mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for DICER1

Gene summary

Basic gene Info.	Gene symbol	DICER1
	Gene name	dicer 1, ribonuclease type III
	Synonyms	DCR1\|Dicer\|Dicer1e\|HERNA\|K12H4.8-LIKE\|MNG1\|RMSE2
	Cytomap	UCSC genome browser: 14q32.13
	Type of gene	protein-coding
	RefGenes	NM_001195573.1, NM_001271282.2,NM_001291628.1,NM_030621.4,NM_177438.2,
	Description	Dicer1, Dcr-1 homologdicer 1, double-stranded RNA-specific endoribonucleaseendoribonuclease Dicerhelicase MOIhelicase with RNAse motif
	Modification date	20141222
dbXrefs	MIM : 606241
	HGNC : HGNC
	Ensembl : ENSG00000100697
	HPRD : 05875
	Vega : OTTHUMG00000166134
Protein	UniProt: Q9UPY3 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_DICER1
	BioGPS: 23405
Pathway	NCI Pathway Interaction Database: DICER1
	KEGG: DICER1
	REACTOME: DICER1
	Pathway Commons: DICER1
Context	iHOP: DICER1
	ligand binding site mutation search in PubMed: DICER1
	UCL Cancer Institute: DICER1
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0030422	production of siRNA involved in RNA interference	15973356
GO:0031054	pre-miRNA processing	15973356
GO:0090501	RNA phosphodiester bond hydrolysis	-
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-

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Ligand binding site mutations for DICER1

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
R788	R790Q	COAD	2
D1709	D1709N	COAD	1
D1810	D1810N	COAD	1
E1705	E1705Q	COAD	1
E1705	E1705Q	GBM	1
E1813	E1813G	GBM	1
Y936	R935K	LUAD	1
E1705	R1703S	SKCM	1
E1813	E1813G	THCA	1
D1810	D1810H	THCA	1
E1813	E1813G	UCEC	1
E1705	E1705A	UCEC	1
H992,S994	T993I	UCEC	1
E1813	E1813A	UCEC	1
F960	F960C	UCEC	1
H943	R944Q	UCEC	1
E1705	R1703C	UCEC	1
D1810	D1810A	UCEC	1
E1705	E1705K	UCEC	1
D1709	D1709N	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for DICER1 from My Cancer Genome.

Dicer 1, ribonuclease type III (DICER1) is a gene that encodes a protein that functions as a ribonuclease. Missense mutations, silent mutations, nonsense mutations, and frameshift deletions are observed in cancers such as pleural cancer, pituitary cancer, and endometrial cancer. Modified: August 27, 2015.

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Protein structure related information for DICER1

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
E1705	R1703S	-1.3087748
H943	R944Q	-1.2341655
Y936	R935K	-1.2307349
F960	F960C	-1.1114153
E1705	R1703C	-1.0797506
D1810	D1810N	-0.98348277
D1810	D1810A	-0.92995575
D1810	D1810H	-0.87215586
E1705	E1705A	-0.86376704
R788	R790Q	-0.84096894
E1705	E1705Q	-0.79157192
E1705	E1705K	-0.77006072
E1813	E1813G	-0.64947994
D1709	D1709N	-0.61028328
H992	T993I	-0.49250314
S994	T993I	-0.49250314
E1813	E1813A	-0.39134654

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DICER1 from PDB

PDB ID	PDB title	PDB structure
2EB1	Crystal Structure of the C-Terminal RNase III Domain of Human Dicer

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Differential gene expression and gene-gene network for DICER1

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of DICER1 and the right PPI network was created from samples without mutations in the LBS of DICER1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for DICER1

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C1266144	Pleuropulmonary blastoma	16	Biomarker, GeneticVariation
umls:C0014175	Endometriosis	1	Biomarker
umls:C0017661	Glomerulonephritis, IGA	1	Biomarker
umls:C0028960	Oligospermia	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for DICER1

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Drug information targeting mutLBSgene (Approved drugs only)

Drug status

DrugBank ID

Name

Type

Drug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DICER1 go to BioLip

Ligand ID

Ligand short name

Ligand long name

PDB ID

PDB name

mutLBS

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Conservation information for LBS of DICER1

