mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for ZNF292

Gene summary

Basic gene Info.	Gene symbol	ZNF292
	Gene name	zinc finger protein 292
	Synonyms	Nbla00365\|ZFP292\|ZN-16\|Zn-15\|bA393I2.3
	Cytomap	UCSC genome browser: 6q14.3
	Type of gene	protein-coding
	RefGenes	NM_015021.1,
	Description	16 zinc-finger domain proteinputative protein product of Nbla00365
	Modification date	20141207
dbXrefs	HGNC : HGNC
	Ensembl : ENSG00000188994
	Vega : OTTHUMG00000015164
Protein	UniProt: O60281 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_ZNF292
	BioGPS: 23036
Pathway	NCI Pathway Interaction Database: ZNF292
	KEGG: ZNF292
	REACTOME: ZNF292
	Pathway Commons: ZNF292
Context	iHOP: ZNF292
	ligand binding site mutation search in PubMed: ZNF292
	UCL Cancer Institute: ZNF292
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO Term

PubMed ID

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Ligand binding site mutations for ZNF292

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
C2116	R2115Q	UCEC	2
H2139	A2137S	LUAD	1
C2121	A2123V	LUAD	1
C2121	Q2119H	LUAD	1
H2134	H2134Y	SKCM	1
H2134	Y2135H	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for ZNF292

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
C2116	R2115Q	-1.212993
H2139	A2137S	-0.93387899
H2134	H2134Y	-0.92401574
H2134	Y2135H	-0.84364212
C2121	Q2119H	-0.64216398
C2121	A2123V	-0.32242681

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ZNF292 from PDB

PDB ID	PDB title	PDB structure
1X3C	Solution structure of the C2H2 type zinc-binding domain of human zinc finger protein 292

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Differential gene expression and gene-gene network for ZNF292

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of ZNF292 and the right PPI network was created from samples without mutations in the LBS of ZNF292. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for ZNF292

Gene level disease information (DisGeNet)

Disease ID

Disease name

# PubMed

Association type

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for ZNF292

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.