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mutLBSgeneDB |
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| Gene summary for USP33 |
 Gene summary |
| Basic gene Info. | Gene symbol | USP33 |
| Gene name | ubiquitin specific peptidase 33 | |
| Synonyms | VDU1 | |
| Cytomap | UCSC genome browser: 1p31.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_015017.4, NM_201624.2,NM_201626.2, | |
| Description | VHL-interacting deubiquitinating enzyme 1deubiquitinating enzyme 33pVHL-interacting deubiquitinating enzyme 1ubiquitin carboxyl-terminal hydrolase 33ubiquitin thioesterase 33ubiquitin thiolesterase 33ubiquitin-specific-processing protease 33 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 615146 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000077254 | ||
| HPRD : 10297 | ||
| Vega : OTTHUMG00000009651 | ||
| Protein | UniProt: Q8TEY7 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_USP33 | |
| BioGPS: 23032 | ||
| Pathway | NCI Pathway Interaction Database: USP33 | |
| KEGG: USP33 | ||
| REACTOME: USP33 | ||
| Pathway Commons: USP33 | ||
| Context | iHOP: USP33 | |
| ligand binding site mutation search in PubMed: USP33 | ||
| UCL Cancer Institute: USP33 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0016579 | protein deubiquitination | 11739384 | GO:0070536 | protein K63-linked deubiquitination | 19363159 | GO:0071108 | protein K48-linked deubiquitination | 19363159 |
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| Ligand binding site mutations for USP33 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C117 | S118I | LUAD | 1 | C64 | D63Y | LUAD | 1 | H41 | L42W | LUSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for USP33 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H41 | L42W | -1.3442042 | C64 | D63Y | -0.74220992 | C117 | S118I | -0.085030751 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for USP33 from PDB |
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| Differential gene expression and gene-gene network for USP33 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for USP33 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for USP33 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of USP33 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 2uzg | A | C64 | ZN | ZINC(2+) | 2uzg | A | H41 C117 |
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| Conservation information for LBS of USP33 |
| Multiple alignments for Q8TEY7 in multiple species |
| LBS | AA sequence | # species | Species | C114 | TLRVWCYACSK | 3 | Homo sapiens, Mus musculus, Bos taurus | C114 | TLRVWCYACTK | 1 | Danio rerio | C114 | TLRVWCYTCSK | 1 | Xenopus tropicalis | C117 | VWCYACSKEVF | 3 | Homo sapiens, Mus musculus, Bos taurus | C117 | VWCYACTKEVF | 1 | Danio rerio | C117 | VWCYTCSKEVF | 1 | Xenopus tropicalis | C39 | AFRNHCPHLDS | 1 | Homo sapiens | C39 | VSSNDCPHLEC | 1 | Danio rerio | C39 | SLVCDCPHLES | 1 | Xenopus tropicalis | C39 | TFRNHCPHLDS | 1 | Mus musculus | C39 | SFRSHCPHLDS | 1 | Bos taurus | C61 | KSLGTCQDCKV | 1 | Homo sapiens | C61 | KSHGQCQDCKV | 1 | Danio rerio | C61 | KSHGSCQDCRV | 1 | Xenopus tropicalis | C61 | KSLGACQDCKV | 1 | Mus musculus | C61 | KSHGSCQDCKV | 1 | Bos taurus | C64 | GTCQDCKVQGP | 1 | Homo sapiens | C64 | GQCQDCKVGGP | 1 | Danio rerio | C64 | GSCQDCRVRGP | 1 | Xenopus tropicalis | C64 | GACQDCKVRGP | 1 | Mus musculus | C64 | GSCQDCKVRGP | 1 | Bos taurus | C74 | PNLWACLENRC | 3 | Homo sapiens, Mus musculus, Bos taurus | C74 | PNLWACLENGC | 2 | Danio rerio, Xenopus tropicalis | C79 | CLENRCSYVGC | 3 | Homo sapiens, Mus musculus, Bos taurus | C79 | CLENGCSYVGC | 2 | Danio rerio, Xenopus tropicalis | C84 | CSYVGCGESQV | 3 | Homo sapiens, Mus musculus, Bos taurus | C84 | CSYVGCGESHA | 1 | Danio rerio | C84 | CSYVGCGESHV | 1 | Xenopus tropicalis | H101 | SQETKHYLTVN | 3 | Homo sapiens, Mus musculus, Bos taurus | H101 | SQETRHNLTVN | 1 | Danio rerio | H101 | SQDTKHCLTVN | 1 | Xenopus tropicalis | H41 | RNHCPHLDSVG | 2 | Homo sapiens, Mus musculus | H41 | SNDCPHLECVG | 1 | Danio rerio | H41 | VCDCPHLESVG | 1 | Xenopus tropicalis | H41 | RSHCPHLDSVG | 1 | Bos taurus | H91 | ESQVDHSTIHS | 3 | Homo sapiens, Mus musculus, Bos taurus | H91 | ESHADHSTVHS | 1 | Danio rerio | H91 | ESHVDHSTLHS | 1 | Xenopus tropicalis | H95 | DHSTIHSQETK | 3 | Homo sapiens, Mus musculus, Bos taurus | H95 | DHSTVHSQETR | 1 | Danio rerio | H95 | DHSTLHSQDTK | 1 | Xenopus tropicalis |
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