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mutLBSgeneDB |
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| Gene summary for FLNC |
 Gene summary |
| Basic gene Info. | Gene symbol | FLNC |
| Gene name | filamin C, gamma | |
| Synonyms | ABP-280|ABP280A|ABPA|ABPL|FLN2|MFM5|MPD4 | |
| Cytomap | UCSC genome browser: 7q32-q35 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001127487.1, NM_001458.4, | |
| Description | ABP-280-like proteinABP-L, gamma filaminactin binding protein 280filamin-2filamin-C | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 102565 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000128591 | ||
| HPRD : 00018 | ||
| Vega : OTTHUMG00000023627 | ||
| Protein | UniProt: Q14315 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FLNC | |
| BioGPS: 2318 | ||
| Pathway | NCI Pathway Interaction Database: FLNC | |
| KEGG: FLNC | ||
| REACTOME: FLNC | ||
| Pathway Commons: FLNC | ||
| Context | iHOP: FLNC | |
| ligand binding site mutation search in PubMed: FLNC | ||
| UCL Cancer Institute: FLNC | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for FLNC |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | V1896 | V1896M | GBM | 1 | S1900 | K1901T | SKCM | 1 | F2387 | I2385M | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for FLNC |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | F2387 | I2385M | -1.1941186 | V1896 | V1896M | -0.95636581 | S1900 | K1901T | -0.69877856 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for FLNC from PDB |
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| Differential gene expression and gene-gene network for FLNC |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for FLNC |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C3279722 | MYOPATHY, DISTAL, 4 | 1 | GeneticVariation |
| umls:C0009404 | Colorectal Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for FLNC |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of FLNC go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of FLNC |
| Multiple alignments for Q14315 in multiple species |
| LBS | AA sequence | # species | Species | D2380 | VQEPGDYEVSI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E1897 | LSLAVEGPSKA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E2382 | EPGDYEVSIKF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F2361 | KAEIAFEDRKD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F2387 | EVSIKFNDEHI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G1898 | SLAVEGPSKAE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G2345 | REAGAGGLSIA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I2349 | AGGLSIAVEGP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I2359 | PSKAEIAFEDR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K2356 | VEGPSKAEIAF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L2347 | AGAGGLSIAVE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P1899 | LAVEGPSKAEI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S1900 | AVEGPSKAEIT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S2348 | GAGGLSIAVEG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T2339 | EFSIWTREAGA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V1896 | GLSLAVEGPSK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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