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mutLBSgeneDB |
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| Gene summary for AHCYL2 |
 Gene summary |
| Basic gene Info. | Gene symbol | AHCYL2 |
| Gene name | adenosylhomocysteinase-like 2 | |
| Synonyms | ADOHCYASE3 | |
| Cytomap | UCSC genome browser: 7q32.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001130720.2, NM_001130722.2,NM_001130723.2,NM_015328.3, | |
| Description | S-adenosyl-L-homocysteine hydrolase 3S-adenosylhomocysteine hydrolase-like 2putative adenosylhomocysteinase 3 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000158467 | ||
| HPRD : 11113 | ||
| Vega : OTTHUMG00000157677 | ||
| Protein | UniProt: Q96HN2 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_AHCYL2 | |
| BioGPS: 23382 | ||
| Pathway | NCI Pathway Interaction Database: AHCYL2 | |
| KEGG: AHCYL2 | ||
| REACTOME: AHCYL2 | ||
| Pathway Commons: AHCYL2 | ||
| Context | iHOP: AHCYL2 | |
| ligand binding site mutation search in PubMed: AHCYL2 | ||
| UCL Cancer Institute: AHCYL2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for AHCYL2 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D369 | F368C | COAD | 1 | N370 | N370Y | HNSC | 1 | G399 | G399D | KIRC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for AHCYL2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | G399 | G399D | -1.3672126 | D369 | F368C | -0.93931027 | N370 | N370Y | -0.50749157 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for AHCYL2 from PDB |
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| Differential gene expression and gene-gene network for AHCYL2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for AHCYL2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for AHCYL2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of AHCYL2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NAD | NAD ZWITTERION | 3gvp | A | D369 N370 G399 | NAD | NAD ZWITTERION | 3gvp | B | D369 N370 G399 | NAD | NAD ZWITTERION | 3gvp | C | D369 N370 G399 | NAD | NAD ZWITTERION | 3gvp | D | D369 N370 G399 |
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| Conservation information for LBS of AHCYL2 |
| Multiple alignments for Q96HN2 in multiple species |
| LBS | AA sequence | # species | Species | C374 | DNLYCCRESIL | 3 | Homo sapiens, Mus musculus, Bos taurus | C374 | DTFYTCRDSIL | 1 | Drosophila melanogaster | C427 | EIDPICALQAC | 3 | Homo sapiens, Mus musculus, Bos taurus | C427 | EVDPICALQAA | 1 | Drosophila melanogaster | C454 | DIVITCTGNKN | 3 | Homo sapiens, Mus musculus, Bos taurus | C454 | DVVVTATGNKN | 1 | Drosophila melanogaster | D369 | TKQKFDNLYCC | 3 | Homo sapiens, Mus musculus, Bos taurus | D369 | TKNKFDTFYTC | 1 | Drosophila melanogaster | D424 | YVTEIDPICAL | 3 | Homo sapiens, Mus musculus, Bos taurus | D424 | YVTEVDPICAL | 1 | Drosophila melanogaster | E402 | VCGYGEVGKGC | 3 | Homo sapiens, Mus musculus, Bos taurus | E402 | ICGYGDVGKGC | 1 | Drosophila melanogaster | E422 | IVYVTEIDPIC | 3 | Homo sapiens, Mus musculus, Bos taurus | E422 | IVYVTEVDPIC | 1 | Drosophila melanogaster | G399 | QVVVCGYGEVG | 3 | Homo sapiens, Mus musculus, Bos taurus | G399 | QVVICGYGDVG | 1 | Drosophila melanogaster | G401 | VVCGYGEVGKG | 3 | Homo sapiens, Mus musculus, Bos taurus | G401 | VICGYGDVGKG | 1 | Drosophila melanogaster | G456 | VITCTGNKNVV | 3 | Homo sapiens, Mus musculus, Bos taurus | G456 | VVTATGNKNVI | 1 | Drosophila melanogaster | G479 | IVCNMGHSNTE | 3 | Homo sapiens, Mus musculus, Bos taurus | G479 | ILCNMGHSCSE | 1 | Drosophila melanogaster | H480 | VCNMGHSNTEI | 3 | Homo sapiens, Mus musculus, Bos taurus | H480 | LCNMGHSCSEI | 1 | Drosophila melanogaster | I423 | VYVTEIDPICA | 3 | Homo sapiens, Mus musculus, Bos taurus | I423 | VYVTEVDPICA | 1 | Drosophila melanogaster | M478 | CIVCNMGHSNT | 3 | Homo sapiens, Mus musculus, Bos taurus | M478 | CILCNMGHSCS | 1 | Drosophila melanogaster | N370 | KQKFDNLYCCR | 3 | Homo sapiens, Mus musculus, Bos taurus | N370 | KNKFDTFYTCR | 1 | Drosophila melanogaster | N457 | ITCTGNKNVVT | 3 | Homo sapiens, Mus musculus, Bos taurus | N457 | VTATGNKNVIT | 1 | Drosophila melanogaster | N525 | EGRLLNLSCST | 3 | Homo sapiens, Mus musculus, Bos taurus | N525 | EGRLVNLSCST | 1 | Drosophila melanogaster | T421 | SIVYVTEIDPI | 3 | Homo sapiens, Mus musculus, Bos taurus | T421 | CIVYVTEVDPI | 1 | Drosophila melanogaster | T455 | IVITCTGNKNV | 3 | Homo sapiens, Mus musculus, Bos taurus | T455 | VVVTATGNKNV | 1 | Drosophila melanogaster | V403 | CGYGEVGKGCC | 3 | Homo sapiens, Mus musculus, Bos taurus | V403 | CGYGDVGKGCA | 1 | Drosophila melanogaster |
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