mutLBSgeneDB |
Gene summary for KDM4B |
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Basic gene Info. | Gene symbol | KDM4B |
Gene name | lysine (K)-specific demethylase 4B | |
Synonyms | JMJD2B|TDRD14B | |
Cytomap | UCSC genome browser: 19p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_015015.2, | |
Description | jmjC domain-containing histone demethylation protein 3Bjumonji domain containing 2Bjumonji domain-containing protein 2Blysine-specific demethylase 4Btudor domain containing 14B | |
Modification date | 20141207 | |
dbXrefs | MIM : 609765 | |
HGNC : HGNC | ||
Ensembl : ENSG00000127663 | ||
HPRD : 11056 | ||
Vega : OTTHUMG00000180281 | ||
Protein | UniProt: O94953 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KDM4B | |
BioGPS: 23030 | ||
Pathway | NCI Pathway Interaction Database: KDM4B | |
KEGG: KDM4B | ||
REACTOME: KDM4B | ||
Pathway Commons: KDM4B | ||
Context | iHOP: KDM4B | |
ligand binding site mutation search in PubMed: KDM4B | ||
UCL Cancer Institute: KDM4B | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for KDM4B |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | E191 | E191K | STAD | 1 | Y133 | P131L | UCEC | 1 | C235 | A237T | UCEC | 1 | M243 | M243I | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for KDM4B |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | Y133 | P131L | 0.10150674 | E191 | E191K | -0.94223048 | C235 | A237T | -0.33911879 | M243 | M243I | -0.33399362 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for KDM4B |
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Phenotype information for KDM4B |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0025149 | Medulloblastoma | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for KDM4B |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 4lxl | A | C235 | III | Peptide ligand (ALA,ARG,LYS,SER,THR,GLY,GLY,LYS) | 4lxl | A | E191 M243 | PD2 | LUTIDINIC ACID | 4lxl | A | Y133 E191 |
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Conservation information for LBS of KDM4B |
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LBS | AA sequence | # species | Species |
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