFALAR1Danio rerio
F143LYPGQFKPTIC3Homo sapiens, Mus musculus, Rattus norvegicus
F143LYPGNFRPSKF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F143LMPEKYRPTYT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F143LYPGSFIPTPA1Drosophila melanogaster
F143LYPGQFKPTVY1Danio rerio
F190EAHGTFYTSHC3Homo sapiens, Mus musculus, Rattus norvegicus
F190EAHGSFAHCHC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F190EAHGSFQYSRC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F190EAHGSFHTNHC1Drosophila melanogaster
F190EAHGTFHTSHC1Danio rerio
F234KPDIVFFGENL3Drosophila melanogaster, Mus musculus, Rattus norvegicus
F234KPDIVFFGESL2Homo sapiens, Danio rerio
F234KPAIVFFGEDL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F234KPMIVFYGEGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F235PDIVFFGENLP3Drosophila melanogaster, Mus musculus, Rattus norvegicus
F235PDIVFFGESLP2Homo sapiens, Danio rerio
F235PAIVFFGEDLP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F235PMIVFYGEGLP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F244LPARFFSCMQS1Homo sapiens
F244LPDSFSETWLN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F244LPMRFFEHMEK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F244LPKRFYSSPEE1Drosophila melanogaster
F244LPSRFFTSMKA1Danio rerio
F244LPSRFFSCMQS1Mus musculus
F244LPPRFFSCMQS1Rattus norvegicus
F296G----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F296GQTDPFLGMMM2Mus musculus, Rattus norvegicus
F296GQSDPFLGMIM1Homo sapiens
F296GQASCVLFM-D1Drosophila melanogaster
F296GQSEFGMGL-F1Danio rerio
F96AGIPDFRSPST3Homo sapiens, Mus musculus, Rattus norvegicus
F96CGIPDFRSPGT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F96AGIPDFRSPET1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F96AGIPDFRSPGS1Drosophila melanogaster
F96AGIPDFRSPGT1Danio rerio
G141KELYPGQFKPT3Homo sapiens, Mus musculus, Rattus norvegicus
G141KELYPGNFRPS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G141HELMPEKYRPT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G141KELYPGSFIPT1Drosophila melanogaster
G141RELYPGQFKPT1Danio rerio
G236DIVFFGESLPA1Homo sapiens
G236AIVFFGEDLPD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G236MIVFYGEGLPM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G236DIVFFGENLPK1Drosophila melanogaster
G236DIVFFGESLPS1Danio rerio
G236DIVFFGENLPS1Mus musculus
G236DIVFFGENLPP1Rattus norvegicus
G261LLIIMGTSLQV3Danio rerio, Mus musculus, Rattus norvegicus
G261LLLVMGTSLQV1Homo sapiens
G261LVIVVGTSLAV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G261MALVIGTSLLV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G261LLIIMGTSLEV1Drosophila melanogaster
G298-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G298TDPFLGMMMGL2Mus musculus, Rattus norvegicus
G298SDPFLGMIMGL1Homo sapiens
G298ASCVLFM-DPN1Drosophila melanogaster
G298SEFGMGL-FSF1Danio rerio
G322DVAWLGDCDQG2Mus musculus, Rattus norvegicus
G322DVAWLGECDQG1Homo sapiens
G322DLIVHQYSDEF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G322DIMILGDCDSQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G322DVAFLGDCDAG1Drosophila melanogaster
G322DVAHLSTCDDG1Danio rerio
G84VICLVGAGIST3Homo sapiens, Mus musculus, Rattus norvegicus
G84VIFMVGAGIST1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G84ICVMVGAGIST1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G84IVTMVGAGIST1Drosophila melanogaster
G84IICMVGAGIST1Danio rerio
G86CLVGAGISTSA3Homo sapiens, Mus musculus, Rattus norvegicus
G86FMVGAGISTSC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G86VMVGAGISTAA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G86TMVGAGISTSA1Drosophila melanogaster
G86CMVGAGISTSA1Danio rerio
H187DLVEAHGTFYT3Homo sapiens, Mus musculus, Rattus norvegicus
H187LIIEAHGSFAH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H187ALIEAHGSFQY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H187KIIEAHGSFHT1Drosophila melanogaster
H187DLIEAHGTFHT1Danio rerio
I118PYPEAIFEISY3Homo sapiens, Mus musculus, Rattus norvegicus
I118PYPEAVFDVDF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I118PYAEAVFDLSY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I118PHPTAIFDLDY1Drosophila melanogaster
I118PYPEAIFQIDY1Danio rerio
I169CYTQNIDTLER4Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus
I169VYTQNIDTLER1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I169HYTQNIDTLDR1Drosophila melanogaster
I169CYSQNIDTLER1Danio rerio
I232VVKPDIVFFGE3Drosophila melanogaster, Mus musculus, Rattus norvegicus
