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mutLBSgeneDB |
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| Gene summary for TNIK |
 Gene summary |
| Basic gene Info. | Gene symbol | TNIK |
| Gene name | TRAF2 and NCK interacting kinase | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 3q26.31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001161560.1, NM_001161561.1,NM_001161562.1,NM_001161563.1,NM_001161564.1, NM_001161565.1,NM_001161566.1,NM_015028.2,NR_027767.1, | |
| Description | TRAF2 and NCK-interacting protein kinase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 610005 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000154310 | ||
| HPRD : 18206 | ||
| Vega : OTTHUMG00000159036 | ||
| Protein | UniProt: Q9UKE5 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TNIK | |
| BioGPS: 23043 | ||
| Pathway | NCI Pathway Interaction Database: TNIK | |
| KEGG: TNIK | ||
| REACTOME: TNIK | ||
| Pathway Commons: TNIK | ||
| Context | iHOP: TNIK | |
| ligand binding site mutation search in PubMed: TNIK | ||
| UCL Cancer Institute: TNIK | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 10521462 | GO:0007256 | activation of JNKK activity | 15342639 | GO:0031532 | actin cytoskeleton reorganization | 15342639 | GO:0035556 | intracellular signal transduction | 10521462 | GO:0046777 | protein autophosphorylation | 10521462 | GO:0048814 | regulation of dendrite morphogenesis | 20159449 |
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| Ligand binding site mutations for TNIK |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G111 | V113A | COAD | 1 | A52 | A52V | KIRC | 1 | M105 | M105I | SKCM | 1 | V39 | Q38K | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TNIK |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | A52 | A52V | -0.94586785 | V39 | Q38K | -0.72887662 | G111 | V113A | -0.25802218 | M105 | M105I | -0.25661752 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TNIK from PDB |
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| Differential gene expression and gene-gene network for TNIK |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TNIK |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0311375 | Arsenic Poisoning | 1 | Biomarker |
| umls:C0037274 | Skin Diseases | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TNIK |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TNIK go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 824 | 9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE | 2x7f | E | A52 M105 G111 | 824 | 9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE | 2x7f | A | V39 A52 M105 G111 | 824 | 9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE | 2x7f | B | V39 A52 M105 G111 | 824 | 9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE | 2x7f | C | V39 A52 M105 G111 | 824 | 9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE | 2x7f | D | V39 A52 M105 G111 |
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| Conservation information for LBS of TNIK |
| Multiple alignments for Q9UKE5 in multiple species |
| LBS | AA sequence | # species | Species |
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