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mutLBSgeneDB |
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| Gene summary for RAB21 |
 Gene summary |
| Basic gene Info. | Gene symbol | RAB21 |
| Gene name | RAB21, member RAS oncogene family | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 12q21.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_014999.2, | |
| Description | ras-related protein Rab-21 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612398 | |
| HGNC : HGNC | ||
| HPRD : 06695 | ||
| Protein | UniProt: Q9UL25 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RAB21 | |
| BioGPS: 23011 | ||
| Pathway | NCI Pathway Interaction Database: RAB21 | |
| KEGG: RAB21 | ||
| REACTOME: RAB21 | ||
| Pathway Commons: RAB21 | ||
| Context | iHOP: RAB21 | |
| ligand binding site mutation search in PubMed: RAB21 | ||
| UCL Cancer Institute: RAB21 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006184 | GTP catabolic process | 16034420 | GO:0017157 | regulation of exocytosis | 22705394 |
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| Ligand binding site mutations for RAB21 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | T51 | L52P | BRCA | 1 | F44 | F44L | COAD | 1 | K164 | Q165P | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RAB21 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | T51 | L52P | -1.0683756 | F44 | F44L | -0.729655 | K164 | Q165P | -0.42752316 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RAB21 from PDB |
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| Differential gene expression and gene-gene network for RAB21 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RAB21 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RAB21 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RAB21 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1z08 | C | F44 K164 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1z08 | D | F44 K164 | GDP | GUANOSINE-5'-DIPHOSPHATE | 1z0i | A | F44 K164 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1yzt | A | F44 T51 K164 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1yzt | B | F44 T51 K164 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1yzu | A | F44 T51 K164 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1yzu | B | F44 T51 K164 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1z08 | A | F44 T51 K164 | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 1z08 | B | F44 T51 K164 | MG | MAGNESIUM(2+) | 1yzt | A | T51 | MG | MAGNESIUM(2+) | 1yzt | B | T51 | MG | MAGNESIUM(2+) | 1yzu | A | T51 | MG | MAGNESIUM(2+) | 1yzu | B | T51 | MG | MAGNESIUM(2+) | 1z08 | A | T51 | MG | MAGNESIUM(2+) | 1z08 | B | T51 |
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| Conservation information for LBS of RAB21 |
| Multiple alignments for Q9UL25 in multiple species |
| LBS | AA sequence | # species | Species | A163 | HYHTSAKQNKG | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | A76 | AIWDTAGQERF | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | C29 | LLGEGCVGKTS | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | D135 | VGNKIDLEKER | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | D46 | ENKFNDKHITT | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | F44 | YCENKFNDKHI | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | G28 | VLLGEGCVGKT | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | G31 | GEGCVGKTSLV | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | G77 | IWDTAGQERFH | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | H48 | KFNDKHITTLQ | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | K133 | CIVGNKIDLEK | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | K164 | YHTSAKQNKGI | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | K32 | EGCVGKTSLVL | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | L136 | GNKIDLEKERH | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | M180 | DLCKRMIETAQ | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | N132 | LCIVGNKIDLE | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | N45 | CENKFNDKHIT | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | S162 | KHYHTSAKQNK | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | S34 | CVGKTSLVLRY | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | T33 | GCVGKTSLVLR | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | T50 | NDKHITTLQAS | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | T51 | DKHITTLQASF | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | V30 | LGEGCVGKTSL | 3 | Homo sapiens, Rattus norvegicus, Mus musculus |
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