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mutLBSgeneDB |
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| Gene summary for FLT1 |
 Gene summary |
| Basic gene Info. | Gene symbol | FLT1 |
| Gene name | fms-related tyrosine kinase 1 | |
| Synonyms | FLT|FLT-1|VEGFR-1|VEGFR1 | |
| Cytomap | UCSC genome browser: 13q12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001159920.1, NM_001160030.1,NM_001160031.1,NM_002019.4, | |
| Description | fms-like tyrosine kinase 1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)tyrosine-protein kinase FRTtyrosine-protein kinase receptor FLTvascular endothelial growth factor receptor 1vascular per | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 165070 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000102755 | ||
| HPRD : 01297 | ||
| Vega : OTTHUMG00000016648 | ||
| Protein | UniProt: P17948 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FLT1 | |
| BioGPS: 2321 | ||
| Pathway | NCI Pathway Interaction Database: FLT1 | |
| KEGG: FLT1 | ||
| REACTOME: FLT1 | ||
| Pathway Commons: FLT1 | ||
| Context | iHOP: FLT1 | |
| ligand binding site mutation search in PubMed: FLT1 | ||
| UCL Cancer Institute: FLT1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0002548 | monocyte chemotaxis | 18079407 | GO:0018108 | peptidyl-tyrosine phosphorylation | 11513746 | GO:0030335 | positive regulation of cell migration | 8605350 | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway | 1312256 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 8605350 | GO:0036323 | vascular endothelial growth factor receptor-1 signaling pathway | 15952180 | GO:0038084 | vascular endothelial growth factor signaling pathway | 1312256 | GO:0043406 | positive regulation of MAP kinase activity | 9299537 | GO:0043410 | positive regulation of MAPK cascade | 9299537 | GO:0046777 | protein autophosphorylation | 11513746 | GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 9299537 |
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| Ligand binding site mutations for FLT1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | L1013 | S1014P | BRCA | 1 | L1013 | S1014F | LUAD | 1 | K861 | A859V | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for FLT1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K861 | A859V | -0.3290401 | L1013 | S1014P | -0.1869952 | L1013 | S1014F | -0.04901632 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for FLT1 from PDB |
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| Differential gene expression and gene-gene network for FLT1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for FLT1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0032914 | Pre-Eclampsia | 20 | AlteredExpression, Biomarker, GeneticVariation |
| umls:C0027627 | Neoplasm Metastasis | 19 | AlteredExpression, Biomarker |
| umls:C0025202 | Melanoma | 12 | AlteredExpression, Biomarker, GeneticVariation |
| umls:C0007134 | Carcinoma, Renal Cell | 7 | Biomarker, Therapeutic |
| umls:C0023890 | Liver Cirrhosis | 2 | Biomarker |
| umls:C0037286 | Skin Neoplasms | 1 | Biomarker, GeneticVariation |
| umls:C2937358 | Cerebral Hemorrhage | 1 | Biomarker |
| umls:C0860207 | Drug-Induced Liver Injury | 1 | Therapeutic |
| umls:C0018923 | Hemangiosarcoma | 1 | Biomarker |
| umls:C0029422 | Osteochondrodysplasias | 1 | Biomarker |
| umls:C0041948 | Uremia | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for FLT1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|investigational | DB00398 | Sorafenib | Small molecule |  |
| Approved|investigational | DB01268 | Sunitinib | Small molecule |  |
| Investigational | DB04879 | Vatalanib | Small molecule |  |
| Investigational | DB05075 | TG100801 | Small molecule |  |
| Investigational | DB05913 | OSI-930 | Small molecule |  |
| Investigational | DB06080 | ABT-869 | Small molecule |  |
| Investigational | DB06101 | IMC-1C11 | Biotech |  |
| Approved | DB06589 | Pazopanib | Small molecule |  |
| Approved|investigational | DB06626 | Axitinib | Small molecule |  |
| Experimental | DB07288 | N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide | Small molecule |  |
| Approved | DB08896 | Regorafenib | Small molecule |  |
| Approved | DB09078 | Lenvatinib | Small molecule |  |
| Approved | DB09079 | Nintedanib | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of FLT1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 8ST | VEGF RECEPTOR TYROSINE KINASE INHIBITOR II | 3hng | A | K861 L1013 |
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| Conservation information for LBS of FLT1 |
| Multiple alignments for P17948 in multiple species |
| LBS | AA sequence | # species | Species | C1039 | NVVKICDFGLA | 3 | Homo sapiens, Gallus gallus, Mus musculus | C912 | VIVEYCKYGNL | 3 | Homo sapiens, Gallus gallus, Mus musculus | D1040 | VVKICDFGLAR | 3 | Homo sapiens, Gallus gallus, Mus musculus | E878 | KALMTELKILT | 2 | Homo sapiens, Mus musculus | E878 | KALMTELKILI | 1 | Gallus gallus | E910 | LMVIVEYCKYG | 3 | Homo sapiens, Gallus gallus, Mus musculus | F1041 | VKICDFGLARD | 3 | Homo sapiens, Gallus gallus, Mus musculus | H1020 | SRKCIHRDLAA | 3 | Homo sapiens, Gallus gallus, Mus musculus | H147 | IPEIIHMTEGR | 1 | Homo sapiens | H147 | IPKIIHMTVGK | 1 | Gallus gallus | H147 | IPKLVHMTEGR | 1 | Mus musculus | H223 | TNYLTHRQTNT | 2 | Homo sapiens, Mus musculus | H223 | TKYLTHRETNT | 1 | Gallus gallus | I1038 | NNVVKICDFGL | 3 | Homo sapiens, Gallus gallus, Mus musculus | K861 | RTVAVKMLKEG | 2 | Homo sapiens, Mus musculus | K861 | RIVAVKMLKEG | 1 | Gallus gallus | L1013 | RGMEFLSSRKC | 3 | Homo sapiens, Gallus gallus, Mus musculus | L1029 | AARNILLSENN | 3 | Homo sapiens, Gallus gallus, Mus musculus | L882 | TELKILTHIGH | 2 | Homo sapiens, Mus musculus | L882 | TELKILIHIGH | 1 | Gallus gallus | V907 | GGPLMVIVEYC | 3 | Homo sapiens, Gallus gallus, Mus musculus | V909 | PLMVIVEYCKY | 3 | Homo sapiens, Gallus gallus, Mus musculus | Y911 | MVIVEYCKYGN | 3 | Homo sapiens, Gallus gallus, Mus musculus |
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