Multiple alignments for Q9UPY3 in multiple species

LBS	AA sequence	# species	Species
A1017	LPLSSAEKRKA	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
A1017	-----------	2	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A1017	IPKSQ------	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A1017	IPQASASDSKE	1	Caenorhabditis elegans
A1017	LPTSSEETKRA	1	Drosophila melanogaster
D1709	LEFLGDAILDY	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
D1709	LEFLGDAVLDY	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Caenorhabditis elegans, Drosophila melanogaster
D1709	LEFLGDSLLDM	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
D1709	LEFLGDALFDM	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D1713	GDAILDYLITK	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
D1713	GDAVLDYIIVQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D1713	GDAVLDYMITR	1	Caenorhabditis elegans
D1713	GDAVLDYLITR	1	Drosophila melanogaster
D1713	GDSLLDMVCVD	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
D1713	GDALFDMVAVD	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D1810	PKAMGDIFESL	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
D1810	PKFISDTLEAM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D1810	PKAMGDIFESV	1	Caenorhabditis elegans
D1810	PKALGDVFESI	1	Drosophila melanogaster
D1810	PKCLPDILEAY	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
D1810	PKCLSDVVEAY	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D940	-YRNFDQPHRF	4	Homo sapiens, Danio rerio, Gallus gallus, Bos taurus
D940	-------PQSI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D940	-YRNLEQPVFY	1	Caenorhabditis elegans
D940	-YRNQDQPQYF	1	Drosophila melanogaster
D940	IYRNFDQPHRF	1	Xenopus tropicalis
D940	----FDGSRKF	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
D940	----YDGARKF	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E1705	CYQRLEFLGDA	7	Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
E1705	NYQQLEFLGDA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E1705	SYQRLEFLGDS	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
E1705	SYQRLEFLGDA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E1813	MGDIFESLAGA	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
E1813	ISDTLEAMICA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E1813	MGDIFESVAGA	1	Caenorhabditis elegans
E1813	LGDVFESIAGA	1	Drosophila melanogaster
E1813	LPDILEAYVGA	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
E1813	LSDVVEAYIGA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F960	TPLSKFPS---	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
F960	-----------	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F960	RPSSKFPD---	1	Caenorhabditis elegans
F960	SPLSCFPG---	1	Drosophila melanogaster
F960	KPQDKVPEGV-	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
F960	KPTDPVPDGIV	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F968	PEYETFA----	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
F968	EQY-AFE----	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F968	THFETFN----	1	Caenorhabditis elegans
F968	DNYRTFK----	1	Drosophila melanogaster
F968	PAPSKWRAV--	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
F968	PNHRAWRGLGT	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H943	NFDQPHRFYVA	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
H943	----PQSIY--	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H943	NLEQPVFYYVA	1	Caenorhabditis elegans
H943	NQDQPQYFYVA	1	Drosophila melanogaster
H943	-FDGSRKFFMR	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
H943	-YDGARKFFTH	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H992	LLDVDHTSSRL	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
H992	SALCKKLPLRL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H992	LLDVDFTSTRL	1	Caenorhabditis elegans
H992	LLDVDHTSARL	1	Drosophila melanogaster
H992	VVEAELAPLRR	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
H992	VVEAALISTRR	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I1032	-QNKQILVPEL	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
I1032	-QVRSFYINDL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I1032	SSQRQILVPEL	1	Caenorhabditis elegans
I1032	-EQKQILVPEL	1	Drosophila melanogaster
I1032	--QTCYLVLET	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
I1032	--QQCFLILEP	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K1021	SAEKRKAKWES	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
K1021	-----------	2	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K1021	Q----------	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K1021	SASDSKESNTS	1	Caenorhabditis elegans
K1021	SEETKRAKREN	1	Drosophila melanogaster
K1030	---QNKQILVP	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
K1030	---QVRSFYIN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K1030	PHSSQRQILVP	1	Caenorhabditis elegans
K1030	---EQKQILVP	1	Drosophila melanogaster
K1030	----QTCYLVL	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
K1030	----QQCFLIL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K975	EYYKTKYNLDL	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
K975	GFVNSEFMIPA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K975	EYFIKKYKLEI	1	Caenorhabditis elegans
K975	HYYLVKYGLTI	1	Drosophila melanogaster
K975	EHTILNYSVSL	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
K975	THDILNYSNSL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L1027	AKWESL---QN	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
L1027	----------Q	2	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L1027	---------QV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L1027	ESNTSVPHSSQ	1	Caenorhabditis elegans
L1027	AKRENL---EQ	1	Drosophila melanogaster
L1033	QNKQILVPELC	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
L1033	QVRSFYINDLY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L1033	SQRQILVPELM	1	Caenorhabditis elegans
L1033	EQKQILVPELC	1	Drosophila melanogaster
L1033	-QTCYLVLETL	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
L1033	-QQCFLILEPM	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P961	PLSKFPS----	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
P961	-----------	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P961	PSSKFPD----	1	Caenorhabditis elegans
