mutLBSgeneDB |
Gene summary for TENC1 |
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Basic gene Info. | Gene symbol | TENC1 |
Gene name | tensin like C1 domain containing phosphatase (tensin 2) | |
Synonyms | C1-TEN|C1TEN|TNS2 | |
Cytomap | UCSC genome browser: 12q13.13 | |
Type of gene | protein-coding | |
RefGenes | NM_015319.2, NM_170754.2,NM_198316.1, | |
Description | C1 domain-containing phosphatase and tensin homologtensin 2tensin like C1 domain-containing phosphatasetensin-2tensin-like C1 domain-containing phosphatase | |
Modification date | 20141207 | |
dbXrefs | MIM : 607717 | |
HGNC : HGNC | ||
Ensembl : ENSG00000111077 | ||
HPRD : 16256 | ||
Vega : OTTHUMG00000169730 | ||
Protein | UniProt: Q63HR2 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TENC1 | |
BioGPS: 23371 | ||
Pathway | NCI Pathway Interaction Database: TENC1 | |
KEGG: TENC1 | ||
REACTOME: TENC1 | ||
Pathway Commons: TENC1 | ||
Context | iHOP: TENC1 | |
ligand binding site mutation search in PubMed: TENC1 | ||
UCL Cancer Institute: TENC1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for TENC1 |
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LBS | AAchange of nsSNV | Cancer type | # samples | T1324 | T1326M | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for TENC1 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | T1324 | T1326M | -0.72532514 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for TENC1 |
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Phenotype information for TENC1 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for TENC1 |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (GLU,ASP,HIS,LYS,PRO,GLY,THR,PHE,PRO,LYS,ALA,LEU,THR,ASN) | 2loz | A | T1324 |
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Conservation information for LBS of TENC1 |
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LBS | AA sequence | # species | Species |
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