I232LVKPDIVFFGE2Homo sapiens, Danio rerio
I232LVKPAIVFFGE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I232LIKPMIVFYGE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I93STSAGIPDFRS5Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
I93STSCGIPDFRS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I93STAAGIPDFRS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K287RLLINKEKTGQ2Mus musculus, Rattus norvegicus
K287RLLINKEKAGQ1Homo sapiens
K287RVLCNLETVG-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K287RVLINREPAG-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K287RLLINRDAVGQ1Drosophila melanogaster
K287RLLINMEKTGQ1Danio rerio
L103SPSTGLYANLE2Mus musculus, Rattus norvegicus
L103SPSTGLYDNLE1Homo sapiens
L103SPGTGLYHNLA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L103SPETGIYNNLQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L103SPGSGLYSNLK1Drosophila melanogaster
L103SPGTGLYANLQ1Danio rerio
L134EPFFALAKELY3Homo sapiens, Mus musculus, Rattus norvegicus
L134LPFYTLAKELY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L134RPFYELAHELM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L134APFFALAKELY1Drosophila melanogaster
L134EPFFALARELY1Danio rerio
L138ALAKELYPGQF3Homo sapiens, Mus musculus, Rattus norvegicus
L138TLAKELYPGNF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L138ELAHELMPEKY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L138ALAKELYPGSF1Drosophila melanogaster
L138ALARELYPGQF1Danio rerio
L206RHEYPLSWMKE1Homo sapiens
L206GKVYPPQVFKS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L206YEMAETEYVRA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L206RKEYDMDWMKA1Drosophila melanogaster
L206RKEYSMDWMKN1Danio rerio
L206RKEYTMGWMKE1Mus musculus
L206GKEYTMSWMKE1Rattus norvegicus
L239FFGESLPARFF1Homo sapiens
L239FFGEDLPDSFS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L239FYGEGLPMRFF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L239FFGENLPKRFY1Drosophila melanogaster
L239FFGESLPSRFF1Danio rerio
L239FFGENLPSRFF1Mus musculus
L239FFGENLPPRFF1Rattus norvegicus
L264IMGTSLQVQPF3Danio rerio, Mus musculus, Rattus norvegicus
L264VMGTSLQVQPF1Homo sapiens
L264VVGTSLAVYPF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L264VIGTSLLVHPF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L264IMGTSLEVQPF1Drosophila melanogaster
L297-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L297QTDPFLGMMMG2Mus musculus, Rattus norvegicus
L297QSDPFLGMIMG1Homo sapiens
L297QASCVLFM-DP1Drosophila melanogaster
L297QSEFGMGL-FS1Danio rerio
M247RFFSCMQSD--3Homo sapiens, Mus musculus, Rattus norvegicus
M247SFSETWLNDSE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M247RFFEHMEKD--1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M247RFYSSPEED--1Drosophila melanogaster
M247RFFTSMKAD--1Danio rerio
M299-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M299DPFLGMMMGLG2Mus musculus, Rattus norvegicus
M299DPFLGMIMGLG1Homo sapiens
M299SCVLFM-DPNT1Drosophila melanogaster
M299EFGMGL-FSFG1Danio rerio
M301-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M301FLGMMMGLGGG2Mus musculus, Rattus norvegicus
M301FLGMIMGLGGG1Homo sapiens
M301VLFM-DPNTRS1Drosophila melanogaster
M301GMGL-FSFGGG1Danio rerio
N168RCYTQNIDTLE3Homo sapiens, Mus musculus, Rattus norvegicus
N168RVYTQNIDTLE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N168KCYTQNIDTLE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N168RHYTQNIDTLD1Drosophila melanogaster
N168RCYSQNIDTLE1Danio rerio
N286PRLLINKEKTG2Mus musculus, Rattus norvegicus
N286PRLLINKEKAG1Homo sapiens
N286KRVLCNLETVG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N286QRVLINREPAG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N286IRLLINRDAVG1Drosophila melanogaster
N286PRLLINMEKTG1Danio rerio
P140AKELYPGQFKP3Homo sapiens, Mus musculus, Rattus norvegicus
P140AKELYPGNFRP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P140AHELMPEKYRP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P140AKELYPGSFIP1Drosophila melanogaster
P140ARELYPGQFKP1Danio rerio
P268SLQVQPFASLI3Homo sapiens, Mus musculus, Rattus norvegicus
P268SLAVYPFASLP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P268SLLVHPFADLP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P268SLEVQPFASLV1Drosophila melanogaster
P268SLQVQPFASLV1Danio rerio
P94TSAGIPDFRSP5Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
