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mutLBSgeneDB |
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| Gene summary for CNOT1 |
 Gene summary |
| Basic gene Info. | Gene symbol | CNOT1 |
| Gene name | CCR4-NOT transcription complex, subunit 1 | |
| Synonyms | CDC39|NOT1|NOT1H | |
| Cytomap | UCSC genome browser: 16q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001265612.1, NM_016284.4,NM_206999.2,NR_049763.1, | |
| Description | CCR4-NOT transcription complex subunit 1CCR4-associated factor 1NOT1 (negative regulator of transcription 1, yeast) homologadrenal gland protein AD-005negative regulator of transcription subunit 1 homolog | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604917 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000125107 | ||
| HPRD : 11999 | ||
| Vega : OTTHUMG00000133487 | ||
| Protein | UniProt: A5YKK6 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CNOT1 | |
| BioGPS: 23019 | ||
| Pathway | NCI Pathway Interaction Database: CNOT1 | |
| KEGG: CNOT1 | ||
| REACTOME: CNOT1 | ||
| Pathway Commons: CNOT1 | ||
| Context | iHOP: CNOT1 | |
| ligand binding site mutation search in PubMed: CNOT1 | ||
| UCL Cancer Institute: CNOT1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 16778766 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly | 21976065 | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway | 16778766 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway | 16778766 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic | 21976065 |
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| Ligand binding site mutations for CNOT1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | N849 | N849Y | BRCA | 1 | M1 | M1V | HNSC | 1 | D845 | I844V | KIRC | 1 | P906 | P906S | SKCM | 1 | A848 | E847D | SKCM | 1 | K2331 | K2331Q | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CNOT1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D845 | I844V | -1.4655679 | A848 | E847D | -1.3169343 | P906 | P906S | -1.1716206 | K2331 | K2331Q | -0.6925775 | M1 | M1V | -0.65705322 | N849 | N849Y | -0.34877229 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CNOT1 from PDB |
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| Differential gene expression and gene-gene network for CNOT1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CNOT1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CNOT1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CNOT1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (PHE,SER,SER,TRP,ASN,ASP,TYR,LEU,GLY,LEU,ALA,THR,LEU,ILE,THR) | 4cqo | A | K2331 | III | Peptide ligand (PHE,SER,SER,TRP,ASN,ASP,TYR,LEU,GLY,LEU,ALA,THR,LEU,ILE) | 4cqo | C | K2331 |
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| Conservation information for LBS of CNOT1 |
| Multiple alignments for A5YKK6 in multiple species |
| LBS | AA sequence | # species | Species | A2357 | LFQSVAQCCMG | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | A848 | EIDDEANSYFQ | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | C890 | REVFNCMLRNL | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | D845 | FSKEIDDEANS | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | E2350 | CAPEIEKLFQS | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | E835 | SQVWPEANQHF | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | E898 | RNLFEEYRFFP | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | E909 | QYPDKELHITA | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | F2353 | EIEKLFQSVAQ | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | F852 | EANSYFQRIYN | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | F901 | FEEYRFFPQYP | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | I2330 | TFIELIKNPAF | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | K2331 | FIELIKNPAFK | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | M1 | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | N849 | IDDEANSYFQR | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | N894 | NCMLRNLFEEY | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | P906 | FFPQYPDKELH | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | Q2354 | IEKLFQSVAQC | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | Q2358 | FQSVAQCCMGQ | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | Q853 | ANSYFQRIYNH | 3 | Homo sapiens, Danio rerio, Mus musculus | Q853 | ANSYFQRIYNQ | 1 | Xenopus tropicalis | Q904 | YRFFPQYPDKE | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | W2338 | PAFKFWNHEFV | 3 | Homo sapiens, Xenopus tropicalis, Mus musculus | W2338 | PAFKFWSHDFV | 1 | Danio rerio | Y856 | YFQRIYNHPPH | 3 | Homo sapiens, Danio rerio, Mus musculus | Y856 | YFQRIYNQPPH | 1 | Xenopus tropicalis | Y905 | RFFPQYPDKEL | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus |
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