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mutLBSgeneDB |
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| Gene summary for RHOQ |
 Gene summary |
| Basic gene Info. | Gene symbol | RHOQ |
| Gene name | ras homolog family member Q | |
| Synonyms | ARHQ|HEL-S-42|RASL7A|TC10|TC10A | |
| Cytomap | UCSC genome browser: 2p21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_012249.3, | |
| Description | RAS-like, family 7, member Aepididymis secretory protein Li 42ras homolog gene family, member Qras-like protein TC10ras-like protein family member 7Arho-related GTP-binding protein RhoQ | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605857 | |
| HGNC : HGNC | ||
| HPRD : 05791 | ||
| Protein | UniProt: P17081 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RHOQ | |
| BioGPS: 23433 | ||
| Pathway | NCI Pathway Interaction Database: RHOQ | |
| KEGG: RHOQ | ||
| REACTOME: RHOQ | ||
| Pathway Commons: RHOQ | ||
| Context | iHOP: RHOQ | |
| ligand binding site mutation search in PubMed: RHOQ | ||
| UCL Cancer Institute: RHOQ | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006184 | GTP catabolic process | 10445846 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 10445846 | GO:0051491 | positive regulation of filopodium assembly | 10445846 |
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| Ligand binding site mutations for RHOQ |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | L166 | T167A | COAD | 2 | F34 | E36K | BLCA | 1 | G66 | E68G | COAD | 1 | Q122 | G120E | THCA | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RHOQ |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | G66 | E68G | -0.96350922 | Q122 | G120E | -0.84457486 | L166 | T167A | -0.77407972 | F34 | E36K | -0.31173605 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RHOQ from PDB |
| PDB ID | PDB title | PDB structure | 2ATX | Crystal Structure of the TC10 GppNHp complex |  |
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| Differential gene expression and gene-gene network for RHOQ |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RHOQ |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RHOQ |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RHOQ go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of RHOQ |
| Multiple alignments for P17081 in multiple species |
| LBS | AA sequence | # species | Species | A165 | YVECSALTQKG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A19 | VVGDGAVGKTC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C24 | AVGKTCLLMSY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D124 | IGTQIDLRDDP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D17 | CVVVGDGAVGK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D63 | LLGLYDTAGQE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F34 | YANDAFPEEYV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G18 | VVVGDGAVGKT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G21 | GDGAVGKTCLL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G66 | LYDTAGQEDYD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K22 | DGAVGKTCLLM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L125 | GTQIDLRDDPK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L166 | VECSALTQKGL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q122 | LLIGTQIDLRD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S164 | CYVECSALTQK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T23 | GAVGKTCLLMS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T41 | EEYVPTVFDHY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V20 | VGDGAVGKTCL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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