P94TSCGIPDFRSP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P94TAAGIPDFRSP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q167LRCYTQNIDTL3Homo sapiens, Mus musculus, Rattus norvegicus
Q167KRVYTQNIDTL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q167QKCYTQNIDTL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q167QRHYTQNIDTL1Drosophila melanogaster
Q167RRCYSQNIDTL1Danio rerio
Q265MGTSLQVQPFA4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
Q265VGTSLAVYPFA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q265IGTSLLVHPFA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q265MGTSLEVQPFA1Drosophila melanogaster
Q267TSLQVQPFASL4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
Q267TSLAVYPFASL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q267TSLLVHPFADL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q267TSLEVQPFASL1Drosophila melanogaster
R97GIPDFRSPSTG3Homo sapiens, Mus musculus, Rattus norvegicus
R97GIPDFRSPGTG2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Danio rerio
R97GIPDFRSPETG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R97GIPDFRSPGSG1Drosophila melanogaster
S238VFFGESLPARF1Homo sapiens
S238VFFGEDLPDSF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S238VFYGEGLPMRF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S238VFFGENLPKRF1Drosophila melanogaster
S238VFFGESLPSRF1Danio rerio
S238VFFGENLPSRF1Mus musculus
S238VFFGENLPPRF1Rattus norvegicus
S263IIMGTSLQVQP3Danio rerio, Mus musculus, Rattus norvegicus
S263LVMGTSLQVQP1Homo sapiens
S263IVVGTSLAVYP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S263LVIGTSLLVHP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S263IIMGTSLEVQP1Drosophila melanogaster
S271VQPFASLISKA3Homo sapiens, Mus musculus, Rattus norvegicus
S271VYPFASLPEEI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S271VHPFADLPEIV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S271VQPFASLVWRP1Drosophila melanogaster
S271VQPFASLVSRV1Danio rerio
S293EKTGQTDPFLG2Mus musculus, Rattus norvegicus
S293EKAGQSDPFLG1Homo sapiens
S293ETVG-------1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S293EPAG-------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S293DAVGQASCVLF1Drosophila melanogaster
S293EKTGQSEFGMG1Danio rerio
S88VGAGISTSAGI5Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
S88VGAGISTSCGI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S88VGAGISTAAGI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S90AGISTSAGIPD5Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
S90AGISTSCGIPD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S90AGISTAAGIPD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S98IPDFRSPSTGL3Homo sapiens, Mus musculus, Rattus norvegicus
S98IPDFRSPGTGL2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Danio rerio
S98IPDFRSPETGI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S98IPDFRSPGSGL1Drosophila melanogaster
T262LIIMGTSLQVQ3Danio rerio, Mus musculus, Rattus norvegicus
T262LLVMGTSLQVQ1Homo sapiens
T262VIVVGTSLAVY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T262ALVIGTSLLVH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T262LIIMGTSLEVQ1Drosophila melanogaster
T89GAGISTSAGIP5Homo sapiens, Drosophila melanogaster, Danio rerio, Mus musculus, Rattus norvegicus
T89GAGISTSCGIP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T89GAGISTAAGIP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V233VKPDIVFFGEN3Drosophila melanogaster, Mus musculus, Rattus norvegicus
V233VKPDIVFFGES2Homo sapiens, Danio rerio
V233VKPAIVFFGED1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V233IKPMIVFYGEG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V266GTSLQVQPFAS4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
V266GTSLAVYPFAS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V266GTSLLVHPFAD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V266GTSLEVQPFAS1Drosophila melanogaster
Y104PSTGLYANLEK2Mus musculus, Rattus norvegicus
Y104PSTGLYDNLEK1Homo sapiens
Y104PGTGLYHNLAR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y104PETGIYNNLQR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y104PGSGLYSNLKK1Drosophila melanogaster
Y104PGTGLYANLQK1Danio rerio
Y139LAKELYPGQFK3Homo sapiens, Mus musculus, Rattus norvegicus
Y139LAKELYPGNFR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y139LAHELMPEKYR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y139LAKELYPGSFI1Drosophila melanogaster
Y139LARELYPGQFK1Danio rerio


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