P961	PLSCFPG----	1	Drosophila melanogaster
P961	PQDKVPEGV--	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
P961	PTDPVPDGIVA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q1028	SL---QNKQIL	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
Q1028	-----QVRSFY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q1028	SVPHSSQRQIL	1	Caenorhabditis elegans
Q1028	NL---EQKQIL	1	Drosophila melanogaster
Q1028	------QTCYL	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Q1028	------QQCFL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q1031	--QNKQILVPE	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
Q1031	--QVRSFYIND	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q1031	HSSQRQILVPE	1	Caenorhabditis elegans
Q1031	--EQKQILVPE	1	Drosophila melanogaster
Q1031	---QTCYLVLE	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Q1031	---QQCFLILE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q941	YRNFDQPHRFY	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
Q941	------PQSIY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q941	YRNLEQPVFYY	1	Caenorhabditis elegans
Q941	YRNQDQPQYFY	1	Drosophila melanogaster
Q941	---FDGSRKFF	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Q941	---YDGARKFF	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R1020	SSAEKRKAKWE	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
R1020	-----------	2	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R1020	SQ---------	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R1020	ASASDSKESNT	1	Caenorhabditis elegans
R1020	SSEETKRAKRE	1	Drosophila melanogaster
R788	DELNFRRRKLY	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
R788	EGDNHIFHPLV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R788	LTLNPKRRKFE	1	Caenorhabditis elegans
R788	EEQNTRGRKIY	1	Drosophila melanogaster
R788	GAAYYHSRPIL	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
R788	DTLGRSSRPLL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R821	FPVYTRSGE--	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
R821	FILNSTVGP--	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R821	FPVFLRQGN--	1	Caenorhabditis elegans
R821	FSIFTRSGE--	1	Drosophila melanogaster
R821	FPLFFGKGSSR	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
R821	FPLFF--GTKR	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R937	R---YRNFDQP	4	Homo sapiens, Danio rerio, Gallus gallus, Bos taurus
R937	N---------P	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R937	W---YRNLEQP	1	Caenorhabditis elegans
R937	W---YRNQDQP	1	Drosophila melanogaster
R937	RQVIYRNFDQP	1	Xenopus tropicalis
R937	P------FDGS	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
R937	P------YDGA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R996	DHTSSRLNLLT	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
R996	KKLPLRLNY--	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R996	DFTSTRLNLLQ	1	Caenorhabditis elegans
R996	DHTSARLNFLT	1	Drosophila melanogaster
R996	ELAPLRRNLLD	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
R996	ALISTRRDFLD	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S1015	--LPLSSAEKR	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
S1015	-----------	2	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S1015	--IPKSQ----	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S1015	SNIPQASASDS	1	Caenorhabditis elegans
S1015	--LPTSSEETK	1	Drosophila melanogaster
S1016	-LPLSSAEKRK	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
S1016	-----------	2	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S1016	-IPKSQ-----	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S1016	NIPQASASDSK	1	Caenorhabditis elegans
S1016	-LPTSSEETKR	1	Drosophila melanogaster
S962	LSKFPS----P	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
S962	----------E	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S962	SSKFPD----T	1	Caenorhabditis elegans
S962	LSCFPG----D	1	Drosophila melanogaster
S962	QDKVPEGV--P	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
S962	TDPVPDGIVAP	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S994	DVDHTSSRLNL	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
S994	LCKKLPLRLNY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S994	DVDFTSTRLNL	1	Caenorhabditis elegans
S994	DVDHTSARLNF	1	Drosophila melanogaster
S994	EAELAPLRRNL	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
S994	EAALISTRRDF	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
W1024	KRKAKWESL--	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
W1024	-----------	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
W1024	DSKESNTSVPH	1	Caenorhabditis elegans
W1024	TKRAKRENL--	1	Drosophila melanogaster
Y936	PR---YRNFDQ	4	Homo sapiens, Danio rerio, Gallus gallus, Bos taurus
Y936	VN---------	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y936	PW---YRNLEQ	1	Caenorhabditis elegans
Y936	PW---YRNQDQ	1	Drosophila melanogaster
Y936	PRQVIYRNFDQ	1	Xenopus tropicalis
Y936	DP------FDG	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Y936	DP------YDG	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y971	----EYYKTKY	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
Y971	----GFVNSEF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y971	----EYFIKKY	1	Caenorhabditis elegans
Y971	----HYYLVKY	1	Drosophila melanogaster
Y971	AV--EHTILNY	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Y971	GLGTTHDILNY	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y972	---EYYKTKYN	5	Homo sapiens, Danio rerio, Xenopus tropicalis, Gallus gallus, Bos taurus
Y972	---GFVNSEFM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y972	---EYFIKKYK	1	Caenorhabditis elegans
Y972	---HYYLVKYG	1	Drosophila melanogaster
Y972	V--EHTILNYS	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Y972	LGTTHDILNYS	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y976	YYKTKYNLDLT	4	Homo sapiens, Xenopus tropicalis, Gallus gallus, Bos taurus
Y976	FVNSEFMIPAK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y976	YFIKKYKLEIY	1	Caenorhabditis elegans
Y976	YYLVKYGLTIQ	1	Drosophila melanogaster
Y976	YYKTKYNLDLS	1	Danio rerio
Y976	HTILNYSVSLW	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Y976	HDILNYSNSLW	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)