mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TRIM32
Gene summary
Basic gene Info.Gene symbolTRIM32
Gene nametripartite motif containing 32
CytomapUCSC genome browser: 9q33.1
Type of geneprotein-coding
Description72 kDa Tat-interacting proteinE3 ubiquitin-protein ligase TRIM32TAT-interactive protein, 72-KDtripartite motif-containing 32tripartite motif-containing protein 32zinc finger protein HT2Azinc-finger protein HT2A
Modification date20141219
dbXrefs MIM : 602290
Ensembl : ENSG00000119401
HPRD : 03797
Vega : OTTHUMG00000021026
ProteinUniProt: Q13049
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TRIM32
BioGPS: 22954
PathwayNCI Pathway Interaction Database: TRIM32
Pathway Commons: TRIM32
ContextiHOP: TRIM32
ligand binding site mutation search in PubMed: TRIM32
UCL Cancer Institute: TRIM32
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0000209protein polyubiquitination18632609
GO:0016567protein ubiquitination16816390
GO:0030307positive regulation of cell growth18632609
GO:0030335positive regulation of cell migration18632609
GO:0032897negative regulation of viral transcription18248090
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling23077300
GO:0045087innate immune response18248090
GO:0045787positive regulation of cell cycle18632609
GO:0045862positive regulation of proteolysis18632609
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity23077300
GO:0051092positive regulation of NF-kappaB transcription factor activity23077300
GO:1902187negative regulation of viral release from host cell18248090
GO:1902230negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage18632609

Ligand binding site mutations for TRIM32

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for TRIM32
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TRIM32 from PDB

Differential gene expression and gene-gene network for TRIM32
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TRIM32 and the right PPI network was created from samples without mutations in the LBS of TRIM32. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for TRIM32
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0270968Limb-girdle muscular dystrophy type 2H9Biomarker, GeneticVariation
umls:C0752166Bardet-Biedl Syndrome7Biomarker, GeneticVariation

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for TRIM32
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TRIM32 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of TRIM32
Multiple alignments for Q13049 in multiple species
LBSAA sequence# speciesSpecies

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